| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Yamamoto, A Kuwahara, M Fujimura, M Kadowaki, M Fujimiy. Involvement of 5-HT3 and 5-HT4 receptors in the motor activity of isolated vascularly perfused rat duodenum. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 11. issue 6. 2000-01-28. PMID:10583853. |
these results suggest that endogenous 5-ht regulates the motor activity of the rat duodenum through 5-ht3 and 5-ht4 receptors, with the former mediating the stimulatory influence and the latter mediating both stimulatory and inhibitory influences. |
2000-01-28 |
2023-08-12 |
rat |
| T Yanagi, A Kitajima, K Anzai, K Kodama, J Mizoguchi, H Fujiwara, H Sakiyama, O Kamoda, C Kame. Synthesis and pharmacological activity of 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-1-ethyl-2-hydroxymethyl-4- pyrrolidinyl]benzamide (TKS159) and its optical isomers. Chemical & pharmaceutical bulletin. vol 47. issue 11. 2000-01-24. PMID:10605060. |
of the benzamide derivatives, four optical isomers, (2s,4s)-1, (2s,4r)-25, (2r,4s)-26 and (2r,4r)-27, showed a relatively potent affinity for 5-hydroxytryptamine 4 (5-ht4) receptors in a radioligand binding assay ([3h]gr113808). |
2000-01-24 |
2023-08-12 |
rat |
| M J Farthin. Irritable bowel syndrome: new pharmaceutical approaches to treatment. Bailliere's best practice & research. Clinical gastroenterology. vol 13. issue 3. 1999-12-29. PMID:10580922. |
identification and characterization of 5-hydroxytryptamine (5-ht) receptors in the gastrointestinal tract particularly 5-ht3 and 5-ht4 receptors, which are involved not only in modulating gut motility but in visceral sensory pathways, has led to a number of studies of 5-ht3 (alosetron, granisetron and ondansetron) and 5-ht4 (sb-207266a) antagonists. |
1999-12-29 |
2023-08-12 |
Not clear |
| N H Prins, M R Briejer, P J Van Bergen, L M Akkermans, J A Schuurke. Evidence for 5-HT7 receptors mediating relaxation of human colonic circular smooth muscle. British journal of pharmacology. vol 128. issue 4. 1999-12-14. PMID:10556917. |
however, after 5-ht4 receptor blockade (sb 204070 10 nm), 5-ht still induced a relaxation (pec50 6.3). |
1999-12-14 |
2023-08-12 |
human |
| N H Prins, M R Briejer, P J Van Bergen, L M Akkermans, J A Schuurke. Evidence for 5-HT7 receptors mediating relaxation of human colonic circular smooth muscle. British journal of pharmacology. vol 128. issue 4. 1999-12-14. PMID:10556917. |
5-ht4 receptors were sufficiently blocked, as the curves to 5-ht obtained in the presence of 10 and 100 nm sb 204070 were indistinguishable. |
1999-12-14 |
2023-08-12 |
human |
| L J Dupont, J L Pype, M G Demedts, P De Leyn, G Deneffe, G M Verlede. The effects of 5-HT on cholinergic contraction in human airways in vitro. The European respiratory journal. vol 14. issue 3. 1999-12-02. PMID:10543288. |
tropisetron (1 microm), a 5-ht3 and 5-ht4 antagonist, completely blocked the facilitatory effect of 5-ht (100 microm), whereas both ondansetron (1 microm) and gr 125478d (1 microm), a selective 5-ht3 and 5-ht4 antagonist, respectively, also attenuated the 5-ht-induced enhancement of cholinergic contraction. |
1999-12-02 |
2023-08-12 |
human |
| L J Dupont, J L Pype, M G Demedts, P De Leyn, G Deneffe, G M Verlede. The effects of 5-HT on cholinergic contraction in human airways in vitro. The European respiratory journal. vol 14. issue 3. 1999-12-02. PMID:10543288. |
this facilitatory effect of 5-ht was partially mimicked by both selective 5-ht3 (2-methyl-5-ht) and 5-ht4 (rs 67333 and 5-methoxytryptamine) agonists. |
1999-12-02 |
2023-08-12 |
human |
| L J Dupont, J L Pype, M G Demedts, P De Leyn, G Deneffe, G M Verlede. The effects of 5-HT on cholinergic contraction in human airways in vitro. The European respiratory journal. vol 14. issue 3. 1999-12-02. PMID:10543288. |
these findings suggest that 5-ht facilitates cholinergic contraction in human airways in vitro through stimulation of both prejunctional 5-ht3 and 5-ht4 receptors. |
1999-12-02 |
2023-08-12 |
human |
| A Sparatore, M Goegan, A Cagnotto, F Sparator. 2-[4-[3-(4-aryl/heteroaryl-1-piperazinyl)propoxy]phenyl]-2H- benzotriazoles and their N-oxides as ligands for serotonin and dopamine receptors. Farmaco (Societa chimica italiana : 1989). vol 54. issue 6. 1999-11-10. PMID:10443019. |
the synthesized compounds were able to bind on some serotonin (5-ht1a, 5-ht2a) and dopamine (d2, d3) receptors, while displaying poor or no affinity for 5-ht1b, 5-ht2c, 5-ht3, and 5-ht4 subtypes. |
1999-11-10 |
2023-08-12 |
mouse |
| A Fortuño, S Ballaz, J Del Río, A Barbe. CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum. Journal of physiology and biochemistry. vol 55. issue 2. 1999-11-02. PMID:10517265. |
the cck receptor antagonists blocked, in a dose-dependent manner, the response to 5-ht and to the selective agonists at 5-ht3 and 5-ht4 receptors, 2-methyl-5-hydroxytryptamine (2-me-5-ht) and 5-methoxytryptamine (5-meot), respectively. |
1999-11-02 |
2023-08-12 |
Not clear |
| J M Kellum, F C Albuquerque, M C Stoner, R P Harri. Stroking human jejunal mucosa induces 5-HT release and Cl- secretion via afferent neurons and 5-HT4 receptors. The American journal of physiology. vol 277. issue 3. 1999-10-28. PMID:10484375. |
stroking human jejunal mucosa induces 5-ht release and cl- secretion via afferent neurons and 5-ht4 receptors. |
1999-10-28 |
2023-08-12 |
human |
| J M Kellum, F C Albuquerque, M C Stoner, R P Harri. Stroking human jejunal mucosa induces 5-HT release and Cl- secretion via afferent neurons and 5-HT4 receptors. The American journal of physiology. vol 277. issue 3. 1999-10-28. PMID:10484375. |
these results suggest that mucosal stroking induces release of mucosal 5-ht, which activates a 5-ht4 receptor on enteric sensory neurons, evoking a neuronal reflex that stimulates chloride secretion. |
1999-10-28 |
2023-08-12 |
human |
| A Lucchelli, M G Santagostino-Barbone, E Masoero, P Baiardi, M Tonin. Influence of fluoxetine and litoxetine on 5-HT4 receptor-mediated relaxation in the rat isolated oesophagus. Fundamental & clinical pharmacology. vol 13. issue 3. 1999-10-22. PMID:10392309. |
the influence of two selective serotonin reuptake inhibitors (ssris), litoxetine and fluoxetine, has been studied on 5-ht4 receptor-mediated relaxation in the rat isolated oesophageal muscularis mucosae. |
1999-10-22 |
2023-08-12 |
rat |
| A Lucchelli, M G Santagostino-Barbone, E Masoero, P Baiardi, M Tonin. Influence of fluoxetine and litoxetine on 5-HT4 receptor-mediated relaxation in the rat isolated oesophagus. Fundamental & clinical pharmacology. vol 13. issue 3. 1999-10-22. PMID:10392309. |
in conclusion, litoxetine up to 1 microm relaxed the rat isolated oesophageal muscularis mucosae through a mechanism involving release of endogenous 5-ht, which in turn activates 5-ht4 receptors. |
1999-10-22 |
2023-08-12 |
rat |
| F A Javid, R J Naylo. Characterization of the 5-hydroxytryptamine receptors mediating contraction in the intestine of Suncus murinus. British journal of pharmacology. vol 127. issue 8. 1999-10-21. PMID:10482918. |
the selective 5-ht4 receptor antagonist sb204070 (1 nm), failed to modify 5-ht induced contractions in any segment examined. |
1999-10-21 |
2023-08-12 |
Not clear |
| E S Hayes, P G Adaikan, S S Ratnam, S C N. 5-HT4 receptors in isolated human corpus cavernosum? International journal of impotence research. vol 11. issue 4. 1999-10-20. PMID:10467522. |
the novel serotonin subtype-4 (5-ht4) receptor agonist, sc53116 (sc), produced a limited relaxation of noradrenaline (na) pre-contracted human corpus cavernosum (cc) smooth muscle in vitro. |
1999-10-20 |
2023-08-12 |
human |
| N H Prins, J F Van Haselen, R A Lefebvre, M R Briejer, L M Akkermans, J A Schuurke. Pharmacological characterization of 5-HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle. British journal of pharmacology. vol 127. issue 6. 1999-10-18. PMID:10455293. |
5-ht, the selective 5-ht4 receptor agonists r076186, prucalopride (r093877) and sdz htf-919 and the 5-ht4 receptor agonists cisapride and 5-meot relaxed the muscle strips with a rank order of potency r076186 = 5-ht > cisapride > prucalopride > or = sdz htf-919 > 5-meot. |
1999-10-18 |
2023-08-12 |
Not clear |
| N H Prins, J F Van Haselen, R A Lefebvre, M R Briejer, L M Akkermans, J A Schuurke. Pharmacological characterization of 5-HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle. British journal of pharmacology. vol 127. issue 6. 1999-10-18. PMID:10455293. |
the selective 5-ht4 receptor antagonists gr 125487, rs 39604 and gr 113808 competitively antagonized the relaxations to 5-ht, yielding pk(b) estimates of 9.7, 7.9 and 9.1, respectively. |
1999-10-18 |
2023-08-12 |
Not clear |
| N H Prins, J F Van Haselen, R A Lefebvre, M R Briejer, L M Akkermans, J A Schuurke. Pharmacological characterization of 5-HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle. British journal of pharmacology. vol 127. issue 6. 1999-10-18. PMID:10455293. |
the selective 5-ht4 receptor antagonist sb 204070 shifted the curve to 5-ht rightward and depressed the maximal response (apparent pa2 10.6). |
1999-10-18 |
2023-08-12 |
Not clear |
| N H Prins, J F Van Haselen, R A Lefebvre, M R Briejer, L M Akkermans, J A Schuurke. Pharmacological characterization of 5-HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle. British journal of pharmacology. vol 127. issue 6. 1999-10-18. PMID:10455293. |
it is concluded that 5-ht induces relaxation of the canine rectum circular muscle through stimulation of a single population of smooth muscle 5-ht4 receptors. |
1999-10-18 |
2023-08-12 |
Not clear |