All Relations between 5-ht receptor 2 and serotonin

Publication Sentence Publish Date Extraction Date Species
M O Den Boer, C M Villalón, P R Saxen. 5-HT1-like receptor mediated changes in porcine carotid haemodynamics: are 5-HT1D receptors involved? Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 5. 1992-10-22. PMID:1326717. 5-hydroxytryptamine (5-ht) reduces porcine arteriovenous shunting in the carotid vascular bed by stimulation of both 5-ht1-like and 5-ht2 receptors and increases capillary flow to some tissues, like the skin and ears, by different 5-ht1-like receptors. 1992-10-22 2023-08-11 Not clear
M O Den Boer, C M Villalón, P R Saxen. 5-HT1-like receptor mediated changes in porcine carotid haemodynamics: are 5-HT1D receptors involved? Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 5. 1992-10-22. PMID:1326717. the effect of metergoline (1 mg.kg-1), a substance with a very high affinity for the 5-ht1d receptor as well as for the 5-ht1a, 5-ht1b, 5-ht1c and 5-ht2 receptors, was studied on the responses to 5-ht and sumatriptan. 1992-10-22 2023-08-11 Not clear
J C Shih, T Gallaher, C D Wang, K Che. Site-directed mutagenesis of serotonin 5-HT2 receptors. Journal of chemical neuroanatomy. vol 5. issue 4. 1992-10-22. PMID:1524714. site-directed mutagenesis of serotonin 5-ht2 receptors. 1992-10-22 2023-08-11 Not clear
H Emanuelsso. Autoradiographic localization in polychaete embryos of tritiated mesulergine, a selective antagonist of serotonin receptors that inhibits early polychaete development. The International journal of developmental biology. vol 36. issue 2. 1992-10-22. PMID:1525017. developing embryos of the polychaete ophryotrochal labronica were exposed to tritiated mesulergine, a selective antagonist of the serotonin receptors 5-ht1c and 5-ht2, that also has significant affinity to dopamine d-2 sites, and the labeling was analyzed by autoradiography. 1992-10-22 2023-08-11 Not clear
L Staner, C Kempenaers, M P Simonnet, L Fransolet, J Mendlewic. 5-HT2 receptor antagonism and slow-wave sleep in major depression. Acta psychiatrica Scandinavica. vol 86. issue 2. 1992-10-20. PMID:1529736. these results are in agreement with a potential 5-ht disturbance, particularly at the 5-ht2 receptor level, in some clinical forms of depression. 1992-10-20 2023-08-11 human
C Moummi, D C Yang, G W Gullikso. 5-HT4 receptor activation induces relaxation and associated cAMP generation in rat esophagus. European journal of pharmacology. vol 216. issue 1. 1992-10-19. PMID:1326439. serotonin (5-ht) and 5 methoxytryptamine (5-mot; 5-ht4 agonist) caused concentration-related relaxation responses, while 5-carboxamidotryptamine (5-ct; 5-ht1 agonist), 1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane (doi; 5-ht2 agonist) and 2-methyl-serotonin (2-methyl-5-ht; 5-ht3 agonist) were less active. 1992-10-19 2023-08-11 rat
C Moummi, D C Yang, G W Gullikso. 5-HT4 receptor activation induces relaxation and associated cAMP generation in rat esophagus. European journal of pharmacology. vol 216. issue 1. 1992-10-19. PMID:1326439. the relaxation was not due to activity at receptors other than the 5-ht4 since methysergide (5-ht1 and 5-ht2 antagonist) and granisetron (5-ht3 antagonist) did not block the relaxant response to 5-ht while ics 205930 (5-ht4 antagonist) antagonized this response (pa2 = 6.45). 1992-10-19 2023-08-11 rat
B J Key, C C Wigfiel. Changes in the tail surface temperature of the rat following injection of 5-hydroxytryptamine into the ventrolateral medulla. Neuropharmacology. vol 31. issue 8. 1992-10-19. PMID:1528403. the 5-ht2 receptor agonist, alpha-methyl 5-hydroxytryptamine (alpha-methyl 5-ht, 5.5-100 nmol) was only effective in increasing tail and plantar foot temperatures, at dose levels above 25 nmol. 1992-10-19 2023-08-11 rat
J T Pan, M H Ta. Effects of ketanserin on DOI-, MCPP- and TRH-induced prolactin secretion in estrogen-treated rats. Life sciences. vol 51. issue 11. 1992-10-14. PMID:1522746. the effects of ketanserin (ket), a serotonin (5-ht2) receptor antagonist, on doi- and mcpp-, two 5-ht agonists, and trh-induced prl secretion were studied. 1992-10-14 2023-08-11 rat
K M Dhasmana, C M Villalón, Y N Zhu, S Tadipatri, P R Saxen. Role of 5-HT1-like receptors in the increase in intragastric pressure induced by 5-hydroxytryptamine in the rat. European journal of pharmacology. vol 213. issue 2. 1992-10-13. PMID:1521563. bolus injections of 5-ht (2.5, 5.0 and 10 micrograms/kg) produced dose-dependent increases in intragastric pressure; these effects were not modified by atropine (up to 0.2 mg/kg) or mepyramine (1 mg/kg), but were blocked by the mixed 5-ht1-like and 5-ht2 receptor antagonists, methiothepin (0.1, 0.3 and 0.5 mg/kg i.v.) 1992-10-13 2023-08-11 rat
U Freo, H W Holloway, K Kalogeras, S I Rapoport, T T Soncran. Adrenalectomy or metyrapone-pretreatment abolishes cerebral metabolic responses to the serotonin agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) in the hippocampus. Brain research. vol 586. issue 2. 1992-10-09. PMID:1521159. 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi), a serotonin type 2 (5-ht2) agonist, elevates plasma corticosterone levels and reduces the cerebral metabolic rate for glucose (rcmrglc) in the hippocampus, a structure which possesses few 5-ht2 receptors but a large number of steroid receptors. 1992-10-09 2023-08-11 rat
L Rény. The involvement of the 5-HT1 and 5-HT2 receptors and of catecholaminergic systems in different components of the 5-HT syndrome in the rat. Polish journal of pharmacology and pharmacy. vol 43. issue 5. 1992-10-09. PMID:1824130. the involvement of the 5-ht1 and 5-ht2 receptors and of catecholaminergic systems in different components of the 5-ht syndrome in the rat. 1992-10-09 2023-08-11 rat
J K Gill, G Stansby, N Shukla, G Hamilton, M A Barradas, J Y Jerem. 5-Hydroxytryptamine stimulates 45Ca2+ uptake by human umbilical vein endothelial cells in culture: mediation by 5-HT2 receptor subtypes. European journal of pharmacology. vol 214. issue 2-3. 1992-10-08. PMID:1516643. 5-hydroxytryptamine stimulates 45ca2+ uptake by human umbilical vein endothelial cells in culture: mediation by 5-ht2 receptor subtypes. 1992-10-08 2023-08-11 human
J K Gill, G Stansby, N Shukla, G Hamilton, M A Barradas, J Y Jerem. 5-Hydroxytryptamine stimulates 45Ca2+ uptake by human umbilical vein endothelial cells in culture: mediation by 5-HT2 receptor subtypes. European journal of pharmacology. vol 214. issue 2-3. 1992-10-08. PMID:1516643. these data indicate that 5-ht stimulates ca2+ uptake by endothelial cells via activation of a 5-ht2 receptor subtype. 1992-10-08 2023-08-11 human
S Leonhardt, E Gorospe, B J Hoffman, M Teitle. Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Molecular pharmacology. vol 42. issue 2. 1992-09-30. PMID:1355262. 5-hydroxytryptamine (5ht)1c and 5ht2 receptors appear to be closely related, from a molecular viewpoint, displaying similar second messenger systems and a high degree of sequence homology. 1992-09-30 2023-08-11 human
S Leonhardt, E Gorospe, B J Hoffman, M Teitle. Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Molecular pharmacology. vol 42. issue 2. 1992-09-30. PMID:1355262. however, there are striking differences in the interactions of 5ht with 5ht1c and 5ht2 receptors; 5ht is generally more potent in stimulating responses mediated through 5ht1c receptors than responses mediated through 5ht2 receptors. 1992-09-30 2023-08-11 human
S Leonhardt, E Gorospe, B J Hoffman, M Teitle. Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Molecular pharmacology. vol 42. issue 2. 1992-09-30. PMID:1355262. also [3h]5ht labels 5ht1c receptors and not 5ht2 receptors. 1992-09-30 2023-08-11 human
S Leonhardt, E Gorospe, B J Hoffman, M Teitle. Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Molecular pharmacology. vol 42. issue 2. 1992-09-30. PMID:1355262. the second messenger studies confirmed the approximately 10-fold higher potency of 5ht in stimulating intracellular responses through 5ht1c receptors (ec50 = 8.3 nm) than in stimulating intracellular responses through 5ht2 receptors (ec50 = 101 nm). 1992-09-30 2023-08-11 human
S Leonhardt, E Gorospe, B J Hoffman, M Teitle. Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Molecular pharmacology. vol 42. issue 2. 1992-09-30. PMID:1355262. an agonist radioligand selective for the 5ht1c and 5ht2 receptors, 2,5-dimethoxy-(4-[125i]iodo)phenylisopropylamine, was used, as well as [3h]5ht, [3h]mesulergine (antagonist radioligand for 5ht1c receptors), and [3h]ketanserin (antagonist radioligand for 5ht2 receptors). 1992-09-30 2023-08-11 human
S Leonhardt, E Gorospe, B J Hoffman, M Teitle. Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Molecular pharmacology. vol 42. issue 2. 1992-09-30. PMID:1355262. the apparent higher affinity of 5ht for the radiolabeled 5ht1c receptors was due to the higher affinity 5ht displayed for the agonist low affinity state of the 5ht1c receptor, compared with the affinity of 5ht for the agonist low affinity state of the 5ht2 receptor. 1992-09-30 2023-08-11 human