All Relations between 5-ht receptor 2 and serotonin

Publication Sentence Publish Date Extraction Date Species
O E Brodd. 5-Hydroxytryptamine-receptor subtypes. Clinical physiology and biochemistry. vol 8 Suppl 3. 1992-01-06. PMID:2132174. with the introduction of radioligand-binding studies and the development of more selective 5-ht agonists and antagonists, it rapidly became apparent that this subclassification is an oversimplification, and it is now accepted that at least three, possibly four main families of 5-ht receptors exist: 5-ht1, 5-ht2, 5-ht3 and possibly 5-ht4 receptors. 1992-01-06 2023-08-11 Not clear
H Dabiré, C Cherqui, M Safar, H Schmit. Haemodynamic aspects and serotonin. Clinical physiology and biochemistry. vol 8 Suppl 3. 1992-01-06. PMID:2132176. however, limited evidence suggests also an implication of 5-ht3 and even 5-ht2 receptors in the dilator effects of 5-ht. 1992-01-06 2023-08-11 Not clear
F D Yocca, A S Eison, D K Hyslop, E Ryan, D P Taylor, G Gianutso. Unique modulation of central 5-HT2 receptor binding sites and 5-HT2 receptor-mediated behavior by continuous gepirone treatment. Life sciences. vol 49. issue 24. 1991-12-26. PMID:1682780. these results suggest that the curious dissociation of behavioral and biochemical indices of 5-ht2 receptor function produced by continuous gepirone treatment may be the result of a dual yet separate action of the drug on central presynaptic noradrenergic and serotonergic mechanisms and postsynaptic 5-ht receptors. 1991-12-26 2023-08-11 rat
A D Levy, Q A Li, J E Kerr, P A Rittenhouse, G Milonas, T M Cabrera, G Battaglia, M C Alvarez Sanz, L D Van de Ka. Cocaine-induced elevation of plasma adrenocorticotropin hormone and corticosterone is mediated by serotonergic neurons. The Journal of pharmacology and experimental therapeutics. vol 259. issue 2. 1991-12-24. PMID:1658300. these data indicate that the cocaine-induced stimulation of acth and corticosterone secretion is mediated by 5-ht neurons in brain, and furthermore, that 5-ht2 or 5-ht1c receptors are responsible for this effect. 1991-12-24 2023-08-11 rat
F P Zemlan, E F Schwa. Characterization of a novel serotonin receptor subtype (5-HT1S) in rat CNS: interaction with a GTP binding protein. Journal of neurochemistry. vol 57. issue 6. 1991-12-18. PMID:1834802. [3h]5-ht competition studies performed in the presence of 100 nm 8-oh-dpat and 10 nm ru 24969 (to block 5-ht1a and 5-ht1b receptors, respectively) indicated that the remaining 49% of [3h]5-ht binding did not possess the pharmacologic profile previous reported for 5-ht1c, 5-ht1d, 5-ht1e, 5-ht2, or 5-ht3 receptors. 1991-12-18 2023-08-11 rat
H Crick, D I Walli. Inhibition of reflex responses of neonate rat lumbar spinal cord by 5-hydroxytryptamine. British journal of pharmacology. vol 103. issue 3. 1991-12-18. PMID:1933139. although depression of the msr was mimicked by 5-htia receptor ligands, the action of endogenous 5-ht may be mediated through 5-ht2 receptors. 1991-12-18 2023-08-11 rat
M L Brandão, J A Lopez-Garcia, F G Graeff, M H Robert. Electrophysiological evidence for excitatory 5-HT2 and depressant 5-HT1A receptors on neurones of the rat midbrain tectum. Brain research. vol 556. issue 2. 1991-12-17. PMID:1682008. the excitatory effects induced by 5-ht on mt neurones were clearly attenuated by concomitant application of ketanserin, a highly specific 5-ht2 antagonist. 1991-12-17 2023-08-11 rat
E Van Obberghen-Schilling, V Vouret-Craviari, R J Haslam, J C Chambard, J Pouysségu. Cloning, functional expression and role in cell growth regulation of a hamster 5-HT2 receptor subtype. Molecular endocrinology (Baltimore, Md.). vol 5. issue 7. 1991-12-13. PMID:1944295. strong activation of plc via 5-ht2 receptors does however contribute to the synergy observed between 5-ht (gi-coupled pathway) and fibroblast growth factor (tyrosine kinase-activated pathway) on dna synthesis reinitiation in transfected cells. 1991-12-13 2023-08-11 rat
M R Pranzatelli, R S Pluchin. The relation of central 5-HT1A and 5-HT2 receptors: low dose agonist-induced selective tolerance in the rat. Pharmacology, biochemistry, and behavior. vol 39. issue 2. 1991-11-26. PMID:1835098. to study the purported relation of 5-ht1a and 5-ht2 receptors, we chronically injected rats with a low dose of selective 5-ht agonists to induce behavioral tolerance and then tested for cross-tolerance. 1991-11-26 2023-08-11 rat
M R Pranzatelli, R S Pluchin. The relation of central 5-HT1A and 5-HT2 receptors: low dose agonist-induced selective tolerance in the rat. Pharmacology, biochemistry, and behavior. vol 39. issue 2. 1991-11-26. PMID:1835098. acutely, in naive rats, both the putative 5-ht2 agonist doi and 5-ht1a agonist 8-oh-dpat induced some behaviors of the "serotonin syndrome" but the two drugs could be differentiated. 1991-11-26 2023-08-11 rat
K Miyata, T Kamato, A Nishida, H Ito, Y Katsuyama, A Iwai, H Yuki, M Yamano, R Tsutsumi, M Oht. Pharmacologic profile of (R)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H- benzimidazole hydrochloride (YM060), a potent and selective 5-hydroxytryptamine3 receptor antagonist, and its enantiomer in the isolated tissue. The Journal of pharmacology and experimental therapeutics. vol 259. issue 1. 1991-11-21. PMID:1656016. ym060 failed to antagonize contractions induced by 5ht in the saphenous vein of the dog (5ht1-like receptor) or in the aorta of the rabbit (5ht2 receptor. 1991-11-21 2023-08-11 dog
K J Ivins, P B Molinof. Desensitization and down-regulation of 5-HT2 receptors in P11 cells. The Journal of pharmacology and experimental therapeutics. vol 259. issue 1. 1991-11-21. PMID:1656028. the effect of exposure to 5-ht on the expression and function of 5-ht2 receptors in p11 cells was investigated. 1991-11-21 2023-08-11 Not clear
K J Ivins, P B Molinof. Desensitization and down-regulation of 5-HT2 receptors in P11 cells. The Journal of pharmacology and experimental therapeutics. vol 259. issue 1. 1991-11-21. PMID:1656028. therefore, the decrease in response to 5-ht represented a selective, homologous desensitization of 5-ht2 receptor-mediated phosphoinositide hydrolysis. 1991-11-21 2023-08-11 Not clear
K J Ivins, P B Molinof. Desensitization and down-regulation of 5-HT2 receptors in P11 cells. The Journal of pharmacology and experimental therapeutics. vol 259. issue 1. 1991-11-21. PMID:1656028. exposure of p11 cells to 5-ht resulted in a decrease in the density of 5-ht2 receptors with no change in the affinity of the receptors for [125i]lysergic acid diethylamide. 1991-11-21 2023-08-11 Not clear
K J Ivins, P B Molinof. Desensitization and down-regulation of 5-HT2 receptors in P11 cells. The Journal of pharmacology and experimental therapeutics. vol 259. issue 1. 1991-11-21. PMID:1656028. a decrease in the density of receptors was observed after exposure to 10 microm 5-ht for 1 hr, and after 24 hr the density of 5-ht2 receptors was approximately 30% of the original value. 1991-11-21 2023-08-11 Not clear
B D Perry, E H Cook, B L Leventhal, M S Wainwright, D X Freedma. Platelet 5-HT2 serotonin receptor binding sites in autistic children and their first-degree relatives. Biological psychiatry. vol 30. issue 2. 1991-11-21. PMID:1912104. we examined platelet serotonin2 [5-hydroxytryptamine2 (5-ht2)] receptor binding sites, whole blood serotonin (5-ht), and plasma norepinephrine (ne) in male autistic children and their first-degree relatives. 1991-11-21 2023-08-11 Not clear
P A Rittenhouse, E A Bakkum, L D Van de Ka. Evidence that the serotonin agonist, DOI, increases renin secretion and blood pressure through both central and peripheral 5-HT2 receptors. The Journal of pharmacology and experimental therapeutics. vol 259. issue 1. 1991-11-21. PMID:1920135. evidence that the serotonin agonist, doi, increases renin secretion and blood pressure through both central and peripheral 5-ht2 receptors. 1991-11-21 2023-08-11 rat
P A Rittenhouse, E A Bakkum, L D Van de Ka. Evidence that the serotonin agonist, DOI, increases renin secretion and blood pressure through both central and peripheral 5-HT2 receptors. The Journal of pharmacology and experimental therapeutics. vol 259. issue 1. 1991-11-21. PMID:1920135. to separate central from peripheral 5-ht receptors, we injected doi into rats pretreated with saline or xylamidine, a 5-ht2 antagonist which does not cross the blood-brain barrier. 1991-11-21 2023-08-11 rat
F Bacic, S Uematsu, R M McCarron, M Spat. Dopaminergic receptors linked to adenylate cyclase in human cerebromicrovascular endothelium. Journal of neurochemistry. vol 57. issue 5. 1991-11-15. PMID:1681036. the effect of alpha 1-adrenergic agonists or 5-ht on da production of cyclic amp was partially prevented by the d2 antagonist, s(-)-sulpiride, or ketanserin (5-ht2 greater than alpha 1 greater than h1 antagonists), respectively. 1991-11-15 2023-08-11 human
J C Garratt, E J Kidd, I K Wright, C A Marsde. Inhibition of 5-hydroxytryptamine neuronal activity by the 5-HT agonist, DOI. European journal of pharmacology. vol 199. issue 3. 1991-11-15. PMID:1915582. the reduction of the firing rate of 5-ht neurons in the dorsal raphe and extracellular 5-ht concentration in the frontal cortex induced by systemic administration of doi could not be blocked by the 5-ht2 antagonist ketanserin, ritanserin (5-ht2/5-ht1c antagonist) or the putative 5-ht1a antagonist, pindolol. 1991-11-15 2023-08-11 Not clear