All Relations between 5-ht receptor 2c and meta-Chlorophenylpiperazine

Publication Sentence Publish Date Extraction Date Species
Vicki Chen, Gia V Shelp, Jacob L Schwartz, Niklas D J Aardema, Madison L Bunnell, Clara E Ch. Modification of the serotonergic systems and phenotypes by gestational micronutrients. The Journal of endocrinology. 2023-03-17. PMID:36930294. we assessed the central function using the 5-ht2c receptor agonist, 1-(3-chlorophenyl)piperazine (mcpp), and found that male offspring from the hv- or hfolrc-fed dams were less responsive (p<0.05) whereas female hfolrc offspring were more responsive to mcpp (p<0.01) at 6 weeks post-weaning. 2023-03-17 2023-08-14 rat
James H Fox, Melissa N Boucher, Khalil S Abedrabbo, Brendan D Hare, Bethany A Grimmig, William A Falls, Sayamwong E Hammac. Exercise reduces the anxiogenic effects of meta-chlorophenylpiperazine: The role of 5-HT2C receptors in the bed nucleus of the stria terminalis. Frontiers in synaptic neuroscience. vol 14. 2023-01-30. PMID:36713088. exercise reduces the anxiogenic effects of meta-chlorophenylpiperazine: the role of 5-ht2c receptors in the bed nucleus of the stria terminalis. 2023-01-30 2023-08-14 mouse
Jürgen Deckert, Jobst Meyer, Marco Catalano, Monica Bosi, Philipp Sand, Daniela DiBella, Gabriela Ortega, Gerald Stöber, Petra Franke, Markus M. Nöthen, Jürgen Fritze, Wolfgang Maier, Helmut Beckmann, Peter Propping, Laura Bellodi, Klaus-Peter Lesc. Novel 5'-regulatory region polymorphisms of the 5-HT2C receptor gene: association study with panic disorder. The international journal of neuropsychopharmacology. vol 3. issue 4. 2019-11-20. PMID:11343611. candidate genes for association studies in panic disorder are often selected on the basis of molecular mechanisms of drugs utilized in challenge tests such as m-chlorophenylpiperazine (mcpp), a non-selective 5-ht2c receptor agonist. 2019-11-20 2023-08-12 Not clear
Adriano Edgar Reimer, Amanda Ribeiro de Oliveira, Juliana Belo Diniz, Marcelo Queiroz Hoexter, Euripedes Constantino Miguel, Mohammed Ragib Milad, Marcus Lira Brandã. Fear extinction in an obsessive-compulsive disorder animal model: Influence of sex and estrous cycle. Neuropharmacology. vol 131. 2018-11-13. PMID:29225044. accordingly, the non-selective 5-ht2c agonist, meta-chlorophenylpiperazine (mcpp), exacerbates symptoms in untreated ocd patients. 2018-11-13 2023-08-13 rat
M Suhaib Azim, Nidhi B Agarwal, Divya Vohor. Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine. Epilepsy & behavior : E&B. vol 72. 2018-03-19. PMID:28578215. in order to explore whether effects are mediated by melatonergic or serotonergic mechanisms, 1-(m-chlorophenyl) piperazine (mcpp), selective 5ht2c receptor agonist and luzindole, melatonergic receptor antagonist, were taken as pharmacological tools. 2018-03-19 2023-08-13 mouse
Katherine M Serafine, Kenner C Rice, Charles P Franc. Characterization of the discriminative stimulus effects of lorcaserin in rats. Journal of the experimental analysis of behavior. vol 106. issue 2. 2018-01-29. PMID:27640338. the 5-ht2c receptor agonist mcpp and the 5-ht2a receptor agonist dom each occasioned greater than 90% lorcaserin-lever responding in seven of eight rats. 2018-01-29 2023-08-13 rat
Olivér Éliás, Katalin Nógrádi, György Domány, Zoltán Szakács, János Kóti, Csaba Szántay, Ákos Tarcsay, György M Keserű, Anikó Gere, Béla Kiss, Dalma Kurkó, Sándor Kolok, Zsolt Némethy, Zoltán Kapui, Éva Hellinger, Mónika Vastag, Katalin Sághy, Rita Kedves, István Gyertyá. The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands. Bioorganic & medicinal chemistry letters. vol 26. issue 3. 2016-10-13. PMID:26748694. from that collection two promising compounds (2 and 3) exhibiting highest 5-ht2c receptor affinity strongly inhibited the 5-ht2c receptor agonist 1-(3-chlorophenyl)piperazine (mcpp) induced hypomotility in mice. 2016-10-13 2023-08-13 mouse
Katherine M Serafine, Kenner C Rice, Charles P Franc. Directly Observable Behavioral Effects of Lorcaserin in Rats. The Journal of pharmacology and experimental therapeutics. vol 355. issue 3. 2016-02-09. PMID:26384326. the 5-ht2c receptor selective agonist 1-(3-chlorophenyl)piperazine (mcpp, 0.032-1.0 mg/kg) and lorcaserin induced yawning which was attenuated by the 5-ht2c receptor selective antagonist 6-chloro-5-methyl-n-(6-[(2-methylpyridin-3-yl)oxy]pydidin-3-yl)indoline-1-carboxamide (1.0 mg/kg). 2016-02-09 2023-08-13 rat
Mirella Nardo, Plinio C Casarotto, Felipe V Gomes, Francisco S Guimarãe. Cannabidiol reverses the mCPP-induced increase in marble-burying behavior. Fundamental & clinical pharmacology. vol 28. issue 5. 2015-05-14. PMID:24118015. meta-chloro-phenyl-piperazine (mcpp) is a nonspecific serotonergic agonist (acting mainly at 5ht1a, 5ht2c and 5ht1d receptors) reported to increase symptoms in ocd patients and block the anticompulsive-like effect of serotonin reuptake inhibitors (sris) in animal models. 2015-05-14 2023-08-12 Not clear
J M Thomas, C T Dourish, J W Tomlinson, Z Hassan-Smith, S Higg. Effects of the 5-HT2C receptor agonist meta-chlorophenylpiperazine on appetite, food intake and emotional processing in healthy volunteers. Psychopharmacology. vol 231. issue 12. 2015-01-15. PMID:24408211. effects of the 5-ht2c receptor agonist meta-chlorophenylpiperazine on appetite, food intake and emotional processing in healthy volunteers. 2015-01-15 2023-08-12 human
Clinton E Canal, Raymond G Booth, Drake Morga. Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model. Neuropharmacology. vol 70. 2013-11-26. PMID:23353901. commercially-available 5-ht2c agonists (cp 809101, ro 60-0175, way 161503, mcpp, and 1-methylpsilocin), novel 4-phenyl-2-n,n-dimethyl-aminotetralin (pat)-type 5-ht2c agonists (with 5-ht2a/2b antagonist activity), and antagonists selective for 5-ht2a (m100907), 5-ht2c (sb-242084), and 5-ht2b/2c (sb-206553) receptors attenuated the doi-elicited-htr. 2013-11-26 2023-08-12 mouse
Qiang Zhang, Yunxia Zhu, Wenbo Zhou, Lu Gao, Li Yuan, Xiao Ha. Serotonin receptor 2C and insulin secretion. PloS one. vol 8. issue 1. 2013-07-24. PMID:23349838. however, it is known that the 5-ht receptor 2c (5-ht(2c)r) agonist, mcpp, decreases plasma insulin concentration in mice. 2013-07-24 2023-08-12 mouse
Marquinta L Harvey, Cody L Swallows, Matthew A Coope. A double dissociation in the effects of 5-HT2A and 5-HT2C receptors on the acquisition and expression of conditioned defeat in Syrian hamsters. Behavioral neuroscience. vol 126. issue 4. 2012-12-20. PMID:22708954. our data suggest that mcpp activates 5-ht2c receptors during testing to enhance the display of submissive and defensive behavior, whereas mdl 11,939 blocks 5-ht2a receptors during social defeat to disrupt the development of the conditioned defeat response. 2012-12-20 2023-08-12 Not clear
Saima Khaliq, Saida Haider, Sadia Saleem, Zahida Memon, Darakhshan J Halee. Influence of serotonergic 5-HT2C receptor antagonist mesulergine in the reversal of memory deficits induced by mCPP. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. vol 22. issue 2. 2012-06-21. PMID:22313641. influence of serotonergic 5-ht2c receptor antagonist mesulergine in the reversal of memory deficits induced by mcpp. 2012-06-21 2023-08-12 Not clear
Saima Khaliq, Saida Haider, Sadia Saleem, Zahida Memon, Darakhshan J Halee. Influence of serotonergic 5-HT2C receptor antagonist mesulergine in the reversal of memory deficits induced by mCPP. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. vol 22. issue 2. 2012-06-21. PMID:22313641. to determine the effect of non-selective 5-ht2c antagonist mesulergine and 5-ht2c agonist mcpp (metachlorophenylpiperazine) on learning acquisition (la), short-term memory (stm) and long-term memory (ltm). 2012-06-21 2023-08-12 Not clear
Elin Sörman, Dannie Wang, Mihaly Hajos, Bernat Kocsi. Control of hippocampal theta rhythm by serotonin: role of 5-HT2c receptors. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21281651. 5-ht2c receptors represent a specific target of psychopharmacology and, in particular, the behavioral effects of the 5-ht2c receptor agonist mcpp have been thoroughly tested. 2011-10-14 2023-08-12 rat
Elin Sörman, Dannie Wang, Mihaly Hajos, Bernat Kocsi. Control of hippocampal theta rhythm by serotonin: role of 5-HT2c receptors. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21281651. under urethane anesthesia, mcpp decreased the power for both spontaneous and elicited theta rhythm in a dose-dependent manner and the 5-ht2c antagonist reversed this effect. 2011-10-14 2023-08-12 rat
Koji Yakabi, Susumu Kurosawa, Mitsuo Tamai, Mitsutoshi Yuzurihara, Miwa Nahata, Shino Ohno, Shoki Ro, Shingo Kato, Toru Aoyama, Tomoya Sakurada, Hidehiko Takabayashi, Tomohisa Hattor. Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction. Regulatory peptides. vol 161. issue 1-3. 2010-07-26. PMID:20171995. we first examined the effects of an intracerebroventricular (icv) injection of exogenous ghrelin on food intake with or without cisplatin treatment, and the effects of cisplatin or m-chlorophenylpiperazine (mcpp), a 5-ht2c receptor agonist, on hypothalamic growth hormone secretagogue receptor 1a (ghs-r1a) mrna expression. 2010-07-26 2023-08-12 rat
Katsunori Nonogaki, Yukie Ohba, Mamoru Wakameda, Tomohiro Tamar. Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene. The international journal of neuropsychopharmacology. vol 12. issue 4. 2009-06-26. PMID:18976545. mcpp suppressed food intake in 5-ht2c receptor mutant mice, 2crend mice and age-matched wild-type mice. 2009-06-26 2023-08-12 mouse
Katsunori Nonogaki, Yukie Ohba, Makiko Sumii, Yoshitomo Ok. Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18477467. the increases in hypothalamic nucb2 expression induced by mcpp were attenuated in 5-ht2c receptor mutant mice. 2008-06-20 2023-08-12 mouse