Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
J C Tinajero, A Fabbri, M L Dufa. Serotonergic inhibition of rat Leydig cell function by propranolol. Endocrinology. vol 133. issue 1. 1993-08-03. PMID:8391422. |
the beta-adrenergic antagonist propranolol binds to serotonin (5ht) receptors (5ht1b > 5ht1a > 5ht2) in brain membranes. |
1993-08-03 |
2023-08-12 |
rat |
J C Tinajero, A Fabbri, M L Dufa. Serotonergic inhibition of rat Leydig cell function by propranolol. Endocrinology. vol 133. issue 1. 1993-08-03. PMID:8391422. |
we have recently demonstrated that 5ht acts through 5ht2 receptors in rat leydig cells to release crf, which, in turn, inhibits hcg-stimulated camp production and steroidogenesis. |
1993-08-03 |
2023-08-12 |
rat |
J C Tinajero, A Fabbri, M L Dufa. Serotonergic inhibition of rat Leydig cell function by propranolol. Endocrinology. vol 133. issue 1. 1993-08-03. PMID:8391422. |
the inhibitory actions of propranolol were exerted through its blockade of the leydig cell 5ht2 low affinity receptor, which has functional properties of an autoreceptor, with consequent increases in 5ht and stimulation of crf release through 5ht action at the high affinity site. |
1993-08-03 |
2023-08-12 |
rat |
I Kusum. [Serotonin-2 receptor-mediated intraplatelet calcium mobilization in affective disorders: relevance to the pathophysiology of depression]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 68. issue 3. 1993-07-30. PMID:8319932. |
these results suggest that 5-ht2 receptor function is increased in some type of affective disorders and that the enhanced ca response to 5-ht may be trait dependent rather than state dependent. |
1993-07-30 |
2023-08-12 |
human |
H Jørgensen, U Knigge, J Warber. Effect of selective serotonin receptor agonists on prolactin secretion in male rats. Neuroendocrinology. vol 57. issue 3. 1993-07-30. PMID:8321411. |
the prl-releasing effect of submaximal doses of 5-carboxamidotryptamine and ru 24969 was blocked by the 5-ht1 + 2 receptor antagonist methysergide and enhanced by other 5-ht agonists, but was unaffected by the 5-ht2 and 5-ht3 receptor antagonists. |
1993-07-30 |
2023-08-12 |
rat |
H Jørgensen, U Knigge, J Warber. Effect of selective serotonin receptor agonists on prolactin secretion in male rats. Neuroendocrinology. vol 57. issue 3. 1993-07-30. PMID:8321411. |
the findings show that 5-ht stimulates prl secretion via 5-ht1 as well as 5-ht2 receptors and that activation of 5-ht2 and 5-ht3 receptors significantly augment the prl-stimulating effect of 5-ht1 receptor activation. |
1993-07-30 |
2023-08-12 |
rat |
M Pertsch, E Krause, R Hirschelman. A comparison of serotonin (5-HT) blood levels and activity of 5-HT2 antagonists in adjuvant arthritic Lewis and Wistar rats. Agents and actions. vol 38 Spec No. 1993-07-29. PMID:8317334. |
a comparison of serotonin (5-ht) blood levels and activity of 5-ht2 antagonists in adjuvant arthritic lewis and wistar rats. |
1993-07-29 |
2023-08-12 |
rat |
M Pertsch, E Krause, R Hirschelman. A comparison of serotonin (5-HT) blood levels and activity of 5-HT2 antagonists in adjuvant arthritic Lewis and Wistar rats. Agents and actions. vol 38 Spec No. 1993-07-29. PMID:8317334. |
the total plasma 5-ht level was significantly decreased by the 5-ht2 antagonists in both strains at various times. |
1993-07-29 |
2023-08-12 |
rat |
F G Szele, D B Pritchet. High affinity agonist binding to cloned 5-hydroxytryptamine2 receptors is not sensitive to GTP analogs. Molecular pharmacology. vol 43. issue 6. 1993-07-23. PMID:8316223. |
the binding of the serotonin 5-hydroxytryptamine (5-ht)2 receptor agonists serotonin (5-ht) and 4-bromo-2,5-dimethoxyphenylisopropylamine is not affected by the presence of gtp analogs when the cloned 5-ht2 receptor is expressed in the 293 human embryonic kidney cell line. |
1993-07-23 |
2023-08-12 |
mouse |
M van Wyk, D K Sommers, J Moncrief. Effects of enhancement and antagonism of 5-hydroxytryptamine activity on the influence of metoclopramide on gastric emptying. Digestion. vol 54. issue 1. 1993-07-22. PMID:8513986. |
six subjects received the following pretreatments before metoclopramide and paracetamol: fluoxetine (5-ht uptake inhibitor); meterogoline (5-ht1 antagonist); pizotifen (5-ht2 antagonist) or methysergide (5-ht1 and 5-ht2 antagonist). |
1993-07-22 |
2023-08-12 |
human |
J N Joyce, A Shane, N Lexow, A Winokur, M F Casanova, J E Kleinma. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 4. 1993-07-20. PMID:8512620. |
serotonin (5-ht) uptake sites were mapped by autoradiographic means with [3h]cyano-imipramine ([3h]cn-imi), the 5-ht1a receptor with [3h]8-hydroxy-2-[di-n-propyl-amino]tetralin ([3h]8-oh-dpat), and the 5-ht2 receptor with both [3h]ketanserin and [125i]lysergic acid diethylamide ([125i]lsd) in eight nonneurologic controls and 10 cases with a diagnosis of schizophrenia. |
1993-07-20 |
2023-08-12 |
Not clear |
J N Joyce, A Shane, N Lexow, A Winokur, M F Casanova, J E Kleinma. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 4. 1993-07-20. PMID:8512620. |
there was a laminar distribution of 5-ht uptake sites that approximated the combined distributions of the 5-ht1a receptor and the 5-ht2 receptor. |
1993-07-20 |
2023-08-12 |
Not clear |
J N Joyce, A Shane, N Lexow, A Winokur, M F Casanova, J E Kleinma. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 4. 1993-07-20. PMID:8512620. |
in the parahippocampal gyrus and hippocampus, the distribution of 5-ht uptake sites was complementary to the distribution of 5-ht1a and 5-ht2 receptors. |
1993-07-20 |
2023-08-12 |
Not clear |
R Corbett, H Hartman, L L Kerman, A T Woods, J T Strupczewski, G C Helsley, P C Conway, R W Dun. Effects of atypical antipsychotic agents on social behavior in rodents. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:7685916. |
in vitro receptor binding studies revealed that only clozapine, risperidone, and hp 873 displayed dopamine to serotonin affinity ratios for both d2/5-hydroxytryptamine2(5-ht2)/ and d1/5-ht1a of greater than or equal to 12.9 and 1.0, respectively. |
1993-07-19 |
2023-08-12 |
rat |
E H Cook, R C Arora, G M Anderson, E M Berry-Kravis, S Y Yan, H C Yeoh, P J Sklena, D A Charak, B L Leventha. Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder. Life sciences. vol 52. issue 25. 1993-07-01. PMID:7684805. |
however, [3h]-lsd labelled 5-ht2 binding and 5-ht uptake were not correlated with each other. |
1993-07-01 |
2023-08-12 |
human |
E H Cook, R C Arora, G M Anderson, E M Berry-Kravis, S Y Yan, H C Yeoh, P J Sklena, D A Charak, B L Leventha. Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder. Life sciences. vol 52. issue 25. 1993-07-01. PMID:7684805. |
hyperserotonemia of autism may be heterogeneous with one subgroup of subjects with increased 5-ht uptake and another subgroup with decreased 5-ht2 binding. |
1993-07-01 |
2023-08-12 |
human |
R C Ferry, C D Unsworth, P B Molinof. Effects of agonists, partial agonists, and antagonists on the regulation of 5-hydroxytryptamine2 receptors in P11 cells. Molecular pharmacology. vol 43. issue 5. 1993-07-01. PMID:8388988. |
studies of the regulation of 5-hydroxytryptamine (5-ht2) receptors in vivo have generated anomalous and sometimes contradictory results. |
1993-07-01 |
2023-08-12 |
Not clear |
R C Ferry, C D Unsworth, P B Molinof. Effects of agonists, partial agonists, and antagonists on the regulation of 5-hydroxytryptamine2 receptors in P11 cells. Molecular pharmacology. vol 43. issue 5. 1993-07-01. PMID:8388988. |
the decrease in the density of 5-ht2 receptors after exposure to 5-ht, lsd, or doi was time dependent and was not a consequence of residual drug in binding assays or irreversibly bound drug. |
1993-07-01 |
2023-08-12 |
Not clear |
R C Ferry, C D Unsworth, P B Molinof. Effects of agonists, partial agonists, and antagonists on the regulation of 5-hydroxytryptamine2 receptors in P11 cells. Molecular pharmacology. vol 43. issue 5. 1993-07-01. PMID:8388988. |
the ability of 5-ht, doi, and lsd to down-regulate 5-ht2 receptors was not proportional to the ability of these compounds to stimulate phosphoinositide hydrolysis. |
1993-07-01 |
2023-08-12 |
Not clear |
M S Choudhary, S Craigo, B L Rot. A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors. Molecular pharmacology. vol 43. issue 5. 1993-07-01. PMID:8388989. |
the molecular processes by which agonists and antagonists bind to serotonin2 [5-hydroxytryptamine (5-ht2)] receptors are currently unknown. |
1993-07-01 |
2023-08-12 |
Not clear |