| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen R Irving, Yean Y Tan, Nathalie Tochon-Danguy, Haihuang Liu, Navinisha Chetty, Paul V Desmond, Colin W Pouton, Ian M Coupa. Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon. Life sciences. vol 80. issue 13. 2007-03-29. PMID:17258778. |
5-ht4 mrna levels were low in five tissues and undetectable in four others, but all responded to 5-ht with an ec50 value of 102.54+/-19.32 nm. |
2007-03-29 |
2023-08-12 |
human |
| J R Grider, B E Pilan. The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. American journal of physiology. Gastrointestinal and liver physiology. vol 292. issue 1. 2007-03-22. PMID:16973914. |
in conclusion, chemical stimulation of the mucosa by scfas triggers a peristaltic reflex mediated by the release of 5-ht from mucosal cells and activation of 5-ht4 receptors on sensory cgrp-containing nerve terminals. |
2007-03-22 |
2023-08-12 |
rat |
| D Vezzosi, D Cartier, C Régnier, P Otal, A Bennet, F Parmentier, M Plantavid, A Lacroix, H Lefebvre, P Caro. Familial adrenocorticotropin-independent macronodular adrenal hyperplasia with aberrant serotonin and vasopressin adrenal receptors. European journal of endocrinology. vol 156. issue 1. 2007-03-07. PMID:17218722. |
in conclusion, this study shows that (i) familial aimah could be an autosomal dominantly inherited disorder; (ii) aberrant 5-ht4 serotonin and vasopressin receptors can be expressed in familial aimah; and (iii) phenotypic expression of familial aimah could be varied in a same family and more pronounced in female than in male patients. |
2007-03-07 |
2023-08-12 |
human |
| N Van Lelyveld, J Ter Linde, A Baron, M Mundt, E Wajs, M Samso. The 5-HT4 antagonist R216073 does not affect gastric motor and sensory function in patients with functional dyspepsia. Alimentary pharmacology & therapeutics. vol 24. issue 4. 2007-03-06. PMID:16827813. |
serotonin and the 5-ht4 receptor play an important role in gastrointestinal motor and sensory functions. |
2007-03-06 |
2023-08-12 |
Not clear |
| Vincenzo Micale, Gian Marco Leggio, Carmen Mazzola, Filippo Drag. Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia. Brain research. vol 1121. issue 1. 2007-02-12. PMID:17011531. |
cognitive effects of sl65.0155, a serotonin 5-ht4 receptor partial agonist, in animal models of amnesia. |
2007-02-12 |
2023-08-12 |
mouse |
| Hitoshi Kita, Satomi Chiken, Yoshihisa Tachibana, Atsushi Namb. Serotonin modulates pallidal neuronal activity in the awake monkey. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 1. 2007-01-29. PMID:17202474. |
previous anatomical studies and in vitro physiological studies in other brain areas have suggested the following possibilities: (1) 5-ht suppresses gabaergic inhibition through presynaptic 5-ht1b receptors; (2) 5-ht decreases the firing of pallidal neurons through postsynaptic 5-ht1a receptors; and (3) 5-ht postsynaptically excites pallidal neurons through activation of 5-ht2c, 5-ht4, or 5-ht7 receptors. |
2007-01-29 |
2023-08-12 |
monkey |
| Alberto J Kaumann, Finn Olav Lev. Fading of 5-HT4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium. British journal of pharmacology. vol 147. issue 2. 2007-01-17. PMID:16331292. |
fading of 5-ht4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium. |
2007-01-17 |
2023-08-12 |
human |
| David A Johnso. Treating chronic constipation : How should we interpret the recommendations? Clinical drug investigation. vol 26. issue 10. 2007-01-03. PMID:17163288. |
lactulose and polyethylene glycol), a serotonin (5-ht4) receptor agonist (e.g. |
2007-01-03 |
2023-08-12 |
Not clear |
| Erik Hedner, Martin Sjögren, Per-Anders Frändberg, Tobias Johansson, Ulf Göransson, Mia Dahlström, Per Jonsson, Fred Nyberg, Lars Bohli. Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. Journal of natural products. vol 69. issue 10. 2006-12-14. PMID:17067154. |
barettin selectively interacted with the serotonin receptors 5-ht2a, 5-ht2c, and 5-ht4 at concentrations close to that of endogenous serotonin, with the corresponding ki values being 1.93, 0.34, and 1.91 microm, respectively. |
2006-12-14 |
2023-08-12 |
human |
| Boris Mlinar, Simona Mascalchi, Guido Mannaioni, Raffaella Morini, Renato Corradett. 5-HT4 receptor activation induces long-lasting EPSP-spike potentiation in CA1 pyramidal neurons. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930402. |
esp(5-ht4) was also induced by transient application of the natural neurotransmitter, 5-ht. |
2006-11-01 |
2023-08-12 |
rat |
| Gerhard J Molderings, Micheal Brüss, Manfred Göther. Functional and molecular identification of 5-hydroxytryptamine receptors in rabbit pulmonary artery: involvement in complex regulation of noradrenaline release. Pharmacological reports : PR. vol 58. issue 2. 2006-10-26. PMID:16702620. |
the 5-ht4 and 5-ht1b/1d receptor agonists 5-ht and 5-methoxytryptamine reduced 3h overflow in the absence and presence of atropine, and this effect was blocked by methiothepin, a non-selective 5-ht receptor antagonist, in the presence of atropine. |
2006-10-26 |
2023-08-12 |
human |
| Marion Raoul, Dominique Patigny, Frédréic Fabis, Françis Dauphin, Sylvain Rault, Janos Sapi, Jean-Yves Laronz. N-arylsulfonyl-2-vinyltryptamines as new 5-HT6 serotonin receptor ligands. Journal of enzyme inhibition and medicinal chemistry. vol 21. issue 3. 2006-09-28. PMID:16918072. |
several new 2-vinyl-nb,nb-dimethyltryptamines were prepared using fischer indole synthesis followed by simple functional group transformations and evaluated on 5-ht4, 5-ht5, 5-ht6 and 5-ht7 serotonin receptors. |
2006-09-28 |
2023-08-12 |
Not clear |
| Liliana Castro, Jeanne Mialet-Perez, Aurélie Guillemeau, Francesca Stillitano, Oliver Zolk, Thomas Eschenhagen, Frank Lezoualc'h, Pascal Bochet, Rodolphe Fischmeiste. Differential functional effects of two 5-HT4 receptor isoforms in adult cardiomyocytes. Journal of molecular and cellular cardiology. vol 39. issue 2. 2006-09-14. PMID:15950987. |
serotonin 5-ht4 receptors are present in human atrial myocytes and have been proposed to contribute to the generation of atrial fibrillation. |
2006-09-14 |
2023-08-12 |
human |
| Liliana Castro, Jeanne Mialet-Perez, Aurélie Guillemeau, Francesca Stillitano, Oliver Zolk, Thomas Eschenhagen, Frank Lezoualc'h, Pascal Bochet, Rodolphe Fischmeiste. Differential functional effects of two 5-HT4 receptor isoforms in adult cardiomyocytes. Journal of molecular and cellular cardiology. vol 39. issue 2. 2006-09-14. PMID:15950987. |
when expressed in the hl-1 murine cell line of atrial origin, both receptors caused specific binding of the 5-ht4 selective antagonist gr113808 and activated adenylyl cyclase in the presence of serotonin (5-ht, 1 microm). |
2006-09-14 |
2023-08-12 |
human |
| N S Tropskay. Role of serotonin in the recovery of electrical activity in the stomach and small intestine of rats during the early postsurgery period. Bulletin of experimental biology and medicine. vol 140. issue 5. 2006-09-11. PMID:16758609. |
the effects of serotonin and 5-ht4 receptor agonist cisapride on electrical activity of the stomach and small intestine were studied in rats with postoperative ileus. |
2006-09-11 |
2023-08-12 |
rat |
| N S Tropskay. Role of serotonin in the recovery of electrical activity in the stomach and small intestine of rats during the early postsurgery period. Bulletin of experimental biology and medicine. vol 140. issue 5. 2006-09-11. PMID:16758609. |
administration of serotonin and 5-ht4 receptor agonist cisapride into the jejunum was followed by the appearance of spike activity, which spread from the stomach to the jejunum. |
2006-09-11 |
2023-08-12 |
rat |
| Juan Guillermo Ariza, Jairo Andrés Martíne. [Pharmacoeconomics and outcome research on Irritable Bowel Syndrome review of findings using Tegaserod]. Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru. vol 26. issue 1. 2006-08-16. PMID:16622489. |
currently tagaserod an agonist of the number 4 serotonin receptors (5-ht4), indicated for ibs-constipation treatment, has demonstrated savings while optimizing health resources and improving the quality of life of patients and their work productivity. |
2006-08-16 |
2023-08-12 |
Not clear |
| Scott R Armstrong, Julia L McCullough, David T Beatti. Measurement of 5-HT4 receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat. Journal of pharmacological and toxicological methods. vol 53. issue 3. 2006-08-03. PMID:16168678. |
the activity of 5-ht and several well-established 5-ht4 receptor agonists (tegaserod, bimu-8, cisapride, renzapride, and mosapride) was investigated in a novel in vivo model designed to measure esophageal relaxation using the technique of digital sonomicrometry. |
2006-08-03 |
2023-08-12 |
rat |
| Scott D Blese. Chronic constipation: let symptom type and severity direct treatment. The Journal of family practice. vol 55. issue 7. 2006-08-02. PMID:16822445. |
tegaserod, a selective 5-hydroxytryptamine type 4 (5-ht4) receptor partial agonist, is more effective than placebo at relieving symptoms of chronic idiopathic constipation in patients younger than 65 years of age. |
2006-08-02 |
2023-08-12 |
Not clear |
| Joris H De Maeyer, Nicolaas H Prins, Jan A J Schuurkes, Romain A Lefebvr. Differential effects of 5-hydroxytryptamine4 receptor agonists at gastric versus cardiac receptors: an operational framework to explain and quantify organ-specific behavior. The Journal of pharmacology and experimental therapeutics. vol 317. issue 3. 2006-06-26. PMID:16501067. |
the model quantified the tissue-dependent partial agonism of the selective 5-ht4 receptor agonists prucalopride, r149402, and r199715, whereas tegaserod and 5-ht were equiefficacious. |
2006-06-26 |
2023-08-12 |
human |