| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Hasséssian, P Poulat, E Hamel, T A Reader, R Coutur. Spinal cord serotonin receptors in cardiovascular regulation and potentiation of the pressor response to intrathecal substance P after serotonin depletion. Canadian journal of physiology and pharmacology. vol 71. issue 7. 1993-12-23. PMID:7694781. |
the results suggest that the receptor mediating the depressor response to 5-ht and 5-ct conforms with the broad pharmacological profile of a 5-ht1-like receptor and is unlikely to be of the 5-ht2 or 5-ht3 subtype. |
1993-12-23 |
2023-08-12 |
rat |
| H Hasséssian, P Poulat, E Hamel, T A Reader, R Coutur. Spinal cord serotonin receptors in cardiovascular regulation and potentiation of the pressor response to intrathecal substance P after serotonin depletion. Canadian journal of physiology and pharmacology. vol 71. issue 7. 1993-12-23. PMID:7694781. |
in addition, the results raise the possibility that a spinal 5-ht input, likely mediated by 5-ht2 receptors, tonically inhibits hr. |
1993-12-23 |
2023-08-12 |
rat |
| N L Barnett, N N Osborn. The effect of serotonin on the rabbit isolated iris sphincter muscle. Current eye research. vol 12. issue 7. 1993-12-13. PMID:8222726. |
while 5-ht3 receptors are not involved in the described process, a minor involvement of 5-ht2 receptors cannot be excluded as methysergide partially counteracted the serotonin response. |
1993-12-13 |
2023-08-12 |
rabbit |
| W A Bax, G J Renzenbrink, D Van Heuven-Nolsen, E J Thijssen, E Bos, P R Saxen. 5-HT receptors mediating contractions of the isolated human coronary artery. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:7693489. |
it is concluded that although 5-ht2 receptors predominantly mediate 5-ht-induced contractions, the 5-ht1-like receptor seems to play a role in coronary vasospasm caused by low concentrations of 5-ht. |
1993-12-01 |
2023-08-12 |
human |
| C Garner, W Feniuk, P D Brow. Serotonin activates Cl- channels in the apical membrane of rat choroid plexus epithelial cells. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:8223911. |
the effect of 1 microm serotonin on channel activity was inhibited by ritanserin (30 and 100 nm) which has a high affinity for serotonin 5-ht1c receptors and 5-ht2 receptors. |
1993-12-01 |
2023-08-12 |
rat |
| C Garner, W Feniuk, P D Brow. Serotonin activates Cl- channels in the apical membrane of rat choroid plexus epithelial cells. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:8223911. |
spiperone (30 nm), which binds weakly to 5-ht1c receptors but has a high affinity for 5-ht2 receptors, did not inhibit the actions of serotonin. |
1993-12-01 |
2023-08-12 |
rat |
| E L Barker, E Sanders-Bus. 5-hydroxytryptamine1C receptor density and mRNA levels in choroid plexus epithelial cells after treatment with mianserin and (-)-1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane. Molecular pharmacology. vol 44. issue 4. 1993-11-29. PMID:8232222. |
5-hydroxytryptamine (5ht)1c and 5ht2 receptors display paradoxical down-regulation when exposed to receptor antagonists in vivo, a property that is unique to these two subtypes of serotonin (5ht) receptors. |
1993-11-29 |
2023-08-12 |
rat |
| J M Azorin, D Dassa, M Jalfr. [The atypical neuroleptic concept]. L'Encephale. vol 18 Spec No 3. 1993-11-19. PMID:1364079. |
relatively higher affinity for the serotonin (5ht2) receptor than for the d2 receptor may be important to the action of clozapine-like compounds. |
1993-11-19 |
2023-08-11 |
Not clear |
| X Huang, D E Nichol. 5-HT2 receptor-mediated potentiation of dopamine synthesis and central serotonergic deficits. European journal of pharmacology. vol 238. issue 2-3. 1993-11-09. PMID:8104811. |
rats were treated with the selective 5-ht2 receptor agonist (r)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (r-doi), the selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindan (mmai), amphetamine, mdma, or a combination of amphetamine and r-doi or mmai, followed by the l-dihydroxyphenylalanine (dopa) decarboxylase inhibitor 3-hydroxybenzylhydrazine (nsd-1015). |
1993-11-09 |
2023-08-12 |
rat |
| B Arranz, A Eriksson, E Mellerup, P Plenge, J Marcusso. Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. Brain research. vol 620. issue 1. 1993-11-09. PMID:8402192. |
5-ht1a, 5-ht1d, 5-ht2 binding sites and affinity and 5-ht uptake sites were simultaneously determined in frontal cortex samples from 23 control subjects, aged 16-75 years. |
1993-11-09 |
2023-08-12 |
human |
| S Rahman, R S Neuma. Multiple mechanisms of serotonin 5-HT2 receptor desensitization. European journal of pharmacology. vol 238. issue 2-3. 1993-11-09. PMID:8405090. |
multiple mechanisms of serotonin 5-ht2 receptor desensitization. |
1993-11-09 |
2023-08-12 |
rat |
| S Rahman, R S Neuma. Multiple mechanisms of serotonin 5-HT2 receptor desensitization. European journal of pharmacology. vol 238. issue 2-3. 1993-11-09. PMID:8405090. |
desensitization of serotonin 5-ht2 receptor-mediated enhancement of the n-methyl-d-aspartate (nmda) depolarization was studied in rat cortical neurons. |
1993-11-09 |
2023-08-12 |
rat |
| S Rahman, R S Neuma. Multiple mechanisms of serotonin 5-HT2 receptor desensitization. European journal of pharmacology. vol 238. issue 2-3. 1993-11-09. PMID:8405090. |
we conclude that serotonin 5-ht2 receptors both induce and undergo several forms of desensitization. |
1993-11-09 |
2023-08-12 |
rat |
| A Siriwardena, J M Kellu. A 5-HT2 receptor mediates serotonin-induced electrolyte transport in rat left colon. The Journal of surgical research. vol 55. issue 3. 1993-11-04. PMID:8412118. |
the preferential 5-ht2 antagonist ketanserin produced a rightward shift of the serotonin concentration-response curve with a pa2 value of 7.7. |
1993-11-04 |
2023-08-12 |
rat |
| M J Martinelli, W Bloomquist, B C Peterson, M L Cohe. Amesergide and structurally related nor-D-ergolines: 5HT2 receptor interactions in the rat. Journal of medicinal chemistry. vol 36. issue 18. 1993-10-29. PMID:8410979. |
the desisopropyl tricyclic ergolines possessed some modest pressor activity that was unlikely to be related to 5ht2 receptor activation since these compounds did not inhibit the pressor response to serotonin. |
1993-10-29 |
2023-08-12 |
rat |
| M F Massey, M G Davies, E Svendsen, M L Klyachkin, L B Schwartz, L Barber, R L McCann, P O Hage. Reduction of experimental vein graft intimal hyperplasia by ketanserin. The Journal of surgical research. vol 54. issue 6. 1993-10-29. PMID:8412062. |
experimental vein grafts (vg) in the rabbit develop intimal hyperplasia and a contractile response to serotonin (5-ht), mediated by a 5-ht2 receptor. |
1993-10-29 |
2023-08-12 |
rabbit |
| A Lund, N Mjelle. Chronic, combined treatment with desipramine and mianserin: enhanced 5-HT1A receptor function and altered 5-HT1A/5-HT2 receptor interaction in rats. Pharmacology, biochemistry, and behavior. vol 45. issue 4. 1993-10-26. PMID:8415816. |
the functional sensitivity of the 5-hydroxytryptamine (5-ht)1a receptor, and the functional interaction between the 5-ht1a and the 5-ht2 receptors were investigated after treatment with desipramine and mianserin either alone or combined for 21-28 days. |
1993-10-26 |
2023-08-12 |
rat |
| S K Min, C S Rhee, C E Kim, D Y Kan. Risperidone versus haloperidol in the treatment of chronic schizophrenic patients: a parallel group double-blind comparative trial. Yonsei medical journal. vol 34. issue 2. 1993-10-20. PMID:7691017. |
this study has demonstrated that the combined serotonin 5-ht2 and dopamine-d2 antagonist risperidone is an antipsychotic as potent as haloperidol. |
1993-10-20 |
2023-08-12 |
Not clear |
| A S Linden, D J Desmecht, H Amory, F A Rollin, P M Lekeu. Comparison of three metrenperone dosage regimens inhibiting the 5-hydroxytryptamine-induced pulmonary dysfunction in cattle. Research in veterinary science. vol 55. issue 1. 1993-10-19. PMID:8378609. |
the effects of a 5-hydroxytryptamine (5-ht) challenge infusion on pulmonary function values were studied in healthy calves, pretreated with varying doses of metrenperone, a selective type 2 serotonergic (5-ht2) antagonist. |
1993-10-19 |
2023-08-12 |
cattle |
| A S Linden, D J Desmecht, H Amory, F A Rollin, P M Lekeu. Comparison of three metrenperone dosage regimens inhibiting the 5-hydroxytryptamine-induced pulmonary dysfunction in cattle. Research in veterinary science. vol 55. issue 1. 1993-10-19. PMID:8378609. |
it is concluded that, if 5-ht is involved in the pathophysiological processes of respiratory diseases in cattle, a 5-ht2 blockade with metrenperone at a dose rate of 0.100 mg kg-1 and with a dosage interval of 12 hours should improve pulmonary function. |
1993-10-19 |
2023-08-12 |
cattle |