| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Hoyer, G R Marti. Classification and nomenclature of 5-HT receptors: a comment on current issues. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788515. |
at the time of the serotonin satellite meeting in chicago, the iuphar classification of receptors for 5-ht recognised four distinct receptor classes (5-ht1, 5-ht2, 5-ht3 and 5-ht4), comprising seven fully characterised functional receptor subtypes and four recombinant receptors (5-ht1d alpha, 5-ht1d beta, 5-ht1e and 5-ht1f). |
1996-12-04 |
2023-08-12 |
Not clear |
| L J Steward, J Ge, R L Stowe, D C Brown, R K Bruton, P R Stokes, N M Barne. Ability of 5-HT4 receptor ligands to modulate rat striatal dopamine release in vitro and in vivo. British journal of pharmacology. vol 117. issue 1. 1996-11-22. PMID:8825343. |
the release of dopamine from slices of rat striatum continually perfused with krebs buffer was enhanced by 5-ht4 receptor agonists; 5-ht (10 microm), 5-methoxytryptamine (5-meot; 10 microm), renzapride (10 microm) and (s)-zacopride (10 microm) maximally increased dopamine release by 133 +/- 5, 214 +/- 25, 232 +/- 29 and 264 +/- 69%, respectively (mean +/- s.e.mean, n = 3-8). |
1996-11-22 |
2023-08-12 |
rat |
| S G Parker, E M Taylor, S A Hamburger, M Vimal, A J Kauman. Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186. Naunyn-Schmiedeberg's archives of pharmacology. vol 353. issue 1. 1996-11-06. PMID:8750913. |
we investigated the blockade of the positive inotropic effects of 5-hydroxytryptamine (5-ht) by sb 203 186 (piperidinoethyl-indole-3-carboxylate hydrochloride) and its affinity for 5-ht4 receptors of human right atrium and piglet left atrium. |
1996-11-06 |
2023-08-12 |
human |
| J Ge, N M Barne. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. British journal of pharmacology. vol 117. issue 7. 1996-10-10. PMID:8730742. |
5-ht4 receptor-mediated modulation of 5-ht release in the rat hippocampus in vivo. |
1996-10-10 |
2023-08-12 |
rat |
| J Ge, N M Barne. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. British journal of pharmacology. vol 117. issue 7. 1996-10-10. PMID:8730742. |
in the present study, the ability of the 5-hydroxytryptamine, receptor (5-ht4 receptor) to modulate the release of 5-ht in the hippocampus of freely-moving rats was investigated by the in vivo microdialysis technique. |
1996-10-10 |
2023-08-12 |
rat |
| J Ge, N M Barne. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. British journal of pharmacology. vol 117. issue 7. 1996-10-10. PMID:8730742. |
the 5-ht4 receptor agonist, renzapride (1.0-100 microm, administered via the microdialysis probe) increased extracellular hippocampal levels of 5-ht in concentration-dependent manner (approximately 200% maximal increase). |
1996-10-10 |
2023-08-12 |
rat |
| J Ge, N M Barne. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. British journal of pharmacology. vol 117. issue 7. 1996-10-10. PMID:8730742. |
furthermore, another 5-ht4 receptor agonist 5-methoxytryptamine (5-meot; 10 microm, administered via the microdialysis probe, in the presence of the non-5-ht4 5-ht receptor antagonists pindolol (10 microm) and methysergide (10 microm)) maximally elevated extracellular levels of 5-ht by approximately 450% in the rat hippocampus. |
1996-10-10 |
2023-08-12 |
rat |
| J Ge, N M Barne. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. British journal of pharmacology. vol 117. issue 7. 1996-10-10. PMID:8730742. |
the elevation of extracellular 5-ht levels induced by either renzapride (100 microm) or 5-meot (10 microm) was completely prevented by combined administration of the selective 5-ht4 receptor antagonist, gr113808 (100 nm, administered via the microdialysis probe). |
1996-10-10 |
2023-08-12 |
rat |
| J Ge, N M Barne. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. British journal of pharmacology. vol 117. issue 7. 1996-10-10. PMID:8730742. |
in conclusion, the present study provides evidence that activation of the 5-ht4 receptor facilitates 5-ht release in the rat hippocampus in vivo. |
1996-10-10 |
2023-08-12 |
rat |
| Y Nagakura, T Kamato, A Nishida, H Ito, M Yamano, K Miyat. Characterization of 5-hydroxytryptamine (5-HT) receptor subtypes influencing colonic motility in conscious dogs. Naunyn-Schmiedeberg's archives of pharmacology. vol 353. issue 5. 1996-10-08. PMID:8740141. |
the activation of 5-ht4 receptors and the blockade of endogenous 5-ht inhibitory regulation via 5-ht1 receptors may be involved in the action of renzapride and methysergide respectively. |
1996-10-08 |
2023-08-12 |
Not clear |
| A J Kaumann, J A Lynham, A M Brow. Comparison of the densities of 5-HT4 receptors, beta 1- and beta 2-adrenoceptors in human atrium: functional implications. Naunyn-Schmiedeberg's archives of pharmacology. vol 353. issue 5. 1996-10-08. PMID:8740155. |
we suggest that the small 5-ht4 receptor population may in part explain why the positive inotropic effects of 5-ht are smaller than those of catecholamines mediated through beta 1- and beta 2-adrenoceptors. |
1996-10-08 |
2023-08-12 |
human |
| S Matsuyama, H Sakiyama, K Nei, C Tanak. Identification of putative 5-hydroxytryptamine(4) (5-HT4) receptors in guinea pig stomach: The effect of TKS159, a novel agonist, on gastric motility and acetylcholine release. The Journal of pharmacology and experimental therapeutics. vol 276. issue 3. 1996-09-20. PMID:8786580. |
identification of putative 5-hydroxytryptamine(4) (5-ht4) receptors in guinea pig stomach: the effect of tks159, a novel agonist, on gastric motility and acetylcholine release. |
1996-09-20 |
2023-08-12 |
Not clear |
| S Matsuyama, H Sakiyama, K Nei, C Tanak. Identification of putative 5-hydroxytryptamine(4) (5-HT4) receptors in guinea pig stomach: The effect of TKS159, a novel agonist, on gastric motility and acetylcholine release. The Journal of pharmacology and experimental therapeutics. vol 276. issue 3. 1996-09-20. PMID:8786580. |
we investigated the existence and the function of 5-hydroxytryptamine(4) (5-ht4) receptors and the effect of tks159, a novel agonist of 5-ht4 receptor, on guinea pig stomach. |
1996-09-20 |
2023-08-12 |
Not clear |
| J D Gal. Serotonergic mediation of vomiting. Journal of pediatric gastroenterology and nutrition. vol 21 Suppl 1. 1996-09-12. PMID:8708863. |
the interaction of 5-ht with non-5-ht3 receptors, particularly 5-ht1a and 5-ht4 receptors, may be important in the emetic reflex. |
1996-09-12 |
2023-08-12 |
Not clear |
| K Miyata, M Yamano, T Kamato, S Akuzaw. Effect of serotonin (5-HT)3-receptor antagonists YM060, YM114 (KAE-393), ondansetron and granisetron on 5-HT4 receptors and gastric emptying in rodents. Japanese journal of pharmacology. vol 69. issue 3. 1996-09-05. PMID:8699628. |
effect of serotonin (5-ht)3-receptor antagonists ym060, ym114 (kae-393), ondansetron and granisetron on 5-ht4 receptors and gastric emptying in rodents. |
1996-09-05 |
2023-08-12 |
rat |
| R B Raffa, E E Cod. Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays). Life sciences. vol 59. issue 2. 1996-08-30. PMID:8699917. |
in the present study, we measured the affinity of acetaminophen at 5-ht3, as well as 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2, 5-ht2c, 5-ht4, 5-ht6, 5-ht7 and eleven other receptor sites and at serotonin and norepinephrine reuptake sites. |
1996-08-30 |
2023-08-12 |
Not clear |
| M Ishizaw. Inhibitory action of 5-hydroxytryptamine on propulsive activity of the guinea-pig isolated colon. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. vol 114. issue 1. 1996-08-27. PMID:8689526. |
these results suggest that 5-ht may inhibit spontaneous propulsive activities of the colonic segment via release of endogenous pgs (e.g., e and i types) in the circular muscle cells mediated by an inhibitory neurotransmitter, which release was stimulated by 5-ht1-like 5-ht2 and 5-ht4 receptors on the myenteric neurones in the circular muscle layer. |
1996-08-27 |
2023-08-12 |
Not clear |
| V Contesse, C Hamel, H Lefebvre, A Dumuis, H Vaudry, C Delaru. Activation of 5-hydroxytryptamine4 receptors causes calcium influx in adrenocortical cells: involvement of calcium in 5-hydroxytryptamine-induced steroid secretion. Molecular pharmacology. vol 49. issue 3. 1996-07-17. PMID:8643088. |
5-hydroxytryptamine (5-ht) stimulates corticosteroid secretion from adrenal cells through activation of 5-ht4 receptors positively coupled to adenylyl-cyclase. |
1996-07-17 |
2023-08-12 |
Not clear |
| V Contesse, C Hamel, H Lefebvre, A Dumuis, H Vaudry, C Delaru. Activation of 5-hydroxytryptamine4 receptors causes calcium influx in adrenocortical cells: involvement of calcium in 5-hydroxytryptamine-induced steroid secretion. Molecular pharmacology. vol 49. issue 3. 1996-07-17. PMID:8643088. |
in the present study, we investigated in frog adrenocortical cells the effect of 5-ht4 receptor agonists on cytosolic calcium concentration ([ca2+]i) and determined the sequence of events associated with 5-ht4 receptor agonist zacopride (10[-8] to 10[-5]m each in the vicinity of cultured adrenocortical cells caused a dose-dependent increase in [ca2+]i. preincubation of the cells with the selective 5-ht4 receptor antagonist [1-[2-(methylsulfonylamino)ethyl]-4- piperidinyl]methyl-1-methyl-1h-indole-3-carboxylate maleate totally blocked the 5-ht-induced stimulation of [ca2+]i. chelation of extracellular calcium with ethylene glycol bis (beta-aminoethyl ether)-n,n,n', n'-tetraacetic acid (10 mm) suppressed the stimulatory effect of 5-ht on [ca2+]i. conversely, thapsigargin, an inhibitor of calcium atpase activity, had no effect on the [ca2+]i rise. |
1996-07-17 |
2023-08-12 |
Not clear |
| S Consolo, S Arnaboldi, S Ramponi, L Nannini, H Ladinsky, G Bald. Endogenous serotonin facilitates in vivo acetylcholine release in rat frontal cortex through 5-HT 1B receptors. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627564. |
investigating the 5-ht receptors that might mediate the d-norfenfluramine cholinergic effect, we found that the 5-ht4 (gr 125487) and 5-ht2a/2c (ritanserin) receptor antagonists, at doses effective in other in vivo tests, did not prevent the increase in cortical ach output induced by the maximal effective does of d-norfenfluramine. |
1996-06-27 |
2023-08-12 |
rat |