Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
M C Buho. Serotonin receptors in cognitive behaviors. Current opinion in neurobiology. vol 7. issue 2. 1997-06-27. PMID:9142756. |
the serotonergic system appears to play a role in behaviors that involve a high cognitive demand and in memory improvement or recovery from impaired cognitive performance, as made evident after administration of serotonin 5-ht2a/5-ht2c or 5-ht4 receptor agonists or 5-ht1a or 5-ht3 receptor antagonists. |
1997-06-27 |
2023-08-12 |
mouse |
K Tokarski, M Bija. Antidepressant-induced adaptive changes in the effects of 5-HT, 5-HT1A and 5-HT4 agonists on the population spike recorded in hippocampal CA1 cells do not involve presynaptic effects on excitatory synaptic transmission. Polish journal of pharmacology. vol 48. issue 6. 1997-06-26. PMID:9112695. |
antidepressant-induced adaptive changes in the effects of 5-ht, 5-ht1a and 5-ht4 agonists on the population spike recorded in hippocampal ca1 cells do not involve presynaptic effects on excitatory synaptic transmission. |
1997-06-26 |
2023-08-12 |
rat |
J Goldhill, M F Porquet, I Ange. Post-synaptic 5-HT4 receptor modulation of tachykinergic excitation of rat oesophageal tunica muscularis mucosae. European journal of pharmacology. vol 323. issue 2-3. 1997-06-16. PMID:9128843. |
substance p- (in the presence of atropine) and carbachol-precontracted tissue was relaxed by tryptamines and the substituted benzamides with the following rank order of potency: 5-ht > 5-methoxytryptamine > cisapride > (r)-zacopride > lintopride > metoclopramide, consistent with 5-ht4 receptor activation. |
1997-06-16 |
2023-08-12 |
rat |
M Bijak, K Tokarski, J Ma. Repeated treatment with antidepressant drugs induces subsensitivity to the excitatory effect of 5-HT4 receptor activation in the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 355. issue 1. 1997-06-09. PMID:9007837. |
because inhibitory 5-ht1a and excitatory 5-ht4 receptors are colocalized on pyramidal neurons, and our previous data demonstrated an increase in the 5-ht1a receptor-mediated inhibition after repeated treatment with antidepressants, we conclude that treatment with antidepressant drugs may enhance the inhibitory effect of 5-ht directly, by increasing the 5-ht1a receptor responsiveness, and indirectly, by inducing subsensitivity to the 5-ht4 receptor activation. |
1997-06-09 |
2023-08-12 |
rat |
A Meneses, E Hon. A pharmacological analysis of serotonergic receptors: effects of their activation of blockade in learning. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 2. 1997-06-05. PMID:9061774. |
the authors have tested several 5-ht selective agonists and antagonists (5-ht1a/1b, 5-ht2a/2b/2c, 5-ht3 or 5-ht4), an uptake inhibitor and 5-ht depletors in the autoshaping learning task. |
1997-06-05 |
2023-08-12 |
Not clear |
A Meneses, E Hon. A pharmacological analysis of serotonergic receptors: effects of their activation of blockade in learning. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 2. 1997-06-05. PMID:9061774. |
the blockade of postsynaptic 5-ht1a, 5-ht1b, 5-ht3 or 5-ht4 receptors and 5-ht inhibition of synthesis and its depletion did no alter learning by themselves. |
1997-06-05 |
2023-08-12 |
Not clear |
V Compan, A Daszuta, P Salin, M Sebben, J Bockaert, A Dumui. Lesion study of the distribution of serotonin 5-HT4 receptors in rat basal ganglia and hippocampus. The European journal of neuroscience. vol 8. issue 12. 1997-05-29. PMID:8996808. |
lesion study of the distribution of serotonin 5-ht4 receptors in rat basal ganglia and hippocampus. |
1997-05-29 |
2023-08-12 |
rat |
V Compan, A Daszuta, P Salin, M Sebben, J Bockaert, A Dumui. Lesion study of the distribution of serotonin 5-HT4 receptors in rat basal ganglia and hippocampus. The European journal of neuroscience. vol 8. issue 12. 1997-05-29. PMID:8996808. |
the regional distribution of 5-hydroxytryptamine (5-ht4) receptors labelled with [3h]gr113808 was examined in rat basal ganglia and hippocampus after specific lesions. |
1997-05-29 |
2023-08-12 |
rat |
V Compan, A Daszuta, P Salin, M Sebben, J Bockaert, A Dumui. Lesion study of the distribution of serotonin 5-HT4 receptors in rat basal ganglia and hippocampus. The European journal of neuroscience. vol 8. issue 12. 1997-05-29. PMID:8996808. |
lesion of serotonin neurons induced by injections of 5,7-dihydroxytryptamine into the dorsal and medial raphe nuclei resulted in increased 5-ht4 receptor binding in most regions examined, compared with controls. |
1997-05-29 |
2023-08-12 |
rat |
N H Prins, M R Briejer, J A Schuurke. Characterization of the contraction to 5-HT in the canine colon longitudinal muscle. British journal of pharmacology. vol 120. issue 4. 1997-05-22. PMID:9051313. |
the selective 5-ht4 receptor antagonist sb 204070 (10 nm) slightly enhanced contractions to 5-ht and therefore it was included in the organ bath solution in all further experiments. |
1997-05-22 |
2023-08-12 |
Not clear |
L M Gaster, F D Kin. Serotonin 5-HT3 and 5-HT4 receptor antagonists. Medicinal research reviews. vol 17. issue 2. 1997-05-21. PMID:9057164. |
serotonin 5-ht3 and 5-ht4 receptor antagonists. |
1997-05-21 |
2023-08-12 |
Not clear |
M J Ramirez, E García-Garayoa, G Romero, A Monge, J Roca, J Del Río, B Lashera. VB20B7, a novel 5-HT-ergic agent with gastrokinetic activity. I. Interaction with 5-HT3 and 5-HT4 receptors. The Journal of pharmacy and pharmacology. vol 49. issue 1. 1997-04-24. PMID:9120772. |
this study describes the in-vitro interaction of the gastrokinetic agent 2[1-(4-piperonyl)piperazinyl]benzothiazole (vb20b7) with the 5-hydroxytryptamine 5-ht3 and 5-ht4 receptor subtypes, using functional as well as radioligand binding studies. |
1997-04-24 |
2023-08-12 |
rat |
M J Ramirez, E García-Garayoa, G Romero, A Monge, J Roca, J Del Río, B Lashera. VB20B7, a novel 5-HT-ergic agent with gastrokinetic activity. I. Interaction with 5-HT3 and 5-HT4 receptors. The Journal of pharmacy and pharmacology. vol 49. issue 1. 1997-04-24. PMID:9120772. |
the new compound lacked any affinity at other 5-ht receptors or at dopaminergic d2 receptors, whereas cisapride showed high affinity for the 5-ht4 receptors from guinea-pig hippocampus and moderate affinity at dopaminergic d2 receptors. |
1997-04-24 |
2023-08-12 |
rat |
S L Lee, W W Wang, B L Fanbur. Association of Tyr phosphorylation of GTPase-activating protein with mitogenic action of serotonin. The American journal of physiology. vol 272. issue 1 Pt 1. 1997-03-28. PMID:9038828. |
in the presence of 3-isobutyl-1-methylxanthine, 5-ht inhibited cellular growth, presumably through its action on 5-ht1a or 5-ht4 receptors and elevation of adenosine 3',5'-cyclic monophosphate, but this was not associated with an alteration of tyr phosphorylation of gap. |
1997-03-28 |
2023-08-12 |
Not clear |
D J Fontana, S E Daniels, R M Eglen, E H Won. Stereoselective effects of (R)- and (S)-zacopride on cognitive performance in a spatial navigation task in rats. Neuropharmacology. vol 35. issue 3. 1997-03-26. PMID:8783207. |
these data demonstrate that the cognition enhancing properties of zacopride in this model of cholinergic hypofunction are exclusive to its (r)-enantiomer and imply that this action is unrelated to 5-ht, receptor antagonism or 5-ht4 receptor agonism. |
1997-03-26 |
2023-08-12 |
rat |
P G McLean, I M Coupar, P Molenaa. Changes in sensitivity of 5-HT receptor mediated functional responses in the rat oesophagus, fundus and jejunum following chronic infusion with 5-hydroxytryptamine. Naunyn-Schmiedeberg's archives of pharmacology. vol 354. issue 4. 1997-03-24. PMID:8897456. |
in the rat oesophagus, chronic treatment produced rightward shifts of the 5-ht4 receptor-mediated concentration-effect curves to 5-ht (dose-ratio = 3.8, day 5 and 2.8, day 10) and sc 53116 (1-s,8-s)-4-amino-5-chloro-n-[(hexahydro-1h-pyrrolizin-1-yl) methyl]-2-methoxy-benzamide hydrochloride, dose-ratio = 7.1, day 5 and 8.9, day 10) as compared to control tissues. |
1997-03-24 |
2023-08-12 |
rat |
P G McLean, I M Coupar, P Molenaa. Changes in sensitivity of 5-HT receptor mediated functional responses in the rat oesophagus, fundus and jejunum following chronic infusion with 5-hydroxytryptamine. Naunyn-Schmiedeberg's archives of pharmacology. vol 354. issue 4. 1997-03-24. PMID:8897456. |
these findings represent the first report that chronic infusion of 5-ht produces a residual desensitisation of the 5-ht4, 5-ht2b, and putative 5-ht7/5-ht3 receptor-mediated responses in rat oesophagus, fundus and jejunum respectively when measured in vitro. |
1997-03-24 |
2023-08-12 |
rat |
G J Sange. 5-Hydroxytryptamine and functional bowel disorders. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 8. issue 4. 1997-03-14. PMID:8959736. |
the strategic locations of 5-ht and its receptors are described, the most dominant being the 5-ht3 and 5-ht4 type. |
1997-03-14 |
2023-08-12 |
Not clear |
G J Sange. 5-Hydroxytryptamine and functional bowel disorders. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 8. issue 4. 1997-03-14. PMID:8959736. |
5-ht, acting at 5-ht4 receptors promotes the sensitivity of enteric neurones that react to luminal stimuli. |
1997-03-14 |
2023-08-12 |
Not clear |
G J Sange. 5-Hydroxytryptamine and functional bowel disorders. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 8. issue 4. 1997-03-14. PMID:8959736. |
5-ht4 and 5-ht3 receptors also mediate, respectively, sensitising and physiological actions of 5-ht on gastro-intestinal motor and secretory functions. |
1997-03-14 |
2023-08-12 |
Not clear |