| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P G McLean, I M Coupa. Investigation into the effect of 5-hydroxytryptamine on fluid transport in the rat small intestine. General pharmacology. vol 30. issue 2. 1998-04-14. PMID:9502178. |
the study also investigated the effect of a selective 5-ht4 receptor antagonist (gr 113808) against the intraluminally administered 5-ht. |
1998-04-14 |
2023-08-12 |
rat |
| D Sarsero, P Molenaar, A J Kauman. Validity of (-)-[3H]-CGP 12177A as a radioligand for the 'putative beta4-adrenoceptor' in rat atrium. British journal of pharmacology. vol 123. issue 3. 1998-04-13. PMID:9504376. |
histamine (1mm), atropine (1 microm), phentolamine (10 microm), 5-ht (100 microm) and the 5-ht4 receptor antagonist sb 207710 ((1-butyl-4-piperidinyl)-methyl 8-amino-7-iodo-1,4-benzodioxan-5-carboxylate, 10nm) caused less than 26% inhibition of binding. |
1998-04-13 |
2023-08-12 |
rat |
| N Amemiya, S Hatta, H Ohshik. Effects of ondansetron on electrically evoked contraction in rat stomach fundus: possible involvement of 5-HT2B receptors. European journal of pharmacology. vol 339. issue 2-3. 1998-03-26. PMID:9473133. |
this study examined the effects of ondansetron, an antagonist of the 5-hydroxytryptamine (5-ht3) receptor without 5-ht4 receptor agonistic activity. |
1998-03-26 |
2023-08-12 |
rat |
| T Yamaguchi, M Suzuki, M Yamamot. Facilitation of acetylcholine release in rat frontal cortex by indeloxazine hydrochloride: involvement of endogenous serotonin and 5-HT4 receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 6. 1998-03-16. PMID:9453456. |
facilitation of acetylcholine release in rat frontal cortex by indeloxazine hydrochloride: involvement of endogenous serotonin and 5-ht4 receptors. |
1998-03-16 |
2023-08-12 |
rat |
| T Yamaguchi, M Suzuki, M Yamamot. Facilitation of acetylcholine release in rat frontal cortex by indeloxazine hydrochloride: involvement of endogenous serotonin and 5-HT4 receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 6. 1998-03-16. PMID:9453456. |
these results suggest that indeloxazine-induced facilitation of ach release in rat frontal cortex is mediated by endogenous 5-ht and involves at least in part cortical 5-ht4 receptors. |
1998-03-16 |
2023-08-12 |
rat |
| N Chairungsrilerd, K I Furukawa, T Ohta, S Nozoe, Y Ohizum. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 1. 1998-03-11. PMID:9459569. |
5-ht amplified, adp-induced aggregation of rabbit platelets (5-ht2a) was inhibited by gamma-mangostin (ic50 = 0.29 microm), whereas that induced by thrombin was not affected, nor did gamma-mangostin affect 5-ht-induced contraction of the guinea-pig ileum (5-ht3)in the presence of 5-ht1, 5-ht2 and 5-ht4 receptor antagonists. |
1998-03-11 |
2023-08-12 |
rat |
| A Cagnotto, D Crespi, L Mancini, C Manzoni, M L Presti, M Gariboldi, A Vezzani, T Mennin. Lasting increase in serotonin 5-HT1A but not 5-HT4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects. Journal of neurochemistry. vol 70. issue 2. 1998-02-24. PMID:9453582. |
lasting increase in serotonin 5-ht1a but not 5-ht4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects. |
1998-02-24 |
2023-08-12 |
rat |
| A Cagnotto, D Crespi, L Mancini, C Manzoni, M L Presti, M Gariboldi, A Vezzani, T Mennin. Lasting increase in serotonin 5-HT1A but not 5-HT4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects. Journal of neurochemistry. vol 70. issue 2. 1998-02-24. PMID:9453582. |
we examined the effect of kindling on serotonergic neurotransmission in the hippocampus by measuring serotonin (5-ht) release and uptake in hippocampal synaptosomes and 5-ht1a and 5-ht4 receptor subtypes during and at different times after electrical kindling of the dentate gyrus. |
1998-02-24 |
2023-08-12 |
rat |
| B Costall, R J Naylo. The influence of 5-HT2 and 5-HT4 receptor antagonists to modify drug induced disinhibitory effects in the mouse light/dark test. British journal of pharmacology. vol 122. issue 6. 1998-02-23. PMID:9401775. |
it was concluded that in bkw mice (a) the failure of 5-ht2 and 5-ht4 receptor antagonists when administered alone to modify behaviour in the light/dark test indicates an absence of an endogenous 5-ht tone at the 5-ht2 and 5-ht4 receptors and (b) the enhancement by the 5-ht2 receptor antagonists and attenuation by the 5-ht4 receptor antagonists of drug-induced disinhibition indicates a plurality of 5-ht receptor involvement in the mediation of drug-induced disinhibitory profiles in the mouse. |
1998-02-23 |
2023-08-12 |
mouse |
| B R Tuladhar, M Kaisar, R J Naylo. Evidence for a 5-HT3 receptor involvement in the facilitation of peristalsis on mucosal application of 5-HT in the guinea pig isolated ileum. British journal of pharmacology. vol 122. issue 6. 1998-02-23. PMID:9401783. |
the concentration-response curve to mucosally applied 5-ht was not altered by the mucosally applied 5-ht1/2 receptor antagonist methiothepine (0.1 microm), the 5-ht2 receptor antagonist ritanserin (0.1 microm) or the 5-ht4 receptor antagonist sb 204070 (0.1 microm). |
1998-02-23 |
2023-08-12 |
Not clear |
| T Yamaguchi, M Suzuki, M Yamamot. Evidence for 5-HT4 receptor involvement in the enhancement of acetylcholine release by p-chloroamphetamine in rat frontal cortex. Brain research. vol 772. issue 1-2. 1998-02-19. PMID:9406960. |
these results suggest that pca-induced enhancement of 5-ht transmission facilitates ach release from rat frontal cortex at least in part through 5-ht4 receptors. |
1998-02-19 |
2023-08-12 |
rat |
| J Hardcastle, P T Hardcastl. Several receptor subtypes contribute to 5-hydroxytryptamine-induced secretion by rat ileum in-vitro. The Journal of pharmacy and pharmacology. vol 49. issue 11. 1998-02-17. PMID:9401948. |
tropisetron, a 5-ht3 and 5-ht4 antagonist, inhibited the response to 5-methoxytryptamine, but had less effect on the response to 5-ht. |
1998-02-17 |
2023-08-12 |
rat |
| M Yamano, T Kamato, K Miyat. Participation of a cholinergic mechanism in 5-hydroxytryptamine (5-HT)3 and 5-HT4 receptor-mediated stimulation of gastric emptying in rats. Arzneimittel-Forschung. vol 47. issue 11. 1998-02-11. PMID:9428982. |
participation of a cholinergic mechanism in 5-hydroxytryptamine (5-ht)3 and 5-ht4 receptor-mediated stimulation of gastric emptying in rats. |
1998-02-11 |
2023-08-12 |
rat |
| M Yamano, T Kamato, K Miyat. Participation of a cholinergic mechanism in 5-hydroxytryptamine (5-HT)3 and 5-HT4 receptor-mediated stimulation of gastric emptying in rats. Arzneimittel-Forschung. vol 47. issue 11. 1998-02-11. PMID:9428982. |
the participation of a cholinergic mechanism in 5-hydroxytryptamine (5-ht)3 and 5-ht4 receptor-mediated stimulation of gastric emptying in rats was investigated. |
1998-02-11 |
2023-08-12 |
rat |
| J Cortijo, M Martí-Cabrera, E Bernabeu, T Domènech, J Bou, A G Fernández, J Beleta, J M Palacios, E J Morcill. Characterization of 5-HT receptors on human pulmonary artery and vein: functional and binding studies. British journal of pharmacology. vol 122. issue 7. 1998-02-05. PMID:9421295. |
way100635 (1 nm to 1 microm), zacopride (1 nm to 1 microm), or sb204070 (1 nm) did not significantly alter the concentration-response curves for 5-ht, sumatriptan, ergotamine, scmgt or 2-me in human pulmonary artery or vein thus indicating that 5-ht1a, 5-ht3 and 5-ht4 receptors are presumably not involved in the contractile response to these agonists. |
1998-02-05 |
2023-08-12 |
human |
| M R Briejer, C Mathis, J A Schuurke. 5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 9. issue 4. 1998-02-04. PMID:9430791. |
the presence of either a selective 5-ht2b (sb 204741), 5-ht3 (granisetron) or 5-ht4 (sb 204070) antagonist, slightly affected the contractions to 5-ht. |
1998-02-04 |
2023-08-12 |
rat |
| J S Jung, S O Oh, M G Kim, D S Kang, S H Le. Cl- secretion induced by 5-hydroxytryptamine and calcitonin gene-related peptide in rat tracheal epithelia. Pflugers Archiv : European journal of physiology. vol 435. issue 1. 1998-01-29. PMID:9359899. |
these results indicate that in the rat tracheal epithelia 5-ht and cgrp increase cl- secretion by an increase in intracellular camp concentration via direct activation of basolateral receptors, and that the response to 5-ht is not mediated via 5-ht4 receptors. |
1998-01-29 |
2023-08-12 |
rat |
| M B Hansen, E Skadhaug. Signal transduction pathways for serotonin as an intestinal secretagogue. Comparative biochemistry and physiology. Part A, Physiology. vol 118. issue 2. 1998-01-14. PMID:9366057. |
5-ht mediates intestinal secretion through activation of at least the epithelial 5-ht2, and neuronal 5-ht3, and 5-ht4 receptors in the submucosal plexus, including a reflex arc. |
1998-01-14 |
2023-08-12 |
human |
| A Lucchelli, M G Santagostino-Barbone, M Tonin. Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. British journal of pharmacology. vol 121. issue 8. 1998-01-05. PMID:9283717. |
in the presence of 5-ht1/2/3 receptor blockade with methysergide (1 microm) and ondansetron (10 microm), melatonin (0.1 nm-10 microm), 5-ht (1 nm-1 microm) and the 5-ht4 receptor agonist, 5-methoxytryptamine (5-meot: 1 nm-1 microm) caused concentration-dependent contractile responses. |
1998-01-05 |
2023-08-12 |
Not clear |
| I Van den Wyngaert, W Gommeren, P Verhasselt, M Jurzak, J Leysen, W Luyten, E Bende. Cloning and expression of a human serotonin 5-HT4 receptor cDNA. Journal of neurochemistry. vol 69. issue 5. 1997-11-20. PMID:9349523. |
cloning and expression of a human serotonin 5-ht4 receptor cdna. |
1997-11-20 |
2023-08-12 |
human |