| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F C Albuquerque, E H Smith, J M Kellu. 5-HT induces cAMP production in crypt colonocytes at a 5-HT4 receptor. The Journal of surgical research. vol 77. issue 2. 1998-09-24. PMID:9733600. |
since this receptor is known to be positively coupled to adenylate cyclase, we postulated that 5-ht should induce generation of camp, which should be inhibited by 5-ht4 antagonists. |
1998-09-24 |
2023-08-12 |
rat |
| F C Albuquerque, E H Smith, J M Kellu. 5-HT induces cAMP production in crypt colonocytes at a 5-HT4 receptor. The Journal of surgical research. vol 77. issue 2. 1998-09-24. PMID:9733600. |
in another series of experiments, 5-ht (0.3 microm) stimulation of camp was similarly measured in the presence and absence of 5-ht receptor antagonists: 10 microm 5-htp-dp (5-ht1p; n = 4), 0.1 microm ketanserin (5-ht2a; n = 4), 0.3 microm ondansetron (5-ht3; n = 4), 3 microm tropisetron (5-ht3 and 5-ht4; n = 4), and 10 nm gr-113808 (5-ht4; n = 5). |
1998-09-24 |
2023-08-12 |
rat |
| F C Albuquerque, E H Smith, J M Kellu. 5-HT induces cAMP production in crypt colonocytes at a 5-HT4 receptor. The Journal of surgical research. vol 77. issue 2. 1998-09-24. PMID:9733600. |
5-ht acts at a 5-ht4 receptor to induce production of camp in rat distal crypt colonocytes. |
1998-09-24 |
2023-08-12 |
rat |
| J Hardcastle, P T Hardcastl. 5-Hydroxytryptamine-induced secretion by rat jejunum in-vitro involves several 5-hydroxytryptamine receptor subtypes. The Journal of pharmacy and pharmacology. vol 50. issue 5. 1998-09-21. PMID:9643448. |
tropisetron, a 5-ht3 and 5-ht4 antagonist, inhibited the response to 5-methoxytryptamine in both preparations, but did not alter the response to 5-ht. |
1998-09-21 |
2023-08-12 |
rat |
| T Suzuki, N Imanishi, H Itahana, S Watanuki, K Miyata, M Ohta, H Nakahara, Y Yamagiwa, T Mas. Novel 5-hydroxytryptamine 4 (5-HT4) receptor agonists. Synthesis and gastroprokinetic activity of 4-amino-N-[2-(1-aminocycloalkan-1-yl)ethyl]-5-chloro-2-methoxybenzamide s. Chemical & pharmaceutical bulletin. vol 46. issue 7. 1998-09-09. PMID:9692218. |
novel 5-hydroxytryptamine 4 (5-ht4) receptor agonists. |
1998-09-09 |
2023-08-12 |
Not clear |
| T Suzuki, N Imanishi, H Itahana, S Watanuki, K Miyata, M Ohta, H Nakahara, Y Yamagiwa, T Mas. Novel 5-hydroxytryptamine 4 (5-HT4) receptor agonists. Synthesis and gastroprokinetic activity of 4-amino-N-[2-(1-aminocycloalkan-1-yl)ethyl]-5-chloro-2-methoxybenzamide s. Chemical & pharmaceutical bulletin. vol 46. issue 7. 1998-09-09. PMID:9692218. |
derivatives (1), which had amines conformationally restricted due to the effect of repulsion by neighboring substituents, were prepared and evaluated for 5-hydroxytryptamine 4 (5-ht4) agonistic activities by using the contraction of longitudinal muscle myenteric plexus (lmmp) of guinea pig ileum. |
1998-09-09 |
2023-08-12 |
Not clear |
| E J Pappert, C G Goetz, G T Stebbins, M Belden, P M Carve. 5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes. European journal of pharmacology. vol 347. issue 1. 1998-09-01. PMID:9650847. |
guinea pigs were pre-treated with carbidopa (50 mg) followed by one of eight 5-ht antagonists: (-)-n-tert-butyl-3-[4-(2-methoxyphenyl) piperazin-1-yl]-2-phenyl propionamide ((-)-way 100135) (5-ht1a), n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-n-(2-pyridyl)-cy clohexancarboxamide (way 100635) (5-ht1a), methiothepin mesylate (5-ht1/2), mesulergine hydrochloride (5-ht2a/2c), n[4-methoxy-3-(4-methyl-l-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2 ,4-oxadizol-3-yl) (gr 127935) (5-ht1d), trans-4-[(3z)3-(2-dimethylaminoethyl)oxyimino-3(2-fluorop hen yl) propen-1-yl]phenol, hemifumarate (sr 46349) (5-ht2), ondansetron hydrochloride (5-ht3), and [1-[2-[methylsulphonyl)amino]ethyl]-4-piperidinyl]methyl-5-fluoro-2-meth oxy-1h-indole-3-carboxylate (gr 125487) (5-ht4). |
1998-09-01 |
2023-08-12 |
Not clear |
| T Yoshikawa, N Yoshida, Y Mine, K Hosok. Affinity of mosapride citrate, a new gastroprokinetic agent, for 5-HT4 receptors in guinea pig ileum. Japanese journal of pharmacology. vol 77. issue 1. 1998-08-24. PMID:9639060. |
the 5-ht4 agonists examined displayed the following inhibition potency order: bimu-8 > cisapride > mosapride > renzapride > 5-ht > zacopride > metoclopramide. |
1998-08-24 |
2023-08-12 |
Not clear |
| T Kakigami, T Usui, T Ikami, K Tsukamoto, Y Miwa, T Taga, T Kataok. Serotonin 5-HT4 receptor agonistic activity of the optical isomers of (+/-)-4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-5-chloro-2,3- dihydro-2-methylbenzo[b]furan-7-carboxamide. Chemical & pharmaceutical bulletin. vol 46. issue 6. 1998-08-05. PMID:9658578. |
serotonin 5-ht4 receptor agonistic activity of the optical isomers of (+/-)-4-amino-n-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-5-chloro-2,3- dihydro-2-methylbenzo[b]furan-7-carboxamide. |
1998-08-05 |
2023-08-12 |
Not clear |
| T Kakigami, T Usui, T Ikami, K Tsukamoto, Y Miwa, T Taga, T Kataok. Serotonin 5-HT4 receptor agonistic activity of the optical isomers of (+/-)-4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-5-chloro-2,3- dihydro-2-methylbenzo[b]furan-7-carboxamide. Chemical & pharmaceutical bulletin. vol 46. issue 6. 1998-08-05. PMID:9658578. |
the serotonin 5-ht4 receptor agonistic activity of (s)-(-)-1 hemifumarate (sk-951) which was hemifumarate of (s)-(+)-1 was about twice that of the other enantiomer (r)-(+)-1 hemifumarate which was hemifumarate of (r)-(-)-1. |
1998-08-05 |
2023-08-12 |
Not clear |
| A M Pugliese, M B Passani, R Corradett. Effect of the selective 5-HT1A receptor antagonist WAY 100635 on the inhibition of e.p.s.ps produced by 5-HT in the CA1 region of rat hippocampal slices. British journal of pharmacology. vol 124. issue 1. 1998-08-04. PMID:9630348. |
in the presence of way 100635, 5-ht elicited a depolarization which was blocked by 10-30 microm rs 23597-190, a selective 5-ht4 receptor antagonist. |
1998-08-04 |
2023-08-12 |
rat |
| A M Pugliese, M B Passani, R Corradett. Effect of the selective 5-HT1A receptor antagonist WAY 100635 on the inhibition of e.p.s.ps produced by 5-HT in the CA1 region of rat hippocampal slices. British journal of pharmacology. vol 124. issue 1. 1998-08-04. PMID:9630348. |
our data demonstrate that way 100635 is devoid of direct effects on ca1 pyramidal cell excitability and on evoked e.p.s.ps, while it fully antagonizes the effects of 5-ht on excitatory synaptic transmission and on hyperpolarization, without affecting the 5-ht4 receptor-mediated response. |
1998-08-04 |
2023-08-12 |
rat |
| S M Dyer, I S de la Lande, D B Frewin, R J Hea. 5-Hydroxytryptamine-induced contraction of the marmoset aorta is mediated by a 5-HT1-like receptor. Clinical and experimental pharmacology & physiology. vol 25. issue 3-4. 1998-06-15. PMID:9590577. |
the effects of agonists and antagonists comprised: (i) agonist potencies in the order 5-carboxamidotryptamine > 5-ht > sumatriptan > 8-hydroxy-2-(di-n-propylamino)tetralin; (ii) inhibition of contractile action of 5-ht by the 5-ht1d antagonist gr 127935; (iii) a contractile response to methysergide; (iv) a lack of effect of tropisetron, an antagonist of 5-ht3 and 5-ht4 receptors; and (v) inhibition of forskolin-stimulated camp formation by 5-ht (in the presence of ly 53857), indicative of negative coupling to adenylate cyclase. |
1998-06-15 |
2023-08-12 |
marmoset |
| O Blondel, M Gastineau, Y Dahmoune, M Langlois, R Fischmeiste. Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. Journal of neurochemistry. vol 70. issue 6. 1998-06-05. PMID:9603189. |
the four splice variants transiently expressed in cos-7 cells displayed an identical 5-ht4 pharmacological profile and showed a similar ability to stimulate adenylyl cyclase activity in the presence of 5-ht. |
1998-06-05 |
2023-08-12 |
human |
| S Läer, F Remmers, H Scholz, B Stein, F U Müller, J Neuman. Receptor mechanisms involved in the 5-HT-induced inotropic action in the rat isolated atrium. British journal of pharmacology. vol 123. issue 6. 1998-05-28. PMID:9559903. |
the selective 5-ht4 receptor antagonists gr 125487 (10 nm and 1 microm) and sb 203186 (1 microm) did not attenuate the positive inotropic effect of 5-ht in rat left atria. |
1998-05-28 |
2023-08-12 |
rat |
| S Läer, F Remmers, H Scholz, B Stein, F U Müller, J Neuman. Receptor mechanisms involved in the 5-HT-induced inotropic action in the rat isolated atrium. British journal of pharmacology. vol 123. issue 6. 1998-05-28. PMID:9559903. |
it is suggested that the positive inotropic effect of 5-ht in electrically driven rat left atria is mediated by ketanserin-sensitive 5-ht2a receptors and not through 5-ht4 receptors. |
1998-05-28 |
2023-08-12 |
rat |
| R Schreiber, C Melon, J De Vr. The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test. Psychopharmacology. vol 135. issue 4. 1998-05-21. PMID:9539263. |
we evaluated whether the anxiolytic effects of selective serotonin reuptake inhibitors (ssris) in the rat ultrasonic vocalization (usv) test are preferentially mediated by (indirect) activation of 5-ht1a, 5-ht1b/1d, 5-ht2a, 5-ht3 or 5-ht4 receptors. |
1998-05-21 |
2023-08-12 |
rat |
| T Kakigami, T Usui, K Tsukamoto, T Kataok. Synthesis and structure-activity relationship of 3-Substituted benzamide, benzo [b]furan-7-carboxamide, 2,3-dihydrobenzo[b]furan-77-carboxamide, and indole-5-carboxamide derivatives as selective serotonin 5-HT4 receptor agonists. Chemical & pharmaceutical bulletin. vol 46. issue 1. 1998-05-13. PMID:9468636. |
synthesis and structure-activity relationship of 3-substituted benzamide, benzo [b]furan-7-carboxamide, 2,3-dihydrobenzo[b]furan-77-carboxamide, and indole-5-carboxamide derivatives as selective serotonin 5-ht4 receptor agonists. |
1998-05-13 |
2023-08-12 |
Not clear |
| T Kakigami, T Usui, K Tsukamoto, T Kataok. Synthesis and structure-activity relationship of 3-Substituted benzamide, benzo [b]furan-7-carboxamide, 2,3-dihydrobenzo[b]furan-77-carboxamide, and indole-5-carboxamide derivatives as selective serotonin 5-HT4 receptor agonists. Chemical & pharmaceutical bulletin. vol 46. issue 1. 1998-05-13. PMID:9468636. |
the title compounds (6-9) were prepared and evaluated for serotonin 5-ht4 agonistic activity in in vitro tests. |
1998-05-13 |
2023-08-12 |
Not clear |
| P G McLean, I M Coupa. Investigation into the effect of 5-hydroxytryptamine on fluid transport in the rat small intestine. General pharmacology. vol 30. issue 2. 1998-04-14. PMID:9502178. |
therefore, it was decided to investigate the effect of 5-ht and selective 5-ht4 receptor agonists (sc 53116 and dau 6236) on intestinal fluid transport in rat jejunum and ileum. |
1998-04-14 |
2023-08-12 |
rat |