| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M I Christie, D Harper, G W Smit. Analysis of the agonist activity of fenoldopam (SKF 82526) at the vascular 5-HT2 receptor. British journal of pharmacology. vol 107. issue 4. 1993-01-28. PMID:1361397. |
fenoldopam was an agonist at the vascular 5-ht2 receptor with lower affinity and efficacy than the naturally occurring agonist 5-hydroxytryptamine (5-ht). |
1993-01-28 |
2023-08-11 |
rabbit |
| M I Christie, D Harper, G W Smit. Analysis of the agonist activity of fenoldopam (SKF 82526) at the vascular 5-HT2 receptor. British journal of pharmacology. vol 107. issue 4. 1993-01-28. PMID:1361397. |
the constrictor effects of fenoldopam and 5-ht were competitively antagonized by the 5-ht2 antagonist, ketanserin, with pkb values of 8.81 +/- 0.11 and 8.83 +/- 0.10 respectively. |
1993-01-28 |
2023-08-11 |
rabbit |
| M I Christie, D Harper, G W Smit. Analysis of the agonist activity of fenoldopam (SKF 82526) at the vascular 5-HT2 receptor. British journal of pharmacology. vol 107. issue 4. 1993-01-28. PMID:1361397. |
this study indicates that the d1 receptor agonist, fenoldopam, acts as an agonist at the vascular 5-ht2 receptor, but with an affinity and efficacy less than that of the naturally occurring agonist, 5-ht. |
1993-01-28 |
2023-08-11 |
rabbit |
| I K Anderson, G R Martin, A G Ramag. Central administration of 5-HT activates 5-HT1A receptors to cause sympathoexcitation and 5-HT2/5-HT1C receptors to release vasopressin in anaesthetized rats. British journal of pharmacology. vol 107. issue 4. 1993-01-28. PMID:1467825. |
administration of 5-ht activates 5-htla receptors to cause sympathoexcitation and 5-ht2 or 5-ht1c receptors to cause the release of vasopressin. |
1993-01-28 |
2023-08-11 |
rat |
| P Govitrapong, C Limthavon, A Srikiatkhachor. 5-HT2 serotonin receptor on blood platelet of migraine patients. Headache. vol 32. issue 10. 1993-01-28. PMID:1468904. |
by using [3h]-spiperone as a radioligand and ketanserin to determine the non-specific binding, the numbers of 5-ht2 serotonin receptors on platelet membrane obtained from normal healthy and migraine subjects were determined. |
1993-01-28 |
2023-08-11 |
human |
| S C Pandey, M R Piano, D W Schwertz, J M Davis, G N Pande. Effect of ethanol administration and withdrawal on serotonin receptor subtypes and receptor-mediated phosphoinositide hydrolysis in rat brain. Alcoholism, clinical and experimental research. vol 16. issue 6. 1993-01-27. PMID:1335222. |
short-term ethanol treatment had no significant effect on serotonin (5ht), norepinephrine (ne), and calcium ionophore (a23187)-stimulated [3h]-inositol-1-phosphate ([3h]-ip1) formation and 5-ht2 receptors as measured by 125i-lysergic acid diethylamide (125i-lsd) binding, in rat cerebral cortex. |
1993-01-27 |
2023-08-11 |
rat |
| M I Noble, A J Drake-Hollan. The possible role of serotonin 5HT2 receptor antagonism in cardioprotection. The Netherlands journal of medicine. vol 41. issue 3-4. 1993-01-27. PMID:1470290. |
the possible role of serotonin 5ht2 receptor antagonism in cardioprotection. |
1993-01-27 |
2023-08-11 |
Not clear |
| R Harhammer, U Schäfer, T Ot. Studies with new ergoline derivatives on the effects of central and peripheral 5-hydroxytryptamine receptors. Arzneimittel-Forschung. vol 42. issue 10. 1993-01-27. PMID:1472137. |
comparison of this two in vitro tests demonstrated a significant correlation (r = 0.636; p < 0.05) between the ability of the ergolines to block the 5-ht aggregation mediated by platelet 5-ht2 receptors and their affinity to [3h]ketanserin-labelled binding sites in rat cortical membranes. |
1993-01-27 |
2023-08-11 |
human |
| H Tsuchihashi, T Sasaki, S Kojima, T Nagatom. Binding of [3H]haloperidol to dopamine D2 receptors in the rat striatum. The Journal of pharmacy and pharmacology. vol 44. issue 11. 1993-01-25. PMID:1361536. |
the present study was designed to examine the properties of [3h]haloperidol binding to dopamine d2-receptors in rat striatum membranes, displacement potencies of various chemicals and differences between the affinities of various chemicals and two new 5-hydroxytryptamine (5-ht2) receptor antagonists, mci-9042, (+/-)-2-(dimethylamino)-1-[[o-(m-methoxyphenetyl)phenoxy]methyl]et hyl hydrogen succinate hydrochloride and one of its metabolites. |
1993-01-25 |
2023-08-11 |
rat |
| T A Pugsley, C L Christofferson, A Corbin, H A DeWald, S Demattos, L T Meltzer, S L Myers, Y H Shih, S Z Whetzel, J N Wile. Pharmacological characterization of PD 118717, a putative piperazinyl benzopyranone dopamine autoreceptor agonist. The Journal of pharmacology and experimental therapeutics. vol 263. issue 3. 1993-01-22. PMID:1361570. |
it also had significant affinity for serotonin-(5-ht)1a but not 5-ht1b and 5-ht2 receptors. |
1993-01-22 |
2023-08-11 |
mouse |
| S W Tam, G F Steinfels, P J Gilligan, W K Schmidt, L Coo. DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'-oxoethyl)- piperidine HBr], a sigma and 5-hydroxytryptamine2 receptor antagonist: receptor-binding, electrophysiological and neuropharmacological profiles. The Journal of pharmacology and experimental therapeutics. vol 263. issue 3. 1993-01-22. PMID:1361572. |
it has been suggested that sigma receptor antagonists may be useful as antipsychotic drugs and that 5-hydroxytryptamine (5-ht2) receptor antagonists produce improvements of the negative symptoms of schizophrenia. |
1993-01-22 |
2023-08-11 |
rat |
| H Ito, K Hidaka, K Miyata, T Kamato, A Nishida, K Hond. Characterization of YM060, a potent and selective 5-hydroxytryptamine3 receptor antagonist, in rabbit nodose ganglion and N1E-115 neuroblastoma cells. The Journal of pharmacology and experimental therapeutics. vol 263. issue 3. 1993-01-22. PMID:1469624. |
methysergide, a 5-ht1-like and 5-ht2 receptor antagonist, at a concentration of 10(-5) m had no effect on responses to 5-ht. |
1993-01-22 |
2023-08-11 |
rabbit |
| G Romero, E Toscano, D Montero, M C De Felipe, J Del Ri. Effect of prenatal exposure to tianeptine on different neurotransmitter receptors and 5-HT-stimulated inositol phosphate formation in rat brain. Journal of neural transmission. General section. vol 90. issue 2. 1993-01-21. PMID:1334416. |
tianeptine, an antidepressant drug enhancing 5-ht uptake, was given to pregnant rats in the last 15 days of gestation and different neurotransmitter receptors as well as 5-ht2 receptor-linked inositol phosphate formation were measured in the brains of the offspring. |
1993-01-21 |
2023-08-11 |
rat |
| G Romero, E Toscano, D Montero, M C De Felipe, J Del Ri. Effect of prenatal exposure to tianeptine on different neurotransmitter receptors and 5-HT-stimulated inositol phosphate formation in rat brain. Journal of neural transmission. General section. vol 90. issue 2. 1993-01-21. PMID:1334416. |
prenatal exposure to tianeptine significantly decreased the density of 3h-imipramine binding sites in the cerebral cortex of the pups without affecting beta-adrenoceptors, serotonin 5-ht2 and 5-ht1b receptors or inositol phosphate formation after a 5-ht challenge. |
1993-01-21 |
2023-08-11 |
rat |
| M J Ramalho, L C Reis, J Antunes-Rodrigues, E De-Castro-e-Silv. Thyroidectomy blocks stress-induced prolactin rise in rats: role of the central serotonergic system. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 24. issue 10. 1993-01-19. PMID:1464410. |
the effect of mk 212 is specifically due to its interaction with 5ht2 receptors, since the injection of ly 53857, a selective blocker of these receptors, 30 min before mk 212, prevents the effect of this serotonin agonist. |
1993-01-19 |
2023-08-11 |
rat |
| R W Fulle. The involvement of serotonin in regulation of pituitary-adrenocortical function. Frontiers in neuroendocrinology. vol 13. issue 3. 1993-01-14. PMID:1334001. |
among the multiple serotonin receptors that exist in brain, at least two--5ht1a and 5ht2 or 5ht1c receptors--seem to mediate activation of pituitary-adrenocortical function. |
1993-01-14 |
2023-08-11 |
rat |
| V Deckert, J A Angu. Evidence that 5-HT2 receptors predominantly mediate the contraction of the rat basilar artery to 5-hydroxytryptamine. European journal of pharmacology. vol 221. issue 1. 1993-01-13. PMID:1459189. |
evidence that 5-ht2 receptors predominantly mediate the contraction of the rat basilar artery to 5-hydroxytryptamine. |
1993-01-13 |
2023-08-11 |
rat |
| V Deckert, J A Angu. Evidence that 5-HT2 receptors predominantly mediate the contraction of the rat basilar artery to 5-hydroxytryptamine. European journal of pharmacology. vol 221. issue 1. 1993-01-13. PMID:1459189. |
we characterised the 5-hydroxytryptamine (5-ht) receptor subtype which mediates the contraction of the rat isolated basilar artery, mounted in a myograph, by using agonists and antagonists for 5-ht1-like, 5-ht2, 5-ht3 and 5-ht4 receptors. |
1993-01-13 |
2023-08-11 |
rat |
| V Deckert, J A Angu. Evidence that 5-HT2 receptors predominantly mediate the contraction of the rat basilar artery to 5-hydroxytryptamine. European journal of pharmacology. vol 221. issue 1. 1993-01-13. PMID:1459189. |
the high potency and efficacy of alpha-methyl-5-ht, poor effect of sumatriptan and antagonism of 5-ht by ergometrine and ketanserin, support the conclusion that the 5-ht2 receptors are primarily responsible for the 5-ht-induced contraction of rat basilar artery. |
1993-01-13 |
2023-08-11 |
rat |
| L M Kow, Y F Tsai, L Wang, D W Pfaf. Electrophysiological analyses of serotonergic actions on neurons in hypothalamic ventromedial nucleus in vitro: receptor subtypes involved and implications for regulation of feeding and lordosis behaviors. The Chinese journal of physiology. vol 35. issue 2. 1993-01-06. PMID:1451570. |
by comparing the actions of 5-ht with the effects of selective agonists and antagonists, the inhibitory action was found to be mediated predominantly, if not exclusively, by 5-ht1a receptors, while the excitatory action was mediated predominantly or exclusively through 5-ht2 receptors. |
1993-01-06 |
2023-08-11 |
rat |