| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C R Ashby, E Edwards, R Y Wan. Action of serotonin in the medial prefrontal cortex: mediation by serotonin3-like receptors. Synapse (New York, N.Y.). vol 10. issue 1. 1992-03-24. PMID:1536032. |
in contrast, the microiontophoresis of 5-ht1 and 5-ht2 receptor antagonists such as (+/-)-pindolol, spiperone, metergoline, and ritanserin (10-20 na) failed to block 5-ht's effect. |
1992-03-24 |
2023-08-11 |
Not clear |
| F Lafaille, S A Welner, B E Suranyi-Cadott. Regulation of serotonin type 2 (5-HT2) and beta-adrenergic receptors in rat cerebral cortex following novel and classical antidepressant treatment. Journal of psychiatry & neuroscience : JPN. vol 16. issue 4. 1992-03-24. PMID:1664741. |
regulation of serotonin type 2 (5-ht2) and beta-adrenergic receptors in rat cerebral cortex following novel and classical antidepressant treatment. |
1992-03-24 |
2023-08-11 |
rat |
| K Njung'e, S L Handle. Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents. British journal of pharmacology. vol 104. issue 1. 1992-03-23. PMID:1686200. |
the action of doi may be attributable to effects at the 5-ht2 receptor but those of the 5-ht agonist and releasing agent mcpp, and the uptake inhibitor zimeldine, could not be attributed to effects at any one 5-ht receptor subtype. |
1992-03-23 |
2023-08-11 |
mouse |
| M Yoshioka, Y Goda, H Togashi, M Matsumoto, H Sait. Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat. The Journal of pharmacology and experimental therapeutics. vol 260. issue 2. 1992-03-17. PMID:1531363. |
these effects of 5-ht on respiration were mimicked by 2-methyl-5-ht (3.125-25 micrograms/kg), a selective 5-ht3 receptor agonist, and by a high dose of alpha-methyl-5-ht, a 5-ht2 receptor agonist, but not by 5-carboxamidotryptamine, a 5-ht1-like receptor agonist. |
1992-03-17 |
2023-08-11 |
rat |
| R H Mach, J R Jackson, R R Luedtke, K J Ivins, P B Molinoff, R L Ehrenkaufe. Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. Journal of medicinal chemistry. vol 35. issue 3. 1992-03-17. PMID:1531364. |
effect of n-alkylation on the affinities of analogues of spiperone for dopamine d2 and serotonin 5-ht2 receptors. |
1992-03-17 |
2023-08-11 |
Not clear |
| R H Mach, J R Jackson, R R Luedtke, K J Ivins, P B Molinoff, R L Ehrenkaufe. Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. Journal of medicinal chemistry. vol 35. issue 3. 1992-03-17. PMID:1531364. |
two series of n-substituted spiperone analogues were prepared and evaluated in vitro to measure their affinities for dopamine d2 and serotonin 5-ht2 receptors. |
1992-03-17 |
2023-08-11 |
Not clear |
| N L Alsip, P D Harris, G E Durran. Multiple serotonin receptors on large arterioles in striated muscle. Blood vessels. vol 28. issue 6. 1992-03-13. PMID:1782409. |
in rat striated muscle, serotonin (5-hydroxytryptamine; 5-ht) constricts large arterioles (first-order; a1) via 5-ht2 receptor activation but dilates smaller arterioles via a 5-ht1-like receptor. |
1992-03-13 |
2023-08-11 |
rat |
| J Mantz, J Azerad, A Limoge, J M Desmont. Transcranial electrical stimulation with Limoge's currents decreases halothane requirements in rats. Evidence for the involvement of endogenous opioids. Anesthesiology. vol 76. issue 2. 1992-03-12. PMID:1736702. |
the present study was designed to analyze the influence of transcranial electrical stimulation (tces) on halothane requirements in rats and the contribution of the central endogenous opioid, alpha 2-adrenergic and 5-hydroxytryptamine (5-ht1 and 5-ht2) serotonergic systems to this effect. |
1992-03-12 |
2023-08-11 |
rat |
| A V Cheng, I N Ferrier, C M Morris, S Jabeen, A Sahgal, I G McKeith, J A Edwardson, R H Perry, E K Perr. Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer's and Parkinson's diseases. Journal of the neurological sciences. vol 106. issue 1. 1992-03-12. PMID:1779239. |
the results confirm an abnormality of serotonin binding in various forms of dementia and suggest that preservation of 5-ht2 receptor in the temporal cortex may differentiate hallucinating from non-hallucinating cases of sdlt. |
1992-03-12 |
2023-08-11 |
human |
| D Rapoza, W L Woolverto. Attenuation of the effects of cocaine on milk consumption in rats by dopamine antagonists. Pharmacology, biochemistry, and behavior. vol 40. issue 1. 1992-03-10. PMID:1838194. |
as a control for the serotonin (5-ht2) antagonist effects of sch 23390, the 5-ht2 antagonist ketanserin (4.0-16 mg/kg) was evaluated as well. |
1992-03-10 |
2023-08-11 |
rat |
| G Gross, X Xin, M Gastpa. Trimipramine: pharmacological reevaluation and comparison with clozapine. Neuropharmacology. vol 30. issue 11. 1992-03-05. PMID:1663593. |
in radioligand binding studies, d,l-trimipramine showed fairly high affinities (ki 10-60 nm) for some dopamine (da), noradrenaline and 5-hydroxytryptamine (5-ht) receptor subtypes (5-ht2 receptors = alpha 1a/b-adrenoceptors greater than or equal to d2 receptors), intermediate affinities (300-550 nm) for d1 receptors, alpha 2b-adrenoceptors and 5-ht1c receptors but only low affinities (greater than 1000 nm) for alpha 2a-adrenoceptors, 5-ht1a, 5-ht1d and 5-ht3 receptors. |
1992-03-05 |
2023-08-11 |
rat |
| T F Meert, F Awouters, C J Niemegeers, K H Schellekens, P A Jansse. Ritanserin reduces abuse of alcohol, cocaine, and fentanyl in rats. Pharmacopsychiatry. vol 24. issue 5. 1992-03-05. PMID:1775520. |
treatment with low doses of ritanserin, a specific central serotonin 5-ht2 antagonist, rapidly reversed drug preference without changing total fluid intake. |
1992-03-05 |
2023-08-11 |
rat |
| P W Sheldon, G K Aghajania. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Synapse (New York, N.Y.). vol 9. issue 3. 1992-03-05. PMID:1776132. |
excitatory responses to serotonin (5-ht) in neurons of the rat piriform cortex: evidence for mediation by 5-ht1c receptors in pyramidal cells and 5-ht2 receptors in interneurons. |
1992-03-05 |
2023-08-11 |
rat |
| P W Sheldon, G K Aghajania. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Synapse (New York, N.Y.). vol 9. issue 3. 1992-03-05. PMID:1776132. |
the 5-ht antagonist spiperone, which has a much higher affinity for 5-ht2 receptors than for 5-ht1c receptors, blocked the excitatory effect of 5-ht at lower concentrations in interneurons (ic50 = 31 nm) than in pyramidal cells (ic50 = 2.1 microm). |
1992-03-05 |
2023-08-11 |
rat |
| P W Sheldon, G K Aghajania. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Synapse (New York, N.Y.). vol 9. issue 3. 1992-03-05. PMID:1776132. |
similarly, ritanserin, a drug which also has a higher affinity for 5-ht2 than 5-ht1c receptors, blocked the effect of 5-ht at lower concentrations in interneurons (ic50 = 400 nm) than in pyramidal cells (ic50 = 8.1 microm). |
1992-03-05 |
2023-08-11 |
rat |
| P W Sheldon, G K Aghajania. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Synapse (New York, N.Y.). vol 9. issue 3. 1992-03-05. PMID:1776132. |
in contrast, ly 53857, an antagonist with higher affinity for 5-ht1c than for 5-ht2 receptors, blocked the effect of 5-ht at lower concentrations in pyramidal cells (ic50 = 26 nm) than in interneurons (ic50 = 364 nm). |
1992-03-05 |
2023-08-11 |
rat |
| P W Sheldon, G K Aghajania. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Synapse (New York, N.Y.). vol 9. issue 3. 1992-03-05. PMID:1776132. |
in that both spiperone and ritanserin have higher affinity for 5-ht2 receptors than for 5-ht1c receptors and ly 53857 has a higher affinity for 5-ht1c receptors than for 5-ht2 receptors, these data suggest that in piriform cortex excitatory effects of 5-ht are mediated by 5-ht1c receptors in pyramidal cells an by 5-ht2 receptors in interneurons. |
1992-03-05 |
2023-08-11 |
rat |
| J M Klancnik, A Obenaus, A G Phillips, K G Baimbridg. The effects of serotonergic compounds on evoked responses in the dentate gyrus and CA1 region of the hippocampal formation of the rat. Neuropharmacology. vol 30. issue 11. 1992-03-05. PMID:1837848. |
the effects of serotonin (5-ht), the 5-ht1a receptor subtype agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and the 5-ht2 receptor subtype agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) on electrophysiological responses in the dentate gyrus and area ca1 were examined in the in vitro hippocampal slice preparation. |
1992-03-05 |
2023-08-11 |
rat |
| C Brazell, S J McClue, G C Preston, B King, S M Stah. 5-Hydroxytryptamine (5-HT)-induced shape change in human platelets determined by computerized data acquisition: correlation with [125I]-iodoLSD binding at 5-HT2 receptors. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. vol 2. issue 1. 1992-03-04. PMID:1772986. |
5-hydroxytryptamine (5-ht)-induced shape change in human platelets determined by computerized data acquisition: correlation with [125i]-iodolsd binding at 5-ht2 receptors. |
1992-03-04 |
2023-08-11 |
human |
| P A McBride, G M Anderson, V D Khait, S R Sunday, K A Halm. Serotonergic responsivity in eating disorders. Psychopharmacology bulletin. vol 27. issue 3. 1992-03-02. PMID:1775611. |
the responsivity of central nervous system (cns) serotonergic pathways is assessed by neuroendocrine challenge with a 60-mg oral dose of dl-fenfluramine, an indirect serotonin agonist, whereas the responsivity of the platelet serotonin2 (5-ht2) receptor complex is evaluated by measurement of the magnitude of serotonin-amplified platelet aggregation. |
1992-03-02 |
2023-08-11 |
human |