| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Y Wang, N J Du. 5-Hydroxytryptamine responses in neonate rat motoneurones in vitro. The Journal of physiology. vol 430. 1991-05-23. PMID:2150862. |
5-ht induced the occurrence in some mns of excitatory postsynaptic potentials (epsps) or inhibitory postsynaptic potentials (ipsps), which were reversibly eliminated by ttx, low-ca2+, high-mg2+ solution or by the 5-ht2 receptor antagonists ketanserin and spiperone. |
1991-05-23 |
2023-08-11 |
rat |
| M Y Wang, N J Du. 5-Hydroxytryptamine responses in neonate rat motoneurones in vitro. The Journal of physiology. vol 430. 1991-05-23. PMID:2150862. |
the depolarizing response was mimicked by the 5-ht2 receptor agonist (+2-)-1(2,5-dimethyoxy-4-iodophenyl)-2-aminopropane hydrochloride (doi) and blocked by 5-ht antagonists methysergide and cyproheptadine and by 5-ht2 antagonists ketanserin and spiperone; methiothepin and mdl 72222 were without effect. |
1991-05-23 |
2023-08-11 |
rat |
| M Y Wang, N J Du. 5-Hydroxytryptamine responses in neonate rat motoneurones in vitro. The Journal of physiology. vol 430. 1991-05-23. PMID:2150862. |
it is suggested that 5-ht, acting on 5-ht2 and 5-ht1a receptors, depolarizes and hyperpolarizes the mns by decreasing and increasing k+ conductance. |
1991-05-23 |
2023-08-11 |
rat |
| M Y Wang, N J Du. 5-Hydroxytryptamine responses in neonate rat motoneurones in vitro. The Journal of physiology. vol 430. 1991-05-23. PMID:2150862. |
additionally, 5-ht activates, via 5-ht2 receptors, excitatory and inhibitory interneurones, thereby indirectly affecting the activity of mns. |
1991-05-23 |
2023-08-11 |
rat |
| E O Mikkelsen, T J Nielsen, N C Nybor. Studies on the stereoselective effects of a novel 5-HT2 receptor antagonist on contractile responses of rat aorta. Chirality. vol 2. issue 4. 1991-05-16. PMID:2083144. |
the effect of the enantiomers of a novel 5-ht2 receptor antagonist, (+/-)-(1r,3s)-1-[2-[4-[3-(p-fluorophenyl)-1-indanyl]-piperazinyl] ethyl]-2-imidazolidinone, was studied on serotonin (5-ht), noradrenaline (na), potassium (k+), and calcium (ca2+)-induced contractions in isolated rat thoracic aorta. |
1991-05-16 |
2023-08-11 |
rat |
| G C Kaye, D Mehta, S Wafa, A J Cam. Acute electrophysiologic effects of an HT2-serotonin antagonist, ketanserin, in humans. Cardiovascular drugs and therapy. vol 4. issue 4. 1991-05-16. PMID:2083196. |
the acute electrophysiologic effects of an intravenous bolus of ketanserin, a 5ht2 serotonin blocker, were studied in ten patients (four females, six males) during invasive electrophysiology. |
1991-05-16 |
2023-08-11 |
Not clear |
| K J Sufka, D B Stratton, J Giordan. Regional differences in serotonergic contractile sensitivity mediated by 5-HT2 receptors in rat aorta. Artery. vol 18. issue 1. 1991-05-16. PMID:2085286. |
increasing concentrations of 5-ht (10 nm-100 microm) in the presence or absence of the selective 5-ht2 antagonist ketanserin (5 nm) produced differential concentration-response curves in thoracic and abdominal aortic ring preparations. |
1991-05-16 |
2023-08-11 |
rat |
| N A Bondarenko, N A Bondarenko, L Baran, A Klodzinsk. [The agonists of I-A serotoninergic receptors restore in rats behavior impaired by L-dihydroxyphenylalanine]. Biulleten' eksperimental'noi biologii i meditsiny. vol 110. issue 12. 1991-05-10. PMID:2083366. |
the ability of selective and nonselective 5-ht1a agonists, nondirect 5-ht agonists and 5-ht2 antagonists influence on the l-dopa-disturbed rats behaviour were studied. |
1991-05-10 |
2023-08-11 |
rat |
| N A Bondarenko, N A Bondarenko, L Baran, A Klodzinsk. [The agonists of I-A serotoninergic receptors restore in rats behavior impaired by L-dihydroxyphenylalanine]. Biulleten' eksperimental'noi biologii i meditsiny. vol 110. issue 12. 1991-05-10. PMID:2083366. |
the results indicate that agonists 5-ht1a like receptors largely than 5-ht2,3 agonists, 5-ht2 antagonists and nondirect 5-ht agonists promote restoration of the l-dopa disturbed escape behaviour in acute stress situation. |
1991-05-10 |
2023-08-11 |
rat |
| J R Lever, U A Scheffel, J L Musachio, M Stathis, H N Wagne. Radioiodinated D-(+)-N1-ethyl-2-iodolysergic acid diethylamide: a ligand for in vitro and in vivo studies of serotonin receptors. Life sciences. vol 48. issue 15. 1991-05-03. PMID:2011045. |
radioiodinated d-(+)-n1-ethyl-2-iodolysergic acid diethylamide ([125i]-eil) has been evaluated as a ligand for in vitro and in vivo studies of cerebral serotonin 5-ht2 receptors. |
1991-05-03 |
2023-08-11 |
mouse |
| I Jansen, T Blackburn, K Eriksen, L Edvinsso. 5-hydroxytryptamine antagonistic effects of ICI 169,369, ICI 170,809 and methysergide in human temporal and cerebral arteries. Pharmacology & toxicology. vol 68. issue 1. 1991-04-30. PMID:2008418. |
ici 169,369 and ici 170,809 are two chemically novel 5-ht antagonists that have high affinity for the 5-ht2 binding site in rat cortex (ki 1.79 x 10(-8)m and 6.6 x 10(-10)m, respectively). |
1991-04-30 |
2023-08-11 |
human |
| E Sanders-Bus. Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 5-6. 1991-04-29. PMID:1964049. |
5-ht2 receptors are not upregulated after denervation of 5-ht neurons and chronic administration of antagonists elicits a paradoxical downregulation of both receptors. |
1991-04-29 |
2023-08-11 |
Not clear |
| G R Marti. Current problems and future requirements for 5-hydroxytryptamine receptor classification. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 5-6. 1991-04-29. PMID:2078269. |
the present scheme for classifying and naming 5-hydroxytryptamine (5-ht) receptors is being challenged by a growing number of reports that describe receptor types that fail to meet the criteria for admission into the "5-ht1-like," 5-ht2 or, 5-ht3 classes. |
1991-04-29 |
2023-08-11 |
Not clear |
| M Hamon, L Lanfumey, S el Mestikawy, C Boni, M C Miquel, F Bolaños, L Schechter, H Gozla. The main features of central 5-HT1 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 5-6. 1991-04-29. PMID:2078271. |
indeed, a higher degree of sequence homology is found between the 5-ht1c and 5-ht2 receptors than between the former and 5-ht1a receptors, suggesting that the 5-ht1c subtype in fact belongs to the 5-ht2 class of central 5-ht receptors. |
1991-04-29 |
2023-08-11 |
human |
| D Hoye. Serotonin 5-HT3, 5-HT4, and 5-HT-M receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 5-6. 1991-04-29. PMID:2078273. |
serotonin (5-hydroxytryptamine [5-ht]) receptors can be classified either pharmacologically, into 5-ht1, 5-ht2, 5-ht3 and 5-ht4 receptors, or functionally, into g-protein-coupled receptors (5-ht1, 5-ht2, and 5-ht4) and ligand-gated ion channels (5-ht3). |
1991-04-29 |
2023-08-11 |
Not clear |
| D C Martin, R J Adams, R S Aronsta. The influence of isoflurane on the synaptic activity of 5-hydroxytryptamine. Neurochemical research. vol 15. issue 10. 1991-04-25. PMID:2150219. |
the effects of isoflurane on uptake of 5-hydroxytryptamine(serotonin; 5-ht) by rat brain synaptosomes and binding of 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and ketanserin to 5-ht1a and 5-ht2 receptors were examined. |
1991-04-25 |
2023-08-11 |
rat |
| H Itoh, R D Buña. Cardiovascular and sympathetic effects of injecting serotonin into the nucleus tractus solitarius in rats. The Journal of pharmacology and experimental therapeutics. vol 256. issue 3. 1991-04-24. PMID:2005578. |
local blockade induced by injecting the 5-ht1a antagonist, wb4101, into the nts abolished all 5-ht responses, but that induced with the 5-ht2 antagonist, ketanserin, inhibited the same responses only partially. |
1991-04-24 |
2023-08-11 |
rat |
| R M Eglen, S R Swank, L K Walsh, R L Whitin. Characterization of 5-HT3 and 'atypical' 5-HT receptors mediating guinea-pig ileal contractions in vitro. British journal of pharmacology. vol 101. issue 3. 1991-04-22. PMID:2076474. |
neuronal 5-hydroxytryptamine (5-ht) receptors mediating contraction of guinea-pig ileal segments have been characterized in vitro by the use of methysergide to block 5-ht1-like and 5-ht2 receptors. |
1991-04-22 |
2023-08-11 |
Not clear |
| R M Eglen, S R Swank, L K Walsh, R L Whitin. Characterization of 5-HT3 and 'atypical' 5-HT receptors mediating guinea-pig ileal contractions in vitro. British journal of pharmacology. vol 101. issue 3. 1991-04-22. PMID:2076474. |
under conditions of 5-ht1-like, 5-ht2 and 5-ht3 receptor blockade, the following rank order of agonism was observed: 5-ht > 5-methoxytryptamine = renzapride > (s)-zacopride > (r,s-zacopride > 5-carboxamidotryptamine > brl 24682 > (r-zacopride > metoclopramide > 2-methyl-5-ht > sulpiride. |
1991-04-22 |
2023-08-11 |
Not clear |
| T Shoji, H Kiyomoto, T Tamaki, H Iwao, Y Ab. Renal vasodilatation induced by DOI, a 5-HT2 receptor agonist, in the canine kidney. European journal of pharmacology. vol 190. issue 1-2. 1991-04-22. PMID:2127572. |
an intrarenal infusion of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi), a selective 5-ht2 agonist, at a rate of 5 micrograms/min in anesthetized dogs resulted in an increase in renal blood flow (rbf) without any transient decrease as usually observed during the infusion of 5-ht. |
1991-04-22 |
2023-08-11 |
Not clear |