| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Craig Blomeley, Enrico Bracc. Excitatory effects of serotonin on rat striatal cholinergic interneurones. The Journal of physiology. vol 569. issue Pt 3. 2006-05-04. PMID:16269435. |
selective agonists of 5-ht(1a), 5-ht3, 5-ht4 and 5-ht7 receptors did not affect cholinergic interneurone firing, while the 5-ht2 receptor agonist alpha-methyl-5-ht (30 microm) mimicked the excitatory effects of serotonin. |
2006-05-04 |
2023-08-12 |
rat |
| Kurt A Krobert, Trond Brattelid, Finn Olav Levy, Alberto J Kauman. Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants. Naunyn-Schmiedeberg's archives of pharmacology. vol 371. issue 6. 2006-04-28. PMID:16012870. |
at the 5-ht4(g) receptor prucalopride acted as a full agonist (-logec50m=8.0) compared with 5-ht in the cell line tested, which was probably due to high receptor expression levels. |
2006-04-28 |
2023-08-12 |
human |
| John McLaughlin, Lesley A Houghto. The rationale, efficacy and safety evidence for tegaserod in the treatment of irritable bowel syndrome. Expert opinion on drug safety. vol 5. issue 2. 2006-03-15. PMID:16503751. |
the authors review the evidence for 5-ht in the aetiology of ibs and its symptoms, and the data available concerning the partial 5-ht4 receptor agonist tegaserod, in terms of rationale, efficacy and safety. |
2006-03-15 |
2023-08-12 |
Not clear |
| Leith C R Meyer, Andrea Fuller, Duncan Mitchel. Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 290. issue 2. 2006-02-23. PMID:16166206. |
neurophysiological studies have shown that serotonergic ligands that bind to 5-ht1a, 5-ht7, and 5-ht4 serotonin receptors in brain stem have beneficial effects on respiratory neurons during opioid-induced respiratory depression. |
2006-02-23 |
2023-08-12 |
Not clear |
| Regina M Day, Abena S Agyeman, Michael J Segel, Rubén D Chévere, Jill M Angelosanto, Yuichiro J Suzuki, Barry L Fanbur. Serotonin induces pulmonary artery smooth muscle cell migration. Biochemical pharmacology. vol 71. issue 3. 2006-02-03. PMID:16316635. |
we conclude that 5-ht stimulates pasmc migration and associated cytoskeletal reorganization through the 5-ht4 receptor and camp activation of a chloride channel. |
2006-02-03 |
2023-08-12 |
cattle |
| Gennady A Buznikov, Robert E Peterson, Lyudmila A Nikitina, Vladimir V Bezuglov, Jean M Laude. The pre-nervous serotonergic system of developing sea urchin embryos and larvae: pharmacologic and immunocytochemical evidence. Neurochemical research. vol 30. issue 6-7. 2006-01-30. PMID:16187217. |
some of these substances (agonists of 5-ht1 receptors, antagonists of 5-ht2, 5-ht3 or 5-ht4 receptors, and inhibitors of the serotonin transporter, sert) perturbed post-blastulation development, eliciting changes in embryonic/larval phenotypes typical for each class of receptor ligand. |
2006-01-30 |
2023-08-12 |
Not clear |
| Hirohide Asai, Fukashi Udaka, Makito Hirano, Takeshi Minami, Masaya Oda, Tamotsu Kubori, Kazuto Nishinaka, Masakuni Kameyama, Satoshi Uen. Increased gastric motility during 5-HT4 agonist therapy reduces response fluctuations in Parkinson's disease. Parkinsonism & related disorders. vol 11. issue 8. 2006-01-17. PMID:16263322. |
we investigated the clinical efficacy and tolerability of 45 mg/day mosapride, a selective 5-hydroxytryptamine type 4 (5-ht4) agonist, in an open-label study involving five patients with parkinson's disease (pd) who had response fluctuations (rfs). |
2006-01-17 |
2023-08-12 |
Not clear |
| B Darblade, D Behr-Roussel, D Gorny, T Lebret, G Benoit, J-P Hieble, D Brooks, L Alexandre, F Giulian. Piboserod (SB 207266), a selective 5-HT4 receptor antagonist, reduces serotonin potentiation of neurally-mediated contractile responses of human detrusor muscle. World journal of urology. vol 23. issue 2. 2005-11-15. PMID:15902472. |
piboserod (sb 207266), a selective 5-ht4 receptor antagonist, reduces serotonin potentiation of neurally-mediated contractile responses of human detrusor muscle. |
2005-11-15 |
2023-08-12 |
human |
| Marjorie Maillet, Monique Gastineau, Pascal Bochet, Marie-Liesse Asselin-Labat, Eric Morel, Jean-Noël Laverrière, Anne-Marie Lompré, Rodolphe Fischmeister, Frank Lezoualc'. Functional studies of the 5'-untranslated region of human 5-HT4 receptor mRNA. The Biochemical journal. vol 387. issue Pt 2. 2005-10-20. PMID:15575821. |
the serotonin 5-ht4 receptor (where 5-ht stands for 5-hydroxy-tryptamine) is a member of the seven transmembrane-spanning g-protein-coupled family of receptors and mediates many cellular functions both in the central nervous system and at the periphery. |
2005-10-20 |
2023-08-12 |
human |
| Patrick Cole, Xavier Rabassed. Tegaserod: a serotonin 5-HT4 receptor agonist for treatment of constipation-predominant irritable bowel syndrome. Drugs of today (Barcelona, Spain : 1998). vol 40. issue 12. 2005-10-20. PMID:15645012. |
tegaserod: a serotonin 5-ht4 receptor agonist for treatment of constipation-predominant irritable bowel syndrome. |
2005-10-20 |
2023-08-12 |
Not clear |
| Eirik Qvigstad, Ivar Sjaastad, Trond Brattelid, Caroline Nunn, Fredrik Swift, Jon Arne Kro Birkeland, Kurt A Krobert, Geir Øystein Andersen, Ole M Sejersted, Jan-Bjørn Osnes, Finn Olav Levy, Tor Skomeda. Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Circulation research. vol 97. issue 3. 2005-10-20. PMID:16002744. |
in chronic chf, the left ventricle has become sensitive to serotonin because of appearance of gs-coupled 5-ht4 receptors. |
2005-10-20 |
2023-08-12 |
rat |
| Eirik Qvigstad, Ivar Sjaastad, Trond Brattelid, Caroline Nunn, Fredrik Swift, Jon Arne Kro Birkeland, Kurt A Krobert, Geir Øystein Andersen, Ole M Sejersted, Jan-Bjørn Osnes, Finn Olav Levy, Tor Skomeda. Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Circulation research. vol 97. issue 3. 2005-10-20. PMID:16002744. |
the acute failing rat ventricle is, thus, dually regulated by serotonin through gq-coupled 5-ht2a receptors and gs-coupled 5-ht4 receptors. |
2005-10-20 |
2023-08-12 |
rat |
| M C Buhot, G Malleret, L Seg. Serotonin receptors and cognitive behaviour--an update. IDrugs : the investigational drugs journal. vol 2. issue 5. 2005-10-13. PMID:16155845. |
this is made evident after administration of 5-ht(2a/2c), and 5-ht4 receptor agonists, or 5-ht1a, 5-ht3 and probably 5-ht1b receptor antagonists. |
2005-10-13 |
2023-08-12 |
mouse |
| Fernando D Saraví, Liliana M Cincunegui, Teobaldo A Saldeña, Graciela E Carra, Jorge E Ibáñe. Increased oxygen consumption caused by cAMP- and Ca(2+)-mediated chloride secretion in rat distal colon. Acta gastroenterologica Latinoamericana. vol 35. issue 1. 2005-10-04. PMID:15954731. |
the effect of serotonin in this tissue is mainly mediated by 5ht4 receptors linked to adenylate cyclase through a stimulant g protein (gs). |
2005-10-04 |
2023-08-12 |
rat |
| Jörn Lötsch, Carsten Skarke, Andreas Schneider, Thomas Hummel, Gerd Geisslinge. The 5-hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine-induced respiratory depression. Clinical pharmacology and therapeutics. vol 78. issue 3. 2005-09-27. PMID:16153398. |
on the basis of experiments in rats, serotonin 4 receptor (5-hydroxytryptamine 4 [5-ht4]) agonists have been proposed as a novel therapeutic strategy for the selective treatment of respiratory depression caused by opioids while leaving analgesic effects unaffected. |
2005-09-27 |
2023-08-12 |
rat |
| R Mitsui, S Ono, S Karaki, A Kuwahar. Neural and non-neural mediation of propionate-induced contractile responses in the rat distal colon. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 17. issue 4. 2005-09-06. PMID:16078948. |
5-ht acts through 5-ht4 receptors on the endings of intrinsic primary afferent neurones that in turn activate cholinergic motor neurones that contract the circular muscle. |
2005-09-06 |
2023-08-12 |
rat |
| Magali Berthouze, Mohammed Ayoub, Olivier Russo, Lucie Rivail, Sames Sicsic, Rodolphe Fischmeister, Isabelle Berque-Bestel, Ralf Jockers, Frank Lezoualc'. Constitutive dimerization of human serotonin 5-HT4 receptors in living cells. FEBS letters. vol 579. issue 14. 2005-07-21. PMID:15896782. |
constitutive dimerization of human serotonin 5-ht4 receptors in living cells. |
2005-07-21 |
2023-08-12 |
human |
| Magali Berthouze, Mohammed Ayoub, Olivier Russo, Lucie Rivail, Sames Sicsic, Rodolphe Fischmeister, Isabelle Berque-Bestel, Ralf Jockers, Frank Lezoualc'. Constitutive dimerization of human serotonin 5-HT4 receptors in living cells. FEBS letters. vol 579. issue 14. 2005-07-21. PMID:15896782. |
serotonin 5-ht4 receptor isoforms are g protein-coupled receptors (gpcrs) with distinct pharmacological properties and may represent a valuable target for the treatment of many human disorders. |
2005-07-21 |
2023-08-12 |
human |
| Marjorie Maillet, Sylvain J Robert, Frank Lezoualc'. New insights into serotonin 5-HT4 receptors : a novel therapeutic target for Alzheimer's disease? Current Alzheimer research. vol 1. issue 2. 2005-07-21. PMID:15975071. |
new insights into serotonin 5-ht4 receptors : a novel therapeutic target for alzheimer's disease? |
2005-07-21 |
2023-08-12 |
Not clear |
| Marjorie Maillet, Sylvain J Robert, Frank Lezoualc'. New insights into serotonin 5-HT4 receptors : a novel therapeutic target for Alzheimer's disease? Current Alzheimer research. vol 1. issue 2. 2005-07-21. PMID:15975071. |
the serotonin 5-ht4 receptor mediates many physiological effects in the central nervous system. |
2005-07-21 |
2023-08-12 |
Not clear |