| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' F Potet, T Bouyssou, D Escande, I Bar\\xc3\\xb. Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-\\xc3\\xa0-gogo K(+) channel. The Journal of pharmacology and experimental therapeutics. vol 299. issue 3. 2001-12-20. PMID:11714889.' |
agonists of the serotonin 5-hydroxytryptamine 4 (5-ht4) receptor are widely used to activate motility in the gastrointestinal tract. |
2001-12-20 |
2023-08-12 |
human |
| J E Kello. Treatment goals in irritable bowel syndrome. International journal of clinical practice. vol 55. issue 8. 2001-12-07. PMID:11695076. |
a new understanding of the role of serotonin (5-ht) and specific receptors (5-ht3 and 5-ht4) found in the gastrointestinal (gi) tract has led to the development of serotonergic agents which have potential clinical benefits. |
2001-12-07 |
2023-08-12 |
Not clear |
| M Bijak, A Zahorodna, K Tokarsk. Opposite effects of antidepressants and corticosterone on the sensitivity of hippocampal CA1 neurons to 5-HT1A and 5-HT4 receptor activation. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 5. 2001-11-01. PMID:11383709. |
using extracellular and intracellular ex vivo recording techniques we studied changes in the reactivity of hippocampal pyramidal ca1 neurons to serotonin (5-ht) and to the 5-ht1a- and 5-ht4 receptor agonists (+/-)-2-dipropylamino-8-hydroxy- 1,2,3 ,4-tetrahydronaphthalene hydrobromide (8-oh-dpat) and zacopride, respectively, evoked by repeated electroconvulsive shock (ecs), imipramine and corticosterone treatments. |
2001-11-01 |
2023-08-12 |
rat |
| S Kajita, C Ito, R Kawamura, S Yasuda, Y Isobe, K Fukushim. Pharmacological characterization of a novel 5-HT4 receptor agonist, TS-951, in vitro. Pharmacology. vol 63. issue 1. 2001-09-27. PMID:11408827. |
the affinity of ts-951 for the 5-ht4 receptor was higher than those of other agonists, 5-ht, cisapride, mosapride and renzapride. |
2001-09-27 |
2023-08-12 |
mouse |
| A D Medhurst, F Lezoualc'h, R Fischmeister, D N Middlemiss, G J Sange. Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR. Brain research. Molecular brain research. vol 90. issue 2. 2001-09-13. PMID:11406291. |
5-ht4 receptors mediate several physiological effects of 5-ht, particularly in the central nervous system (cns), heart and gut. |
2001-09-13 |
2023-08-12 |
human |
| M D Crowel. The role of serotonin in the pathophysiology of irritable bowel syndrome. The American journal of managed care. vol 7. issue 8 Suppl. 2001-09-13. PMID:11474910. |
recent studies have demonstrated that serotonin, acting primarily through 5-ht3 and 5-ht4 receptors, is intricately involved in initiating the peristaltic reflex and facilitating intraluminal secretions. |
2001-09-13 |
2023-08-12 |
Not clear |
| M D Crowel. The role of serotonin in the pathophysiology of irritable bowel syndrome. The American journal of managed care. vol 7. issue 8 Suppl. 2001-09-13. PMID:11474910. |
serotonin agonists and antagonists such as tegaserod, a 5-ht4 agonist, may offer new treatments that normalize gi motor and sensory functions in patients with disorders of gi function. |
2001-09-13 |
2023-08-12 |
Not clear |
| N J Talle. Drug therapy options for patients with irritable bowel syndrome. The American journal of managed care. vol 7. issue 8 Suppl. 2001-09-13. PMID:11474911. |
acting primarily through 5-ht3 and 5-ht4 receptors, serotonin elicits changes in motor function and possibly visceral sensation. |
2001-09-13 |
2023-08-12 |
Not clear |
| N J Talle. Drug therapy options for patients with irritable bowel syndrome. The American journal of managed care. vol 7. issue 8 Suppl. 2001-09-13. PMID:11474911. |
two serotonin agents were developed specifically for ibs: tegaserod, a 5-ht4 receptor partial agonist, and alosetron, a 5-ht3 receptor antagonist (which is no longer available). |
2001-09-13 |
2023-08-12 |
Not clear |
| F De Ponti, M Tonin. Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. Drugs. vol 61. issue 3. 2001-07-12. PMID:11293643. |
serotonin receptors belonging to the 5-ht3 and 5-ht4 subtype are the most extensively studied in gastroenterology, although hitherto 'orphan' receptor subtypes, such as the 5-ht7 and the 5-ht(1b/d) receptors, are now emerging. |
2001-07-12 |
2023-08-12 |
human |
| T Bach, T Syversveen, A M Kvingedal, K A Krobert, T Brattelid, A J Kaumann, F O Lev. 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218067. |
5-hydroxytryptamine (5-ht) increases human heart rate and atrial contractile force and hastens atrial relaxation through 5-ht4 receptors. |
2001-05-03 |
2023-08-12 |
mouse |
| T Bach, T Syversveen, A M Kvingedal, K A Krobert, T Brattelid, A J Kaumann, F O Lev. 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218067. |
it is not clear which splice variant(s) of the 5-ht4 receptor is expressed and mediates these effects of 5-ht in the human heart. |
2001-05-03 |
2023-08-12 |
mouse |
| T Bach, T Syversveen, A M Kvingedal, K A Krobert, T Brattelid, A J Kaumann, F O Lev. 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218067. |
the similar pharmacological properties of the two human 5-ht4 receptor splice variants together with their expression in human atrium would be consistent with mediation of the cardiostimulant effects of 5-ht through both variants. |
2001-05-03 |
2023-08-12 |
mouse |
| C Stenfors, H Yu, S B Ros. Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218075. |
the 5-ht2a/2c receptor antagonist ketanserin, the 5-ht3 receptor antagonist ondansetron and the 5-ht4 receptor antagonist rs-39604 had no effect on the citalopram-induced decrease in 5-ht synthesis. |
2001-05-03 |
2023-08-12 |
mouse |
| A Lacroix, N Ndiaye, J Tremblay, P Hame. Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Endocrine reviews. vol 22. issue 1. 2001-04-26. PMID:11159817. |
these include ectopic receptors for gastric inhibitory polypeptide (gip), beta-adrenergic agonists, or lh/hcg; a similar outcome can result from altered activity of eutopic receptors, such as those for vasopressin (v1-avpr), serotonin (5-ht4), or possibly leptin. |
2001-04-26 |
2023-08-12 |
Not clear |
| M Suzuki, Y Ohuchi, H Asanuma, T Kaneko, S Yokomori, C Ito, Y Isobe, M Muramats. Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as serotonin 5-HT4 receptor agonists. Chemical & pharmaceutical bulletin. vol 48. issue 12. 2001-04-19. PMID:11145160. |
synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as serotonin 5-ht4 receptor agonists. |
2001-04-19 |
2023-08-12 |
Not clear |
| M Suzuki, Y Ohuchi, H Asanuma, T Kaneko, S Yokomori, C Ito, Y Isobe, M Muramats. Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as serotonin 5-HT4 receptor agonists. Chemical & pharmaceutical bulletin. vol 48. issue 12. 2001-04-19. PMID:11145160. |
a series of n-azabicycloalkyl-1-alkyl-2-oxo-1,2-dihydro-3-quinolinecarboxamides were synthesized and tested for serotonin 5-ht4 receptor-stimulating effects in the regulation of electrically-evoked contraction in guinea pig muscle. |
2001-04-19 |
2023-08-12 |
Not clear |
| M Suzuki, Y Ohuchi, H Asanuma, T Kaneko, S Yokomori, C Ito, Y Isobe, M Muramats. Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as serotonin 5-HT4 receptor agonists. Chemical & pharmaceutical bulletin. vol 48. issue 12. 2001-04-19. PMID:11145160. |
among them, n-azabicycloalkyl-1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxamide (8c, 9c, 10c, 11c, 12c) exhibited potent serotonin 5-ht4 receptor-stimulating activity. |
2001-04-19 |
2023-08-12 |
Not clear |
| K Satoh, T Hayakawa, Y Kase, A Ishige, H Sasaki, S Nishikawa, S Kurosawa, K Yakabi, T Nakamur. Mechanisms for contractile effect of Dai-kenchu-to in isolated guinea pig ileum. Digestive diseases and sciences. vol 46. issue 2. 2001-04-12. PMID:11281170. |
this effect was partially suppressed in the presence of high concentrations of ics 205-930, a serotonin 4 (5-ht4) receptor antagonist. |
2001-04-12 |
2023-08-12 |
Not clear |
| M Suzuki, Y Ohuchi, H Asanuma, T Kaneko, S Yokomori, C Ito, Y Isobe, M Muramats. Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as potent and selective serotonin 5-HT4 receptor agonists. Chemical & pharmaceutical bulletin. vol 49. issue 1. 2001-03-29. PMID:11201221. |
synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as potent and selective serotonin 5-ht4 receptor agonists. |
2001-03-29 |
2023-08-12 |
Not clear |