| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guillaume Lucas, Guy Debonne. 5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphé nucleus 5-HT neuronal activity. The European journal of neuroscience. vol 16. issue 5. 2002-12-09. PMID:12372017. |
in a separate set of experiments, the selective 5-ht4 agonist, prucalopride (500 micro g/kg, i.v), increased the firing activity (+35%) of 5-ht neurons displaying a high basal firing rate; subsequent injection of gr 125487 (500 micro g/kg, i.v.) |
2002-12-09 |
2023-08-12 |
rat |
| Guillaume Lucas, Guy Debonne. 5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphé nucleus 5-HT neuronal activity. The European journal of neuroscience. vol 16. issue 5. 2002-12-09. PMID:12372017. |
these results indicate that 5-ht4 receptors exert both a tonic and a phasic, positive, frequency-related control on drn 5-ht neuronal activity. |
2002-12-09 |
2023-08-12 |
rat |
| D Cavill, S Waterman, T P Gordo. Failure to detect antibodies to the second extracellular loop of the serotonin 5-HT4 receptor in systemic lupus erythematosus and primary Sjögren's syndrome. Lupus. vol 11. issue 3. 2002-11-27. PMID:11999887. |
failure to detect antibodies to the second extracellular loop of the serotonin 5-ht4 receptor in systemic lupus erythematosus and primary sjögren's syndrome. |
2002-11-27 |
2023-08-12 |
Not clear |
| B R Tuladhar, B Costall, R J Naylo. Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine. British journal of pharmacology. vol 136. issue 1. 2002-08-15. PMID:11976280. |
modulation of 5-ht4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine. |
2002-08-15 |
2023-08-12 |
rat |
| B R Tuladhar, B Costall, R J Naylo. Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine. British journal of pharmacology. vol 136. issue 1. 2002-08-15. PMID:11976280. |
the effect of the selective serotonin reuptake inhibitor fluoxetine was examined on the 5-ht4 receptor-mediated relaxation in the rat isolated ileum. |
2002-08-15 |
2023-08-12 |
rat |
| B R Tuladhar, B Costall, R J Naylo. Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine. British journal of pharmacology. vol 136. issue 1. 2002-08-15. PMID:11976280. |
fluoxetine (10 microm) also failed to prevent the relaxation due to exogenous 5-ht and the 5-ht4 receptor agonist 5-methoxytryptamine in tissues taken from the rats treated with para-chlorophenylalanine (300 mg kg-1) for 3 and 6 days, which reduced the 5-ht level in the mucosa by 88 and 97.5% respectively. |
2002-08-15 |
2023-08-12 |
rat |
| B R Tuladhar, B Costall, R J Naylo. Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine. British journal of pharmacology. vol 136. issue 1. 2002-08-15. PMID:11976280. |
the contraction of the tissues with gr113808 indicates the presence of an endogenous 5-ht tone at the 5-ht4 receptor in the rat ileum. |
2002-08-15 |
2023-08-12 |
rat |
| D E Bake. Tegaserod for the treatment of constipation-predominant irritable bowel syndrome. Reviews in gastroenterological disorders. vol 1. issue 4. 2002-08-02. PMID:12120185. |
tegaserod, a potent, partial serotonin 4 receptor (5-ht4) agonist, is an effective agent for the treatment of females with constipation-predominant irritable bowel syndrome. |
2002-08-02 |
2023-08-12 |
Not clear |
| Osama Alaradi, Jamie S Barki. Irritable bowel syndrome: update on pathogenesis and management. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 11. issue 1. 2002-07-31. PMID:12116690. |
5-hydroxytryptamine (5-ht; serotonin), a major neurotransmitter in the gastrointestinal tract, and its receptors 5-ht3 and 5-ht4 are involved in the control of gastrointestinal function. |
2002-07-31 |
2023-08-12 |
Not clear |
| H Elliott Albers, Mary Karom, Debra Smit. Serotonin and vasopressin interact in the hypothalamus to control communicative behavior. Neuroreport. vol 13. issue 7. 2002-07-16. PMID:12004193. |
in addition, the finding that 8-oh-dpat, cgs-12066a and sc53116 also inhibited avp-induced flank marking suggests that 5-ht could also inhibit flank marking by acting through 5-ht1a, 5-ht7, 5-ht1b and/or 5-ht4 receptor subtypes. |
2002-07-16 |
2023-08-12 |
Not clear |
| James Fidelholtz, William Smith, James Rawls, Yingqi Shi, Anna Zack, Peter Rüegg, Martin Lefkowit. Safety and tolerability of tegaserod in patients with irritable bowel syndrome and diarrhea symptoms. The American journal of gastroenterology. vol 97. issue 5. 2002-06-07. PMID:12014724. |
tegaserod is a selective serotonin (5-ht4) receptor partial agonist effective in providing relief from abdominal pain, bloating, and constipation in patients with irritable bowel syndrome. |
2002-06-07 |
2023-08-12 |
Not clear |
| M Nemoto, T Endo, M Minami, M Yoshioka, H Ito, H Sait. 5-Hydroxytryptamine (5-HT)-induced depolarization in isolated abdominal vagus nerves in the rat: involvement of 5-HT3 and 5-HT4 receptors. Research communications in molecular pathology and pharmacology. vol 109. issue 3-4. 2002-04-29. PMID:11758651. |
5-hydroxytryptamine (5-ht)-induced depolarization in isolated abdominal vagus nerves in the rat: involvement of 5-ht3 and 5-ht4 receptors. |
2002-04-29 |
2023-08-12 |
rat |
| M Nemoto, T Endo, M Minami, M Yoshioka, H Ito, H Sait. 5-Hydroxytryptamine (5-HT)-induced depolarization in isolated abdominal vagus nerves in the rat: involvement of 5-HT3 and 5-HT4 receptors. Research communications in molecular pathology and pharmacology. vol 109. issue 3-4. 2002-04-29. PMID:11758651. |
in isolated abdominal vagus nerves, selective 5-ht4 antagonist, sb204070, produced parallel and concentration-dependent shifts to the right on the concentration-response curves to 5-ht in vitro. |
2002-04-29 |
2023-08-12 |
rat |
| C Beglinge. Tegaserod: a novel, selective 5-HT4 receptor partial agonist for irritable bowel syndrome. International journal of clinical practice. vol 56. issue 1. 2002-04-02. PMID:11831835. |
tegaserod is a novel selective serotonin receptor type-4 (5-ht4) partial agonist with structural similarity to 5-ht tegaserod stimulates small bowel and colonic motility and helps to normalise gi function. |
2002-04-02 |
2023-08-12 |
Not clear |
| C Ulens, J Tytga. Gi- and Gs-coupled receptors up-regulate the cAMP cascade to modulate HCN2, but not HCN1 pacemaker channels. Pflugers Archiv : European journal of physiology. vol 442. issue 6. 2002-02-21. PMID:11680627. |
in this study, we investigated the modulation of two cloned pacemaker channels, hcn1 and hcn2, by activation of coexpressed inhibitory g protein (gi)-coupled (p-opioid) or stimulatory g protein (gs)-coupled [serotonin 5-ht4(a)] receptors in xenopus oocytes. |
2002-02-21 |
2023-08-12 |
xenopus_laevis |
| M T Vilaró, T Doménech, J M Palacios, G Mengo. Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants. Neuropharmacology. vol 42. issue 1. 2002-02-20. PMID:11750916. |
we have cloned a novel c-terminal splice variant of serotonin 5-ht4 receptors from human hippocampus. |
2002-02-20 |
2023-08-12 |
human |
| M T Vilaró, T Doménech, J M Palacios, G Mengo. Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants. Neuropharmacology. vol 42. issue 1. 2002-02-20. PMID:11750916. |
the 5-ht4 receptor antagonist gr 113808 blocked the effects of 5-ht and brought intracellular camp below basal constitutive levels, indicating inverse agonism of this compound in this system. |
2002-02-20 |
2023-08-12 |
human |
| G E Boeckxstaens, J F W M Bartelsman, L Lauwers, G N J Tytga. Treatment of GI dysmotility in scleroderma with the new enterokinetic agent prucalopride. The American journal of gastroenterology. vol 97. issue 1. 2002-02-07. PMID:11811166. |
recently, a new serotonin (5-ht4) receptor agonist prucalopride was shown to have remarkable prokinetic properties, resulting in symptomatic improvement and increased frequency of defecation in patients with chronic functional constipation. |
2002-02-07 |
2023-08-12 |
Not clear |
| S J Robert, J L Zugaza, R Fischmeister, A M Gardier, F Lezoualc'. The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein. The Journal of biological chemistry. vol 276. issue 48. 2002-01-10. PMID:11584021. |
the human serotonin 5-ht4 receptor regulates secretion of non-amyloidogenic precursor protein. |
2002-01-10 |
2023-08-12 |
human |
| M R Briejer, N H Prins, J A Schuurke. Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 13. issue 5. 2001-12-31. PMID:11696108. |
the novel enterokinetic drug prucalopride was tested at various intravenous and oral doses in fasted dogs to assess: (i) the effects on colonic contractile motility patterns; and (ii) the mediation of these effects by 5-hydroxytryptamine (5-ht4) receptors. |
2001-12-31 |
2023-08-12 |
dog |