| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Takahashi, H Hisa, S Sato. Serotonin-induced renin release in the dog kidney. European journal of pharmacology. vol 193. issue 3. 1991-07-31. PMID:1905236. |
these results suggest that stimulation of renal 5-ht receptors, probably of the 5-ht2 type, can induce renin release from the dog kidney, which may be dependent on renal prostaglandin production. |
1991-07-31 |
2023-08-11 |
dog |
| L Zhan. Effects of 5-hydroxytryptamine on cat spinal motoneurons. Canadian journal of physiology and pharmacology. vol 69. issue 2. 1991-07-31. PMID:2054730. |
the slow hyperpolarization was prevented by the 5-ht antagonists ketanserin (5-ht2), methysergide, and spiperone (5-ht1,2) and mimicked by the agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (5-ht2). |
1991-07-31 |
2023-08-11 |
cat |
| E J Mylecharan. 5-HT2 receptor antagonists and migraine therapy. Journal of neurology. vol 238 Suppl 1. 1991-07-18. PMID:2045831. |
5-hydroxytryptamine (5-ht; serotonin) has been implicated in the pathophysiology of migraine, and several drugs with potent 5-ht2 receptor blocking activity (methysergide, pizotifen, cyproheptadine and mianserin) have been recognized as being clinically effective in migraine prophylaxis, although the selective 5-ht2 receptor antagonist ketanserin (the principal agent used to identify 5-ht2 receptor-mediated actions) seems to be ineffective in migraine. |
1991-07-18 |
2023-08-11 |
Not clear |
| E Arzt, M Costas, S Finkielman, V E Nahmo. Serotonin inhibition of tumor necrosis factor-alpha synthesis by human monocytes. Life sciences. vol 48. issue 26. 1991-07-18. PMID:2046478. |
the inhibitory effect was specifically blocked by the 5-ht1 and 5-ht2 serotonin antagonist methysergide and the 5-ht2 receptor antagonist ketanserin. |
1991-07-18 |
2023-08-11 |
human |
| A Y Deutch, B Moghaddam, R B Innis, J H Krystal, G K Aghajanian, B S Bunney, D S Charne. Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Schizophrenia research. vol 4. issue 2. 1991-07-11. PMID:1674882. |
the second hypothesis has been previously advanced, and suggests that a relatively high ratio of serotonin 5-ht2:dopamine d2 receptor antagonism may subserve the atypical profile. |
1991-07-11 |
2023-08-11 |
Not clear |
| Y Torii, H Saito, N Matsuk. Selective blockade of cytotoxic drug-induced emesis by 5-HT3 receptor antagonists in Suncus murinus. Japanese journal of pharmacology. vol 55. issue 1. 1991-07-10. PMID:2041220. |
serotonin 5-ht1 and 5-ht2 receptor antagonists were less effective. |
1991-07-10 |
2023-08-11 |
Not clear |
| S L'Héreault, N Barde. Monoaminergic regulation of proopiomelanocortin messenger RNA concentrations in primary cell cultures of rat hypothalamus. Brain research. Molecular brain research. vol 9. issue 4. 1991-06-28. PMID:1710012. |
serotonin caused a 15% increase in pomc mrna levels, an effect which was blocked by the 5-ht2 receptor antagonist ketanserin. |
1991-06-28 |
2023-08-11 |
rat |
| K Gradin, T Hedner, B Persso. Antihypertensive effects of chronic 5-hydroxytryptamine (5-HT2) receptor blockade with irindalone in the spontaneously hypertensive rat. Journal of neural transmission. General section. vol 83. issue 3. 1991-06-24. PMID:1674420. |
antihypertensive effects of chronic 5-hydroxytryptamine (5-ht2) receptor blockade with irindalone in the spontaneously hypertensive rat. |
1991-06-24 |
2023-08-11 |
rat |
| M E Clement, R B McCal. Pharmacological characterization of medullary serotonin neurons. Brain research. vol 542. issue 2. 1991-06-19. PMID:2029631. |
microiontophoretic or intravenous administration of the 5-ht2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) did not alter the firing rate of medullary 5-ht neurons. |
1991-06-19 |
2023-08-11 |
Not clear |
| N V Watson, B B Gorzalk. Relation of spontaneous wet dog shakes and copulatory behavior in male rats. Pharmacology, biochemistry, and behavior. vol 37. issue 4. 1991-06-17. PMID:2093184. |
"wet dog shake" (wds), a component of the serotonin behavioral syndrome, is largely mediated by 5-ht2 receptors. |
1991-06-17 |
2023-08-11 |
rat |
| R A Glennon, J De Vry, D G Spencer, T Glase. Stimulus properties of tiflucarbine: a novel antidepressant agent. Pharmacology, biochemistry, and behavior. vol 37. issue 4. 1991-06-17. PMID:2151199. |
to further characterize the serotonergic actions of this agent, tiflucarbine was evaluated in groups of rats trained to discriminate the 5-ht1a agonist 8-oh dpat, the 5-ht2 agonist dom, and the nonselective 5-ht agonist 5-ome dmt from saline. |
1991-06-17 |
2023-08-11 |
rat |
| G Bersani, F Pozzi, S Marini, A Grispini, A Pasini, N Cian. 5-HT2 receptor antagonism in dysthymic disorder: a double-blind placebo-controlled study with ritanserin. Acta psychiatrica Scandinavica. vol 83. issue 4. 1991-06-13. PMID:1903019. |
these data are consistent with the hypothesis of serotonin abnormalities in dysthymic disorder and suggest a therapeutic role of 5-ht2 antagonists. |
1991-06-13 |
2023-08-11 |
Not clear |
| S L Lee, W W Wang, B J Moore, B L Fanbur. Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture. Circulation research. vol 68. issue 5. 1991-05-30. PMID:1850332. |
this inhibitory effect was not blocked by either inhibition of 5ht uptake or 5ht-receptor antagonists ketanserin (5ht2); methiothepin, spiperone, and mianserin (5ht1/5ht2); and 3-tropanyl-indole-3-carboxylate and 3-tropanyl-3,5-dichlorobenzoate (5ht3). |
1991-05-30 |
2023-08-11 |
cattle |
| R M Danzebrink, G F Gebhar. Evidence that spinal 5-HT1, 5-HT2 and 5-HT3 receptor subtypes modulate responses to noxious colorectal distension in the rat. Brain research. vol 538. issue 1. 1991-05-29. PMID:2018933. |
administration of serotonin (5-hydroxytryptamine, 5-ht) and other 5-ht receptor agonists in a model of visceral pain that utilizes colorectal distension (crd) as the noxious visceral stimulus is mediated through interaction with spinal 5-ht1, 5-ht2, or 5-ht3 receptor subtypes. |
1991-05-29 |
2023-08-11 |
rat |
| R R Ben-Harari, B A Dalton, R Osman, S Maayan. Kinetic characterization of 5-hydroxytryptamine receptor desensitization in isolated guinea-pig trachea and rabbit aorta. The Journal of pharmacology and experimental therapeutics. vol 257. issue 1. 1991-05-24. PMID:1850475. |
the observed values of the rate constants for desensitization and of the peak tension (t peak) in trachea show a saturable dependence on the concentration of 5-ht, indicating that occupancy of the 5-ht2 receptor is needed for desensitization. |
1991-05-24 |
2023-08-11 |
rabbit |
| H S Sharma, J Cervós-Navarr. Brain oedema and cellular changes induced by acute heat stress in young rats. Acta neurochirurgica. Supplementum. vol 51. 1991-05-24. PMID:2089947. |
these results point out a probable role of 5-ht in pathophysiology of hs via 5-ht2 receptors. |
1991-05-24 |
2023-08-11 |
rat |
| R J Barrett, K F Wright, A D Allen, D R Taylo. Cardiovascular and renal actions of AHR-16303B, an antagonist of 5-HT2 receptors and calcium channels, in hypertensive and normotensive rats. Journal of cardiovascular pharmacology. vol 17. issue 1. 1991-05-23. PMID:1708047. |
the cardiovascular and renal responses to ahr-16303b, a novel antagonist of 5-hydroxytryptamine (5-ht2) receptors and calcium channels, were examined in spontaneously hypertensive (shr) and normotensive rats (ntr) and compared with verapamil and ritanserin. |
1991-05-23 |
2023-08-11 |
rat |
| R J Barrett, K C Appell, B F Kilpatrick, A G Proakis, J C Nolan, D A Wals. AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels. Journal of cardiovascular pharmacology. vol 17. issue 1. 1991-05-23. PMID:1708055. |
the 5-ht2 receptor-antagonistic properties of ahr-16303b were demonstrated by inhibition of (a) [3h]ketanserin binding to rat cerebral cortical membranes (ic50 = 165 nm); (b) 5-hydroxytryptamine (5-ht)-induced foot edema in rats (minimum effective dose, (med) = 0.32 mg/kg orally, p.o. |
1991-05-23 |
2023-08-11 |
rat |
| I Sahin-Erdemli, D Hoyer, A Stoll, M P Seiler, P Schoeffte. 5-HT1-like receptors mediate 5-hydroxytryptamine-induced contraction of guinea-pig isolated iliac artery. British journal of pharmacology. vol 102. issue 2. 1991-05-23. PMID:1849768. |
the 5-ht2 receptor antagonist, ketanserin (1 microm) caused only small rightward shifts (concentration-ratios, about 2) in the concentration-response curves to 5-ht, 5-ct and sumatriptan without significantly depressing the maximum effects. |
1991-05-23 |
2023-08-11 |
Not clear |
| D van Heuven-Nolsen, T H Tysse Klasen, Q F Luo, P R Saxen. 5-HT1-like receptors mediate contractions of the rabbit saphenous vein. European journal of pharmacology. vol 191. issue 3. 1991-05-23. PMID:2086249. |
the high activity of 5-ct and methiothepin compared to, respectively, 5-ht and ketanserin (and spiperone) suggests that the contraction of the rabbit saphenous vein is not mediated by 5-ht2 receptors. |
1991-05-23 |
2023-08-11 |
human |