All Relations between 5-ht receptor 2 and serotonin

Publication Sentence Publish Date Extraction Date Species
R D Tanz, W G Nayle. Concentration-dependent desensitization of isolated porcine coronary arterial segments to acetylcholine. Archives internationales de pharmacodynamie et de therapie. vol 312. 1992-02-27. PMID:1663335. although atropine completely antagonized the effect of acetylcholine, pretreatment with methysergide (5-ht2), mepyramine (h1) and prazosin (alpha 1) did not attenuate acetylcholine-induced desensitization, indicating that the phenomenon is unrelated to either serotonin, h1- or alpha-adrenergic receptor activation. 1992-02-27 2023-08-11 Not clear
E A Audi, R M de Oliveira, F G Graef. Microinjection of propranolol into the dorsal periaqueductal gray causes an anxiolytic effect in the elevated plus-maze antagonized by ritanserin. Psychopharmacology. vol 105. issue 4. 1992-02-27. PMID:1685253. the present as well as previously reported results suggest that the anxiolytic effect of propranolol injected into the dpag is due to increased release of 5-ht acting on post-synaptic 5-ht2 receptors, resultant from blockade of 5-ht1b autoreceptors that inhibit amine release from serotonergic nerve endings. 1992-02-27 2023-08-11 rat
E J Kidd, J C Garratt, C A Marsde. Effects of repeated treatment with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the autoregulatory control of dorsal raphe 5-HT neuronal firing and cortical 5-HT release. European journal of pharmacology. vol 200. issue 1. 1992-02-25. PMID:1837523. repeated doi treatment decreased the behavioural responsiveness (wet-dog shakes) of 5-ht2 receptors and attenuated the inhibitory effects of the 5-ht1a receptor agonist, 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)tetralin), on both cortical 5-ht release and drn 5-ht neuronal firing. 1992-02-25 2023-08-11 Not clear
E J Kidd, J C Garratt, C A Marsde. Effects of repeated treatment with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the autoregulatory control of dorsal raphe 5-HT neuronal firing and cortical 5-HT release. European journal of pharmacology. vol 200. issue 1. 1992-02-25. PMID:1837523. the results demonstrate that changes in the responsiveness of 5-ht2 receptor function may influence the responsiveness of presynaptic 5-ht1a receptors regulating 5-ht neuronal function. 1992-02-25 2023-08-11 Not clear
E J Kidd, J C Garratt, C A Marsde. Effects of repeated treatment with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the autoregulatory control of dorsal raphe 5-HT neuronal firing and cortical 5-HT release. European journal of pharmacology. vol 200. issue 1. 1992-02-25. PMID:1837523. the results also provide further evidence that the inhibition of cortical 5-ht release and drn 5-ht neuronal firing produced by doi is not mediated by 5-ht2 receptor activation. 1992-02-25 2023-08-11 Not clear
Y Shigeri, S Watanabe, M Fujimot. Dibutyryl-cAMP increases functions of 5-hydroxytryptamine2 receptors, but not of beta 2-adrenergic receptors, in a clonal cell line of rat neurotumor RT4. Journal of cellular physiology. vol 150. issue 1. 1992-02-18. PMID:1309826. the increase in the 5-ht response paralleled the increase in the density of 5-ht2 receptors. 1992-02-18 2023-08-11 rat
A A Megens, F H Awouters, T F Meert, K H Schellekens, C J Niemegeers, P A Jansse. Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). The Journal of pharmacology and experimental therapeutics. vol 260. issue 1. 1992-02-18. PMID:1370538. ocaperidone is concluded to be a highly potent and efficacious dopamine-d2 antagonist with concomitant, equivalent serotonin 5-ht2 antagonism. 1992-02-18 2023-08-11 Not clear
B W Rigatti, G A Paleos, J J Man. Simultaneous effects of the platelet 5-HT2 and alpha 2-adrenergic receptor populations on phosphoinositide hydrolysis. Life sciences. vol 50. issue 3. 1992-02-14. PMID:1309935. the pi turnover response to serotonin was mediated by the 5-ht2 receptor. 1992-02-14 2023-08-11 human
J Lappalainen, J Hietala, M Koulu, B Sjöholm, E Syvälaht. Effects of acute administration of SCH 23390 on dopamine and serotonin turnover in major dopaminergic areas and mesencephalic raphe nuclei--comparison with ritanserin. Progress in neuro-psychopharmacology & biological psychiatry. vol 15. issue 6. 1992-02-13. PMID:1722342. the lack of effect of ritanserin on da or 5-ht turnover in nigrostriatal and mesolimbic daergic areas suggests that under basal conditions the blockade of 5-ht2 receptors do not change monoamine metabolism in these areas. 1992-02-13 2023-08-11 rat
M R Pranzatelli, A Dailey, M Levy, A Dolliso. Absence of tolerance to the excitatory effects of benzodiazepines: clonazepam-evoked shaking behavior in the rat. Pharmacology, biochemistry, and behavior. vol 39. issue 4. 1992-02-10. PMID:1684867. to further study the role of serotonin (5-ht) and bdz receptors in bdz-induced wds, we injected adult rats daily for 21 days with clonazepam and measured wds and 5-ht1, 5-ht2, and bdz receptors. 1992-02-10 2023-08-11 rat
A G Saltzman, B Morse, M M Whitman, Y Ivanshchenko, M Jaye, S Felde. Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes. Biochemical and biophysical research communications. vol 181. issue 3. 1992-02-07. PMID:1722404. cloning of the human serotonin 5-ht2 and 5-ht1c receptor subtypes. 1992-02-07 2023-08-11 human
A G Saltzman, B Morse, M M Whitman, Y Ivanshchenko, M Jaye, S Felde. Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes. Biochemical and biophysical research communications. vol 181. issue 3. 1992-02-07. PMID:1722404. we report the cloning and the deduced amino acid sequence of cdnas encoding both the human serotonin 5-ht2 and 5-ht1c receptors. 1992-02-07 2023-08-11 human
A Dedeoğlu, L A Fishe. Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms. The Journal of pharmacology and experimental therapeutics. vol 259. issue 3. 1992-02-07. PMID:1762059. the mechanisms underlying the cardiovascular effects of central and peripheral administration of the 5-ht2 (serotonin) receptor agonist (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (doi) were studied in conscious rats. 1992-02-07 2023-08-11 rat
L Zhang, J E Barret. Imipramine as a discriminative stimulus. The Journal of pharmacology and experimental therapeutics. vol 259. issue 3. 1992-02-07. PMID:1762063. the alpha-2 agonist clonidine, the 5-ht2 antagonist ritanserin or the 5-ht reuptake inhibitor fluoxetine also did not occasion drug-key responding. 1992-02-07 2023-08-11 Not clear
M A Lee, H Y Meltze. Neuroendocrine responses to serotonergic agents in alcoholics. Biological psychiatry. vol 30. issue 10. 1992-02-06. PMID:1756196. in order to further assess the serotonergic system in alcoholism, the plasma cortisol and prolactin (prl) responses following 6-chloro-2-[1-piperazinyl]pyrazine (mk-212), a direct-acting serotonin2 (5-ht2)/5-ht1c receptor agonist, l-5-hydroxytryptophan (l-5-htp), a precursor of 5-ht, and placebo were compared in male alcoholics and normal controls. 1992-02-06 2023-08-11 human
R Walden, A Bass, I Rabi, R Ada. Randomized placebo-controlled, double-blind trial of ketanserin in treatment of intermittent claudication. The Journal of cardiovascular surgery. vol 32. issue 6. 1992-01-30. PMID:1752890. ketanserin, a selective serotonin (5-ht) antagonist at 5-ht2 receptors, was investigated in a 12-month, double-blind placebo-controlled study in 35 patients with intermittent claudication. 1992-01-30 2023-08-11 Not clear
D P Sachs, S J Leischo. Pharmacologic approaches to smoking cessation. Clinics in chest medicine. vol 12. issue 4. 1992-01-23. PMID:1747993. other agents in various phases of preclinical and clinical evaluation include 5-ht1a partial agonists such as buspirone; alpha 2-noradrenergic agonists such as clonidine; tricyclics such as doxepin; serotonin re-uptake antagonists such as fluoxetine; acth; 5-ht2 antagonists such as ritanserin; central excitatory amino acid inhibitors such as kynurenate; and calcium channel blockers. 1992-01-23 2023-08-11 Not clear
A Zschauer, C van Breemen, H Uusital. Serotonergic responses in rabbit ophthalmic artery: a pharmacological characterization. The American journal of physiology. vol 261. issue 6 Pt 2. 1992-01-23. PMID:1836310. the high-potency portion of the 5-ht drc was inhibited only by metitepine, whereas the low-potency portion was blocked by metitepine, methysergide, spiperone, and ketanserin, indicating that in this preparation the 5-ht1 receptor subtypes are more sensitive to 5-ht than the 5-ht2 receptor subtypes. 1992-01-23 2023-08-11 rabbit
H C Wilson, W Coffman, A L Killam, M L Cohe. LY53857, a 5HT2 receptor antagonist, delays occlusion and inhibits platelet aggregation in a rabbit model of carotid artery occlusion. Thrombosis and haemostasis. vol 66. issue 3. 1992-01-15. PMID:1746008. the effectiveness of this ergoline 5ht2 receptor antagonist in blocking aggregation to adp, collagen and u46619 may be related to its ability to inhibit a serotonin component of platelet aggregation since rabbit platelets possess high concentrations of serotonin that may be released during aggregation produced by other agents. 1992-01-15 2023-08-11 rabbit
M I Noble, A J Drake-Hollan. Evidence for a role of serotonin in initiation of coronary arterial thrombosis in dog and man. Clinical physiology and biochemistry. vol 8 Suppl 3. 1992-01-06. PMID:1966730. in which the accumulation of platelet thrombi in canine coronary arteries was abolished by the specific serotonin 5ht2 receptor antagonist, ritanserin. 1992-01-06 2023-08-11 human