| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Konstantin Glebov, Marie Löchner, Ronald Jabs, Thorsten Lau, Olaf Merkel, Patrick Schloss, Christian Steinhäuser, Jochen Walte. Serotonin stimulates secretion of exosomes from microglia cells. Glia. vol 63. issue 4. 2015-10-29. PMID:25451814. |
here, we demonstrate expression of serotonin receptors, including 5-ht2a,b and 5-ht4 in microglial cells and their functional involvement in the modulation of exosome release by serotonin. |
2015-10-29 |
2023-08-13 |
Not clear |
| Xiaofang Zhang, Bojun Yuan, Yu Mao, Xiaoyu Dai, Xiaodong Zhang, Guocai L. Acute and subchronic toxicities of QX100626, a 5-HT4 receptor agonist, in rodents and Beagle dogs. Regulatory toxicology and pharmacology : RTP. vol 70. issue 1. 2015-10-15. PMID:25108057. |
serotonin 5-hydroxytryptamine 4(5-ht4) receptor agonists have been widely prescribed as a prokinetics drug for patients with gastro-esophageal reflux disease and functional dyspepsia. |
2015-10-15 |
2023-08-13 |
rat |
| Xiaoli Zhang, Yun Li, Chenzhe Liu, Ruifang Fan, Ping Wang, Lifei Zheng, Feng Hong, Xiaoyan Feng, Yue Zhang, Lisheng Li, Jinxia Zh. Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-hydroxydopamine-induced Parkinson's disease rats. Translational research : the journal of laboratory and clinical medicine. vol 166. issue 2. 2015-10-08. PMID:25766133. |
blocking d1-like receptor and β3-adrenoceptor (β3-ar) significantly reduced the inhibition of da and ne on the colonic motility, respectively, whereas the 5-ht and 5-ht4 receptor agonists promoted the colonic motility. |
2015-10-08 |
2023-08-13 |
rat |
| Yin Shi, Yue-Hua Chen, Xiao-Jun Yin, An-Qi Wang, Xing-Kui Chen, Jin-Hua Lu, Rong Ji, Chun-Hui Bao, Jie Sun, Ji-Meng Zhao, Huan-Gan W. Electroacupuncture versus Moxibustion for Irritable Bowel Syndrome: A Randomized, Parallel-Controlled Trial. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-08-21. PMID:26294923. |
before and after the treatment, the visual analogue scale for irritable bowel syndrome (vas-ibs) was used to evaluate the gastrointestinal symptoms and mental well-being; and the expression of serotonin (5-hydroxytryptamine, 5-ht), 5-ht3 receptor (5-ht3r), and 5-ht4 receptor (5-ht4r) in sigmoid mucosal tissue were detected. |
2015-08-21 |
2023-08-13 |
Not clear |
| Patrick M Fisher, Klaus K Holst, Dea Adamsen, Anders Bue Klein, Vibe G Frokjaer, Peter S Jensen, Claus Svarer, Nic Gillings, William F C Baare, Jens D Mikkelsen, Gitte M Knudse. BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels. Human brain mapping. vol 36. issue 1. 2015-08-19. PMID:25220079. |
to address this, we evaluated whether bdnf val66met was predictive of a putative marker of brain serotonin levels, serotonin 4 receptor (5-ht4 ) binding assessed with [11c]sb207145 positron emission tomography, which has also been associated with the serotonin-transporter-linked polymorphic region (5-httlpr) polymorphism. |
2015-08-19 |
2023-08-13 |
human |
| Alfredo Menese. Serotonin, neural markers, and memory. Frontiers in pharmacology. vol 6. 2015-08-10. PMID:26257650. |
5-ht1a, 5-ht4, 5-ht5, 5-ht6, and 5-ht7 receptors as well as sert (serotonin transporter) seem to be useful neural markers and/or therapeutic targets. |
2015-08-10 |
2023-08-13 |
Not clear |
| Céline Duparc, Lucile Moreau, Jose Felipe Golib Dzib, Hadrien-Gaël Boyer, Milène Tetsi Nomigni, Isabelle Boutelet, Sheerazed Boulkroun, Kuniaki Mukai, Arndt G Benecke, Laurence Amar, Françoise Gobet, Tchao Meatchi, Pierre-François Plouin, Maria-Christina Zennaro, Estelle Louiset, Hervé Lefebvr. Mast cell hyperplasia is associated with aldosterone hypersecretion in a subset of aldosterone-producing adenomas. The Journal of clinical endocrinology and metabolism. vol 100. issue 4. 2015-08-06. PMID:25599386. |
adrenal mast cells can stimulate aldosterone secretion through the local release of serotonin (5-ht) and activation of the 5-ht4 receptor (5-ht4). |
2015-08-06 |
2023-08-13 |
Not clear |
| Yunpeng Du, Megan Cramer, Chieh Allen Lee, Jie Tang, Arivalagan Muthusamy, David A Antonetti, Hui Jin, Krzysztof Palczewski, Timothy S Ker. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25667222. |
this response was reduced or ablated by pharmacologic inhibition of the α1-ar (a gq-coupled receptor) or gs-coupled serotonin (5-ht2, 5-ht4, 5-ht6, and 5-ht7) receptors or by activation of the gi-coupled α2-ar. |
2015-07-30 |
2023-08-13 |
mouse |
| Nor S Yaakob, Kenneth A Chinkwo, Navinisha Chetty, Ian M Coupar, Helen R Irvin. Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon. Journal of neurogastroenterology and motility. vol 21. issue 3. 2015-07-01. PMID:26130632. |
several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-ht) signaling or metabolism where the 5-ht3 and 5-ht4 receptors are clinically relevant. |
2015-07-01 |
2023-08-13 |
human |
| Christopher S Reigstad, Charles E Salmonson, John F Rainey, Joseph H Szurszewski, David R Linden, Justin L Sonnenburg, Gianrico Farrugia, Purna C Kashya. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 4. 2015-06-22. PMID:25550456. |
microbiota from hm and conventionally raised (cr) mice significantly increased colonic mrnas tph1 [(tryptophan hydroxylase) 1, rate limiting for mucosal 5-ht synthesis; p < 0.01] and chromogranin a (neuroendocrine secretion; p < 0.01), with no effect on monoamine oxidase a (serotonin catabolism), serotonin receptor 5-ht4, or mouse serotonin transporter. |
2015-06-22 |
2023-08-13 |
mouse |
| Shengyuan Ding, Fu-Ming Zho. Serotonin regulation of subthalamic neurons. Reviews in the neurosciences. vol 25. issue 4. 2015-05-26. PMID:24717335. |
first, 5-ht may affect stn neuron excitability directly by either inhibiting a subpopulation of stn neurons via activation of 5-ht1a receptors or exciting stn neurons through activation of 5-ht2c and 5-ht4 receptors. |
2015-05-26 |
2023-08-13 |
Not clear |
| Maria J Ramirez, Mitchell K P Lai, Rosa M Tordera, Paul T Franci. Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status. Drugs. vol 74. issue 7. 2015-05-25. PMID:24802806. |
based on preclinical studies, certain serotonin (5-ht) receptor ligands have been suggested to have the ability to modify or improve memory/cognition, specifically 5-ht receptors acting at 5-ht1a, 5-ht4 and 5-ht6 receptors. |
2015-05-25 |
2023-08-13 |
Not clear |
| Kay Diederen, Suzanne Marian Mugie, Marc Alexander Benning. Efficacy and safety of prucalopride in adults and children with chronic constipation. Expert opinion on pharmacotherapy. vol 16. issue 3. 2015-05-18. PMID:25539475. |
prucalopride is a first-in-class selective, high affinity serotonin 5-hydroxytryptamine type 4 (5-ht4) receptor agonist promoting gastro-intestinal prokinetic activity and has been evaluated for the treatment of cc. |
2015-05-18 |
2023-08-13 |
Not clear |
| S Weninger, K Van Craenenbroeck, R T Cameron, F Vandeput, M A Movsesian, G S Baillie, R A Lefebvr. Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling. Cellular signalling. vol 26. issue 11. 2015-05-15. PMID:25101859. |
pde activity measurements in immunoprecipitates of the 5-ht4(b) receptor confirm the association of pde4d3 with the receptor and provide evidence that the activity of this pde may be increased upon receptor stimulation with 5-ht. |
2015-05-15 |
2023-08-13 |
Not clear |
| Kenjiro Matsumot. [Immunohistochemical analysis of altered serotonin signaling and transient receptor potential vanilloid 1 channels in experimental colitis mice]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 134. issue 11. 2015-05-15. PMID:25366913. |
the current study was designed to investigate the time-dependent dynamic changes of 5-ht3 receptors, 5-ht4 receptors, trpv1 channels, and 5-ht regulatory factors in dss-induced colitis model mice. |
2015-05-15 |
2023-08-13 |
mouse |
| Sudhakar Selvaraj, Danilo Arnone, Alessandra Cappai, Oliver Howe. Alterations in the serotonin system in schizophrenia: a systematic review and meta-analysis of postmortem and molecular imaging studies. Neuroscience and biobehavioral reviews. vol 45. 2015-04-16. PMID:24971825. |
the evidence for alterations in serotonin transporter availability or other serotonin receptors (5-ht1b; 5-ht1d; 5-ht3; 5-ht4; 5-ht7) is limited. |
2015-04-16 |
2023-08-13 |
Not clear |
| Federica Castriconi, Marco Paolino, Germano Giuliani, Maurizio Anzini, Giuseppe Campiani, Laura Mennuni, Chiara Sabatini, Marco Lanza, Gianfranco Caselli, Francesca De Rienzo, Maria Cristina Menziani, Maria Sbraccia, Paola Molinari, Tommaso Costa, Andrea Cappell. Synthesis and structure-activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold. European journal of medicinal chemistry. vol 82. 2015-03-30. PMID:24871995. |
synthesis and structure-activity relationship studies in serotonin 5-ht4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold. |
2015-03-30 |
2023-08-13 |
Not clear |
| Federica Castriconi, Marco Paolino, Germano Giuliani, Maurizio Anzini, Giuseppe Campiani, Laura Mennuni, Chiara Sabatini, Marco Lanza, Gianfranco Caselli, Francesca De Rienzo, Maria Cristina Menziani, Maria Sbraccia, Paola Molinari, Tommaso Costa, Andrea Cappell. Synthesis and structure-activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold. European journal of medicinal chemistry. vol 82. 2015-03-30. PMID:24871995. |
a small series of serotonin 5-ht4 receptor ligands has been designed from flexible 2-methoxyquinoline compounds 7a,b by applying the conformational constraint approach. |
2015-03-30 |
2023-08-13 |
Not clear |
| Rebeca Vidal, Elena Castro, Fuencisla Pilar-Cuéllar, Jesús Pascual-Brazo, Alvaro Díaz, María Luisa Rojo, Raquel Linge, Alicia Martín, Elsa M Valdizán, Angel Pazo. Serotonin 5-HT4 receptors: A new strategy for developing fast acting antidepressants? Current pharmaceutical design. vol 20. issue 23. 2015-01-30. PMID:24180399. |
serotonin 5-ht4 receptors: a new strategy for developing fast acting antidepressants? |
2015-01-30 |
2023-08-12 |
Not clear |
| Simona Bertoni, Valentina Arcaro, Valentina Vivo, Alberto Rapalli, Massimiliano Tognolini, Anna Maria Cantoni, Francesca Saccani, Lisa Flammini, Giuseppe Domenichini, Vigilio Ballabeni, Elisabetta Barocell. Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice. Pharmacological research. vol 81. 2014-12-15. PMID:24548822. |
second, the effects produced by intravenous administration of 5-ht1a ligands (partial agonist buspirone 10mgkg(-1), antagonist way100135 0.5-5mgkg(-1)), 5-ht2a antagonist sarpogrelate (10mgkg(-1)), 5-ht3 antagonist alosetron (0.1mgkg(-1)), 5-ht4 antagonist gr125487 (5mgkg(-1)) and 5-ht re-uptake inhibitor fluoxetine (10mgkg(-1)) on i/r-induced inflammatory response were investigated in i/r mice and compared to those obtained in sham-operated animals (s). |
2014-12-15 |
2023-08-12 |
mouse |