| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Fontain. Novel serotonergic mechanisms and clinical experience with nefazodone. Clinical neuropharmacology. vol 16 Suppl 3. 1994-04-21. PMID:8131154. |
the two primary effects on serotonergic neurotransmission, 5-ht2 antagonism and 5-ht reuptake inhibition, are thought to contribute importantly to nefazodone's therapeutic efficacy and clinical utility. |
1994-04-21 |
2023-08-12 |
Not clear |
| R Fontain. Novel serotonergic mechanisms and clinical experience with nefazodone. Clinical neuropharmacology. vol 16 Suppl 3. 1994-04-21. PMID:8131154. |
it is postulated that 5-ht2 antagonism dampens the activating side effects experienced by some patients when treated with existing 5-ht reuptake inhibitors. |
1994-04-21 |
2023-08-12 |
Not clear |
| B A Ellenbroek, E P Prinssen, A R Cool. The role of serotonin receptor subtypes in the behavioural effects of neuroleptic drugs. A paw test study in rats. The European journal of neuroscience. vol 6. issue 1. 1994-04-20. PMID:7907518. |
the present study was designed to evaluate the roles of serotonin 5-ht1a and 5-ht2 receptors in the effects of neuroleptic drugs in the paw test. |
1994-04-20 |
2023-08-12 |
rat |
| H Pert. 5-Hydroxytryptamine (5-HT) contracts the guinea-pig isolated iliac artery via 5-HT1-like and 5-HT2 receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 6. 1994-04-20. PMID:8133899. |
5-hydroxytryptamine (5-ht) contracts the guinea-pig isolated iliac artery via 5-ht1-like and 5-ht2 receptors. |
1994-04-20 |
2023-08-12 |
Not clear |
| A Srikiatkhachorn, P Govitrapong, C Limthavo. Up-regulation of 5-HT2 serotonin receptor: a possible mechanism of transformed migraine. Headache. vol 34. issue 1. 1994-04-15. PMID:8132444. |
in order to understand the mechanism underlying this condition, 5-ht2 serotonin receptors on platelets were assayed by the radioligand binding technique. |
1994-04-15 |
2023-08-12 |
Not clear |
| D E Seyler, I R Cohen, S Saute. Effects of the serotonin antagonist amesergide on reproduction in female rats. Reproductive toxicology (Elmsford, N.Y.). vol 7. issue 6. 1994-04-06. PMID:8118111. |
amesergide, a serotonin (5-ht2) antagonist intended to treat depression, was administered orally to female cd rats (20/group) at doses of 0, 3, 10, or 30 mg/kg to evaluate effects on mating, fertility, litter size, live birth index (100 x total liveborn progeny/litter size), progeny survival, and weight gain of each litter. |
1994-04-06 |
2023-08-12 |
rat |
| A C Rovescalli, N Brunello, J Perez, S Vitali, L Steardo, G Racagn. Heterologous sensitization of adenylate cyclase activity by serotonin in the rat cerebral cortex. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 3. issue 4. 1994-03-31. PMID:7906577. |
serotonergic 5ht2 receptors are involved in the sensitization of adenylate cyclase to gppnhp, since the selective 5ht2 antagonist ketanserin inhibits the effect of 5ht, whereas the 5ht2 agonist doi mimics 5ht. |
1994-03-31 |
2023-08-12 |
rat |
| A C Rovescalli, N Brunello, J Perez, S Vitali, L Steardo, G Racagn. Heterologous sensitization of adenylate cyclase activity by serotonin in the rat cerebral cortex. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 3. issue 4. 1994-03-31. PMID:7906577. |
the involvement of 5ht2 receptor-coupled activation of protein kinase c is also demonstrated: direct protein kinase c activators such as phorbol esters and s,n-dioctanoylglycerol behave in the same manner as 5ht, while the protein kinase c inhibitor cgp 41251 prevents 5ht from increasing adenylate cyclase responsiveness to gppnhp. |
1994-03-31 |
2023-08-12 |
rat |
| M P Johnson, R J Loncharich, M Baez, D L Nelso. Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines. Molecular pharmacology. vol 45. issue 2. 1994-03-31. PMID:8114677. |
previous work has suggested that species differences in the structure-activity relationship for ergolines and tryptamines at the 5-hydroxytryptamine (5-ht)2a (formerly known as the 5-ht2) receptor are related to aliphatic substitution at the n1-position on the indole nucleus. |
1994-03-31 |
2023-08-12 |
human |
| A S Eison, M S Eiso. Serotonergic mechanisms in anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 18. issue 1. 1994-03-31. PMID:8115673. |
the advent of selective agonists and antagonists for 5-ht receptor subtypes (5-ht1, 5-ht2, 5-ht3) has rekindled investigation of the role of 5-ht in anxiety mechanisms. |
1994-03-31 |
2023-08-12 |
Not clear |
| K Yanai, T Watanab. [Visualization of neurotransmitter receptors in the living human brain by position emission tomography (PET)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 103. issue 2. 1994-03-28. PMID:8112689. |
pet also makes it possible for the first time to evaluate the states of various types of neurotransmitter receptors, such as dopamine d2 and d1, serotonin 5-ht2, muscarinic cholinergic, opiate, benzodiazepine and histamine h1, and to determine the state of monoamine oxidase (a and b) under in vivo conditions. |
1994-03-28 |
2023-08-12 |
human |
| S W Watts, M L Cohen, P Q Mooney, B G Johnson, D D Schoepp, M Bae. Disruption of potential alpha-helix in the G loop of the guinea pig 5-hydroxytryptamine2 receptor does not prevent receptor coupling to phosphoinositide hydrolysis. Journal of neurochemistry. vol 62. issue 3. 1994-03-28. PMID:8113814. |
5-ht and the 5-ht2 receptor agonist alpha-methyl-5-ht increased pi hydrolysis in guinea pig cortical slices whereas the 5-ht1c receptor agonist 5-methyltryptamine was significantly less potent. |
1994-03-28 |
2023-08-12 |
rat |
| H Shimamoto, Y Shimamoto, C Y Kwan, E E Danie. Amplification of 5-hydroxytryptamine-induced contractile responses via 5-hydroxytryptamine receptors and alpha-adrenoceptors in dog mesenteric artery and vein. The Journal of pharmacology and experimental therapeutics. vol 268. issue 2. 1994-03-28. PMID:8113990. |
in the dog mesenteric vein, kcl enhanced 5-ht responses via amplification of both 5-ht2 receptor- and alpha-2 adrenoceptor-mediated responses. |
1994-03-28 |
2023-08-12 |
dog |
| M J Owens, C B Nemerof. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clinical chemistry. vol 40. issue 2. 1994-03-24. PMID:7508830. |
these findings include the following: (a) reduced cerebrospinal fluid (csf) concentrations of 5-hydroxyindoleacetic acid (5-hiaa), the major metabolite of serotonin (5-ht) in drug-free depressed patients; (b) reduced concentrations of 5-ht and 5-hiaa in postmortem brain tissue of depressed and (or) suicidal patients; (c) decreased plasma tryptophan concentrations in depressed patients and a profound relapse in remitted depressed patients who have responded to a serotonergic antidepressant when brain tryptophan availability is reduced; (d) in general, all clinically efficacious antidepressants augment 5-ht neurotransmission following chronic treatment; (e) clinically efficacious antidepressant action by all inhibitors of 5-ht uptake; (f) increases in the density of 5-ht2 binding sites in postmortem brain tissue of depressed patients and suicide victims, as well as in platelets of drug-free depressed patients; (g) decreased number of 5-ht transporter (determined with [3h]imipramine or [3h]paroxetine) binding sites in postmortem brain tissue of suicide victims and depressed patients and in platelets of drug-free depressed patients. |
1994-03-24 |
2023-08-12 |
Not clear |
| J G Csernansky, Y I Shelin. Abnormalities of serotonin metabolism and nonpsychotic psychiatric disorders. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 5. issue 4. 1994-03-23. PMID:8312985. |
results from studies that have employed a variety of 5-ht measures, including the assessment of cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations, 5-ht uptake site densities, and 5-ht2 receptor densities in brain tissue and on platelets, and prolactin increases following fenfluramine administration, provide support for these two hypotheses. |
1994-03-23 |
2023-08-12 |
Not clear |
| S W Ying, D X Zhang, B Rusa. Effects of serotonin agonists and melatonin on photic responses of hamster intergeniculate leaflet neurons. Brain research. vol 628. issue 1-2. 1994-03-23. PMID:8313174. |
neither of two 5-ht2 antagonists tested was able to block the effects of 5-ht. |
1994-03-23 |
2023-08-12 |
Not clear |
| J L Cummings, E V Cilento, F D Reill. Hepatic microvascular regulatory mechanisms. XII. Effects of 5-HT2-receptor blockade on serotonin-induced intralobular hypoperfusion. International journal of microcirculation, clinical and experimental. vol 13. issue 2. 1994-03-17. PMID:8307709. |
these results, in the concert with those from previous studies characterizing 5-ht vasoresponsiveness in the liver, suggest that: a) constrictor 5-ht2 receptors are localized on hepatic sinusoids, and b) 5-ht-provoked hypoperfusion is mediated by activation of the 5-ht2-receptor subtype. |
1994-03-17 |
2023-08-12 |
rat |
| P J Gilligan, A A Kergaye, B M Lewis, J F McElro. Piperidinyltetralin sigma ligands. Journal of medicinal chemistry. vol 37. issue 3. 1994-03-15. PMID:7905926. |
compound 15 (dup 734) is a combined antagonist of sigma-1 and serotonin 5ht2 receptors, which has been entered into phase i clinical trials as a potential antipsychotic drug. |
1994-03-15 |
2023-08-12 |
rat |
| P J Gilligan, A A Kergaye, B M Lewis, J F McElro. Piperidinyltetralin sigma ligands. Journal of medicinal chemistry. vol 37. issue 3. 1994-03-15. PMID:7905926. |
a reduced derivative, 14, had high affinity for sigma-1 and serotonin 5ht2 receptors as well as excellent oral activity in some animal antipsychotic models. |
1994-03-15 |
2023-08-12 |
rat |
| F Hery, M Hamo. [Neuroleptics and serotonin]. L'Encephale. vol 19. issue 5. 1994-03-14. PMID:7905821. |
these studies not only demonstrate the existence of several classes of serotonin receptors called 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, 5-ht2, 5-ht3 and 5-ht4, but led also to the development of novel agonists and antagonists for the stimulation or blockade of each of them. |
1994-03-14 |
2023-08-12 |
Not clear |