| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Van Oosterhout, G Hofman, F M Woutersen-Van Nijnanten, F P Nijkam. 5-HT1-like receptors mediate potentiation of cholinergic nerve-mediated contraction of isolated mouse trachea. European journal of pharmacology. vol 209. issue 3. 1992-04-15. PMID:1797565. |
the 5-ht1a,b antagonist pindolol (10(-6) m), the combined 5-ht2 and 5-ht1c receptor antagonist, ketanserin (10(-6) m), or the combined 5-ht1 and 5-ht2 receptor antagonist, methysergide (10(-6) m), all partially inhibited the effect of 5-ht on the twitch responses. |
1992-04-15 |
2023-08-11 |
mouse |
| A J Van Oosterhout, G Hofman, F M Woutersen-Van Nijnanten, F P Nijkam. 5-HT1-like receptors mediate potentiation of cholinergic nerve-mediated contraction of isolated mouse trachea. European journal of pharmacology. vol 209. issue 3. 1992-04-15. PMID:1797565. |
alkylation of the 5-ht2 receptor by phenoxybenzamine (3 x 10(-7) m) treatment did not significantly affect the potentiation of the twitch responses by 5-ht. |
1992-04-15 |
2023-08-11 |
mouse |
| S W Watts, M L Cohe. Characterization of the contractile serotonergic receptor in guinea pig trachea with agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1312158. |
previously, the contraction of guinea pig trachea to 5-ht was shown to be antagonized by the 5-ht2 receptor antagonists ketanserin and ly53857. |
1992-04-13 |
2023-08-11 |
Not clear |
| S W Watts, M L Cohe. Characterization of the contractile serotonergic receptor in guinea pig trachea with agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1312158. |
however, 5-ht did not dramatically increase phosphoinositide turnover in guinea pig trachea, suggesting that the contractile receptor may be different from the classically defined 5-ht2 receptor. |
1992-04-13 |
2023-08-11 |
Not clear |
| S W Watts, M L Cohe. Characterization of the contractile serotonergic receptor in guinea pig trachea with agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1312158. |
as occurred with agonist potencies, strong correlations were found between reported 5-ht1c (r = 0.814) and 5-ht2 (r = 0.912) receptor binding affinities in brain membranes and apparent dissociation constants (kb) for the 10 antagonists of 5-ht induced contraction in guinea pig trachea. |
1992-04-13 |
2023-08-11 |
Not clear |
| C E Ybema, J L Slangen, B Olivier, J Mo. Discriminative stimulus properties of the serotonergic compound eltoprazine. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1532031. |
during tests of antagonism, neither mesulergine, the nonspecific 5-ht antagonist methysergide, the 5-ht2 antagonist ketanserin, the 5-ht3 antagonist tropisetron (ics 205-930), nor (+/-)-pindolol and (+/-)-propranolol attenuated the stimulus effect of eltoprazine. |
1992-04-13 |
2023-08-11 |
rat |
| F Chaouloff, S H Gunn, J B Youn. Central 5-hydroxytryptamine2 receptors are involved in the adrenal catecholamine-releasing and hyperglycemic effects of the 5-hydroxytryptamine indirect agonist d-fenfluramine in the conscious rat. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1545373. |
stimulation of either the 5-hydroxytryptamine (5-ht)1a, the 5-ht1c or the 5-ht2 receptor subtype triggers adrenal catecholamine release and hyperglycemia. |
1992-04-13 |
2023-08-11 |
rat |
| Y Claustre, B Eudeline, J Benavides, B Scatto. 5-HT1C receptors mediate phosphoinositide turnover activation in the immature rat hippocampus. European journal of pharmacology. vol 225. issue 1. 1992-04-08. PMID:1311687. |
the specific 5-ht2 receptor antagonist spiperone only partially antagonizes (37% inhibition at 1 microm) the stimulation by 5-ht of phosphoinositide turnover in the hippocampus. |
1992-04-08 |
2023-08-11 |
rat |
| J A Apud, D R Grayson, E De Erausquin, E Cost. Pharmacological characterization of regulation of phosphoinositide metabolism by recombinant 5-HT2 receptors of the rat. Neuropharmacology. vol 31. issue 1. 1992-04-08. PMID:1311807. |
addition of 1 microm 5-ht induced a time-dependent increase of phosphoinositide (pi) metabolism in sense but not in antisense, 5-ht2 receptor cdna transfected cells. |
1992-04-08 |
2023-08-11 |
rat |
| J A Apud, D R Grayson, E De Erausquin, E Cost. Pharmacological characterization of regulation of phosphoinositide metabolism by recombinant 5-HT2 receptors of the rat. Neuropharmacology. vol 31. issue 1. 1992-04-08. PMID:1311807. |
graded concentrations of 5-ht and of different serotonergic agonists showed different potencies (doi greater than 5-ht greater than quipazine greater than dom greater than alpha-methyl-5-ht greater than 8-oh-dpat greater than 2-methyl-5-ht greater than cgs-12066b) in stimulating turnover of pi in cells transfected with cdna encoding for 5-ht2 receptors of the rat. |
1992-04-08 |
2023-08-11 |
rat |
| K P Datla, S K Mitra, S K Bhattachary. Serotonergic modulation of footshock induced aggression in paired rats. Indian journal of experimental biology. vol 29. issue 7. 1992-04-08. PMID:1839019. |
the serotonin synthesis inhibitor, p-chlorophenylalanine and the selective serotonin receptor (5-ht2) antagonist, ketanserin, augmented all paradigms of fia per se and apomorphine induced augmentation of fia. |
1992-04-08 |
2023-08-11 |
rat |
| H H Berendsen, C L Broekkam. Attenuation of 5-HT1A and 5-HT2 but not 5-HT1C receptor mediated behaviour in rats following chronic treatment with 5-HT receptor agonists, antagonists or anti-depressants. Psychopharmacology. vol 105. issue 2. 1992-04-07. PMID:1839064. |
the effects of chronic (10 days) treatment with serotonin (5-ht) receptor agonists on 5-ht1a receptor mediated lower lip retraction (llr), 5-ht1c receptor mediated penile erections (pe) or 5-ht2 receptor mediated head shakes (hs) were studied in rats. |
1992-04-07 |
2023-08-11 |
rat |
| P Govitrapong, V Prapapanich, M Ebad. Identification of serotonin 5HT2 receptors in bovine pineal gland. Journal of pineal research. vol 11. issue 3-4. 1992-04-06. PMID:1795228. |
identification of serotonin 5ht2 receptors in bovine pineal gland. |
1992-04-06 |
2023-08-11 |
rat |
| P Govitrapong, V Prapapanich, M Ebad. Identification of serotonin 5HT2 receptors in bovine pineal gland. Journal of pineal research. vol 11. issue 3-4. 1992-04-06. PMID:1795228. |
by using [3h]-spiperone as a ligand, and ketanserine as a selective serotonin 5ht2 receptor antagonist, we have identified 5ht2 receptor in the bovine pineal gland, revealing a single population of binding sites with a dissociation equilibrium constant (kd) value of 1.26 +/- 0.41 nm and a receptor density (bmax) value of 193 +/- 38.85 fmol/mg protein. |
1992-04-06 |
2023-08-11 |
rat |
| P Govitrapong, V Prapapanich, M Ebad. Identification of serotonin 5HT2 receptors in bovine pineal gland. Journal of pineal research. vol 11. issue 3-4. 1992-04-06. PMID:1795228. |
the results of these studies are interpreted to indicate that the bovine pineal gland possess serotonin 5ht2 receptor. |
1992-04-06 |
2023-08-11 |
rat |
| R A Glennon, R Raghupathi, P Bartyzel, M Teitler, S Leonhard. Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity. Journal of medicinal chemistry. vol 35. issue 4. 1992-04-03. PMID:1542100. |
binding of phenylalkylamine derivatives at 5-ht1c and 5-ht2 serotonin receptors: evidence for a lack of selectivity. |
1992-04-03 |
2023-08-11 |
Not clear |
| R A Glennon, R Raghupathi, P Bartyzel, M Teitler, S Leonhard. Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity. Journal of medicinal chemistry. vol 35. issue 4. 1992-04-03. PMID:1542100. |
certain phenylalkylamine derivatives have been considered to bind selectively at 5-ht2 serotonin receptors. |
1992-04-03 |
2023-08-11 |
Not clear |
| M R Pranzatelli, J Ballett. Serotonin receptors in human neuroblastoma: a possible biologic tumor marker. Experimental neurology. vol 115. issue 3. 1992-04-02. PMID:1537397. |
no 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, 5-ht2, or 5-ht uptake sites were found in any of the tumors, although all were detected in human or rat brain. |
1992-04-02 |
2023-08-11 |
human |
| D Bakis. Fluoxetine potentiation by buspirone: three case histories. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 36. issue 10. 1992-04-01. PMID:1790522. |
the possibility of synergy between drugs that affect serotonin reuptake inhibition, 5ht1a receptors and 5ht2 receptors is discussed. |
1992-04-01 |
2023-08-11 |
Not clear |
| H Ouadid, J Seguin, A Dumuis, J Bockaert, J Nargeo. Serotonin increases calcium current in human atrial myocytes via the newly described 5-hydroxytryptamine4 receptors. Molecular pharmacology. vol 41. issue 2. 1992-03-27. PMID:1311410. |
the effects of 5-ht were not blocked by antagonists of 5-ht1 (methiothepin), 5-ht2 (ketanserin), or 5-ht3 (ics 205-930 at a low concentration) receptors. |
1992-03-27 |
2023-08-11 |
human |