| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vignir Isberg, James Paine, Sebastian Leth-Petersen, Jesper L Kristensen, David E Gloria. Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-HT2 receptors. PloS one. vol 8. issue 11. 2014-07-22. PMID:24244317. |
structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-ht2 receptors. |
2014-07-22 |
2023-08-12 |
human |
| James R Austgen, David D Klin. Endocannabinoids blunt the augmentation of synaptic transmission by serotonin 2A receptors in the nucleus tractus solitarii (nTS). Brain research. vol 1537. 2014-06-25. PMID:24041777. |
serotonin (5-hydroxytryptamine, 5-ht) and the 5-ht2 receptor modulate cardiovascular and autonomic function in part through actions in the nts, the primary termination and integration point for cardiorespiratory afferents in the brainstem. |
2014-06-25 |
2023-08-12 |
Not clear |
| Cristiano Bombard. Neuronal localization of the 5-HT2 receptor family in the amygdaloid complex. Frontiers in pharmacology. vol 5. 2014-06-24. PMID:24782772. |
serotonin (5-hydroxytryptamine, 5-ht) regulates amygdalar activity through the activation of the 5-ht2 receptor family, which includes three receptor subtypes: 5-ht2a, 5-ht2b, and 5-ht2c. |
2014-06-24 |
2023-08-13 |
Not clear |
| L Ratna, S Mukerge. The long term effects of childhood sexual abuse: rationale for and experience of pharmacotherapy with nefazodone. International journal of psychiatry in clinical practice. vol 2. issue 2. 2014-06-21. PMID:24946288. |
drugs such as nefazodone which block 5ht2 receptors and inhibit the uptake of serotonin may be of particular value. |
2014-06-21 |
2023-08-13 |
Not clear |
| Hisato Matsunaga, Tokuzo Matsui, Kenzo Ohya, Kenya Okino, Kazuhisa Hayashida, Kensei Maebayashi, Nobuo Kiriike, Dan J Stei. A benzisothiazole derivative and antipsychotic agent, perospirone, for augmentation of selective serotonin reuptake inhibitors (SSRIs) in refractory obsessive-compulsive disorder (OCD): two patient case series. International journal of psychiatry in clinical practice. vol 10. issue 2. 2014-06-20. PMID:24940965. |
the benzisothiazole derivative perospirone is a new serotonin 5-ht2 and dopamine d2 antagonist available in japan for the treatment of schizophrenia. |
2014-06-20 |
2023-08-13 |
Not clear |
| Ilia D Kostadinov, Delian P Delev, Marianna A Murdjeva, Ivanka I Kostadinov. Experimental study on the role of 5-HT2 serotonin receptors in the mechanism of anti-inflammatory and antihyperalgesic action of antidepressant fluoxetine. Folia medica. vol 56. issue 1. 2014-06-05. PMID:24812922. |
experimental study on the role of 5-ht2 serotonin receptors in the mechanism of anti-inflammatory and antihyperalgesic action of antidepressant fluoxetine. |
2014-06-05 |
2023-08-13 |
Not clear |
| Félix Calderón, Jaume Vidal-Mas, Jeremy Burrows, Juan Carlos de la Rosa, María Belén Jiménez-Díaz, Teresa Mulet, Sara Prats, Jorge Solana, Michael Witty, Francisco Javier Gamo, Esther Fernánde. A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold. ACS medicinal chemistry letters. vol 3. issue 5. 2014-06-05. PMID:24900481. |
one of the most promising hits was the tcmdc-139046, a molecule presenting an indoline core, which is well-known for its anxiolytic properties by interacting with serotonin antagonist receptors 5-ht2. |
2014-06-05 |
2023-08-13 |
Not clear |
| Mitsuko Kanamaru, Toshihisa Sugita, Ikuo Homm. Effects of dorsomedial medullary 5-HT2 receptor antagonism on initial ventilatory airway responses to hypercapnic hypoxia in mice. Experimental brain research. vol 230. issue 4. 2014-05-27. PMID:23543107. |
the increases in dorsomedial medullary 5-ht release and ventilatory volume were not affected with or without 5-ht2 activity. |
2014-05-27 |
2023-08-12 |
mouse |
| Vasileios Boulougouris, Ioannis Malogiannis, George Lockwood, Iannis Zervas, Giuseppe Di Giovann. Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy. Experimental brain research. vol 230. issue 4. 2014-05-27. PMID:23975151. |
the association of the serotonin transporter gene, the 5-ht2 receptors and its metabolite 5-hydroxyindoleacetic acid with suicidal behaviour and animal models that may capture the complexity of suicidal behaviour will be discussed. |
2014-05-27 |
2023-08-12 |
human |
| Ming-Jen Lee, Jiann-Wu We. The influences of reserpine and imipramine on the 5-HT2 receptor binding site and its coupled second messenger in rat cerebral cortex. The Chinese journal of physiology. vol 56. issue 4. 2014-05-06. PMID:23806035. |
the level of inositol 4-monophosphate (ip1) accumulation elicited by 100 microm 5-ht via activation of the 5-ht2 receptor on cerebral cortical slices at twelve hours after a single dose of reserpine (2 mg/kg, i.p.) |
2014-05-06 |
2023-08-12 |
rat |
| Marek Krzystanek, Ewa Krzystanek, Henryk I Trzeciak, Andrzej Małecki, Irena Krupka-Matuszczyk, Małgorzata Janas-Kozik, Janusz K Rybakowsk. Effects of olanzapine and paroxetine on phospholipase D activity in the rat brain. Pharmacological reports : PR. vol 65. issue 3. 2014-04-24. PMID:23950596. |
phospholipase d (pld) plays a key role in a second messenger system producing phosphatidic acid, mediating, among others, serotonin 5-ht2 receptor activity. |
2014-04-24 |
2023-08-12 |
rat |
| Takuji Machida, Kenji Iizuka, Masahiko Hirafuj. 5-hydroxytryptamine and its receptors in systemic vascular walls. Biological & pharmaceutical bulletin. vol 36. issue 9. 2014-04-01. PMID:23995652. |
stimulation of 5-ht1 and/or 5-ht2 receptors has been implicated in the angiogenic effect of 5-ht. |
2014-04-01 |
2023-08-12 |
Not clear |
| Janardhan P Bhattarai, Juan Roa, Allan E Herbison, Seong Kyu Ha. Serotonin acts through 5-HT1 and 5-HT2 receptors to exert biphasic actions on GnRH neuron excitability in the mouse. Endocrinology. vol 155. issue 2. 2014-03-20. PMID:24265447. |
serotonin acts through 5-ht1 and 5-ht2 receptors to exert biphasic actions on gnrh neuron excitability in the mouse. |
2014-03-20 |
2023-08-12 |
mouse |
| Dong Jun Sung, Hyun Ju Noh, Jae Gon Kim, Sang Woong Park, Bokyung Kim, Hana Cho, Young Min Ba. Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase. Experimental & molecular medicine. vol 45. 2014-03-20. PMID:24336234. |
consistently, α-methyl 5-ht, a 5-ht2 receptor agonist, mimicked the 5-ht action on kv channels. |
2014-03-20 |
2023-08-12 |
rat |
| Drake Morgan, Krishnakanth Kondabolu, Allison Kuipers, Rajeev Sakhuja, Kimberly L Robertson, Neil E Rowland, Raymond G Boot. Molecular and behavioral pharmacology of two novel orally-active 5HT2 modulators: potential utility as antipsychotic medications. Neuropharmacology. vol 72. 2014-02-11. PMID:23665356. |
desired serotonin 5ht2 receptor pharmacology for treatment of psychoses is 5ht2a antagonism and/or 5ht2c agonism. |
2014-02-11 |
2023-08-12 |
Not clear |
| Katarzyna Nawrot-Porąbka, Jolanta Jaworek, Anna Leja-Szpak, Joanna Szklarczyk, Stanisław J Konturek, Russel J Reite. Luminal melatonin stimulates pancreatic enzyme secretion via activation of serotonin-dependent nerves. Pharmacological reports : PR. vol 65. issue 2. 2014-02-07. PMID:23744434. |
5-ht, via the activation of 5-ht2 and 5-ht3 receptors on vagal fibers, mediates pancreatic secretion through the mechanism independent from cholecystokinin. |
2014-02-07 |
2023-08-12 |
rat |
| Clinton E Canal, Tania Cordova-Sintjago, Yue Liu, Myong S Kim, Drake Morgan, Raymond G Boot. Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands. The Journal of pharmacology and experimental therapeutics. vol 347. issue 3. 2014-01-23. PMID:24080681. |
during translational studies to develop 4-phenyl-2-dimethylaminotetralin (pat) compounds for neuropsychiatric disorders, the (2r,4s)-trans-(+)- and (2s,4r)-trans-(-)-enantiomers of the analog 6-hydroxy-7-chloro-pat (6-oh-7-cl-pat) demonstrated unusual pharmacology at serotonin (5-ht) 5-ht2 g protein-coupled receptors (gpcrs). |
2014-01-23 |
2023-08-12 |
mouse |
| A E Lychkov. [Nervous regulation of thyroid function]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 6. 2014-01-16. PMID:24340635. |
this stimulatory effect is mediated by the serotonin 5-ht2 receptors. |
2014-01-16 |
2023-08-12 |
Not clear |
| Alexander W Frere, M Danielle McDonal. The effect of stress on gill basolateral membrane binding kinetics of 5-ht2 receptor ligands: potential implications for urea excretion mechanisms. Journal of experimental zoology. Part A, Ecological genetics and physiology. vol 319. issue 5. 2013-12-31. PMID:23495168. |
furthermore, no significant difference was measured in [(3) h]-5-ht binding kinetics or in the competitive binding of the 5-ht2 agonist, α-methyl 5-ht, to isolated gill basolateral membranes of uncrowded or crowded toadfish. |
2013-12-31 |
2023-08-12 |
Not clear |
| Alexander W Frere, M Danielle McDonal. The effect of stress on gill basolateral membrane binding kinetics of 5-ht2 receptor ligands: potential implications for urea excretion mechanisms. Journal of experimental zoology. Part A, Ecological genetics and physiology. vol 319. issue 5. 2013-12-31. PMID:23495168. |
furthermore, metyrapone-treated fish excreted approximately twofold more urea compared to controls when injected with α-methyl 5-ht, a 5-ht2 receptor agonist shown to stimulate urea excretion. |
2013-12-31 |
2023-08-12 |
Not clear |