| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A F Schatzberg, A J Rothschil. Serotonin activity in psychotic (delusional) major depression. The Journal of clinical psychiatry. vol 53 Suppl. 1992-12-11. PMID:1429484. |
future studies on serotonin as well as on 5-ht2 antagonists in delusional depression are warranted. |
1992-12-11 |
2023-08-11 |
Not clear |
| X N Li, P Stulz, R P Siebenmann, Z Yang, T F Lüsche. Different effects of activated platelets in the right gastroepiploic and internal mammary arteries. Implications for coronary artery grafting. The Journal of thoracic and cardiovascular surgery. vol 104. issue 5. 1992-12-11. PMID:1434709. |
in contrast, in the porcine and human mammary arteries, endothelium-dependent relaxations to platelets mediated by nitric oxide were noted, particularly in rings preincubated with the thromboxane a2 receptor antagonist sq-30741 and the 5-hydroxytryptamine (5ht2)-serotonergic receptor antagonist ketanserin. |
1992-12-11 |
2023-08-11 |
human |
| E R Korpi, P Päivärinta, A Abi-Dargham, A Honkanen, M Laruelle, K Tuominen, L A Hilakiv. Binding of serotonergic ligands to brain membranes of alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol (Fayetteville, N.Y.). vol 9. issue 5. 1992-12-10. PMID:1418660. |
in the present study, the 5-ht1, 5-ht2, and 5-ht3 receptors were studied with [3h]5-ht, [3h]ketanserin, and [3h]ly278584, respectively, in membrane homogenates from different brain regions of both rat lines using in vitro binding assays. |
1992-12-10 |
2023-08-11 |
rat |
| G Blaise, L Dumont, J Buluran, A Omri, C Sill, A De Lea. Mechanism of halothane attenuation of isometric tension induced by serotonin in isolated canine coronary artery rings. Journal of cardiovascular pharmacology. vol 20. issue 3. 1992-12-09. PMID:1279291. |
halothane attenuated the coronary artery response to serotonin (5-hydroxytryptamine, 5-ht), and specific 5-ht1 and 5-ht2 agonists, and prostaglandin f2 alpha (pgf2 alpha). |
1992-12-09 |
2023-08-11 |
Not clear |
| I Krisch, M V Budihna, R Rucma. Structure-activity study of some newly synthesized ergoline derivatives on 5-HT2 receptors and alpha-adrenoceptors in rabbit isolated aorta. Pharmacology. vol 45. issue 4. 1992-12-09. PMID:1332086. |
the parent compound lek 8842 showed strong alpha-adrenoceptor agonistic activity and partial 5-ht2 receptor agonistic activity, and its potency (pd2 = 6.41) was comparable with that of 5-hydroxytryptamine (5-ht, pd2 = 6.84) and noradrenaline (pd2 = 6.82). |
1992-12-09 |
2023-08-11 |
rabbit |
| K D Burris, E Sanders-Bus. Unsurmountable antagonism of brain 5-hydroxytryptamine2 receptors by (+)-lysergic acid diethylamide and bromo-lysergic acid diethylamide. Molecular pharmacology. vol 42. issue 5. 1992-12-09. PMID:1359397. |
the present studies investigate the mechanism of antagonism of brain 5-hydroxytryptamine (5ht)2 receptors, utilizing cells transfected with 5ht2 receptor cdna cloned from rat brain. |
1992-12-09 |
2023-08-11 |
rat |
| R J Baldessarini, N S Kula, A Campbell, V Bakthavachalam, J Yuan, J L Neumeye. Prolonged D2 antidopaminergic activity of alkylating and nonalkylating derivatives of spiperone in rat brain. Molecular pharmacology. vol 42. issue 5. 1992-12-09. PMID:1435753. |
nps, naps, and nips showed little or no affinity for 34 non-da binding sites defined by radioligand assays for monoamine, amino acid, and peptide neurotransmitters, ion channels, peptide growth factors, and transmission mediators but did show low alpha 2 and moderate alpha 1 and 5-hydroxytryptamine (5-ht2) affinity with rat forebrain tissue in vitro; nips showed a marked gain in d2 versus 5-ht2 selectivity, compared with spiperone (1520- versus 26-fold). |
1992-12-09 |
2023-08-11 |
rat |
| R W Fuller, H D Snodd. Neuroendocrine evidence for antagonism of serotonin and dopamine receptors by olanzapine (LY170053), an antipsychotic drug candidate. Research communications in chemical pathology and pharmacology. vol 77. issue 1. 1992-12-07. PMID:1359615. |
these relative potencies in blocking quipazine and pergolide effects are taken as indices of antagonism of serotonin 5ht2 and of dopamine d2 receptors, respectively. |
1992-12-07 |
2023-08-11 |
rat |
| R A Glennon, M Teitler, E Sanders-Bus. Hallucinogens and serotonergic mechanisms. NIDA research monograph. vol 119. 1992-12-07. PMID:1435968. |
serotonin, with an intrinsic activity of 1.0, is not hallucinogenic whereas hallucinogens may be hallucinogenic because they are high-affinity 5-ht2 partial agonists. |
1992-12-07 |
2023-08-11 |
human |
| M E Alburges, M E Hunt, R D McQuade, J K Wamsle. D1-receptor antagonists: comparison of [3H]SCH39166 to [3H]SCH23390. Journal of chemical neuroanatomy. vol 5. issue 5. 1992-12-04. PMID:1358117. |
low levels of binding (not significantly above background) were detected with [3h]sch39166 in lamina iv of the cortex and in choroid plexus; areas which had significant [3h]sch23390 binding and are known to have a high density of 5-ht (5-ht2 and 5-ht1c respectively) receptors. |
1992-12-04 |
2023-08-11 |
Not clear |
| A Albinsson, G Andersso. The effect of amperozide, a new antipsychotic drug, on plasma corticosterone concentration in the rat. Life sciences. vol 51. issue 19. 1992-12-04. PMID:1359366. |
amperozide is an atypical antipsychotic drug with high affinity for the serotonin 5-ht2 receptor but with low affinity for the dopamine d1 and d2 receptors. |
1992-12-04 |
2023-08-11 |
rat |
| I S de la Land. Evidence for a 5-HT1-like receptor mediating the amplifying action of 5-HT in the rabbit ear artery. British journal of pharmacology. vol 107. issue 1. 1992-12-04. PMID:1422578. |
the amplifying effect of 5-ht (method i) was unaffected by prazosin (0.08 microm), was partly depressed by 5-ht2-receptor antagonists in high concentrations (ketanserin 0.5 microm, ly53857, 1.0 microm), and was abolished by a non-selective antagonist of 5-ht1 and 5-ht2 receptors (methiothepin, 0.01 microm). |
1992-12-04 |
2023-08-11 |
dog |
| E F Bond, M M Heitkemper, M K Gruve. Mediation of thyrotropin-releasing hormone induced gastric motility increases in developing rats. European journal of pharmacology. vol 217. issue 2-3. 1992-12-04. PMID:1425933. |
a serotonin (5-ht) antagonist (5-ht2, ketanserin or xylamidine; 5-ht3, mdl 72222) or an acetylcholine receptor blocker (atropine) was administered intraperitoneally 30 min prior to intracisternal trh (5-10 micrograms). |
1992-12-04 |
2023-08-11 |
rat |
| R M Eglen, L A Perkins, L K Walsh, R L Whitin. Agonist action of indole derivatives at 5-HT1-like, 5-HT3, and 5HT4 receptors in vitro. Journal of autonomic pharmacology. vol 12. issue 5. 1992-12-04. PMID:1429745. |
these have been compared to other 5-ht receptors in canine saphenous vein (5-ht1-like), rabbit aorta (5-ht2), and guinea-pig ileum (5-ht3). |
1992-12-04 |
2023-08-11 |
rat |
| H Y Meltze. The importance of serotonin-dopamine interactions in the action of clozapine. The British journal of psychiatry. Supplement. issue 17. 1992-12-02. PMID:1358125. |
the atypical antipsychotic drugs also differ from the typical antipsychotic drugs by a relatively high affinity for the serotonin (5-ht2) receptor. |
1992-12-02 |
2023-08-11 |
Not clear |
| C Gerdes, A Richter, R Annies, W Lösche. Increase of serotonin in plasma during onset of halothane-induced malignant hyperthermia in pigs. European journal of pharmacology. vol 220. issue 1. 1992-12-02. PMID:1425984. |
since pharmacological stimulation of 5-ht2 receptors has recently been shown to trigger mh in susceptible pigs, the finding of increased 5-ht plasma levels during onset of halothane-induced mh may indicate that 5-ht is involved in the mechanisms by which volatile anesthetics trigger this myopathic syndrome. |
1992-12-02 |
2023-08-11 |
Not clear |
| A E Busch, M P Kavanaugh, M D Varnum, J P Adelman, R A Nort. Regulation by second messengers of the slowly activating, voltage-dependent potassium current expressed in Xenopus oocytes. The Journal of physiology. vol 450. 1992-12-02. PMID:1432714. |
in oocytes that had also been injected with rna encoding the 5-hydroxytryptamine (5-ht2) receptor, 5-ht increased the potassium current. |
1992-12-02 |
2023-08-11 |
xenopus_laevis |
| M Y Globus, P Wester, R Busto, W D Dietric. Ischemia-induced extracellular release of serotonin plays a role in CA1 neuronal cell death in rats. Stroke. vol 23. issue 11. 1992-12-01. PMID:1279842. |
serotonin, via 5-ht2 receptors, exerts an excitatory effect on ca1 neurons and may play a role in ischemia-induced excitotoxic damage. |
1992-12-01 |
2023-08-11 |
rat |
| I Heuzé-Joubert, P Mennecier, S Simonet, M Laubie, T J Verbeure. Effect of vasodilators, including nitric oxide, on the release of cGMP and cAMP in the isolated perfused rat kidney. European journal of pharmacology. vol 220. issue 2-3. 1992-12-01. PMID:1330617. |
the vasodilator responses to 5-hydroxytryptamine (5-ht; 0.25-2 mumol), obtained in presence of the 5-ht2 receptor blocker ritanserin (10 nm) and the 5-ht3 blocker ics 205930 (10 nm), were markedly reduced by l-nna; however, they were not accompanied by the renal release of cgmp. |
1992-12-01 |
2023-08-11 |
rat |
| J D Kursar, D L Nelson, D B Wainscott, M L Cohen, M Bae. Molecular cloning, functional expression, and pharmacological characterization of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus. Molecular pharmacology. vol 42. issue 4. 1992-12-01. PMID:1331748. |
cell lines stably expressing the 5-ht2f receptor were established and demonstrated functional coupling to phosphatidylinositol hydrolysis upon 5-ht stimulation analagous to that observed for the 5-ht1c and 5-ht2 receptors. |
1992-12-01 |
2023-08-11 |
rat |