| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Choudhary, S Craigo, B L Rot. A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors. Molecular pharmacology. vol 43. issue 5. 1993-07-01. PMID:8388989. |
three molecular models have proposed that conserved aromatic residues help to anchor the phenyl ring of 5-ht via stacking or pi-pi-type interactions with the 5-ht2 receptor. |
1993-07-01 |
2023-08-12 |
Not clear |
| M S Choudhary, S Craigo, B L Rot. A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors. Molecular pharmacology. vol 43. issue 5. 1993-07-01. PMID:8388989. |
to test these models we made single point mutations (phe339-->leu339 and phe340-->leu340) of two aromatic residues that are conserved among all guanine nucleotide-binding protein-coupled 5-ht receptors and a single point mutation (phe125-->leu125) that exchanges a 5-ht2 for a 5-ht1c sequence. |
1993-07-01 |
2023-08-12 |
Not clear |
| J Yamada, Y Sugimoto, I Kimura, Y Watanabe, N Takeuchi, K Horisak. Peripherally administered serotonin induces hyperglucagonemia in mice. Life sciences. vol 52. issue 23. 1993-06-30. PMID:8502121. |
the hyperglucagonemic effects of 5-ht were completely antagonized by methysergide, ketanserin and ritanserin which have a high affinity for 5-ht2 receptors. |
1993-06-30 |
2023-08-12 |
mouse |
| N Weiner, H W Clement, D Gemsa, W Weseman. Circadian and seasonal rhythms of 5-HT receptor subtypes, membrane anisotropy and 5-HT release in hippocampus and cortex of the rat. Neurochemistry international. vol 21. issue 1. 1993-06-24. PMID:1363861. |
specific serotonin binding (5-ht1, 5-ht1a, and 5-ht2 subtypes) and membrane anisotropy were measured at 2 h intervals over a 24 h period in the hippocampus and cortex of wistar wu rats, housed under a 12 h light-dark cycle, with lights on at 07.00. |
1993-06-24 |
2023-08-11 |
rat |
| I Panocka, P Pompei, M Mass. Suppression of alcohol preference in rats induced by risperidone, a serotonin 5-HT2 and dopamine D2 receptor antagonist. Brain research bulletin. vol 31. issue 5. 1993-06-22. PMID:7684315. |
suppression of alcohol preference in rats induced by risperidone, a serotonin 5-ht2 and dopamine d2 receptor antagonist. |
1993-06-22 |
2023-08-12 |
rat |
| J Y Lin, C S Li, J T Pa. Effects of various neuroactive substances on single-unit activities of hypothalamic arcuate neurons in brain slices. Brain research bulletin. vol 31. issue 5. 1993-06-22. PMID:8098656. |
neither ketanserin, a 5-ht2, nor domperidone, a d2 receptor antagonist, had much effect on blocking the actions of 5-ht or da. |
1993-06-22 |
2023-08-12 |
Not clear |
| R E Mewshaw, L S Silverman, R M Mathew, C Kaiser, R G Sherrill, M Cheng, C W Tiffany, E W Karbon, M A Bailey, S A Borosk. Bridged gamma-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors. Journal of medicinal chemistry. vol 36. issue 10. 1993-06-22. PMID:8496917. |
structural modifications of the lead compound, 11-[4-(4-fluorobenzoyl)propyl]-5,6,7,8,9,10-hexahydro-7,10- iminocyclohept[b]indole (5, ki = 0.82 nm vs [3h]ketanserin) enabled the identification of the functionality necessary for high affinity at serotonin 5-ht2 and dopamine d2 receptors in ligand binding studies. |
1993-06-22 |
2023-08-12 |
Not clear |
| R P Hellendall, U B Schambra, J P Liu, J M Laude. Prenatal expression of 5-HT1C and 5-HT2 receptors in the rat central nervous system. Experimental neurology. vol 120. issue 2. 1993-06-17. PMID:8491279. |
the expression of mrnas for two 5-ht receptors (5-ht1c, 5-ht2) has been investigated by evaluating in situ hybridization in the prenatal rat cns. |
1993-06-17 |
2023-08-12 |
rat |
| A R Johnston, B Murnion, D S McQueen, M B Duti. Excitation and inhibition of rat medial vestibular nucleus neurones by 5-hydroxytryptamine. Experimental brain research. vol 93. issue 2. 1993-06-16. PMID:8491267. |
the excitatory effects of 5-ht were mimicked by alpha-methyl-5-ht and antagonised by ketanserin and ritanserin, indicating the involvement of the 5-ht2 subtype of 5-ht receptor. |
1993-06-16 |
2023-08-12 |
rat |
| L H Parsons, J B Justic. Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis. Brain research. vol 606. issue 2. 1993-06-14. PMID:8490716. |
the serotonin-induced increase in dialysate da was attenuated by co-perfusion of 0.4 microm 5-ht with 4 microm concentrations of pindolol (a relatively non-specific 5-ht1 antagonist; 151 +/- 7% vs. 332 +/- 35% baseline dialysate da for 5-ht/antagonist and 5-ht-only perfusates, respectively), ly 53,857 (a specific 5-ht2 antagonist; 130 +/- 17% vs. 332 +/- 35%) and mdl 7222 (a specific 5-ht3 antagonist; 143 +/- 19% vs. 332 +/- 35%). |
1993-06-14 |
2023-08-12 |
Not clear |
| F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research. vol 606. issue 2. 1993-06-14. PMID:8490720. |
serotonin 5-ht1 and 5-ht2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. |
1993-06-14 |
2023-08-12 |
rat |
| F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research. vol 606. issue 2. 1993-06-14. PMID:8490720. |
5-ht1a, 5-ht1b, 5ht1nonab and 5-ht2 sites were labeled with [3h]8-oh-dpat, [125i]cyanopindolol, [3h]5-ht and [125i]doi, respectively, and measured in the rostral and caudal halves of neostriatum and selected forebrain or midbrain regions. |
1993-06-14 |
2023-08-12 |
rat |
| F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research. vol 606. issue 2. 1993-06-14. PMID:8490720. |
even though the exact cause(s) of these receptor increases could not be determined, their anatomical distribution suggested that they were somehow related to the initial dopamine denervation in the case of the 5-ht1b and 5-ht1nonab receptors, and more tightly linked to the 5-ht hyperinnervation in the case of the 5-ht2 receptors. |
1993-06-14 |
2023-08-12 |
rat |
| T Siegal, T Siega. Serotonergic manipulations in experimental neoplastic spinal cord compression. Journal of neurosurgery. vol 78. issue 6. 1993-06-10. PMID:7683713. |
serotonergic manipulations include in vivo inhibition of serotonin (5-ht) synthesis by p-chlorophenylalanine (p-cpa) and in vivo blockage of serotonin type 2 (5-ht2) receptors either by the selective antagonist ketanserin or by cyproheptadine. |
1993-06-10 |
2023-08-12 |
rat |
| R S Neuman, G Zebrowsk. Serotonin (5-HT2) receptor mediated enhancement of cortical unit activity. Canadian journal of physiology and pharmacology. vol 70. issue 12. 1993-06-03. PMID:1301238. |
serotonin (5-ht2) receptor mediated enhancement of cortical unit activity. |
1993-06-03 |
2023-08-11 |
rat |
| E Fiorica-Howells, P R Wade, M D Gersho. Serotonin-induced increase in cAMP in ganglia isolated from the myenteric plexus of the guinea pig small intestine: mediation by a novel 5-HT receptor. Synapse (New York, N.Y.). vol 13. issue 4. 1993-05-25. PMID:8386861. |
increases in camp were also evoked by the 5-ht1 agonist, 5-carboxyamidotryptamine (10.0 microm), the 5-ht2 agonist, (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi; 1.0-10.0 microm), and by the 5-ht4 agonists, renzapride (1.0-10.0 microm) and 5-methoxytryptamine (1.0-10.0 microm); however, neither the 5-ht1/5-ht2 antagonists, spiperone, methysergide, and methiothepin, nor the 5-ht4 antagonist, tropisetron (ics 205-930; 10.0 microm), were able to inhibit the rise in camp evoked by these compounds or by 5-ht (0.1-10.0 microm). |
1993-05-25 |
2023-08-12 |
rat |
| L Rydelek-Fitzgerald, B D Wilcox, M Teitler, J J Jeffre. Serotonin-dependent collagenase induction in rat myometrial smooth muscle cells: mediation by the 5-HT2 receptor. Molecular and cellular endocrinology. vol 91. issue 1-2. 1993-05-20. PMID:8472855. |
in addition, a number of selective 5-ht2 receptor agonists (quipazine, alpha-methyl-serotonin, doi) mimicked the ability of serotonin to induce collagenase production, whereas compounds selective for 5-ht1 and 5-ht3 receptor subtypes had little effect. |
1993-05-20 |
2023-08-12 |
human |
| E Glusa, E Müller-Schweinitze. Heterogeneity of 5-HT receptor subtypes in isolated human femoral and saphenous veins. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 2. 1993-05-20. PMID:8474533. |
further evidence for this was obtained by the observation that spiperone (a 5-ht receptor blocker with high affinity for 5-ht2 and 5-ht1a sites) produced a parallel shift to the right of the 5-ht curve in femoral veins but elicited a biphasic displacement of the 5-ht curve in saphenous veins. |
1993-05-20 |
2023-08-12 |
human |
| J L Goudreau, J Manzanares, K J Lookingland, K E Moor. 5HT2 receptors mediate the effects of stress on the activity of periventricular hypophysial dopaminergic neurons and the secretion of alpha-melanocyte-stimulating hormone. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8386238. |
these results reveal that 5ht neurons, acting via 5ht2 receptors, mediate the inhibitory effects of stress on periventricular hypophysial dopaminergic neurons and the consequent increase in secretion of alpha msh. |
1993-05-18 |
2023-08-12 |
rat |
| S Benloucif, M J Keegan, M P Gallowa. Serotonin-facilitated dopamine release in vivo: pharmacological characterization. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8474019. |
the 5-ht2 antagonist ritanserin (6-[2-[4[bis(4-fluorophenyl)methylene]-1-piperadinyl]- ethyl]-7-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one) did not antagonize the effect of either 5-ht or 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hcl on da levels. |
1993-05-18 |
2023-08-12 |
rat |