| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A L Killam, M L Cohe. Characterization of rat platelet serotonin receptors with tryptamine agonists and the antagonists: ketanserin and SCH 23390. Thrombosis research. vol 64. issue 3. 1992-05-06. PMID:1805448. |
in contrast, alpha-ch3-5-ht-induced shape change and enhancement of adp aggregation were superimposable with that of 5-ht itself suggesting 5-ht2 receptor activation. |
1992-05-06 |
2023-08-11 |
rat |
| A L Killam, M L Cohe. Characterization of rat platelet serotonin receptors with tryptamine agonists and the antagonists: ketanserin and SCH 23390. Thrombosis research. vol 64. issue 3. 1992-05-06. PMID:1805448. |
the antagonists, ketanserin and sch 23390, inhibited 5-ht enhancement of adp-induced aggregation with affinity constants consistent with the presence of 5-ht2 receptors as well. |
1992-05-06 |
2023-08-11 |
rat |
| A L Killam, M L Cohe. Characterization of rat platelet serotonin receptors with tryptamine agonists and the antagonists: ketanserin and SCH 23390. Thrombosis research. vol 64. issue 3. 1992-05-06. PMID:1805448. |
thus, although reports of multiple platelet 5-ht receptors exist, the only detectable, functional 5-ht receptor to enhance aggregation in rat platelets was probably of the 5-ht2 type. |
1992-05-06 |
2023-08-11 |
rat |
| O Stücker, E Vicaut, B Teisseir. Specific esponse to 5-HT2 agonists by arterioles linked to Meth A tumors in mice. The American journal of physiology. vol 262. issue 3 Pt 2. 1992-05-04. PMID:1558179. |
using intravital microscopy, we compared the responses to serotonin [5-hydroxytryptamine (5-ht)] and to a specific 5-ht2 agonist [1-(2,5-dimethoxy-4-bromo-phenyl)-2-aminopropane (dob)] by normal arterioles and by the host-modified arterioles feeding a meth a tumor implanted into the flank of female balb/c mice. |
1992-05-04 |
2023-08-11 |
mouse |
| W M Selig, M A Bloomquist, M L Cohen, J H Fleisc. Serotonin-induced pulmonary responses in the perfused guinea pig lung: evidence for 5HT2 receptor-mediated pulmonary vascular and airway smooth muscle constriction. Pulmonary pharmacology. vol 1. issue 2. 1992-04-30. PMID:2980293. |
furthermore, vasoconstriction and bronchoconstriction elicited by serotonin were antagonized by the potent 5ht2 receptor antagonists, ly53857, ketanserin, and ritanserin. |
1992-04-30 |
2023-08-11 |
Not clear |
| W M Selig, M A Bloomquist, M L Cohen, J H Fleisc. Serotonin-induced pulmonary responses in the perfused guinea pig lung: evidence for 5HT2 receptor-mediated pulmonary vascular and airway smooth muscle constriction. Pulmonary pharmacology. vol 1. issue 2. 1992-04-30. PMID:2980293. |
thus, both the pulmonary vascular and airway constriction to serotonin were predominantly due to 5ht2 receptor activation. |
1992-04-30 |
2023-08-11 |
Not clear |
| P G Kostyuk, E A Lukyanetz, P A Doroshenk. Effects of serotonin and cAMP on calcium currents in different neurones of Helix pomatia. Pflugers Archiv : European journal of physiology. vol 420. issue 1. 1992-04-29. PMID:1313172. |
methiothepin (10-50 microm), a 5-ht1,2 receptor antagonist, irreversibly inhibited the potentiating effect of 5-ht, while antagonists of 5-ht2 receptors cyproheptadine (10-50 microm) or ketanserine (10-60 microm) and of 5-ht3 receptors isc 205-930 (10-50 microm) or cocaine (5-25 microm) had no effect on ica and its enhancement by 5-ht. |
1992-04-29 |
2023-08-11 |
Not clear |
| J Perregaard, J Arnt, K P Bøgesø, J Hyttel, C Sánche. Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles. Journal of medicinal chemistry. vol 35. issue 6. 1992-04-28. PMID:1348090. |
noncataleptogenic, centrally acting dopamine d-2 and serotonin 5-ht2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1h-indoles. |
1992-04-28 |
2023-08-11 |
mouse |
| J Perregaard, J Arnt, K P Bøgesø, J Hyttel, C Sánche. Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles. Journal of medicinal chemistry. vol 35. issue 6. 1992-04-28. PMID:1348090. |
within all three subseries potent dopamine d-2 and serotonin 5-ht2 receptor affinity was found in ligand binding studies. |
1992-04-28 |
2023-08-11 |
mouse |
| G Maura, R Carbone, M Guido, M Pestarino, M Raiter. 5-HT2 presynaptic receptors mediate inhibition of glutamate release from cerebellar mossy fibre terminals. European journal of pharmacology. vol 202. issue 2. 1992-04-28. PMID:1839384. |
the k(+)-evoked overflow of glutamate was inhibited in a concentration-dependent manner by 5-hydroxytryptamine (5-ht) and by the 5-ht2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hcl (doi), but not by the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat). |
1992-04-28 |
2023-08-11 |
rat |
| G Maura, R Carbone, M Guido, M Pestarino, M Raiter. 5-HT2 presynaptic receptors mediate inhibition of glutamate release from cerebellar mossy fibre terminals. European journal of pharmacology. vol 202. issue 2. 1992-04-28. PMID:1839384. |
the 5-ht2 receptor antagonist ketanserin counteracted the inhibitory effect of 5-ht. |
1992-04-28 |
2023-08-11 |
rat |
| S C Mangel, W J Brunke. The effects of serotonin drugs on horizontal and ganglion cells in the rabbit retina. Visual neuroscience. vol 8. issue 3. 1992-04-23. PMID:1532124. |
we have investigated the effects of a serotonin 5-ht2 antagonist and a 5-ht1a agonist on horizontal and ganglion cells in the rabbit retina. |
1992-04-23 |
2023-08-11 |
rabbit |
| J C Tinajero, A Fabbri, M L Dufa. Regulation of corticotropin-releasing factor secretion from Leydig cells by serotonin. Endocrinology. vol 130. issue 4. 1992-04-22. PMID:1312425. |
the selective 5ht2 receptor antagonist ketanserin prevented crf stimulation and blocked the inhibitory actions of 5ht and doi, while the alpha 1-adrenergic antagonist prazosin had no effect. |
1992-04-22 |
2023-08-11 |
Not clear |
| J C Tinajero, A Fabbri, M L Dufa. Regulation of corticotropin-releasing factor secretion from Leydig cells by serotonin. Endocrinology. vol 130. issue 4. 1992-04-22. PMID:1312425. |
these results demonstrate that 5ht acts on 5ht2 receptors in leydig cells that are distinct from those in the brain to stimulate crf secretion through a pertussis toxin-insensitive g-protein. |
1992-04-22 |
2023-08-11 |
Not clear |
| C Zech, R Staudinger, J Mühlbacher, H Glossman. Novel sites for phenylalkylamines: characterisation of a sodium-sensitive drug receptor with (-)-[3H]emopamil. European journal of pharmacology. vol 208. issue 2. 1992-04-21. PMID:1800125. |
(-)-emopamil ((s)-emopamil, (2s)-2-isopropyl-5-(methylphenethylamino)- 2-phenylvaleronitrile hydrochloride) is a ca(2+)-antagonistic phenylalkylamine which also blocks serotonin (5-ht2) receptors and has antiischemic properties. |
1992-04-21 |
2023-08-11 |
Not clear |
| H Ono, S S Ono, H Fukud. 5-HT receptor-mediated regulation of thyrotropin-releasing hormone release in rat spinal cord. European journal of pharmacology. vol 203. issue 2. 1992-04-21. PMID:1839283. |
this effect of 5-ht was reduced by pre-exposure of the tissue to 10 microm ketanserin and methysergide, which both have 5-ht2 antagonistic activity. |
1992-04-21 |
2023-08-11 |
rat |
| J E Leysen, P M Janssen, W Gommeren, J Wynants, P J Pauwels, P A Jansse. In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone. Molecular pharmacology. vol 41. issue 3. 1992-04-16. PMID:1372084. |
the in vitro receptor binding and monoamine uptake inhibition profiles, comprising 29 receptors and four monoamine uptake systems, revealed that ocaperidone and risperidone bound primarily, and with the highest affinity thus far reported, to serotonin 5ht2 receptors (ki values of 0.14 and 0.12 nm, respectively). |
1992-04-16 |
2023-08-11 |
human |
| S T Meller, S J Lewis, M J Brody, G F Gebhar. The peripheral nociceptive actions of intravenously administered 5-HT in the rat requires dual activation of both 5-HT2 and 5-HT3 receptor subtypes. Brain research. vol 561. issue 1. 1992-04-16. PMID:1797350. |
the peripheral nociceptive actions of intravenously administered 5-ht in the rat requires dual activation of both 5-ht2 and 5-ht3 receptor subtypes. |
1992-04-16 |
2023-08-11 |
rat |
| S T Meller, S J Lewis, M J Brody, G F Gebhar. The peripheral nociceptive actions of intravenously administered 5-HT in the rat requires dual activation of both 5-HT2 and 5-HT3 receptor subtypes. Brain research. vol 561. issue 1. 1992-04-16. PMID:1797350. |
in the same rats, a 1:1 combination of alpha-methyl 5-ht (a 5-ht2, receptor selective agonist) and 2-methyl 5-ht (a 5-ht3 receptor selective agonist) (3-192 micrograms/kg, i.v. |
1992-04-16 |
2023-08-11 |
rat |
| P E Pérgola, R H Alpe. Pharmacological evidence that circumventricular organs may participate in the pressor effect of central serotonin. European journal of pharmacology. vol 203. issue 1. 1992-04-16. PMID:1797553. |
5-ht (2.5 micrograms) was attenuated by intravenous pretreatment will, the peripheral 5-ht2 antagonist xylamidine (100 or 300 micrograms/kg). |
1992-04-16 |
2023-08-11 |
rat |