| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P D Hrdina, E Demeter, T B Vu, P Sótónyi, M Palkovit. 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala. Brain research. vol 614. issue 1-2. 1993-09-14. PMID:8348328. |
the ratio between the density of presynaptic 5-ht uptake sites and postsynaptic 5-ht2 receptors in amygdala was significantly lower in suicide/depressives than in controls. |
1993-09-14 |
2023-08-12 |
Not clear |
| E Tanaka, N Baba, K Toshida, K Suzuk. Serotonin stimulates steroidogenesis in rat preovulatory follicles: involvement of 5-HT2 receptor. Life sciences. vol 53. issue 7. 1993-09-10. PMID:8350670. |
serotonin stimulates steroidogenesis in rat preovulatory follicles: involvement of 5-ht2 receptor. |
1993-09-10 |
2023-08-12 |
rat |
| E Tanaka, N Baba, K Toshida, K Suzuk. Serotonin stimulates steroidogenesis in rat preovulatory follicles: involvement of 5-HT2 receptor. Life sciences. vol 53. issue 7. 1993-09-10. PMID:8350670. |
the role of serotonin (5-ht) in the regulation of steroidogenesis in the ovary via 5-ht2 receptor was studied in normal cycling rats and their preovulatory follicles. |
1993-09-10 |
2023-08-12 |
rat |
| E Tanaka, N Baba, K Toshida, K Suzuk. Serotonin stimulates steroidogenesis in rat preovulatory follicles: involvement of 5-HT2 receptor. Life sciences. vol 53. issue 7. 1993-09-10. PMID:8350670. |
the present study suggests that 5-ht stimulates steroidogenesis in the metabolic pathway prior to pregnenolone in rat preovulatory follicles and the action of 5-ht could possibly be mediated by a 5-ht2 receptor. |
1993-09-10 |
2023-08-12 |
rat |
| B Genicot, F Mouligneau, J K Lindsey, P Lambert, R Close, P Lekeu. Induction of serotonin-S2 receptor blockade during early or late stage of acute respiratory distress syndrome in double-muscled calves: a comparative study. Zentralblatt fur Veterinarmedizin. Reihe A. vol 40. issue 4. 1993-09-02. PMID:8342355. |
metrenperone, a 5-hydroxytryptamine (5-ht2) blocker, was injected (intramuscularly, 5 times, at 12 hourly intervals, dose rate: 0.1 mg/kg) to (1) 58 calves referred to our laboratory after a treatment (group i) which lasted from 3 to 5 days and which did not improve the clinical status of the animals and (2) 36 calves investigated as soon as first clinical signs occurred (group ii). |
1993-09-02 |
2023-08-12 |
Not clear |
| W Loots, F De Clerc. 5-Hydroxytryptamine dominates over thromboxane A2 in reducing collateral blood flow by activated platelets. The American journal of physiology. vol 265. issue 1 Pt 2. 1993-08-27. PMID:8342629. |
blockade of 5-hydroxytryptamine (5-ht) subtype 2 (5-ht2) receptors for 5-ht (ketanserin or ritanserin, 0.63 mg/kg iv, -10 min) or amine depletion (reserpine, 0.1 mg/kg im, -10 days, + parachlorophenylalanine 100 mg/kg sc daily for 3 days), but not cyclooxygenase inhibition (indomethacin, 5 mg/kg iv) or thromboxane (tx) a2/prostaglandin endoperoxide receptor antagonism (sulotroban, 2.5 mg/kg iv), largely prevented the collagen-induced perfusion defect without interfering substantially with the platelet activation process. |
1993-08-27 |
2023-08-12 |
cat |
| P Roevens, F De Clerck, D de Chaffoy de Courcelle. The synergistic effect of 5-hydroxytryptamine and epinephrine on the human platelet is related to the activation of phospholipase C. European journal of pharmacology. vol 245. issue 3. 1993-08-26. PMID:8335063. |
ketanserin, a 5ht2 receptor antagonist completely blocked the response of 5-ht plus epinephrine and this in the nanomolar concentration range in which the drug selectively antagonizes 5-ht2 receptor-mediated responses. |
1993-08-26 |
2023-08-12 |
human |
| S Wieland, C T Fischette, I Luck. Effect of chronic treatments with tandospirone and imipramine on serotonin-mediated behavioral responses and monoamine receptors. Neuropharmacology. vol 32. issue 6. 1993-08-25. PMID:8393153. |
the behaviors examined were the 5-ht behavioral syndrome elicited by the 5-ht1a receptor agonist 8-oh-dpat and the head shake response produced by the 5-ht2 receptor agonist dob. |
1993-08-25 |
2023-08-12 |
rat |
| R F Kauffman, J S Bean, W E Bloomquist, M L Cohe. Vascular serotonin 5-hydroxytryptamine2 receptor blockade by LY215840: lack of effect upon neointima formation in balloon-injured rat carotid arteries. The Journal of pharmacology and experimental therapeutics. vol 266. issue 1. 1993-08-19. PMID:8331571. |
5-hydroxytryptamine (5-ht) is mitogenic for vascular smooth muscle cells, an effect that may result from 5-ht2 receptor activation. |
1993-08-19 |
2023-08-12 |
rat |
| M Oka, K Hasunuma, S A Webb, T J Stelzner, D M Rodman, I F McMurtr. EDRF suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs. The American journal of physiology. vol 264. issue 6 Pt 1. 1993-08-13. PMID:8333550. |
bioassay of hypertensive lung perfusate did not detect a circulating vasoconstrictor, and l-nna vasoconstriction was not inhibited by blockers of cyclooxygenase, 5-lipoxygenase, platelet-activating factor receptors, alpha-adrenoceptors, and serotonin 5-ht2 receptors or by scavengers of superoxide anion and h2o2. |
1993-08-13 |
2023-08-12 |
rat |
| L Rydelek-Fitzgerald, B D Wilcox, M Teitler, J J Jeffre. Serotonin-mediated 5-HT2 receptor gene regulation in rat myometrial smooth muscle cells. Molecular and cellular endocrinology. vol 92. issue 2. 1993-08-05. PMID:8319829. |
northern blot analysis indicates that serotonin increases levels of 5-ht2 receptor mrna in cells by approximately 4-fold. |
1993-08-05 |
2023-08-12 |
rat |
| L Rydelek-Fitzgerald, B D Wilcox, M Teitler, J J Jeffre. Serotonin-mediated 5-HT2 receptor gene regulation in rat myometrial smooth muscle cells. Molecular and cellular endocrinology. vol 92. issue 2. 1993-08-05. PMID:8319829. |
detectable increases in mrna levels occur within 2 h after administration of serotonin with maximal levels occurring after 12 h. the 5-ht2 receptor antagonists, ketanserin and spiperone, inhibit the serotonin-mediated increase in receptor mrna. |
1993-08-05 |
2023-08-12 |
rat |
| L Rydelek-Fitzgerald, B D Wilcox, M Teitler, J J Jeffre. Serotonin-mediated 5-HT2 receptor gene regulation in rat myometrial smooth muscle cells. Molecular and cellular endocrinology. vol 92. issue 2. 1993-08-05. PMID:8319829. |
selective 5-ht2 receptor agonists ((+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hcl (doi) and quipazine) mimic the effect of serotonin, whereas 5-ht1 and 5-ht3 receptor agonists ((+/-)-8-hydroxydipropylaminotetralin (8-oh-dpat), 1-(3-chlorophenyl)piperazine dihydrochloride (mcpp), m-phenylbiguanide) have no effect. |
1993-08-05 |
2023-08-12 |
rat |
| L Rydelek-Fitzgerald, B D Wilcox, M Teitler, J J Jeffre. Serotonin-mediated 5-HT2 receptor gene regulation in rat myometrial smooth muscle cells. Molecular and cellular endocrinology. vol 92. issue 2. 1993-08-05. PMID:8319829. |
these data demonstrate that serotonin induces an increase in 5-ht2 receptor mrna by interacting with the 5-ht2 receptor itself. |
1993-08-05 |
2023-08-12 |
rat |
| L Rydelek-Fitzgerald, B D Wilcox, M Teitler, J J Jeffre. Serotonin-mediated 5-HT2 receptor gene regulation in rat myometrial smooth muscle cells. Molecular and cellular endocrinology. vol 92. issue 2. 1993-08-05. PMID:8319829. |
nuclear run-on analysis revealed that serotonin increases the initiation of 5-ht2 receptor mrna synthesis. |
1993-08-05 |
2023-08-12 |
rat |
| E Glusa, M Richte. Endothelium-dependent relaxation of porcine pulmonary arteries via 5-HT1C-like receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 5. 1993-08-05. PMID:8391650. |
the 5-ht1c and 5-ht2 receptor agonist alpha-methyl-5-ht was as potent as 5-ht in inducing relaxation. |
1993-08-05 |
2023-08-12 |
Not clear |
| D I Lewis, E Sermasi, J H Coot. Excitatory and indirect inhibitory actions of 5-hydroxytryptamine on sympathetic preganglionic neurones in the neonate rat spinal cord in vitro. Brain research. vol 610. issue 2. 1993-08-03. PMID:8319089. |
the results suggest that the excitatory action of 5-ht on spn is mediated via an atypical 5-ht2 receptor or a 5-ht1c-like receptor. |
1993-08-03 |
2023-08-12 |
rat |
| F Cerrito, M P Lazzaro, E Gaudio, P Arminio, G Alois. 5HT2-receptors and serotonin release: their role in human platelet aggregation. Life sciences. vol 53. issue 3. 1993-08-03. PMID:8321084. |
in fact, although it is known that 5-ht added to prp was only able to induce a moderate platelet aggregation, the 5-ht2 antagonist ketanserin counteracted the aggregation induced by adp, epinephrine and thrombin. |
1993-08-03 |
2023-08-12 |
human |
| F Cerrito, M P Lazzaro, E Gaudio, P Arminio, G Alois. 5HT2-receptors and serotonin release: their role in human platelet aggregation. Life sciences. vol 53. issue 3. 1993-08-03. PMID:8321084. |
these results suggest that a 5ht2 antagonist could be therapeutically important in those pathological states in which serotonin, released by activated platelets, may increase aggregation. |
1993-08-03 |
2023-08-12 |
human |
| M H Pietraszek, Y Takada, A Taminato, T Yoshimi, I Watanabe, A Takad. The effect of MCI-9042 on serotonin-induced platelet aggregation in type 2 diabetes mellitus. Thrombosis research. vol 70. issue 2. 1993-08-03. PMID:8322284. |
mci-9042, a potent inhibitor of 5ht2 receptor, was used to examine its effects on serotonin induced-aggregation of platelets obtained from patients with type 2 diabetes mellitus (dm). |
1993-08-03 |
2023-08-12 |
Not clear |