| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Henrik Stig Jørgense. Studies on the neuroendocrine role of serotonin. Danish medical bulletin. vol 54. issue 4. 2008-02-14. PMID:18208678. |
the acth response to 5-ht is mediated via 5-ht1a, 5-ht1b, 5-ht2a and 5-ht2c receptors and an involvement of the 5-ht4, 5-ht5 and 5-ht7 receptors is proposed. |
2008-02-14 |
2023-08-12 |
rat |
| Henrik Stig Jørgense. Studies on the neuroendocrine role of serotonin. Danish medical bulletin. vol 54. issue 4. 2008-02-14. PMID:18208678. |
peripheral secretion of avp upon stimulation with 5-ht is mediated via 5-ht2c, 5-ht4 and 5-ht7 receptors but not 5-ht1a receptors. |
2008-02-14 |
2023-08-12 |
rat |
| Anna Moskwa, Patrycja Boznańsk. [Role of serotonin in the pathophysiology of the irritable bowel syndrome]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 60. issue 7-8. 2008-02-08. PMID:18175558. |
serotonin is secreted by enterochromaffin (ec) cells and acts on receptors located on smooth muscles, enterocytes and nerves (5-ht1, 5-ht2, 5-ht3, 5-ht4, 5-ht7). |
2008-02-08 |
2023-08-12 |
Not clear |
| Trond Brattelid, Eirik Qvigstad, Jon Arne Kro Birkeland, Fredrik Swift, Silje V S Bekkevold, Kurt A Krobert, Ole M Sejersted, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy, Ivar Sjaasta. Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Journal of molecular and cellular cardiology. vol 43. issue 6. 2008-02-07. PMID:17936780. |
serotonin responsiveness through 5-ht2a and 5-ht4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. |
2008-02-07 |
2023-08-12 |
human |
| Alfredo Menese. Stimulation of 5-HT1A, 5-HT1B, 5-HT2A/2C, 5-HT3 and 5-HT4 receptors or 5-HT uptake inhibition: short- and long-term memory. Behavioural brain research. vol 184. issue 1. 2008-01-09. PMID:17692935. |
stimulation of 5-ht1a, 5-ht1b, 5-ht2a/2c, 5-ht3 and 5-ht4 receptors or 5-ht uptake inhibition: short- and long-term memory. |
2008-01-09 |
2023-08-12 |
Not clear |
| Mikhail A Kutuzov, Alexandra V Andreeva, Tatyana A Voyno-Yasenetskay. Regulation of apoptosis signal-regulating kinase 1 degradation by G alpha13. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 13. 2007-12-03. PMID:17595347. |
short-term activation of a serotonin 5-ht4 receptor that is coupled to g alpha13 also increased ask1 expression. |
2007-12-03 |
2023-08-12 |
human |
| Alexandra Jean, Grégory Conductier, Christine Manrique, Constantin Bouras, Philippe Berta, René Hen, Yves Charnay, Joël Bockaert, Valérie Compa. Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 41. 2007-11-28. PMID:17913892. |
anorexia induced by activation of serotonin 5-ht4 receptors is mediated by increases in cart in the nucleus accumbens. |
2007-11-28 |
2023-08-12 |
mouse |
| A E Foxx-Orenstein, M Camilleri, L A Szarka, S McKinzie, D Burton, G Thomforde, K Baxter, A R Zinsmeiste. Does co-administration of a non-selective opiate antagonist enhance acceleration of transit by a 5-HT4 agonist in constipation-predominant irritable bowel syndrome? A randomized controlled trial. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 19. issue 10. 2007-11-21. PMID:17539894. |
in vitro, 5-hydroxytryptamine (5-ht4) agonists combined with selective opioid antagonists significantly increased colonic propulsion relative to a 5-ht4 agonist alone. |
2007-11-21 |
2023-08-12 |
Not clear |
| Jon Arne Kro Birkeland, Fredrik Swift, Nils Tovsrud, Ulla Enger, Per Kristian Lunde, Eirik Qvigstad, Finn Olav Levy, Ole M Sejersted, Ivar Sjaasta. Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes. American journal of physiology. Heart and circulatory physiology. vol 293. issue 4. 2007-11-21. PMID:17660386. |
serotonin increases l-type ca2+ current and sr ca2+ content through 5-ht4 receptors in failing rat ventricular cardiomyocytes. |
2007-11-21 |
2023-08-12 |
human |
| Paola Bonsi, Dario Cuomo, Jun Ding, Giuseppe Sciamanna, Sasha Ulrich, Anne Tscherter, Giorgio Bernardi, D James Surmeier, Antonio Pisan. Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 8. 2007-09-26. PMID:17203014. |
the depolarization/inward current induced by 5-ht was partially mimicked by the 5-ht2 receptor agonist 2,5-dimethoxy-4-iodoamphetamine and antagonized by both ketanserin and the selective 5-ht2c antagonist rs102221, whereas the selective 5-ht3 and 5-ht4 receptor antagonists tropisetron and rs23597-190 had no effect. |
2007-09-26 |
2023-08-12 |
rat |
| A Papageorgiou, C Dene. Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors. Endocrinology. vol 148. issue 9. 2007-09-26. PMID:17584957. |
in aggregates cultured with 1 nm estradiol for expression of the 5-ht4, -5, and -6 receptor (r), 5-ht promptly stimulated gh secretion with a dose dependency between 1 and 10 nm. |
2007-09-26 |
2023-08-12 |
rat |
| Robert Mader, Thomas Kocher, Joerg Haier, Grazyna Wieczorek, Hans-Juergen Pfannkuche, Moriko It. Investigation of serotonin type 4 receptor expression in human and non-human primate gastrointestinal samples. European journal of gastroenterology & hepatology. vol 18. issue 9. 2007-07-26. PMID:16894306. |
the serotonin type 4 (5-ht4) receptor has been associated with functions of the gastrointestinal tract such as modulation of the peristaltic reflex, smooth muscle tone, intestinal secretion and visceral sensitivity. |
2007-07-26 |
2023-08-12 |
human |
| Frank Lezoualc'h, Klaudia Steplewski, Laura Sartiani, Alessandro Mugelli, Rodolphe Fischmeister, Antoine Bri. Quantitative mRNA analysis of serotonin 5-HT4 receptor isoforms, calcium handling proteins and ion channels in human atrial fibrillation. Biochemical and biophysical research communications. vol 357. issue 1. 2007-06-12. PMID:17418812. |
quantitative mrna analysis of serotonin 5-ht4 receptor isoforms, calcium handling proteins and ion channels in human atrial fibrillation. |
2007-06-12 |
2023-08-12 |
human |
| Michelle L Delco, Jorge E Nieto, Arthur L Craigmill, Scott D Stanley, Jack R Snyde. Pharmacokinetics and in vitro effects of tegaserod, a serotonin 5-hydroxytryptamine 4 (5-HT4) receptor agonist with prokinetic activity in horses. Veterinary therapeutics : research in applied veterinary medicine. vol 8. issue 1. 2007-05-31. PMID:17447227. |
pharmacokinetics and in vitro effects of tegaserod, a serotonin 5-hydroxytryptamine 4 (5-ht4) receptor agonist with prokinetic activity in horses. |
2007-05-31 |
2023-08-12 |
Not clear |
| Elisabetta Cervio, Mariangela Rondanelli, Barbara Balestra, Antonio Dellabianca, Alessandro Agazzi, Attilio Giacosa, Marcello Tonin. [Recent insights into the pathogenesis of abdominal symptoms in functional bowel disorders]. Recenti progressi in medicina. vol 98. issue 2. 2007-05-04. PMID:17439064. |
among all 5-ht receptors, those belonging to the 5-ht3 (a ionotropic receptor) and 5-ht4 (a metabotropic receptor) type are the most extensively studied in gastroenterology, resulting in commercially available (although not worldwide) serotonergic agents for the treatment of ibs and functional dyspepsia. |
2007-05-04 |
2023-08-12 |
Not clear |
| Orazio Prezzavento, Agata Campisi, Simone Ronsisvalle, Giovanni Li Volti, Agostino Marrazzo, Vincenzo Bramanti, Giuseppe Cannavò, Luca Vanella, Alfredo Cagnotto, Tiziana Mennini, Riccardo Ientile, Giuseppe Ronsisvall. Novel sigma receptor ligands: synthesis and biological profile. Journal of medicinal chemistry. vol 50. issue 5. 2007-04-23. PMID:17328523. |
binding affinity studies showed that 4b binding on n-methyl-d-aspartate (nmda), dopaminergic (d1, d2, d3), muscarinic, histaminergic h1, adrenergic (alpha1, alpha2), serotoninergic (5-ht2a, 5-ht2c, 5-ht3, 5-ht4, 5-ht6), da (dat), and 5-ht (sert) transporters was not significant. |
2007-04-23 |
2023-08-12 |
Not clear |
| K D Alex, E A Pehe. Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacology & therapeutics. vol 113. issue 2. 2007-04-19. PMID:17049611. |
several subtypes, including the 5-ht1a, 5-ht1b, 5-ht2a, 5-ht3 and 5-ht4 receptors, act to facilitate da release, while the 5-ht2c receptor mediates an inhibitory effect of 5-ht on da release. |
2007-04-19 |
2023-08-12 |
Not clear |
| Pramodini B Kale-Pradhan, Sheila M Wilhel. Tegaserod for constipation-predominant irritable bowel syndrome. Pharmacotherapy. vol 27. issue 2. 2007-04-05. PMID:17253916. |
tegaserod, a selective and partial agonist at the 5-hydroxytryptamine (5-ht [serotonin]) receptor subtype 4 (5-ht4), is the only united states food and drug administration-approved drug for the treatment of constipation-predominant irritable bowel syndrome (ibs) in women. |
2007-04-05 |
2023-08-12 |
Not clear |
| A Papageorgiou, C Dene. Estradiol induces expression of 5-hydroxytryptamine (5-HT) 4, 5-HT5, and 5-HT6 receptor messenger ribonucleic acid in rat anterior pituitary cell aggregates and allows prolactin release via the 5-HT4 receptor. Endocrinology. vol 148. issue 3. 2007-04-04. PMID:17122082. |
estradiol induces expression of 5-hydroxytryptamine (5-ht) 4, 5-ht5, and 5-ht6 receptor messenger ribonucleic acid in rat anterior pituitary cell aggregates and allows prolactin release via the 5-ht4 receptor. |
2007-04-04 |
2023-08-12 |
rat |
| Helen R Irving, Yean Y Tan, Nathalie Tochon-Danguy, Haihuang Liu, Navinisha Chetty, Paul V Desmond, Colin W Pouton, Ian M Coupa. Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon. Life sciences. vol 80. issue 13. 2007-03-29. PMID:17258778. |
part of the relaxant response to 5-ht was due to activation of 5-ht4 receptors as the apparent pkb value of the selective 5-ht4 antagonist, gr 113808, was 9.36. |
2007-03-29 |
2023-08-12 |
human |