| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Beele, H Thierens, L de Ridde. Role of the 5HT2 receptor in the effects of serotonin and ketanserin on proliferation and differentiation of embryonic chick skin. Progress in histochemistry and cytochemistry. vol 26. issue 1-4. 1993-02-12. PMID:1484967. |
role of the 5ht2 receptor in the effects of serotonin and ketanserin on proliferation and differentiation of embryonic chick skin. |
1993-02-12 |
2023-08-11 |
chicken |
| J Perregaard, K Andersen, J Hyttel, C Sánche. Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles. Journal of medicinal chemistry. vol 35. issue 26. 1993-02-08. PMID:1336053. |
selective, centrally acting serotonin 5-ht2 antagonists. |
1993-02-08 |
2023-08-11 |
mouse |
| K Andersen, J Perregaard, J Arnt, J B Nielsen, M Begtru. Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles. Journal of medicinal chemistry. vol 35. issue 26. 1993-02-08. PMID:1336054. |
selective, centrally acting serotonin 5-ht2 antagonists. |
1993-02-08 |
2023-08-11 |
rat |
| J F Kuemmerle, D C Martin, K S Murthy, J M Kellum, J R Grider, G M Makhlou. Coexistence of contractile and relaxant 5-hydroxytryptamine receptors coupled to distinct signaling pathways in intestinal muscle cells: convergence of the pathways on Ca2+ mobilization. Molecular pharmacology. vol 42. issue 6. 1993-02-08. PMID:1336114. |
in naive cells from both regions, 5-ht caused contraction and stimulated increases in cytosolic free calcium concentration ([ca2+]i) (3-fold; p < 0.01) and camp levels (40-60%; p < 0.01) that were inhibited, respectively, by the 5-ht2 antagonist ketanserin and the 5-ht1p antagonist n-acetyl-5-hydroxytryptophyl 5-hydroxytryptophan amide (5-htp-dp). |
1993-02-08 |
2023-08-11 |
Not clear |
| J F Kuemmerle, D C Martin, K S Murthy, J M Kellum, J R Grider, G M Makhlou. Coexistence of contractile and relaxant 5-hydroxytryptamine receptors coupled to distinct signaling pathways in intestinal muscle cells: convergence of the pathways on Ca2+ mobilization. Molecular pharmacology. vol 42. issue 6. 1993-02-08. PMID:1336114. |
in cells maximally contracted with a non-5-ht agonist (cholecystokinin octapeptide), 5-ht caused relaxation when the contractile effect mediated by 5-ht2 receptors was blocked with ketanserin; relaxation and the concomitant increase in camp were inhibited by 5-htp-dp. |
1993-02-08 |
2023-08-11 |
Not clear |
| J F Kuemmerle, D C Martin, K S Murthy, J M Kellum, J R Grider, G M Makhlou. Coexistence of contractile and relaxant 5-hydroxytryptamine receptors coupled to distinct signaling pathways in intestinal muscle cells: convergence of the pathways on Ca2+ mobilization. Molecular pharmacology. vol 42. issue 6. 1993-02-08. PMID:1336114. |
in cells with only 5-ht2 receptors, 5-ht caused contraction and an increase in [ca2+]i but not in camp levels; contraction and the increase in [ca2+]i were inhibited by ketanserin. |
1993-02-08 |
2023-08-11 |
Not clear |
| H Tamir, S C Hsiung, P Y Yu, K P Liu, M Adlersberg, E A Nunez, M D Gersho. Serotonergic signalling between thyroid cells: protein kinase C and 5-HT2 receptors in the secretion and action of serotonin. Synapse (New York, N.Y.). vol 12. issue 2. 1993-02-08. PMID:1336223. |
serotonergic signalling between thyroid cells: protein kinase c and 5-ht2 receptors in the secretion and action of serotonin. |
1993-02-08 |
2023-08-11 |
Not clear |
| H Tamir, S C Hsiung, P Y Yu, K P Liu, M Adlersberg, E A Nunez, M D Gersho. Serotonergic signalling between thyroid cells: protein kinase C and 5-HT2 receptors in the secretion and action of serotonin. Synapse (New York, N.Y.). vol 12. issue 2. 1993-02-08. PMID:1336223. |
all of these 5-ht effects were inhibited by 5-ht2 receptor antagonists (spiperone and ketanserin) and by pertussis toxin (ptx), suggesting that the actions of 5-ht are mediated by 5-ht2 receptors, which are coupled to a g protein. |
1993-02-08 |
2023-08-11 |
Not clear |
| J L Herndon, A Ismaiel, S P Ingher, M Teitler, R A Glenno. Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. Journal of medicinal chemistry. vol 35. issue 26. 1993-02-08. PMID:1479590. |
ketanserin is the prototypic 5-ht2 serotonin antagonist; although it has been an important tool for the study of serotonin pharmacology, it has had relatively little impact on drug design because remarkably little is known about its structure-affinity relationships. |
1993-02-08 |
2023-08-11 |
Not clear |
| J Sawynok, A Rei. Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes. European journal of pharmacology. vol 223. issue 1. 1993-02-05. PMID:1362158. |
the present study examined the involvement of spinal noradrenergic mechanisms in spinal antinociception by the 5-hydroxy-tryptamine (5-ht) receptor-selective agonists cgs 12066b (5-ht1b; 7-trifluoromethyl-4(4-methyl-1-piperazinyl)-pyrrolo[1,2-a]quinoxaline), tfmpp (5-ht1c; m-trifluoromethylphenyl-piperazine) and doi (5-ht2; 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) using the rat hot plate test. |
1993-02-05 |
2023-08-11 |
rat |
| C J Schmidt, G M Fadayel, C K Sullivan, V L Taylo. 5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine. European journal of pharmacology. vol 223. issue 1. 1993-02-05. PMID:1362159. |
the highly selective 5-ht2 receptor antagonist, mdl 100,907, was used to explore the role of serotonin in the stimulation of dopaminergic function produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine (mdma). |
1993-02-05 |
2023-08-11 |
Not clear |
| C S Venugopalan, E P Holme. Blockade of electrical field stimulation-induced nonadrenergic noncholinergic (NANC) excitatory response of the guinea pig ileum. Research communications in chemical pathology and pharmacology. vol 78. issue 2. 1993-02-03. PMID:1282271. |
the nanc-e responses obtained before and after treatment of the tissues with receptor antagonists of histamine (pyrilamine), substance p ([d-arg1,d-pro2,d-trp7,9,leu11]-sp) and serotonin (5-ht1 & 5-ht2) indicated that the response could be blocked by substance p and serotonin antagonists. |
1993-02-03 |
2023-08-11 |
Not clear |
| M Suehiro, U Scheffel, R F Dannals, H T Ravert, G A Ricaurte, H N Wagne. A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 34. issue 1. 1993-02-03. PMID:8418252. |
the specificity and selectivity of 11c-mcn-5652 binding to the 5-ht transporter were tested by preinjecting blocking doses of known 5-ht, dopamine and norepinephrine uptake inhibitors, and a 5-ht2 receptor blocker before injection of the radiotracer. |
1993-02-03 |
2023-08-12 |
mouse |
| M S Barnette, M Grous, C D Manning, W J Price, A H Nelson, W E Bondinell, F C Barone, H S Ormsbe. 5-Hydroxytryptamine (5-HT) and SK&F 103829 contract canine lower esophageal sphincter smooth muscle by stimulating 5-HT2 receptors. Receptor. vol 2. issue 3. 1993-02-02. PMID:1472950. |
5-hydroxytryptamine (5-ht) and sk&f 103829 contract canine lower esophageal sphincter smooth muscle by stimulating 5-ht2 receptors. |
1993-02-02 |
2023-08-11 |
Not clear |
| M S Barnette, M Grous, C D Manning, W J Price, A H Nelson, W E Bondinell, F C Barone, H S Ormsbe. 5-Hydroxytryptamine (5-HT) and SK&F 103829 contract canine lower esophageal sphincter smooth muscle by stimulating 5-HT2 receptors. Receptor. vol 2. issue 3. 1993-02-02. PMID:1472950. |
nonsurmountable antagonism of the contraction induced by 5-ht and sk&f 103289 was observed with several 5-ht2 antagonists, i.e., methysergide, ketanserin, cyproheptadine, and ly 53857. |
1993-02-02 |
2023-08-11 |
Not clear |
| M S Barnette, M Grous, C D Manning, W J Price, A H Nelson, W E Bondinell, F C Barone, H S Ormsbe. 5-Hydroxytryptamine (5-HT) and SK&F 103829 contract canine lower esophageal sphincter smooth muscle by stimulating 5-HT2 receptors. Receptor. vol 2. issue 3. 1993-02-02. PMID:1472950. |
results suggested that both 5-ht and sk&f 103829 contract the canine les by interacting at the same receptor site and that this receptor site has characteristics of the 5-ht2 receptor. |
1993-02-02 |
2023-08-11 |
Not clear |
| M R Briejer, L M Akkermans, A L Meulemans, R A Lefebvre, J A Schuurke. Nitric oxide is involved in 5-HT-induced relaxations of the guinea-pig colon ascendens in vitro. British journal of pharmacology. vol 107. issue 3. 1993-02-02. PMID:1472972. |
in the guinea-pig colon ascendens, 5-hydroxytryptamine (5-ht) induces contractions, mediated by 5-ht2, 5-ht3 and 5-ht4 receptors, and relaxations, through a 5-ht1 receptor subtype, that triggers the release of an inhibitory neurotransmitter. |
1993-02-02 |
2023-08-11 |
Not clear |
| M R Briejer, L M Akkermans, A L Meulemans, R A Lefebvre, J A Schuurke. Nitric oxide is involved in 5-HT-induced relaxations of the guinea-pig colon ascendens in vitro. British journal of pharmacology. vol 107. issue 3. 1993-02-02. PMID:1472972. |
antagonists to block the contractile responses to 5-ht via 5-ht2, 5-ht3 and 5-ht4 receptors were present throughout the experiments and methacholine was administered to precontract the strips. |
1993-02-02 |
2023-08-11 |
Not clear |
| T Yakushiji, N Akaik. Blockade of 5-HT3 receptor-mediated currents in dissociated frog sensory neurones by benzoxazine derivative, Y-25130. British journal of pharmacology. vol 107. issue 3. 1993-02-02. PMID:1472977. |
the 5-ht response was reversibly antagonized by the 5-ht3 receptor antagonists, ics 205-930, metoclopramide and y-25130, but not by a 5-htia receptor antagonist, spiperone, and a 5-ht2 receptor antagonist, ketanserin. |
1993-02-02 |
2023-08-11 |
Not clear |
| P A Palumbo, J C Winte. Stimulus effects of ibogaine in rats trained with yohimbine, DOM, or LSD. Pharmacology, biochemistry, and behavior. vol 43. issue 4. 1993-02-01. PMID:1475306. |
the stimulus effects of ibogaine were compared with those of yohimbine, an alpha 2-adrenoceptor antagonist, 2,5-dimethoxy-4-methylamphetamine (dom), a 5-hydroxytryptamine2 (5-ht2) agonist, and lysergic acid diethylamide (lsd), a nonspecific 5-ht agonist. |
1993-02-01 |
2023-08-11 |
rat |