| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Elliott, D I Walli. Serotonin and L-norepinephrine as mediators of altered excitability in neonatal rat motoneurons studied in vitro. Neuroscience. vol 47. issue 3. 1992-06-16. PMID:1584408. |
it is proposed that the depolarization and increase in excitability of spinal motoneurons is mediated by a serotonin (5-ht2) receptor subtype. |
1992-06-16 |
2023-08-11 |
rat |
| K Nordlind, E Sundström, L Bondesso. Inhibiting effects of serotonin antagonists on the proliferation of mercuric chloride stimulated human peripheral blood T lymphocytes. International archives of allergy and immunology. vol 97. issue 2. 1992-06-15. PMID:1582705. |
it thus seems as if the inhibiting effect of serotonin on t lymphocytes is mediated by 5-ht1c or 5-ht2 receptors, while the mechanism for the intrinsic inhibiting effect of the antagonists at present is unknown. |
1992-06-15 |
2023-08-11 |
human |
| T Nabeshima, K Ichihara, K Tohyama, K Murase, T Suzuki, T Kameyam. Involvement of serotonergic neuronal systems in the anti-amnesic action of naftidrofuryl oxalate. European journal of pharmacology. vol 205. issue 1. 1992-06-09. PMID:1811997. |
a binding study revealed that naftidrofuryl oxalate inhibited the binding of [3h]ketanserin to 5-ht2 receptors in mouse brain synaptic membrane in a dose-dependent fashion (ic50 = 1.42 x 10(-7) m), but did not inhibit that of [3h]serotonin to 5-ht1 receptors. |
1992-06-09 |
2023-08-11 |
mouse |
| R A Foy, J L Myles, R D Wilkerso. Characterization of 5-hydroxytryptamine receptors in bovine coronary arteries. The Journal of pharmacology and experimental therapeutics. vol 261. issue 2. 1992-06-05. PMID:1533667. |
concentration-response relationships for 8-hydroxy-2-(di-n-propylamino)-tetralin (5-ht1a agonist) (0.3-100 microm), cgs-12066b maleate (5-ht1b agonist) (0.01-30 microm), alpha-methylserotonin maleate (5-ht2 agonist) (0.01-30 microm), 1-(m-chlorophenyl)-biguanide (5-ht3 agonist) (0.1-100 microm) and serotonin (0.1-300 microm) were studied in vitro using 2-mm segments of bovine proximal left anterior descending coronary artery. |
1992-06-05 |
2023-08-11 |
cattle |
| R A Foy, J L Myles, R D Wilkerso. Characterization of 5-hydroxytryptamine receptors in bovine coronary arteries. The Journal of pharmacology and experimental therapeutics. vol 261. issue 2. 1992-06-05. PMID:1533667. |
pretreatment with s(-)propranolol or ketanserin also attenuated serotonin-induced contraction, demonstrating that serotonin mediates contraction through both 5-ht1a and 5-ht2 receptors in bovine large coronary arteries. |
1992-06-05 |
2023-08-11 |
cattle |
| S W Johnson, N B Mercuri, R A Nort. 5-hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 5. 1992-06-05. PMID:1578282. |
(+/-)-cyanopindolol (100 nm), a 5-ht1b antagonist, blocked the effect of 5-ht (10 microm); spiperone (1 microm), which is an antagonist at 5-ht1a and 5-ht2 receptors, had no effect. |
1992-06-05 |
2023-08-11 |
rat |
| J Blin, C Crouze. Blood-cerebrospinal fluid and blood-brain barriers imaged by 18F-labeled metabolites of 18F-setoperone studied in humans using positron emission tomography. Journal of neurochemistry. vol 58. issue 6. 1992-06-04. PMID:1573409. |
18f-setoperone, a sensitive radioligand for brain serotonin 5-ht2 receptor positron emission tomography studies, is metabolized into 18f-labeled metabolites, which participate in blood 18f radioactivity. |
1992-06-04 |
2023-08-11 |
Not clear |
| S Tadipatri, D van Heuven-Nolsen, W Feniuk, P R Saxen. Analysis of the 5-HT receptors mediating contractions in the rabbit isolated renal artery. British journal of pharmacology. vol 104. issue 4. 1992-06-03. PMID:1667289. |
these data suggest that: (i) 5-ht receptors mediating vasodilatation are not present in the rabbit renal artery smooth muscle or endothelium; (ii) the contractile effect of 5-ht does not involve the release of noradrenaline from sympathetic nerve stores; (iii) the 5-ht receptor in the rabbit renal artery is not of the 5-ht2, 5-ht3 or 5-ht4 type. |
1992-06-03 |
2023-08-11 |
rabbit |
| H Gürdal, F C Tuluna. Heterogeneous inhibitory effect of nitrendipine on 5-HT-responses in rabbit vascular tissues. General pharmacology. vol 22. issue 6. 1992-06-03. PMID:1810803. |
although 5-ht2 receptor reserve seems to be similar in these preparations, nitrendipine had a heterogeneous inhibitory effect on the contractile response to 5-ht. |
1992-06-03 |
2023-08-11 |
rabbit |
| C J Thompson, I R Jones, M Walker, P H Baylis, P Kendall-Taylo. The effects of the specific serotonin antagonist ICI 169,369 on the pituitary hormone response to insulin-induced hypoglycaemia in humans. Clinical endocrinology. vol 36. issue 3. 1992-05-21. PMID:1314144. |
to examine the role of serotonin in pituitary hormone release by studying the effect of a specific 5ht2 receptor antagonist, ici 169,369, on the acth, prolactin, growth hormone and avp response to insulin-induced hypoglycaemia in healthy humans. |
1992-05-21 |
2023-08-11 |
Not clear |
| J Hallmayer, J L Kennedy, L Wetterberg, B Sjögren, K K Kidd, L L Cavalli-Sforz. Exclusion of linkage between the serotonin2 receptor and schizophrenia in a large Swedish kindred. Archives of general psychiatry. vol 49. issue 3. 1992-05-20. PMID:1348924. |
recently a copy dna encoding the serotonin 5-ht2 receptor has been isolated and with a human 5-ht2 receptor copy dna probe the htr2 locus has been mapped to chromosome 13. |
1992-05-20 |
2023-08-11 |
human |
| J Hallmayer, J L Kennedy, L Wetterberg, B Sjögren, K K Kidd, L L Cavalli-Sforz. Exclusion of linkage between the serotonin2 receptor and schizophrenia in a large Swedish kindred. Archives of general psychiatry. vol 49. issue 3. 1992-05-20. PMID:1348924. |
given this result, we conclude that the serotonin 5-ht2 receptor gene itself is not a major susceptibility gene for schizophrenia in this family. |
1992-05-20 |
2023-08-11 |
human |
| E Chojnacka-Wójcik, A Kłodzińsk. Involvement of 5-HT1B receptors in the anticonflict effect of m-CPP in rats. Journal of neural transmission. General section. vol 87. issue 2. 1992-05-12. PMID:1348421. |
on the other hand, the 5-ht1a receptor antagonist nan-190 (0.5 and 1 mg/kg), the 5-ht2 receptor antagonist ritanserin (0.25 and 0.5 mg/kg), and the beta-blockers betaxolol (8 mg/kg) and ici 118,551 (8 mg/kg) with no affinity for 5-ht receptors did not affect the effect of m-cpp. |
1992-05-12 |
2023-08-11 |
rat |
| M R Pranzatelli, J N Murthy, R S Pluchin. Identification of spinal 5-HT1C binding sites in the rat: characterization of [3H]mesulergine binding. The Journal of pharmacology and experimental therapeutics. vol 261. issue 1. 1992-05-12. PMID:1560361. |
there was a high correlation between drug affinities for [3h]mesulergine-labeled 5-ht1c sites in spinal cord and those reported in pig cortex (r = 0.94) and choroid plexus (r = 0.93), but poor correlation with 5-ht2 (high or low affinity states) or other 5-ht sites. |
1992-05-12 |
2023-08-11 |
rat |
| M R Pranzatelli, J N Murthy, R S Pluchin. Identification of spinal 5-HT1C binding sites in the rat: characterization of [3H]mesulergine binding. The Journal of pharmacology and experimental therapeutics. vol 261. issue 1. 1992-05-12. PMID:1560361. |
limited competition studies suggest that [3h]5-ht labels 5-ht1c sites, [3h]ketanserin labels spinal 5-ht2 sites and [3h]mianserin labels both sites under the assay conditions studied, but the population of spinal 5-ht2 is small and not well characterized by these [3h]radioligands. |
1992-05-12 |
2023-08-11 |
rat |
| M L Cohen, D W Robertson, W E Bloomquist, H C Wilso. LY215840, a potent 5-hydroxytryptamine (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2 receptors and delays occlusion in a rabbit model of thrombosis. The Journal of pharmacology and experimental therapeutics. vol 261. issue 1. 1992-05-12. PMID:1560366. |
ly215840, a potent 5-hydroxytryptamine (5-ht)2 receptor antagonist, blocks vascular and platelet 5-ht2 receptors and delays occlusion in a rabbit model of thrombosis. |
1992-05-12 |
2023-08-11 |
human |
| M L Cohen, D W Robertson, W E Bloomquist, H C Wilso. LY215840, a potent 5-hydroxytryptamine (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2 receptors and delays occlusion in a rabbit model of thrombosis. The Journal of pharmacology and experimental therapeutics. vol 261. issue 1. 1992-05-12. PMID:1560366. |
in the rat jugular vein, ly215840 (3 x 109-10) to 10(-8) m) blocked 5-ht2 receptors mediating contraction to 5-ht in vitro. |
1992-05-12 |
2023-08-11 |
human |
| M L Cohen, D W Robertson, W E Bloomquist, H C Wilso. LY215840, a potent 5-hydroxytryptamine (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2 receptors and delays occlusion in a rabbit model of thrombosis. The Journal of pharmacology and experimental therapeutics. vol 261. issue 1. 1992-05-12. PMID:1560366. |
administration to rats, ly215840 was a potent 5-ht2 receptor antagonist, documented by its ability to block the pressor response to 5-ht administered i.v. |
1992-05-12 |
2023-08-11 |
human |
| J M Seager, A H Clark, C J Garlan. Endothelium-dependent contractile responses to 5-hydroxytryptamine in the rabbit basilar artery. British journal of pharmacology. vol 105. issue 2. 1992-05-08. PMID:1532763. |
2 the additional contractions to 5-ht were not altered by the 5-ht2 antagonist, ketanserin (1 microm), but were abolished in the presence of the cyclo-oxygenase inhibitor indomethacin (3 microm). |
1992-05-08 |
2023-08-11 |
rabbit |
| A L Killam, M L Cohe. Characterization of rat platelet serotonin receptors with tryptamine agonists and the antagonists: ketanserin and SCH 23390. Thrombosis research. vol 64. issue 3. 1992-05-06. PMID:1805448. |
current literature suggests that the platelet 5-ht2 receptor, thought to be the only active platelet serotonin (5-ht) receptor, may be both heterogeneous and not the sole 5-ht receptor subtype on platelet membranes. |
1992-05-06 |
2023-08-11 |
rat |