| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hannah Twarkowski, Hardy Hagena, Denise Manahan-Vaugha. The 5-hydroxytryptamine4 receptor enables differentiation of informational content and encoding in the hippocampus. Hippocampus. vol 26. issue 7. 2018-01-08. PMID:26800645. |
neuromodulators such as serotonin regulate hippocampal function, and the 5-ht4 -receptor contributes to processes underlying cognition. |
2018-01-08 |
2023-08-13 |
rat |
| Mohammad Nasehi, Maryam Farrahizadeh, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindas. Modulation of cannabinoid signaling by hippocampal 5-HT4 serotonergic system in fear conditioning. Journal of psychopharmacology (Oxford, England). vol 30. issue 9. 2018-01-04. PMID:27296273. |
to clarify the interaction between the hippocampal serotonin (5-ht4) receptor and the cannabinoid cb1 receptor in the acquisition of fear memory, the effects of 5-ht4 agents, arachidonylcyclopropylamide (acpa; cb1 receptor agonist), and the combined use of these drugs on fear learning were studied in a fear conditioning task in adult male nmri mice. |
2018-01-04 |
2023-08-13 |
mouse |
| R Forcén, E Latorre, J Pardo, A I Alcalde, M D Murillo, L Gras. Toll-like receptors 2 and 4 exert opposite effects on the contractile response induced by serotonin in mouse colon: role of serotonin receptors. Experimental physiology. vol 101. issue 8. 2018-01-01. PMID:27282784. |
alterations in 5-ht2c and 5-ht4 receptors explain the suppression of the response to serotonin in tlr4(-/-) mice. |
2018-01-01 |
2023-08-13 |
mouse |
| R Forcén, E Latorre, J Pardo, A I Alcalde, M D Murillo, L Gras. Toll-like receptors 2 and 4 exert opposite effects on the contractile response induced by serotonin in mouse colon: role of serotonin receptors. Experimental physiology. vol 101. issue 8. 2018-01-01. PMID:27282784. |
in wt, tlr2(-/-) and tlr2/4 dko mice, 5-ht2 , 5-ht3 , 5-ht4 and 5-ht7 receptor antagonists reduced or blocked the contractile response evoked by 5-ht. |
2018-01-01 |
2023-08-13 |
mouse |
| Panayotis K Thanos, Lauren Malave, Foteini Delis, Paul Mangine, Katie Kane, Adam Grunseich, Melissa Vitale, Paul Greengard, Nora D Volko. Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice. Synapse (New York, N.Y.). vol 70. issue 7. 2017-12-22. PMID:26990537. |
here we examined the role of the protein p11, which recruits serotonin 5ht1b and 5ht4 receptors to the cell surface, in cocaine reward. |
2017-12-22 |
2023-08-13 |
mouse |
| Mohammad Nasehi, Elnaz Rostam-Nezhad, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindas. Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection. Behavioural brain research. vol 317. 2017-11-29. PMID:27686024. |
the present study investigated the effect of serotonin 5-ht4 agents into the dorsal hippocampus (the ca1 region) on spatial and object novelty detection deficits induced by activation of cannabinoid cb1 receptors (cb1rs) using arachidonylcyclopropylamide (acpa) in a non-associative behavioral task designed to forecast the ability of rodents to encode spatial and non-spatial relationships between distinct stimuli. |
2017-11-29 |
2023-08-13 |
Not clear |
| Emanuel Berk, Torsten Christ, Simon Schwarz, Ursula Ravens, Michael Knaut, Alberto J Kauman. In permanent atrial fibrillation, PDE3 reduces force responses to 5-HT, but PDE3 and PDE4 do not cause the blunting of atrial arrhythmias. British journal of pharmacology. vol 173. issue 16. 2017-10-12. PMID:27238373. |
5-ht increases force and l-type ca(2) (+) current (ica,l ) and causes arrhythmias through 5-ht4 receptors in human atrium. |
2017-10-12 |
2023-08-13 |
human |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
physiological effects of 5-ht are mediated by about 15 serotoninergic receptors grouped into seven broad families (5-ht1, 5-ht2, 5-ht3, 5-ht4, 5-ht5, 5-ht6, 5-ht7 receptor families). |
2017-09-20 |
2023-08-13 |
Not clear |
| Naoki Kozono, Akiko Ohtani, Takashi Shig. Roles of the serotonin 5-HT4 receptor in dendrite formation of the rat hippocampal neurons in vitro. Brain research. vol 1655. 2017-08-08. PMID:27894797. |
roles of the serotonin 5-ht4 receptor in dendrite formation of the rat hippocampal neurons in vitro. |
2017-08-08 |
2023-08-13 |
rat |
| Tong Zhu, Juanjuan Qiu, Jiajia Wan, Fengyun Wang, Xudong Tang, Huishu Gu. Expression of serotonin receptors in the colonic tissue of chronic diarrhea rats. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. vol 22. issue 3. 2017-04-24. PMID:27184643. |
this study aimed to investigate the difference among the expression of serotonin receptors (5-ht3, 5-ht4, and 5-ht7receptors) in colonic tissue of chronic diarrhea rats. |
2017-04-24 |
2023-08-13 |
rat |
| Yasuhiro Nakamura, Kazue Ise, Yuto Yamazaki, Fumiyoshi Fujishima, Keely M McNamara, Hironobu Sasan. Serotonin receptor 4 (5-hydroxytryptamine receptor Type 4) regulates expression of estrogen receptor beta and cell migration in hormone-naive prostate cancer. Indian journal of pathology & microbiology. vol 60. issue 1. 2017-03-13. PMID:28195088. |
serotonin receptor 4 (5-hydroxytryptamine receptor type 4) regulates expression of estrogen receptor beta and cell migration in hormone-naive prostate cancer. |
2017-03-13 |
2023-08-13 |
Not clear |
| J Tack, A Rotondo, A Meulemans, L Thielemans, M Cool. Randomized clinical trial: a controlled pilot trial of the 5-HT4 receptor agonist revexepride in patients with symptoms suggestive of gastroparesis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 28. issue 4. 2017-01-05. PMID:27010235. |
revexepride, a 5-hydroxytryptamine (serotonin) receptor (5-ht4 r) agonist, could be a good candidate drug for the gastroparesis treatment. |
2017-01-05 |
2023-08-13 |
Not clear |
| K Ito, M Kawachi, Y Matsunaga, Y Hori, T Ozaki, K Nagahama, M Hirayama, Y Kawabata, Y Shiraishi, M Takei, T Tanak. Acotiamide Hydrochloride, a Therapeutic Agent for Functional Dyspepsia, Enhances Acetylcholine-induced Contraction via Inhibition of Acetylcholinesterase Activity in Circular Muscle Strips of Guinea Pig Stomach. Drug research. vol 66. issue 4. 2016-12-23. PMID:26418413. |
we also investigated the serotonin 5-ht4 receptor agonist mosapride, dopamine d2 receptor and ache inhibitor itopride, and representative ache inhibitor neostigmine. |
2016-12-23 |
2023-08-13 |
rat |
| Mohammad Nasehi, Kamelia Davoudi, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindas. Interplay between serotonin and cannabinoid function in the amygdala in fear conditioning. Brain research. vol 1636. 2016-12-21. PMID:26820636. |
in view of the key role of the amygdala in the acquisition and expression of fear memory, we investigated the involvement of basolateral amygdala (bla) serotonin 5-ht4 receptors in arachidonylcyclopropylamide (acpa; selective cb1 cannabinoid receptor agonist)-induced fear memory consolidation impairment. |
2016-12-21 |
2023-08-13 |
mouse |
| Mohammad Nasehi, Kamelia Davoudi, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindas. Interplay between serotonin and cannabinoid function in the amygdala in fear conditioning. Brain research. vol 1636. 2016-12-21. PMID:26820636. |
it is concluded that bla serotonin 5-ht4 receptors are involved in tone-dependent fear memory consolidation impairment induced by cb1 activation using acpa, suggesting a modulatory role for serotonin 5-ht4 receptor. |
2016-12-21 |
2023-08-13 |
mouse |
| Sofi da Cunha-Bang, Brenda Mc Mahon, Patrick MacDonald Fisher, Peter Steen Jensen, Claus Svarer, Gitte Moos Knudse. High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT4 receptor binding. Social cognitive and affective neuroscience. vol 11. issue 4. 2016-12-13. PMID:26772668. |
high trait aggression in men is associated with low 5-ht levels, as indexed by 5-ht4 receptor binding. |
2016-12-13 |
2023-08-13 |
human |
| Sofi da Cunha-Bang, Brenda Mc Mahon, Patrick MacDonald Fisher, Peter Steen Jensen, Claus Svarer, Gitte Moos Knudse. High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT4 receptor binding. Social cognitive and affective neuroscience. vol 11. issue 4. 2016-12-13. PMID:26772668. |
as cerebral 5-ht4 receptor (5-ht4r) binding has recently been recognized as a proxy for stable brain levels of 5-ht, we here test the hypothesis in healthy men and women that brain 5-ht levels, as indexed by cerebral 5-ht4r, are inversely correlated with trait aggression and impulsivity. |
2016-12-13 |
2023-08-13 |
human |
| Hamid Moha ou Maati, Céline Bourcier-Lucas, Julie Veyssiere, Ameni Kanzari, Catherine Heurteaux, Marc Borsotto, Nasser Haddjeri, Guillaume Luca. The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function. Brain structure & function. vol 221. issue 1. 2016-10-14. PMID:25233810. |
among the few receptor subtypes known to modulate trek-1, the stimulation of 5-ht4 receptors and the blockade of mglur2/3 ones both activated 5-ht impulse flow, effects also suppressed by mpfc lesion. |
2016-10-14 |
2023-08-13 |
Not clear |
| Hamid Moha ou Maati, Céline Bourcier-Lucas, Julie Veyssiere, Ameni Kanzari, Catherine Heurteaux, Marc Borsotto, Nasser Haddjeri, Guillaume Luca. The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function. Brain structure & function. vol 221. issue 1. 2016-10-14. PMID:25233810. |
the combination of spadin with the 5-ht4 agonist rs 67333 paradoxically reduced 5-ht firing, an effect reversed by acutely administering the 5-ht1a agonist flesinoxan. |
2016-10-14 |
2023-08-13 |
Not clear |
| Karly P Garnock-Jone. Prucalopride: A Review in Chronic Idiopathic Constipation. Drugs. vol 76. issue 1. 2016-10-07. PMID:26628294. |
prucalopride (resolor®), a highly selective serotonin 5-ht4 receptor agonist, is indicated in the european economic area for the treatment of adults with chronic idiopathic constipation (cic) in whom laxatives have failed to provide adequate relief. |
2016-10-07 |
2023-08-13 |
Not clear |