| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John K DiBais. Tegaserod-associated ischemic colitis. Pharmacotherapy. vol 25. issue 4. 2005-07-20. PMID:15977922. |
tegaserod, a potent partial agonist of the serotonin 5-ht4 receptor, is used to treat women with constipation-predominant irritable bowel syndrome. |
2005-07-20 |
2023-08-12 |
Not clear |
| P G Leclere, N H Prins, J A J Schuurkes, R A Lefebvr. 5-HT4 receptors located on cholinergic nerves in human colon circular muscle. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 17. issue 3. 2005-06-27. PMID:15916624. |
5-hydroxytryptamine 4 (5-ht4) receptor agonists promote colonic propulsion. |
2005-06-27 |
2023-08-12 |
human |
| E Louiset, D Cartier, V Contesse, C Duparc, I Lihrmann, J Young, J Bertherat, Y Reznik, J M Kuhn, A Laquerrière, H Vaudry, Herve Lefebvr. Paradoxical inhibitory effect of serotonin on cortisol production from adrenocortical lesions causing Cushing's syndrome. Endocrine research. vol 30. issue 4. 2005-06-10. PMID:15666851. |
in the human adrenal gland, serotonin (5-ht) stimulates cortisol production through a paracrine mechanism involving 5-ht4 receptors positively-coupled to adenylyl cyclase. |
2005-06-10 |
2023-08-12 |
human |
| E Louiset, D Cartier, V Contesse, C Duparc, I Lihrmann, J Young, J Bertherat, Y Reznik, J M Kuhn, A Laquerrière, H Vaudry, Herve Lefebvr. Paradoxical inhibitory effect of serotonin on cortisol production from adrenocortical lesions causing Cushing's syndrome. Endocrine research. vol 30. issue 4. 2005-06-10. PMID:15666851. |
the specific 5-ht4 antagonist gr 113808 failed to influence the 5-ht-induced decrease in cortisol production by the two tissues, indicating that the paradoxical inhibitory effect of 5-ht could not be accounted for by activation of eutopic 5-ht4 receptors. |
2005-06-10 |
2023-08-12 |
human |
| Vincent Contesse, Yves Reznik, Estelle Louiset, Céline Duparc, Dorthe Cartier, Flavie Sicard, Annie Laquerriere, Francoise Parmentier, Jean-Marc Kuhn, Hubert Vaudry, Hervé Lefebvr. Abnormal sensitivity of cortisol-producing adrenocortical adenomas to serotonin: in vivo and in vitro studies. The Journal of clinical endocrinology and metabolism. vol 90. issue 5. 2005-06-09. PMID:15705918. |
the corticotropic effect of 5-ht was inhibited by the specific 5-ht4 receptor antagonist gr 113808 and more potently by methiothepin, a nonspecific serotonergic antagonist having no affinity for the 5-ht4 receptor. |
2005-06-09 |
2023-08-12 |
human |
| Vincent Contesse, Yves Reznik, Estelle Louiset, Céline Duparc, Dorthe Cartier, Flavie Sicard, Annie Laquerriere, Francoise Parmentier, Jean-Marc Kuhn, Hubert Vaudry, Hervé Lefebvr. Abnormal sensitivity of cortisol-producing adrenocortical adenomas to serotonin: in vivo and in vitro studies. The Journal of clinical endocrinology and metabolism. vol 90. issue 5. 2005-06-09. PMID:15705918. |
these results show that the hypersensitivity of the tumors to 5-ht was related to tissue expression of an ectopic serotonergic receptor in addition to the eutopic 5-ht4 receptor. |
2005-06-09 |
2023-08-12 |
human |
| Dean G Smith, Victoria Barghout, Kristijan H Kahle. Tegaserod treatment for IBS: a model of indirect costs. The American journal of managed care. vol 11. issue 1 Suppl. 2005-06-09. PMID:15926763. |
this article presents a productivity model demonstrating the indirect costs associated with ibs and the reduction in those costs for a cohort of female employees hypothetically treated with tegaserod, a new selective serotonin (5-hydroxytryptamine [5-ht]) type 4 (5-ht4) receptor agonist, which is approved by the us food and drug administration for treating women with ibs-c. |
2005-06-09 |
2023-08-12 |
Not clear |
| M Teresa Vilaró, Roser Cortés, Guadalupe Mengo. Serotonin 5-HT4 receptors and their mRNAs in rat and guinea pig brain: distribution and effects of neurotoxic lesions. The Journal of comparative neurology. vol 484. issue 4. 2005-06-08. PMID:15770652. |
serotonin 5-ht4 receptors and their mrnas in rat and guinea pig brain: distribution and effects of neurotoxic lesions. |
2005-06-08 |
2023-08-12 |
rat |
| M Teresa Vilaró, Roser Cortés, Guadalupe Mengo. Serotonin 5-HT4 receptors and their mRNAs in rat and guinea pig brain: distribution and effects of neurotoxic lesions. The Journal of comparative neurology. vol 484. issue 4. 2005-06-08. PMID:15770652. |
serotonin 5-ht4 receptors are widely distributed in the periphery and in brain, where they modulate the release of various neurotransmitters and have been implicated in learning and memory. |
2005-06-08 |
2023-08-12 |
rat |
| Takeshi Sugiuar, Klaus Bielefeldt, G F Gebhar. TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 43. 2005-05-19. PMID:15509739. |
5-ht (1 microm) significantly increased capsaicin-evoked (100 nm) and proton-evoked (ph 5.5) currents 1.6- and 4.7-fold, respectively, and significantly decreased the threshold temperature for heat current activation from 42 to 38 degrees c. the enhancement of trpv1 by 5-ht was significantly attenuated by selective 5-ht2 and 5-ht4 receptor antagonists, but not by a 5-ht3 receptor antagonist. |
2005-05-19 |
2023-08-12 |
mouse |
| Takeshi Sugiuar, Klaus Bielefeldt, G F Gebhar. TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 43. 2005-05-19. PMID:15509739. |
in support, 5-ht2 and 5-ht4 receptor agonists mimicked the facilitating effects of 5-ht on trpv1 function. |
2005-05-19 |
2023-08-12 |
mouse |
| Davide Pau, Antony J Workman, Kathleen A Kane, Andrew C Ranki. Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists. The Journal of pharmacology and experimental therapeutics. vol 313. issue 1. 2005-05-19. PMID:15644433. |
prucalopride is a selective 5-hydroxytryptamine type 4 (5-ht4) receptor agonist developed for the treatment of gastrointestinal disorders. |
2005-05-19 |
2023-08-12 |
human |
| Davide Pau, Antony J Workman, Kathleen A Kane, Andrew C Ranki. Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists. The Journal of pharmacology and experimental therapeutics. vol 313. issue 1. 2005-05-19. PMID:15644433. |
the endogenous agonist 5-ht acting via 5-ht4 receptors increases the l-type ca2+ current (i(cal)) with potentially proarrhythmic consequences (pau et al., 2003). |
2005-05-19 |
2023-08-12 |
human |
| Guillaume Lucas, Valérie Compan, Yves Charnay, Rachael L Neve, Eric J Nestler, Joël Bockaert, Michel Barrot, Guy Debonne. Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists. Biological psychiatry. vol 57. issue 8. 2005-05-16. PMID:15820713. |
we recently identified a facilitory control exerted by serotonin4 (5-ht4) receptors on the in vivo firing activity of dorsal raphe nucleus (drn) serotonergic (5-ht) neurons. |
2005-05-16 |
2023-08-12 |
Not clear |
| Guillaume Lucas, Valérie Compan, Yves Charnay, Rachael L Neve, Eric J Nestler, Joël Bockaert, Michel Barrot, Guy Debonne. Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists. Biological psychiatry. vol 57. issue 8. 2005-05-16. PMID:15820713. |
however, these findings were based on acute administrations of 5-ht4 receptor agonists and antagonists, which were active only in a subpopulation of 5-ht neurons. |
2005-05-16 |
2023-08-12 |
Not clear |
| Ravinder K Gill, Seema Saksena, Sangeeta Tyagi, Waddah A Alrefai, Jaleh Malakooti, Zaheer Sarwar, Jerrold R Turner, Krishnamurthy Ramaswamy, Pradeep K Dudej. Serotonin inhibits Na+/H+ exchange activity via 5-HT4 receptors and activation of PKC alpha in human intestinal epithelial cells. Gastroenterology. vol 128. issue 4. 2005-05-12. PMID:15825078. |
serotonin inhibits na+/h+ exchange activity via 5-ht4 receptors and activation of pkc alpha in human intestinal epithelial cells. |
2005-05-12 |
2023-08-12 |
human |
| Zixiu Xiang, Lie Wang, Stephen T Kita. Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. Journal of neurophysiology. vol 93. issue 3. 2005-05-02. PMID:15738272. |
the increased firing by 5-ht was mimicked by 5-ht(2/4) receptor agonist alpha-methyl-5-ht and was partially mimicked by 5-ht2 receptor agonist doi or 5-ht4 receptor agonist cisapride. |
2005-05-02 |
2023-08-12 |
rat |
| Zixiu Xiang, Lie Wang, Stephen T Kita. Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. Journal of neurophysiology. vol 93. issue 3. 2005-05-02. PMID:15738272. |
the 5-ht action was partially reversed by 5-ht4 receptor antagonist sb 23597-190, 5-ht2 receptor antagonist ketanserin, and 5-ht2c receptor antagonist rs 102221. |
2005-05-02 |
2023-08-12 |
rat |
| Zixiu Xiang, Lie Wang, Stephen T Kita. Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. Journal of neurophysiology. vol 93. issue 3. 2005-05-02. PMID:15738272. |
our data indicate that 5-ht has significant ability to modulate membrane excitability in stn neurons; modulation is accomplished by decreasing potassium conductance by activating 5-ht4 and 5-ht2c receptors. |
2005-05-02 |
2023-08-12 |
rat |
| Seema Saksena, Ravinder K Gill, Sangeeta Tyagi, Waddah A Alrefai, Zaheer Sarwar, Krishnamurthy Ramaswamy, Pradeep K Dudej. Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15637072. |
our results demonstrate that serotonin inhibits cl(-)/oh- exchange activity in caco-2 cells via both tyrosine kinase and ca(2+)-independent protein kinase c delta-mediated pathways involving either 5-ht3 or 5-ht4 receptor subtype. |
2005-04-21 |
2023-08-12 |
human |