| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Reeves, K T Bunce, P P Humphre. Investigation into the 5-hydroxytryptamine receptor mediating smooth muscle relaxation in the rat oesophagus. British journal of pharmacology. vol 103. issue 1. 1991-09-27. PMID:1878746. |
the relaxation responses to 5-ht were neither inhibited by antagonists selective for 5-ht1 or 5-ht2 receptors nor by the 5-ht3 receptor antagonists, ondansetron, granisetron or mdl 72222. |
1991-09-27 |
2023-08-11 |
rat |
| J J Reeves, K T Bunce, P P Humphre. Investigation into the 5-hydroxytryptamine receptor mediating smooth muscle relaxation in the rat oesophagus. British journal of pharmacology. vol 103. issue 1. 1991-09-27. PMID:1878746. |
the 5-ht receptor mediating relaxation in rat oesophagus cannot be designated 5-ht1, 5-ht2 or 5-ht3 under the current 5-ht classification, but the observed effects are consistent with stimulation of the putative 5-ht4 receptor. |
1991-09-27 |
2023-08-11 |
rat |
| R Hensman, F S Guimarães, M Wang, J F Deaki. Effects of ritanserin on aversive classical conditioning in humans. Psychopharmacology. vol 104. issue 2. 1991-09-26. PMID:1908584. |
according to one formulation of the behavioural functions of 5ht, aversive conditioned stimuli mediate their behavioural and emotional effects through activation of 5ht projections from dorsal raphe nucleus to receptors of the 5ht2 family in amygdala and elsewhere. |
1991-09-26 |
2023-08-11 |
human |
| G M Somoza, R E Pete. Effects of serotonin on gonadotropin and growth hormone release from in vitro perifused goldfish pituitary fragments. General and comparative endocrinology. vol 82. issue 1. 1991-09-20. PMID:1874380. |
these results demonstrate that 5-ht has a stimulatory effect on gonadotropin secretion, probably through a 5-ht2 receptor type, and an inhibitory effect on growth hormone through an unidentified receptor type. |
1991-09-20 |
2023-08-11 |
Not clear |
| A Charles, S Rounds, H W Farbe. Neutrophil chemoattractant production by cultured serotonin-stimulated bovine and human endothelial cells. The American journal of physiology. vol 261. issue 2 Pt 1. 1991-09-19. PMID:1872407. |
elaboration of nca and baec and huvec was apparently mediated by 5-ht1 receptors and did not require uptake of 5-ht, whereas its elaboration from bpaec required 5-ht uptake and was apparently mediated by 5-ht2 receptors. |
1991-09-19 |
2023-08-11 |
human |
| M P Kavanaugh, M J Christie, P B Osborne, A E Busch, K Z Shen, Y N Wu, P H Seeburg, J P Adelman, R A Nort. Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes. The Biochemical journal. vol 277 ( Pt 3). 1991-09-17. PMID:1651707. |
voltage-dependent k+ channels (rbk1, rbk2 and rgk5) were co-expressed in xenopus oocytes with 5-hydroxytryptamine (5-ht2) receptors. |
1991-09-17 |
2023-08-11 |
xenopus_laevis |
| S Y Lu, M T Shipley, A B Norman, P R Sanber. Striatal, ventral mesencephalic and cortical transplants into the intact rat striatum: a neuroanatomical study. Experimental neurology. vol 113. issue 2. 1991-09-13. PMID:1651254. |
autoradiography for dopamine d1 and d2, muscarinic cholinergic, and serotonin 5-ht1 and 5-ht2 receptors at 5-15 months after transplantation was also investigated. |
1991-09-13 |
2023-08-11 |
rat |
| G Maura, A Barzizza, S Folghera, M Raiter. Release of endogenous aspartate from rat cerebellum slices and synaptosomes: inhibition mediated by a 5-HT2 receptor and by a 5-HT1 receptor of a possibly novel subtype. Naunyn-Schmiedeberg's archives of pharmacology. vol 343. issue 3. 1991-09-12. PMID:1830929. |
the effect of 10 nmol/l 5-ht was partly but maximally counteracted by ketanserin (300-1000 nmol/l), a 5-ht2 receptor antagonist, but fully blocked by 300 nmol/l of the mixed 5-ht1/5-ht2 receptor antagonist methiothepin. |
1991-09-12 |
2023-08-11 |
rat |
| M W Jan. Clozapine. Pharmacotherapy. vol 11. issue 3. 1991-09-04. PMID:1677765. |
other neuroreceptors are involved, as the drug has potent binding affinity for serotonin receptors 5-ht1a and 5-ht2. |
1991-09-04 |
2023-08-11 |
Not clear |
| H Tamir, K P Liu, S C Hsiung, P Y Yu, A L Kirchgessner, M D Gersho. Identification of serotonin receptors recognized by anti-idiotypic antibodies. Journal of neurochemistry. vol 57. issue 3. 1991-09-04. PMID:1861158. |
it is concluded that the anti-idiotypic antibodies generated with anti-5-ht serum recognize the 5-ht1b, 5-ht1c, and 5-ht2 receptor subtypes; however, neither 5-ht1a receptors nor 5-ht uptake sites appear to react with these antibodies. |
1991-09-04 |
2023-08-11 |
Not clear |
| H S Sharma, J Cervós-Navarro, P K De. Increased blood-brain barrier permeability following acute short-term swimming exercise in conscious normotensive young rats. Neuroscience research. vol 10. issue 3. 1991-08-30. PMID:1650437. |
this increased permeability appears to be mediated through serotonin via 5-ht2 receptors. |
1991-08-30 |
2023-08-11 |
rat |
| S Uma, I Sahin-Erdeml. Receptors mediating the contractile effect of serotonin (5-HT) in the isolated common bile duct of guinea-pig. Archives internationales de physiologie, de biochimie et de biophysique. vol 99. issue 1. 1991-08-30. PMID:1713488. |
the results led us to conclude that 5-ht evoked contractions at low concentrations are predominantly mediated by 5-ht2 receptors whereas those at high concentrations are dependent on acetylcholine release via the stimulation of 5-ht3 receptors. |
1991-08-30 |
2023-08-11 |
Not clear |
| H W Farber, D J Bee. Restricted secretion of a T-lymphocyte chemotactic cytokine by serotonin-stimulated cultured aortic endothelial cells. Circulation research. vol 69. issue 2. 1991-08-30. PMID:1860174. |
ed-lca was not stored in an active form in baecs; its secretion occurred within 60 minutes of exposure to 5-ht and was blocked by two different 5-ht2 receptor antagonists. |
1991-08-30 |
2023-08-11 |
human |
| I Macquin-Mavier, P H Jarreau, N Istin, A Har. 5-Hydroxytryptamine-induced bronchoconstriction in the guinea-pig: effect of 5-HT2 receptor activation on acetylcholine release. British journal of pharmacology. vol 102. issue 4. 1991-08-28. PMID:1855111. |
to characterize the subtype of 5-ht receptors involved in the activation of the parasympathetic system by 5-ht, dose-response curves to 5-ht were constructed for four groups of vagotomized guinea-pigs treated with saline, 1 mg kg-1 of the 5-ht3 antagonist ics 205-930, or either 0.01 or 0.1 mg kg-1 of the 5-ht2 antagonist ketanserin. |
1991-08-28 |
2023-08-11 |
Not clear |
| K T Bunce, C J Elswood, M T Bal. Investigation of the 5-hydroxytryptamine receptor mechanism mediating the short-circuit current response in rat colon. British journal of pharmacology. vol 102. issue 4. 1991-08-28. PMID:1855112. |
it is concluded that 5-ht stimulates an scc response in rat colon via a receptor mechanism that cannot be clearly identified as 5-ht1-like, 5-ht2 or 5-ht3. |
1991-08-28 |
2023-08-11 |
rat |
| M J Sumne. Characterization of the 5-HT receptor mediating endothelium-dependent relaxation in porcine vena cava. British journal of pharmacology. vol 102. issue 4. 1991-08-28. PMID:1855122. |
in ring preparations contracted with the stable thromboxane-a2-mimetic, u-46619 (10 nm), and in the presence of the 5-ht2 receptor antagonist ketanserin (1 microm), low concentrations of 5-ht (1-100 nm) evoked an endothelium-dependent, rapid, 'spike-like' relaxation. |
1991-08-28 |
2023-08-11 |
Not clear |
| M J Sumne. Characterization of the 5-HT receptor mediating endothelium-dependent relaxation in porcine vena cava. British journal of pharmacology. vol 102. issue 4. 1991-08-28. PMID:1855122. |
these results suggest that the endothelium-dependent relaxation of porcine vena cava induced by 5-ht is largely mediated by the release of no (although other endothelium-derived relaxing factors may also be involved) and that 5-ht is acting at a receptor which is not '5-ht1-like', 5-ht2, 5-ht3 or 5-ht4 and is not comparable to recognised 5-ht receptor ligand binding sites. |
1991-08-28 |
2023-08-11 |
Not clear |
| A Siriwardena, C Booker, J Pratt, J M Kellu. Pathways of serotonin-induced electrolyte transport in rat distal colon. Surgery. vol 110. issue 2. 1991-08-28. PMID:1858049. |
in nonstripped colon, the action of serotonin (5-hydroxytrytamine [5-ht]) on short-circuit current was inhibited by a factor of 60% by tetrodotoxin (p less than 0.05; t test) and was also inhibited by the 5ht2 antagonist ketanserin (p less than 0.05 vs serotonin; t test) and the 5-ht3 antagonist ics 205-930 (p less than 0.05 vs serotonin, t test). |
1991-08-28 |
2023-08-11 |
rat |
| K A Sharkey, D G Gall, W K MacNaughto. Distribution and function of brain natriuretic peptide in the stomach and small intestine of the rat. Regulatory peptides. vol 34. issue 1. 1991-08-27. PMID:1857779. |
the response to bnp was reduced by 88% in chloride free kreb's buffer, by 83% in tissues pretreated with cinanserin, an antagonist of the 5-ht2 subtype of the 5-hydroxytryptamine receptor, and by 96% in tissues pretreated with tetrodotoxin, a blocker of axonal conduction. |
1991-08-27 |
2023-08-11 |
rat |
| P D Walker, L A Riley, R P Hart, G M Jonakai. Serotonin regulation of tachykinin biosynthesis in the rat neostriatum. Brain research. vol 546. issue 1. 1991-08-23. PMID:1713119. |
to determine whether 5-ht receptors played a role in mediating the changes in ppt mrna, animals were treated with the 5-ht2 agonist doi. |
1991-08-23 |
2023-08-11 |
rat |