| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' K Andersen, T Liljefors, K Gundertofte, J Perregaard, K P B\\xc3\\xb8ges\\xc3\\xb. Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors. Journal of medicinal chemistry. vol 37. issue 7. 1994-05-12. PMID:8151622.' |
other serotonin 5-ht2 receptor antagonists, such as ketanserin and mdl 11,939, are well accommodated into the model. |
1994-05-12 |
2023-08-12 |
Not clear |
| b' K Andersen, T Liljefors, K Gundertofte, J Perregaard, K P B\\xc3\\xb8ges\\xc3\\xb. Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors. Journal of medicinal chemistry. vol 37. issue 7. 1994-05-12. PMID:8151622.' |
comparison of the model with a recently described receptor-interaction model for dopamine d2 receptor antagonists suggests a common pharmacophore for dopamine d2 and serotonin 5-ht2 receptor antagonists. |
1994-05-12 |
2023-08-12 |
Not clear |
| b' K Andersen, T Liljefors, K Gundertofte, J Perregaard, K P B\\xc3\\xb8ges\\xc3\\xb. Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors. Journal of medicinal chemistry. vol 37. issue 7. 1994-05-12. PMID:8151622.' |
important steric differences between 5-ht2 receptor antagonists with additional high affinity for dopamine d2 receptors and serotonin 5-ht2 receptor antagonists with high selectivity versus d2 receptors are described. |
1994-05-12 |
2023-08-12 |
Not clear |
| S De. Physical exercise as a novel antidepressant agent: possible role of serotonin receptor subtypes. Physiology & behavior. vol 55. issue 2. 1994-05-11. PMID:8153173. |
5-ht1a autoreceptor sensitivity was assessed by hyperphagic response induced by 8-oh-dpat (0.25 mg/kg, ip); 5-ht1a postsynaptic receptor by 5-ht syndrome induced by 8-oh-dpat (0.75 mg/kg, ip), and 5 me-odmt (5 mg/kg, ip); and 5-ht2 receptor by wet dog shakes response induced by quipazine (1 mg/kg, ip) and 5meodmt (5 mg/kg, ip). |
1994-05-11 |
2023-08-12 |
rat |
| V Klimek, J Zak-Knapik, M Mackowia. Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain. Journal of psychiatry & neuroscience : JPN. vol 19. issue 1. 1994-05-06. PMID:8148368. |
effects of repeated treatment with fluoxetine and citalopram, 5-ht uptake inhibitors, on 5-ht1a and 5-ht2 receptors in the rat brain. |
1994-05-06 |
2023-08-12 |
rat |
| V Klimek, J Zak-Knapik, M Mackowia. Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain. Journal of psychiatry & neuroscience : JPN. vol 19. issue 1. 1994-05-06. PMID:8148368. |
repeated treatment with fluoxetine and citalopram, which are potent 5-ht reuptake inhibitors, resulted in different regulation of 5-ht1a and 5-ht2 receptors in the rat brain. |
1994-05-06 |
2023-08-12 |
rat |
| V Klimek, J Zak-Knapik, M Mackowia. Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain. Journal of psychiatry & neuroscience : JPN. vol 19. issue 1. 1994-05-06. PMID:8148368. |
the obtained results indicate that besides 5-ht reuptake inhibiting properties of both compounds, there may exist an additional mechanism(s) of their action, which leads to different regulation of 5-ht1a and 5-ht2 receptors. |
1994-05-06 |
2023-08-12 |
rat |
| J M Dickenson, S Bulmer, A Whittaker, M Salwey, J Hawley, S J Hil. Bradykinin B2- and 5-hydroxytryptamine (5-HT2)-receptor stimulated increases in intracellular calcium in cultured guinea-pig aortic smooth muscle cells. Biochemical pharmacology. vol 47. issue 6. 1994-05-05. PMID:8147914. |
bradykinin b2- and 5-hydroxytryptamine (5-ht2)-receptor stimulated increases in intracellular calcium in cultured guinea-pig aortic smooth muscle cells. |
1994-05-05 |
2023-08-12 |
Not clear |
| J M Dickenson, S Bulmer, A Whittaker, M Salwey, J Hawley, S J Hil. Bradykinin B2- and 5-hydroxytryptamine (5-HT2)-receptor stimulated increases in intracellular calcium in cultured guinea-pig aortic smooth muscle cells. Biochemical pharmacology. vol 47. issue 6. 1994-05-05. PMID:8147914. |
the response to 5-ht (100 microm) was abolished by the 5-ht2 receptor antagonist ketanserin (ic50 = 2 +/- 0.4 nm; n = 3). |
1994-05-05 |
2023-08-12 |
Not clear |
| M B Hansen, B M Jaff. 5-HT receptor subtypes involved in luminal serotonin-induced secretion in rat intestine in vivo. The Journal of surgical research. vol 56. issue 3. 1994-05-04. PMID:8145546. |
these results suggest that (1) in both segments of the intestine, 5-ht2, 5-ht3, and/or 5-ht4 receptor subtypes are involved in the regulation of intestinal transport of water and electrolytes under basal conditions; (2) serotonin-induced water and electrolyte secretion is mediated by pathways involving 5-ht2, 5-ht3, and 5-ht4 receptor subtypes in both rat jejunum and ileum; (3) 5-ht1 receptors do not seem to be involved in the mediation of intestinal water and electrolyte transport; (4) these effects are similar to those described for systemically administered 5-ht. |
1994-05-04 |
2023-08-12 |
rat |
| B R Pitt, W Weng, A R Steve, R D Blakely, I Reynolds, P Davie. Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. The American journal of physiology. vol 266. issue 2 Pt 1. 1994-04-28. PMID:8141313. |
cultured smooth muscle cells obtained from rat lung periphery (rpc) and proximal pulmonary artery (rsmc) expressed mrna for serotonin (5-ht) type 2 receptor (5-ht2) and 5-ht transporter (by northern blot analysis). |
1994-04-28 |
2023-08-12 |
rat |
| B R Pitt, W Weng, A R Steve, R D Blakely, I Reynolds, P Davie. Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. The American journal of physiology. vol 266. issue 2 Pt 1. 1994-04-28. PMID:8141313. |
the 5-ht-induced increase in dna synthesis was significantly inhibited in both cell types by the 5-ht2 receptor antagonist, ketanserin (10(-7)-10(-6) m), and by fluoxetine (10(-6) m), a putative 5-ht transport inhibitor. |
1994-04-28 |
2023-08-12 |
rat |
| B R Pitt, W Weng, A R Steve, R D Blakely, I Reynolds, P Davie. Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. The American journal of physiology. vol 266. issue 2 Pt 1. 1994-04-28. PMID:8141313. |
therefore, the 5-ht2 receptor, but not the transporter, is responsible for initiating the acute effects (e.g., calcium transients) of 5-ht in cultured rat pulmonary vascular smooth muscle cells and fluoxetine (1 microm) may have 5-ht2-receptor antagonist properties. |
1994-04-28 |
2023-08-12 |
rat |
| J Yamada, Y Sugimoto, I Kimura, Y Watanabe, K Horisak. Effects of tryptamine on plasma glucagon levels in mice. Neurochemical research. vol 19. issue 1. 1994-04-26. PMID:7908128. |
these findings indicate that tryptamine-induced hyperglucagonemia is elicited by its direct activation of 5-ht2 receptors and is not mediated by levels of endogenous 5-ht and catecholamines. |
1994-04-26 |
2023-08-12 |
mouse |
| J Weidenfeld, A P Corcos, A Wohlman, S Feldma. Characterization of the 2-deoxyglucose effect on the adrenocortical axis. Endocrinology. vol 134. issue 4. 1994-04-26. PMID:8137760. |
the results suggest that: 1) the lateral hypothalamic area is involved in the mediation of the hpa axis responses to 2-dg; 2) crf-41 released from the me plays a dynamic role in mediating the 2-dg-induced adrenocortical response; 3) the effect of 2-dg is sensitive to inhibition by dexamethasone, and the feedback effect exerted by endogenous glucocorticoids is mediated by both type i and type ii corticosteroid receptors; and 4) 5-ht is involved in the activation of the hpa axis after 2-dg via its interactions with 5-ht2 receptors. |
1994-04-26 |
2023-08-12 |
rat |
| M I Noble, A J Drake-Hollan. The role of serotonin 5HT2 receptor antagonism in the control of coronary artery disease. The Quarterly journal of medicine. vol 87. issue 1. 1994-04-25. PMID:8140212. |
the role of serotonin 5ht2 receptor antagonism in the control of coronary artery disease. |
1994-04-25 |
2023-08-12 |
Not clear |
| A Schotte, P F Janssen, A A Megens, J E Leyse. Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography. Brain research. vol 631. issue 2. 1994-04-21. PMID:7510574. |
these particular properties have been attributed to the predominant and very potent serotonin 5-ht2 receptor antagonism of the drug combined with less potent dopamine d2 antagonism. |
1994-04-21 |
2023-08-12 |
rat |
| S Rahman, R S Neuma. Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and heterologous desensitization. Brain research. vol 631. issue 2. 1994-04-21. PMID:8131066. |
myo-inositol reduces serotonin (5-ht2) receptor induced homologous and heterologous desensitization. |
1994-04-21 |
2023-08-12 |
rat |
| R Fontain. Novel serotonergic mechanisms and clinical experience with nefazodone. Clinical neuropharmacology. vol 16 Suppl 3. 1994-04-21. PMID:8131154. |
nefazodone acts both as a 5-ht2 receptor antagonist and as a serotonin (5-ht) reuptake inhibitor. |
1994-04-21 |
2023-08-12 |
Not clear |
| R Fontain. Novel serotonergic mechanisms and clinical experience with nefazodone. Clinical neuropharmacology. vol 16 Suppl 3. 1994-04-21. PMID:8131154. |
nefazodone's potent 5-ht2 antagonism in combination with 5-ht reuptake inhibition appears to enhance 5-ht1a-mediated neurotransmission. |
1994-04-21 |
2023-08-12 |
Not clear |