All Relations between 5-ht receptor 2 and serotonin

Publication Sentence Publish Date Extraction Date Species
D F Avgustinovic. [The effect of the domestication of Norway rats and silver foxes on the serotonin S1A- and S2-receptors of the brain]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 28. issue 4. 1993-01-06. PMID:1455952. the specific radioligand binding of serotonin 5-ht1a and 5-ht2 receptors was determined in the frontal cortex and in the hypothalamus of norway rats and silver foxes. 1993-01-06 2023-08-11 rat
M T Barrús, J Marín, J Villamor, G Balfagó. Receptors involved in the modulation of 5-hydroxytryptamine release in bovine cerebral arteries. The Journal of pharmacy and pharmacology. vol 44. issue 10. 1993-01-04. PMID:1360508. electrically-stimulated tritium release was decreased by tetrodotoxin (0.8 microm), ca-free medium, denervation with 6-ohda (1.46 mm, 10 min), 5-ht (10 microm), noradrenaline (1 microm) and the agonist of alpha 2-adrenoceptors b-ht 920 (0.1 and 1 microm), enhanced by metitepine (1 microm, antagonists of presynaptic 5-ht1 receptors) and rauwolscine (1 microm, antagonist at alpha 2-adrenoceptors, and also of 5-ht1d receptors) and not affected by ketanserin (1 microm, antagonist of 5-ht2 receptors), methysergide (0.1 microm, antagonist of 5-ht1 and 5-ht2 receptors) and phentolamine (1 and 3 microm antagonist of alpha-adrenoceptors and less potent of 5-ht1 receptors). 1993-01-04 2023-08-11 cattle
T Takahashi, H Hisa, S Sato. Serotonin-induced vasoconstriction in dog kidney. Journal of cardiovascular pharmacology. vol 20. issue 5. 1992-12-31. PMID:1280741. these results suggest that 5-ht activates 5-ht1 receptors to induce vasoconstriction by mobilization of extracellular and intracellular ca2+, but simultaneous activation of 5-ht2 receptors attenuates the vasoconstriction, probably by causing vasodilation in dog kidney. 1992-12-31 2023-08-11 dog
J L Herndon, M E Pierson, R A Glenno. Mechanistic investigation of the stimulus properties of 1-(3-trifluoromethylphenyl)piperazine. Pharmacology, biochemistry, and behavior. vol 43. issue 3. 1992-12-30. PMID:1333084. the results of these and other published studies suggest roles for 5-hydroxytryptamine 1b (5-ht1b), 5-ht1c, and, possibly, sigma-receptors in the mediation of the tfmpp stimulus and indicate a lack of involvement of 5-ht1a, 5-ht2, dopaminergic, and adrenergic mechanisms in this behavior. 1992-12-30 2023-08-11 rat
Y Takiguchi, K Wada, M Nakashim. Comparison of the inhibitory effects of the TXA2 receptor antagonist, vapiprost, and other antiplatelet drugs on arterial thrombosis in rats: possible role of TXA2. Thrombosis and haemostasis. vol 68. issue 4. 1992-12-30. PMID:1448780. the potency ranking of antithrombotic effect was vapiprost > ketanserin (serotonin 5-ht2 receptor antagonist) >> ticlopidine (inhibitor of adp-induced platelet aggregation) = dipyridamole (adenosine uptake inhibitor) > aspirin (cyclooxygenase inhibitor). 1992-12-30 2023-08-11 rat
J Butler, A O'Halloran, B E Leonar. The Galway Study of Panic Disorder. II: Changes in some peripheral markers of noradrenergic and serotonergic function in DSM III-R panic disorder. Journal of affective disorders. vol 26. issue 2. 1992-12-29. PMID:1447432. the results of this study suggest that, despite clinical improvement, the peripheral markers of both adrenergic (platelet aggregation to noradrenaline, platelet alpha 2 receptor density and lymphocyte beta receptor density) and serotonergic (platelet aggregation to serotonin, 3h-ketanserin binding to platelet 5ht2 receptors and 3h-5ht uptake into platelets) function largely remained abnormal. 1992-12-29 2023-08-11 Not clear
P J Gilligan, G A Cain, T E Christos, L Cook, S Drummond, A L Johnson, A A Kergaye, J F McElroy, K W Rohrbach, W K Schmid. Novel piperidine sigma receptor ligands as potential antipsychotic drugs. Journal of medicinal chemistry. vol 35. issue 23. 1992-12-28. PMID:1360026. selectivity for sigma sites over dopamine d2 or serotonin 5-ht2 receptors appears to be governed by the chemical nature of the piperidine nitrogen substituent, its distance from the basic nitrogen, and its orientation relative to the other piperidine substituent. 1992-12-28 2023-08-11 rat
H Jørgensen, U Knigge, J Warber. Effect of serotonin 5-HT1, 5-HT2, and 5-HT3 receptor antagonists on the prolactin response to restraint and ether stress. Neuroendocrinology. vol 56. issue 3. 1992-12-22. PMID:1436375. effect of serotonin 5-ht1, 5-ht2, and 5-ht3 receptor antagonists on the prolactin response to restraint and ether stress. 1992-12-22 2023-08-11 rat
H Jørgensen, U Knigge, J Warber. Effect of serotonin 5-HT1, 5-HT2, and 5-HT3 receptor antagonists on the prolactin response to restraint and ether stress. Neuroendocrinology. vol 56. issue 3. 1992-12-22. PMID:1436375. in order further to elucidate the role of 5-ht and the type of 5-ht receptor(s) involved in the prl response to stress, we investigated the effect of blockade of 5-ht1, 5-ht2 or 5-ht3 receptors on the restraint or ether stress-induced release of prl in male rats. 1992-12-22 2023-08-11 rat
D Pawlak, D Krygicz, E Chabielska, W Buczk. Influence of acetaldehyde on the vasopressor effect of serotonin in pithed rats. Alcohol and alcoholism (Oxford, Oxfordshire). vol 27. issue 4. 1992-12-18. PMID:1418111. our data suggested that the action of acetaldehyde on the effects of serotonin in pithed rats was non-specific and independent of its interaction with serotonergic 5-ht1 and 5-ht2 receptors in blood vessels. 1992-12-18 2023-08-11 rat
S J MacLennan, G R Marti. Effect of the thromboxane A2-mimetic U46619 on 5-HT1-like and 5-HT2 receptor-mediated contraction of the rabbit isolated femoral artery. British journal of pharmacology. vol 107. issue 2. 1992-12-18. PMID:1422590. in the absence of u46619, 5-ht responses were mediated predominantly by 5-ht2-receptors as judged by potent, surmountable antagonism by the selective 5-ht2 receptor antagonists, spiperone and ketanserin. 1992-12-18 2023-08-11 rabbit
S J MacLennan, G R Marti. Effect of the thromboxane A2-mimetic U46619 on 5-HT1-like and 5-HT2 receptor-mediated contraction of the rabbit isolated femoral artery. British journal of pharmacology. vol 107. issue 2. 1992-12-18. PMID:1422590. in the presence of u46619 (3-10 nm), 5-ht-induced contractions were largely resistant to blockade by 5-ht2 receptor antagonists since 5-ht1-like receptor-mediated contraction now accounted for approximately 60% of the 5-ht maximum response. 1992-12-18 2023-08-11 rabbit
T M Cocks, P J Arnol. 5-Hydroxytryptamine (5-HT) mediates potent relaxation in the sheep isolated pulmonary vein via activation of 5-HT4 receptors. British journal of pharmacology. vol 107. issue 2. 1992-12-18. PMID:1422600. ketanserin, methiothepin, methysergide and mdl 72222 at concentrations that selectively block 5-ht2, 5-ht1-like and 5-ht3 receptors respectively, had no effect on the concentration-relaxation curve to 5-ht. 1992-12-18 2023-08-11 Not clear
J E Macor, C B Fox, C Johnson, B K Koe, L A Lebel, S H Zor. 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. Journal of medicinal chemistry. vol 35. issue 20. 1992-12-18. PMID:1433172. the high affinity and potency of 5 for 5-ht2 receptors suggests that the c5-hydroxy group in serotonin can function as a hydrogen bond acceptor in a 5-ht2 receptor with a directionality of interaction which is down and away from c6 in serotonin (figure 5). 1992-12-18 2023-08-11 rat
J E Macor, C B Fox, C Johnson, B K Koe, L A Lebel, S H Zor. 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. Journal of medicinal chemistry. vol 35. issue 20. 1992-12-18. PMID:1433172. furthermore, the potent affinity of these compounds for 5-ht2 receptors coupled with their poor affinity for 5-ht1 receptors indicates that the aminoethyl side chain of serotonin adopts significantly different conformations in 5-ht1 versus 5-ht2 receptors. 1992-12-18 2023-08-11 rat
H Muramatsu, H Sawanishi, N Iwasaki, M Kakiuchi, T Ohashi, H Kato, Y It. [Studies on zwitter-ionization of drugs. I. Synthesis and pharmacological activities of N-alkylcarboxylic acid derivatives of 4-(2-chlorodibenz-[b,f][1,4]oxazepin-11-yl)piperazine, 4-(2-chlorodibenzo[b, f]-[1,4]thiazepin-11-yl)piperazine, and 4-(11H-dibenz-[b,e]azepin-6-yl)piperazine]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 112. issue 7. 1992-12-15. PMID:1432598. compared with the parent compounds (1a-c), 3a-c (n = 1-5) showed weak inhibitory activities on the uptake of noradrenaline and 5-hydroxytryptamine (5-ht) into hypothalamus vesicles and moderate antagonistic actions to 5-ht2 and h1 in several tissues. 1992-12-15 2023-08-11 Not clear
O Edvardsen, I Sylte, S G Dah. Molecular dynamics of serotonin and ritanserin interacting with the 5-HT2 receptor. Brain research. Molecular brain research. vol 14. issue 3. 1992-12-14. PMID:1331649. molecular dynamics of serotonin and ritanserin interacting with the 5-ht2 receptor. 1992-12-14 2023-08-11 Not clear
O Edvardsen, I Sylte, S G Dah. Molecular dynamics of serotonin and ritanserin interacting with the 5-HT2 receptor. Brain research. Molecular brain research. vol 14. issue 3. 1992-12-14. PMID:1331649. a three-dimensional model of the serotonin (5-hydroxytrytamine; 5-ht) 5-ht2 receptor was constructed from the amino acid sequence by molecular graphics techniques, molecular mechanics energy calculations and molecular dynamics simulations. 1992-12-14 2023-08-11 Not clear
H Tan, V Mileti. Diverse actions of 5-hydroxytryptamine on frog spinal dorsal horn neurons in vitro. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1436488. in some neurons depolarized by serotonin, the amine's responses could be mimicked by the selective 5-ht2 agonist (+/-)-1(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride and the 5-ht1c/2 agonist alpha-methyl-5-hydroxytryptamine, and blocked by the 5-ht1c/2 antagonists ketanserin and mianserin. 1992-12-14 2023-08-11 Not clear
S C Risch, C B Nemerof. Neurochemical alterations of serotonergic neuronal systems in depression. The Journal of clinical psychiatry. vol 53 Suppl. 1992-12-11. PMID:1331029. specifically, studies have revealed (1) decreases in brain concentrations of serotonin and decreases in cerebrospinal fluid (csf) concentrations of 5-hydroxyindoleacetic acid (5-hiaa) in a sizeable subgroup of depressed patients; (2) alterations in both presynaptic and postsynaptic cns serotonergic receptors in depressed patients; (3) alterations in putative peripheral markers of cns serotonergic function such as platelet serotonin uptake, platelet [3h]imipramine or [3h]paroxetine binding, platelet 5-ht2 receptor density, and whole blood serotonin content in depressed patients; (4) that virtually all known antidepressant agents, regardless of their receptor-specific properties, have been shown to increase the efficacy of cns serotonergic neurotransmission; (5) that in patients treated with antidepressants who exhibit a remission, rapid depletion of serotonin results in a prompt clinical relapse; and (6) that all known serotonin re-uptake blockers thus far studied have been demonstrated to be clinically effective antidepressant medications. 1992-12-11 2023-08-11 Not clear