All Relations between 5-ht receptor 4 and serotonin

Publication Sentence Publish Date Extraction Date Species
Sylvie Claeysen, Romain Donneger, Patrizia Giannoni, Florence Gaven, Lucie P Pellissie. Serotonin type 4 receptor dimers. Methods in cell biology. vol 117. 2014-06-03. PMID:24143975. moreover, dimerization appears to be essential for the function of serotonin type 2c (5-ht2c) and type 4 (5-ht4) receptors and required to obtain full receptor activity. 2014-06-03 2023-08-12 Not clear
Mette Ewers Haahr, Patrick Fisher, Klaus Holst, Karine Madsen, Christian Gaden Jensen, Lisbeth Marner, Szabols Lehel, William Baaré, Gitte Knudsen, Steen Hasselbalc. The 5-HT4 receptor levels in hippocampus correlates inversely with memory test performance in humans. Human brain mapping. vol 34. issue 11. 2014-05-28. PMID:22736538. the cerebral serotonin (5-ht) system is involved in cognitive functions such as memory and learning and animal studies have repeatedly shown that stimulation of the 5-ht type 4 receptor (5-ht4 r) facilitates memory and learning and further that the 5-ht4 r modulates cellular memory processes in hippocampus. 2014-05-28 2023-08-12 human
Bjarne Brudeli, Kjetil Wessel Andressen, Lise Román Moltzau, Nils Olav Nilsen, Finn Olav Levy, Jo Klavenes. Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists. Bioorganic & medicinal chemistry. vol 21. issue 22. 2014-05-14. PMID:24113240. serotonin mediates a positive chronotropic and inotropic response through 5-ht4 receptors in the atrium and ventricle of the heart. 2014-05-14 2023-08-12 rat
Alfredo Menese. 5-HT systems: emergent targets for memory formation and memory alterations. Reviews in the neurosciences. vol 24. issue 6. 2014-04-22. PMID:24259245. at least agonists and antagonists for 5-ht1a/1b, 5-ht2a/2b/2c, 5-ht3, 5-ht4, 5-ht6, and 5-ht7 receptors as well as serotonin uptake inhibitors seem to have a promnesic and/or antiamnesic effect in different conditions and 5-ht markers seem to be associated to neural changes. 2014-04-22 2023-08-12 human
Li Zhang, Qinghua Liu, Chengfang Liu, Xuwen Zhai, Qilong Feng, Ruiling Xu, Xiangli Cui, Zhiqing Zhao, Jimin Cao, Bowei W. Zacopride selectively activates the Kir2.1 channel via a PKA signaling pathway in rat cardiomyocytes. Science China. Life sciences. vol 56. issue 9. 2014-03-17. PMID:23929001. in addition, 5-hydroxytryptamine (5-ht)3 receptor was undetectable, whereas 5-ht4 receptor was weakly expressed in hek293 cells. 2014-03-17 2023-08-12 human
Simon Nennstiel, Monther Bajbouj, Roland M Schmid, Valentin Becke. Prucalopride reduces the number of reflux episodes and improves subjective symptoms in gastroesophageal reflux disease: a case series. Journal of medical case reports. vol 8. 2014-02-14. PMID:24502186. prucalopride, a selective high affinity serotonin (5-ht4) receptor agonist, might offer a possible new therapeutic alterative. 2014-02-14 2023-08-12 Not clear
Sabine Weninger, Joris H De Maeyer, Romain A Lefebvr. Influence of phosphodiesterases and cGMP on cAMP generation and on phosphorylation of phospholamban and troponin I by 5-HT4 receptor activation in porcine left atrium. Naunyn-Schmiedeberg's archives of pharmacology. vol 386. issue 8. 2014-01-28. PMID:23549671. electrically paced porcine left atrial muscles, mounted in organ baths, received stimulators of particulate guanylyl cyclase (pgc) or soluble guanylyl cyclase (sgc) and/or specific pde inhibitors followed by 5-ht or the 5-ht4 receptor agonist prucalopride. 2014-01-28 2023-08-12 Not clear
Shannon R Murphy, Edward S Schelegle, Lisa A Miller, Dallas M Hyde, Laura S Van Winkl. Ozone exposure alters serotonin and serotonin receptor expression in the developing lung. Toxicological sciences : an official journal of the Society of Toxicology. vol 134. issue 1. 2014-01-28. PMID:23570994. we hypothesized that ozone exposure alters the normal pattern of serotonin, its transporter (5-htt), and two key receptors (5-ht2a and 5-ht4), a pathway involved in postnatal airway neural, epithelial, and immune processes. 2014-01-28 2023-08-12 monkey
Shannon R Murphy, Edward S Schelegle, Lisa A Miller, Dallas M Hyde, Laura S Van Winkl. Ozone exposure alters serotonin and serotonin receptor expression in the developing lung. Toxicological sciences : an official journal of the Society of Toxicology. vol 134. issue 1. 2014-01-28. PMID:23570994. ozone exposure increases serotonin in airway epithelium regardless of airway level, age, and exposure history and changes the spatial pattern of serotonin receptor protein (5-ht2a and 5-ht4) and 5-htt gene expression depending on compartment, age, and exposure history. 2014-01-28 2023-08-12 monkey
Vera Van de Velde, Lieve Vandeplassche, Mieke Hoppenbrouwers, Mark Boterman, Jannie Ausm. Effect of prucalopride on the pharmacokinetics of oral contraceptives in healthy women. Drugs in R&D. vol 13. issue 1. 2014-01-20. PMID:23539257. prucalopride is a selective, high-affinity, 5-hydroxytryptamine 4 (5-ht4) receptor agonist, which is approved for the symptomatic treatment of chronic constipation in women in whom laxatives fail to provide adequate relief. 2014-01-20 2023-08-12 Not clear
Ulrich Gergs, Anne Böckler, Henning Ebelt, Steffen Hauptmann, Nicolas Keller, Volker Otto, Klaus Pönicke, Wilhelm Schmitz, Joachim Neuman. Human 5-HT₄receptor stimulation in atria of transgenic mice. Naunyn-Schmiedeberg's archives of pharmacology. vol 386. issue 5. 2014-01-16. PMID:23307014. in human atrium, serotonin (5-ht) exerts pleiotropic effects, which are thought to be mediated via 5-ht4 receptors. 2014-01-16 2023-08-12 mouse
Ulrich Gergs, Anne Böckler, Henning Ebelt, Steffen Hauptmann, Nicolas Keller, Volker Otto, Klaus Pönicke, Wilhelm Schmitz, Joachim Neuman. Human 5-HT₄receptor stimulation in atria of transgenic mice. Naunyn-Schmiedeberg's archives of pharmacology. vol 386. issue 5. 2014-01-16. PMID:23307014. the contractile effects of 5-ht in left atrial preparations from tg could be blocked by the 5-ht4 receptor-specific antagonists gr125487 or gr113808. 2014-01-16 2023-08-12 mouse
Ulrich Gergs, Anne Böckler, Henning Ebelt, Steffen Hauptmann, Nicolas Keller, Volker Otto, Klaus Pönicke, Wilhelm Schmitz, Joachim Neuman. Human 5-HT₄receptor stimulation in atria of transgenic mice. Naunyn-Schmiedeberg's archives of pharmacology. vol 386. issue 5. 2014-01-16. PMID:23307014. only in right atrial preparations from tg but not wt, 5-ht exerted a positive chronotropic effect that could be attenuated by 5-ht4 receptor-specific antagonists. 2014-01-16 2023-08-12 mouse
Patrizia Giannoni, Florence Gaven, Dimitri de Bundel, Kevin Baranger, Evelyne Marchetti-Gauthier, François S Roman, Emmanuel Valjent, Philippe Marin, Joël Bockaert, Santiago Rivera, Sylvie Claeyse. Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease. Frontiers in aging neuroscience. vol 5. 2014-01-08. PMID:24399967. serotonin 5-ht4 receptor activation stimulates α-cleavage of the amyloid precursor protein (app), leading to the release of the soluble and neurotrophic sappα fragment and thus precluding aβ formation. 2014-01-08 2023-08-12 mouse
Pius S Padayatti, Liwen Wang, Sayan Gupta, Tivadar Orban, Wenyu Sun, David Salom, Steven R Jordan, Krzysztof Palczewski, Mark R Chanc. A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Molecular & cellular proteomics : MCP. vol 12. issue 5. 2013-12-09. PMID:23378516. a hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-ht4). 2013-12-09 2023-08-12 human
T C Sia, N Flack, L Robinson, M Kyloh, S J Nicholas, S J Brookes, D A Wattchow, P Dinning, J Oliver, N J Spence. Is serotonin in enteric nerves required for distension-evoked peristalsis and propulsion of content in guinea-pig distal colon? Neuroscience. vol 240. 2013-11-13. PMID:23500097. taken together, we suggest that the intrinsic mechanisms that generate peristalsis and entrain propagation along the isolated guinea-pig distal colon are independent of 5-ht in enteric neurons or the mucosa, and do not require the activation of 5-ht3 or 5-ht4 receptors. 2013-11-13 2023-08-12 Not clear
Bjarne Brudeli, Lise Román Moltzau, Cam H T Nguyen, Kjetil Wessel Andressen, Nils Olav Nilsen, Finn Olav Levy, Jo Klavenes. Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European journal of medicinal chemistry. vol 64. 2013-11-05. PMID:23711770. serotonin may also have beneficial effects in the central nervous system (cns) through stimulation of the 5-ht4 receptor, and reduced distribution of 5-ht4 antagonists to the cns may therefore be an advantage. 2013-11-05 2023-08-12 Not clear
Ramakrishna Nirogi, Vishwottam Kandikere, Gopinadh Bhyrapuneni, Ramanatha Saralaya, Devender Reddy Ajjala, Raghupathi Reddy Aleti, Mohammed Abdul Rashee. In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145. The Journal of pharmacy and pharmacology. vol 65. issue 5. 2013-10-28. PMID:23600388. the objective of the current investigation was to develop a simple, rapid method for determining in-vivo 5-hydroxytryptamine type 4 receptor (5-ht4 r) occupancy in rat brain using non-radiolabelled sb207145 as a tracer for accelerating the drug discovery process. 2013-10-28 2023-08-12 rat
W J Xu, Y Zhao, F Q Huo, J Q Du, J S Tan. Involvement of ventrolateral orbital cortex 5-HT 1-7 receptors in 5-HT induced depression of spared nerve injury allodynia. Neuroscience. vol 238. 2013-10-17. PMID:23485814. microinjection of selective 5-ht1a, 5-ht2, 5-ht3, 5-ht4, 5-ht5a, 5-ht6 and 5-ht7 receptor antagonists, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (nan-190) (10μg), cyproheptadine (50ng), granisetron hydrochloride (granisetron) (10μg), 1-[2-[(methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl1-methyl-1h-indole-3-carboxylate (gr113808) (5μg), sb699551 dihydrochloride (sb699551) (10μg), sb258585 dihydrochloride (sb258585) (2μg) or sb269970 hydrochloride (sb269970) (10μg) into the vlo 5-min prior to 5-ht (10μg) injection, all antagonized the 5-ht-induced inhibition of allodynia. 2013-10-17 2023-08-12 rat
Tiong C Sia, Malcolm Whiting, Melinda Kyloh, Sarah J Nicholas, John Oliver, Simon J Brookes, Phil G Dinning, David A Wattchow, Nick J Spence. 5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT. Frontiers in neuroscience. vol 7. 2013-08-12. PMID:23935564. 5-ht3 and 5-ht4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-ht. 2013-08-12 2023-08-12 Not clear