| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Zhang, I Crees. Antisense oligodeoxynucleotide reduces brain dopamine D2 receptors: behavioral correlates. Neuroscience letters. vol 161. issue 2. 1994-02-03. PMID:7903803. |
intraventricular infusion of an antisense oligodeoxynucleotide corresponding to the rat dopamine d2 receptor mrna reduced rat striatal d2 receptors by 485, as measured by homogenate binding assays, while d1, muscarinic, and serotonin 5-ht2 receptors were unaffected. |
1994-02-03 |
2023-08-12 |
rat |
| S Elz, H Zimmermann, K Rehs. Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure-activity relationships and in vitro pharmacology of N-alkyl- and N,N-dialkyl-3- indolylbicyclo-[2.2.1]-heptane-2-amines. Archiv der Pharmazie. vol 326. issue 11. 1994-02-03. PMID:8274071. |
twenty-four norbornane analogues of tryptamine and 5-methoxytryptamine were investigated for affinity at 5-ht2 receptors of the rat tail artery and proved to be weak non-competitive antagonists of 5-ht. |
1994-02-03 |
2023-08-12 |
rat |
| N N Osborne, F Fitzgibbon, M Nash, N P Liu, R Leslie, A Cholewinsk. Serotonergic, 5-HT2, receptor-mediated phosphoinositide turnover and mobilization of calcium in cultured rat retinal pigment epithelium cells. Vision research. vol 33. issue 16. 1994-02-02. PMID:8273284. |
serotonin analogues like tryptamine, 5-methoxytryptamine, alpha-methyl-serotonin and the 5-ht2 agonists quipazine and doi (1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane) all stimulated insps accumulation to some degree. |
1994-02-02 |
2023-08-12 |
rat |
| B C Baguley, G Cole, L L Thomsen, Z L. Serotonin involvement in the antitumour and host effects of flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid. Cancer chemotherapy and pharmacology. vol 33. issue 1. 1994-02-01. PMID:8269593. |
on the other hand, administration of the serotonin 5-hydroxytryptamine-2 (5-ht2) antagonist cyproheptadine (20 mg/kg) inhibited both the plasma nitrate response and, to a lesser extent, the induction of tumour haemorrhagic necrosis by 5,6-mexaa, faa and tnf. |
1994-02-01 |
2023-08-12 |
Not clear |
| R G Johnson, D Fiorella, R A Rabi. Effects of chronic cocaine administration on the serotonergic system in the rat brain. Pharmacology, biochemistry, and behavior. vol 46. issue 2. 1994-01-27. PMID:7505454. |
thus, repeated administration of cocaine causes region-specific alterations in 5-ht levels but does not change the properties of the 5-ht1a, 5-ht1c, or 5-ht2 receptors. |
1994-01-27 |
2023-08-12 |
rat |
| C K Buckner, N Liberati, D Dea, D Lengel, C Stinson-Fisher, J Campbell, S Miller, A Shenvi, R D Krel. Differential blockade by tachykinin NK1 and NK2 receptor antagonists of bronchoconstriction induced by direct-acting agonists and the indirect-acting mimetics capsaicin, serotonin and 2-methyl-serotonin in the anesthetized guinea pig. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263778. |
when used alone, only (+/-)-sr48968 was found to block bronchoconstriction caused by capsaicin, serotonin (after blockade of 5-ht2 receptors by ly53857) and 2-methyl-serotonin. |
1994-01-27 |
2023-08-12 |
Not clear |
| C L Lawton, J E Blundel. 5-HT and carbohydrate suppression: effects of 5-HT antagonists on the action of d-fenfluramine and DOI. Pharmacology, biochemistry, and behavior. vol 46. issue 2. 1994-01-27. PMID:8265689. |
therefore, the suppressive effect of these two 5-ht drugs on total and polycose intake appears to be mediated, respectively, by 5-ht1b/5-ht1c receptors (d-fenfluramine) and 5-ht2 receptors (doi). |
1994-01-27 |
2023-08-12 |
rat |
| T J Verbeure. Vasodilator effect of tertatolol in isolated perfused rat kidneys: involvement of endothelial 5-HT1A receptors. Cardiology. vol 83 Suppl 1. 1994-01-25. PMID:7903215. |
in the presence of ritanserin and ics 205930, to block 5-ht2 and 5-ht3 receptors, tertatolol, 5-ht, 5-carboxamidotryptamine (5-ct) and 8-hydroxy-2 (di-n-propylamino) tetralin (8-oh-dpat) all evoked renal vasodilator responses that were significantly reduced by the nonselective 5-ht antagonist metergoline and by the selective 5-ht1a antagonist bmy 7378 suggesting that 5-ht1 receptors resembling the 5-ht1a subtype were involved. |
1994-01-25 |
2023-08-12 |
rat |
| P J Kontur, M al-Tikriti, R B Innis, R H Rot. Postmortem stability of monoamines, their metabolites, and receptor binding in rat brain regions. Journal of neurochemistry. vol 62. issue 1. 1994-01-24. PMID:7505313. |
binding of raclopride to dopamine d2, sch-23390 to dopamine d1, ketanserin to serotonin 5-ht2, 8-hydroxy-2-(di-n-propylamino)tetralin to serotonin 5-ht1a, and cholecystokinin (cck)-8 to cck-b sites was measured in tissue homogenates from the striatum or fronto-parietal cortex. |
1994-01-24 |
2023-08-12 |
human |
| G J Grover, C A Sargent, S Dzwonczyk, D E Normandin, M J Antonacci. Protective effect of serotonin (5-HT2) receptor antagonists in ischemic rat hearts. Journal of cardiovascular pharmacology. vol 22. issue 4. 1994-01-24. PMID:7505371. |
protective effect of serotonin (5-ht2) receptor antagonists in ischemic rat hearts. |
1994-01-24 |
2023-08-12 |
rat |
| G J Grover, C A Sargent, S Dzwonczyk, D E Normandin, M J Antonacci. Protective effect of serotonin (5-HT2) receptor antagonists in ischemic rat hearts. Journal of cardiovascular pharmacology. vol 22. issue 4. 1994-01-24. PMID:7505371. |
therefore, 5-ht may exacerbate ischemic injury in rat heart, and this exacerbation appears to be mediated specifically by 5-ht2 receptors. |
1994-01-24 |
2023-08-12 |
rat |
| F van Huizen, M T Bansse, N J Sta. Agonist-induced down-regulation of human 5-HT1A and 5-HT2 receptors in Swiss 3T3 cells. Neuroreport. vol 4. issue 12. 1994-01-24. PMID:8260615. |
the pertussis toxin insensitive, 5-ht mediated pi turnover in 5-ht2 receptor transfected cells was decreased by 65% after pre-treatment. |
1994-01-24 |
2023-08-12 |
human |
| A Agarwal, P P Pearson, E W Taylor, H B Li, T Dahlgren, M Herslöf, Y Yang, G Lambert, D L Nelson, J W Rega. Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods. Journal of medicinal chemistry. vol 36. issue 25. 1994-01-18. PMID:8258822. |
a series of new derivatives of 3-(1,2,5,6-tetrahydropyridin-4-yl)indole (4-thpi) has been synthesized, and their dissociation constants at the 5-ht1a and 5-ht2 serotonin (5-ht) receptor subtypes have been determined. |
1994-01-18 |
2023-08-12 |
Not clear |
| C M Faull, J A Charlton, T J Butler, P H Bayli. The effect of acute pharmacological manipulation of central serotonin neurotransmission on osmoregulated secretion of arginine vasopressin in the rat. The Journal of endocrinology. vol 139. issue 1. 1994-01-10. PMID:8254296. |
fluoxetine (fl) a 5-ht reuptake inhibitor (10 mg/kg body weight), ritanserin (rit), an antagonist at the 5-ht2 and 5-ht1c receptor subtypes (1 mg/kg body weight), 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (doi), a 5-ht2 receptor agonist (1 mg/kg body weight) or vehicle to rats 30 min before they were given an osmotic challenge. |
1994-01-10 |
2023-08-12 |
rat |
| J C Tinajero, A Fabbri, D R Ciocca, M L Dufa. Serotonin secretion from rat Leydig cells. Endocrinology. vol 133. issue 6. 1994-01-06. PMID:8243331. |
in rat leydig cells, serotonin (5ht) binds to 5ht2 receptors and stimulates the secretion of crf which in turn acts as an inhibitor of gonadotropin-induced camp formation and androgen production. |
1994-01-06 |
2023-08-12 |
rat |
| R H Mach, R R Luedtke, C D Unsworth, V A Boundy, P A Nowak, J G Scripko, S T Elder, J R Jackson, P L Hoffman, P H Evor. 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. Journal of medicinal chemistry. vol 36. issue 23. 1994-01-06. PMID:8246241. |
two series of (n-benzylpiperidin-4-yl)- and (9-azabicyclo[3.3.1]nonan- 3 beta-yl)benzamides were prepared, and in vitro binding assays were used to measure the affinity of these compounds for dopamine d2, dopamine d3, serotonin 5-ht2, and alpha 2-adrenergic receptors. |
1994-01-06 |
2023-08-12 |
Not clear |
| P D Hrdina, T B V. Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: an autoradiographic study. Synapse (New York, N.Y.). vol 14. issue 4. 1994-01-03. PMID:8248854. |
chronic fluoxetine treatment upregulates 5-ht uptake sites and 5-ht2 receptors in rat brain: an autoradiographic study. |
1994-01-03 |
2023-08-12 |
rat |
| P D Hrdina, T B V. Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: an autoradiographic study. Synapse (New York, N.Y.). vol 14. issue 4. 1994-01-03. PMID:8248854. |
this study was undertaken to investigate the effect of chronic treatment with fluoxetine, a selective serotonin uptake inhibitor used widely in the treatment of depression, on the distribution and density of 5-ht uptake sites, 5-ht2 receptors, and vesicular amine uptake sites in rat brain. |
1994-01-03 |
2023-08-12 |
rat |
| P D Hrdina, T B V. Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: an autoradiographic study. Synapse (New York, N.Y.). vol 14. issue 4. 1994-01-03. PMID:8248854. |
the density of 5-ht uptake sites labelled by [3h]paroxetine, 5-ht2 receptors labelled by [3h]ketanserin in presence of tetrabenazine and vesicular amine uptake sites labelled by [3h]ketanserin in the presence of mianserin were measured by quantitative autoradiography in 22 areas of rat brain, using coronal tissue sections. |
1994-01-03 |
2023-08-12 |
rat |
| P D Hrdina, T B V. Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: an autoradiographic study. Synapse (New York, N.Y.). vol 14. issue 4. 1994-01-03. PMID:8248854. |
the observed alterations in 5-ht uptake site and 5-ht2 receptor densities are likely a part of adaptive neuronal changes that occur after chronic administration of fluoxetine and may be related to the antidepressant effect of the drug. |
1994-01-03 |
2023-08-12 |
rat |