Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
D F Avgustinovic. [The effect of the domestication of Norway rats and silver foxes on the serotonin S1A- and S2-receptors of the brain]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 28. issue 4. 1993-01-06. PMID:1455952. |
the specific radioligand binding of serotonin 5-ht1a and 5-ht2 receptors was determined in the frontal cortex and in the hypothalamus of norway rats and silver foxes. |
1993-01-06 |
2023-08-11 |
rat |
M T Barrús, J Marín, J Villamor, G Balfagó. Receptors involved in the modulation of 5-hydroxytryptamine release in bovine cerebral arteries. The Journal of pharmacy and pharmacology. vol 44. issue 10. 1993-01-04. PMID:1360508. |
electrically-stimulated tritium release was decreased by tetrodotoxin (0.8 microm), ca-free medium, denervation with 6-ohda (1.46 mm, 10 min), 5-ht (10 microm), noradrenaline (1 microm) and the agonist of alpha 2-adrenoceptors b-ht 920 (0.1 and 1 microm), enhanced by metitepine (1 microm, antagonists of presynaptic 5-ht1 receptors) and rauwolscine (1 microm, antagonist at alpha 2-adrenoceptors, and also of 5-ht1d receptors) and not affected by ketanserin (1 microm, antagonist of 5-ht2 receptors), methysergide (0.1 microm, antagonist of 5-ht1 and 5-ht2 receptors) and phentolamine (1 and 3 microm antagonist of alpha-adrenoceptors and less potent of 5-ht1 receptors). |
1993-01-04 |
2023-08-11 |
cattle |
T Takahashi, H Hisa, S Sato. Serotonin-induced vasoconstriction in dog kidney. Journal of cardiovascular pharmacology. vol 20. issue 5. 1992-12-31. PMID:1280741. |
these results suggest that 5-ht activates 5-ht1 receptors to induce vasoconstriction by mobilization of extracellular and intracellular ca2+, but simultaneous activation of 5-ht2 receptors attenuates the vasoconstriction, probably by causing vasodilation in dog kidney. |
1992-12-31 |
2023-08-11 |
dog |
J L Herndon, M E Pierson, R A Glenno. Mechanistic investigation of the stimulus properties of 1-(3-trifluoromethylphenyl)piperazine. Pharmacology, biochemistry, and behavior. vol 43. issue 3. 1992-12-30. PMID:1333084. |
the results of these and other published studies suggest roles for 5-hydroxytryptamine 1b (5-ht1b), 5-ht1c, and, possibly, sigma-receptors in the mediation of the tfmpp stimulus and indicate a lack of involvement of 5-ht1a, 5-ht2, dopaminergic, and adrenergic mechanisms in this behavior. |
1992-12-30 |
2023-08-11 |
rat |
Y Takiguchi, K Wada, M Nakashim. Comparison of the inhibitory effects of the TXA2 receptor antagonist, vapiprost, and other antiplatelet drugs on arterial thrombosis in rats: possible role of TXA2. Thrombosis and haemostasis. vol 68. issue 4. 1992-12-30. PMID:1448780. |
the potency ranking of antithrombotic effect was vapiprost > ketanserin (serotonin 5-ht2 receptor antagonist) >> ticlopidine (inhibitor of adp-induced platelet aggregation) = dipyridamole (adenosine uptake inhibitor) > aspirin (cyclooxygenase inhibitor). |
1992-12-30 |
2023-08-11 |
rat |
J Butler, A O'Halloran, B E Leonar. The Galway Study of Panic Disorder. II: Changes in some peripheral markers of noradrenergic and serotonergic function in DSM III-R panic disorder. Journal of affective disorders. vol 26. issue 2. 1992-12-29. PMID:1447432. |
the results of this study suggest that, despite clinical improvement, the peripheral markers of both adrenergic (platelet aggregation to noradrenaline, platelet alpha 2 receptor density and lymphocyte beta receptor density) and serotonergic (platelet aggregation to serotonin, 3h-ketanserin binding to platelet 5ht2 receptors and 3h-5ht uptake into platelets) function largely remained abnormal. |
1992-12-29 |
2023-08-11 |
Not clear |
P J Gilligan, G A Cain, T E Christos, L Cook, S Drummond, A L Johnson, A A Kergaye, J F McElroy, K W Rohrbach, W K Schmid. Novel piperidine sigma receptor ligands as potential antipsychotic drugs. Journal of medicinal chemistry. vol 35. issue 23. 1992-12-28. PMID:1360026. |
selectivity for sigma sites over dopamine d2 or serotonin 5-ht2 receptors appears to be governed by the chemical nature of the piperidine nitrogen substituent, its distance from the basic nitrogen, and its orientation relative to the other piperidine substituent. |
1992-12-28 |
2023-08-11 |
rat |
H Jørgensen, U Knigge, J Warber. Effect of serotonin 5-HT1, 5-HT2, and 5-HT3 receptor antagonists on the prolactin response to restraint and ether stress. Neuroendocrinology. vol 56. issue 3. 1992-12-22. PMID:1436375. |
effect of serotonin 5-ht1, 5-ht2, and 5-ht3 receptor antagonists on the prolactin response to restraint and ether stress. |
1992-12-22 |
2023-08-11 |
rat |
H Jørgensen, U Knigge, J Warber. Effect of serotonin 5-HT1, 5-HT2, and 5-HT3 receptor antagonists on the prolactin response to restraint and ether stress. Neuroendocrinology. vol 56. issue 3. 1992-12-22. PMID:1436375. |
in order further to elucidate the role of 5-ht and the type of 5-ht receptor(s) involved in the prl response to stress, we investigated the effect of blockade of 5-ht1, 5-ht2 or 5-ht3 receptors on the restraint or ether stress-induced release of prl in male rats. |
1992-12-22 |
2023-08-11 |
rat |
D Pawlak, D Krygicz, E Chabielska, W Buczk. Influence of acetaldehyde on the vasopressor effect of serotonin in pithed rats. Alcohol and alcoholism (Oxford, Oxfordshire). vol 27. issue 4. 1992-12-18. PMID:1418111. |
our data suggested that the action of acetaldehyde on the effects of serotonin in pithed rats was non-specific and independent of its interaction with serotonergic 5-ht1 and 5-ht2 receptors in blood vessels. |
1992-12-18 |
2023-08-11 |
rat |
S J MacLennan, G R Marti. Effect of the thromboxane A2-mimetic U46619 on 5-HT1-like and 5-HT2 receptor-mediated contraction of the rabbit isolated femoral artery. British journal of pharmacology. vol 107. issue 2. 1992-12-18. PMID:1422590. |
in the absence of u46619, 5-ht responses were mediated predominantly by 5-ht2-receptors as judged by potent, surmountable antagonism by the selective 5-ht2 receptor antagonists, spiperone and ketanserin. |
1992-12-18 |
2023-08-11 |
rabbit |
S J MacLennan, G R Marti. Effect of the thromboxane A2-mimetic U46619 on 5-HT1-like and 5-HT2 receptor-mediated contraction of the rabbit isolated femoral artery. British journal of pharmacology. vol 107. issue 2. 1992-12-18. PMID:1422590. |
in the presence of u46619 (3-10 nm), 5-ht-induced contractions were largely resistant to blockade by 5-ht2 receptor antagonists since 5-ht1-like receptor-mediated contraction now accounted for approximately 60% of the 5-ht maximum response. |
1992-12-18 |
2023-08-11 |
rabbit |
T M Cocks, P J Arnol. 5-Hydroxytryptamine (5-HT) mediates potent relaxation in the sheep isolated pulmonary vein via activation of 5-HT4 receptors. British journal of pharmacology. vol 107. issue 2. 1992-12-18. PMID:1422600. |
ketanserin, methiothepin, methysergide and mdl 72222 at concentrations that selectively block 5-ht2, 5-ht1-like and 5-ht3 receptors respectively, had no effect on the concentration-relaxation curve to 5-ht. |
1992-12-18 |
2023-08-11 |
Not clear |
J E Macor, C B Fox, C Johnson, B K Koe, L A Lebel, S H Zor. 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. Journal of medicinal chemistry. vol 35. issue 20. 1992-12-18. PMID:1433172. |
the high affinity and potency of 5 for 5-ht2 receptors suggests that the c5-hydroxy group in serotonin can function as a hydrogen bond acceptor in a 5-ht2 receptor with a directionality of interaction which is down and away from c6 in serotonin (figure 5). |
1992-12-18 |
2023-08-11 |
rat |
J E Macor, C B Fox, C Johnson, B K Koe, L A Lebel, S H Zor. 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. Journal of medicinal chemistry. vol 35. issue 20. 1992-12-18. PMID:1433172. |
furthermore, the potent affinity of these compounds for 5-ht2 receptors coupled with their poor affinity for 5-ht1 receptors indicates that the aminoethyl side chain of serotonin adopts significantly different conformations in 5-ht1 versus 5-ht2 receptors. |
1992-12-18 |
2023-08-11 |
rat |
H Muramatsu, H Sawanishi, N Iwasaki, M Kakiuchi, T Ohashi, H Kato, Y It. [Studies on zwitter-ionization of drugs. I. Synthesis and pharmacological activities of N-alkylcarboxylic acid derivatives of 4-(2-chlorodibenz-[b,f][1,4]oxazepin-11-yl)piperazine, 4-(2-chlorodibenzo[b, f]-[1,4]thiazepin-11-yl)piperazine, and 4-(11H-dibenz-[b,e]azepin-6-yl)piperazine]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 112. issue 7. 1992-12-15. PMID:1432598. |
compared with the parent compounds (1a-c), 3a-c (n = 1-5) showed weak inhibitory activities on the uptake of noradrenaline and 5-hydroxytryptamine (5-ht) into hypothalamus vesicles and moderate antagonistic actions to 5-ht2 and h1 in several tissues. |
1992-12-15 |
2023-08-11 |
Not clear |
O Edvardsen, I Sylte, S G Dah. Molecular dynamics of serotonin and ritanserin interacting with the 5-HT2 receptor. Brain research. Molecular brain research. vol 14. issue 3. 1992-12-14. PMID:1331649. |
molecular dynamics of serotonin and ritanserin interacting with the 5-ht2 receptor. |
1992-12-14 |
2023-08-11 |
Not clear |
O Edvardsen, I Sylte, S G Dah. Molecular dynamics of serotonin and ritanserin interacting with the 5-HT2 receptor. Brain research. Molecular brain research. vol 14. issue 3. 1992-12-14. PMID:1331649. |
a three-dimensional model of the serotonin (5-hydroxytrytamine; 5-ht) 5-ht2 receptor was constructed from the amino acid sequence by molecular graphics techniques, molecular mechanics energy calculations and molecular dynamics simulations. |
1992-12-14 |
2023-08-11 |
Not clear |
H Tan, V Mileti. Diverse actions of 5-hydroxytryptamine on frog spinal dorsal horn neurons in vitro. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1436488. |
in some neurons depolarized by serotonin, the amine's responses could be mimicked by the selective 5-ht2 agonist (+/-)-1(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride and the 5-ht1c/2 agonist alpha-methyl-5-hydroxytryptamine, and blocked by the 5-ht1c/2 antagonists ketanserin and mianserin. |
1992-12-14 |
2023-08-11 |
Not clear |
S C Risch, C B Nemerof. Neurochemical alterations of serotonergic neuronal systems in depression. The Journal of clinical psychiatry. vol 53 Suppl. 1992-12-11. PMID:1331029. |
specifically, studies have revealed (1) decreases in brain concentrations of serotonin and decreases in cerebrospinal fluid (csf) concentrations of 5-hydroxyindoleacetic acid (5-hiaa) in a sizeable subgroup of depressed patients; (2) alterations in both presynaptic and postsynaptic cns serotonergic receptors in depressed patients; (3) alterations in putative peripheral markers of cns serotonergic function such as platelet serotonin uptake, platelet [3h]imipramine or [3h]paroxetine binding, platelet 5-ht2 receptor density, and whole blood serotonin content in depressed patients; (4) that virtually all known antidepressant agents, regardless of their receptor-specific properties, have been shown to increase the efficacy of cns serotonergic neurotransmission; (5) that in patients treated with antidepressants who exhibit a remission, rapid depletion of serotonin results in a prompt clinical relapse; and (6) that all known serotonin re-uptake blockers thus far studied have been demonstrated to be clinically effective antidepressant medications. |
1992-12-11 |
2023-08-11 |
Not clear |