| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Apeksha Parajulee, Kuglae Ki. Structural studies of serotonin receptor family. BMB reports. 2023-10-11. PMID:37817438. |
the functions of serotonin are mediated by a family of 5-ht receptors including 12 gpcrs belonging to six major families: 5-ht1, 5-ht2, 5-ht4, 5-ht5, 5-ht6 and 5-ht7. |
2023-10-11 |
2023-10-15 |
Not clear |
| Hari Shanker Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Igor Bryukhovetskiy, Igor Manzhulo, Lars Wiklund, Aruna Sharm. Stress induced exacerbation of Alzheimer's disease brain pathology is thwarted by co-administration of nanowired cerebrolysin and monoclonal amyloid beta peptide antibodies with serotonin 5-HT6 receptor antagonist SB-399885. International review of neurobiology. vol 171. 2023-10-02. PMID:37783559. |
stress induced exacerbation of alzheimer's disease brain pathology is thwarted by co-administration of nanowired cerebrolysin and monoclonal amyloid beta peptide antibodies with serotonin 5-ht6 receptor antagonist sb-399885. |
2023-10-02 |
2023-10-07 |
Not clear |
| Hari Shanker Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Igor Bryukhovetskiy, Igor Manzhulo, Lars Wiklund, Aruna Sharm. Stress induced exacerbation of Alzheimer's disease brain pathology is thwarted by co-administration of nanowired cerebrolysin and monoclonal amyloid beta peptide antibodies with serotonin 5-HT6 receptor antagonist SB-399885. International review of neurobiology. vol 171. 2023-10-02. PMID:37783559. |
our observations clearly show that restraint stress significantly exacerbate alzheimer's disease brain pathology and nanodelivery of a multimodal drug cerebrolysin together with monoclonal antibodies (mab) to amyloid beta peptide (aβp) together with a serotonin 5-ht6 receptor antagonist sb399885 significantly thwarted alzheimer's disease brain pathology exacerbated by restraint stress, not reported earlier. |
2023-10-02 |
2023-10-07 |
Not clear |
| Xiaolong Gao, Mo Zhang, Shihui Lin, Mingxin Lyu, Xuan Luo, Weiwei You, Caihuan K. Reproduction strategy of nocturnal marine molluscs: running for love. Integrative zoology. 2023-01-07. PMID:36609825. |
after 24 h uninterrupted sampling, the concentration of 5-ht and the expression levels of the 5-ht2 and 5-ht6 receptors in am were significantly higher than those in jm. |
2023-01-07 |
2023-08-14 |
Not clear |
| Xiaolong Gao, Mo Zhang, Shihui Lin, Mingxin Lyu, Xuan Luo, Weiwei You, Caihuan K. Reproduction strategy of nocturnal marine molluscs: running for love. Integrative zoology. 2023-01-07. PMID:36609825. |
after further injection of 5-ht2 and 5-ht6 receptor antagonists, the concentrations of camp and pka rose again, but the cumulative movement duration and distance of male abalones decreased significantly, showing that 5-ht was involved in the regulation of movement behavior of male abalones through the 5-ht2 and 5-ht6 receptor-activated camp-pka pathways. |
2023-01-07 |
2023-08-14 |
Not clear |
| Grace E Anderson, Alexandra Sharp, Wayne E Prat. Stimulation of nucleus accumbens 5-HT6 receptors increases both appetitive and consummatory motivation in an effort-based choice task. Neuroreport. vol 34. issue 2. 2023-01-06. PMID:36608167. |
activity of the serotonin 6(5-ht6) receptor impacts food intake and body weight in animal models and has also shown potential as a target for treatment of anhedonia, a symptom of major depressive disorder. |
2023-01-06 |
2023-08-14 |
rat |
| Syed Nasir Abbas Bukhari, Mervat Abdelaziz Elsherif, Kashaf Junaid, Hasan Ejaz, Pravej Alam, Abdul Samad, Rahul D Jawarkar, Vijay H Masan. Perceiving the Concealed and Unreported Pharmacophoric Features of the 5-Hydroxytryptamine Receptor Using Balanced QSAR Analysis. Pharmaceuticals (Basel, Switzerland). vol 15. issue 7. 2022-07-27. PMID:35890133. |
the 5-hydroxytryptamine receptor 6 (5-ht6) has gained attention as a target for developing therapeutics for alzheimer's disease, schizophrenia, cognitive dysfunctions, anxiety, and depression, to list a few. |
2022-07-27 |
2023-08-14 |
Not clear |
| Tijana Bojić, Milan Sencanski, Vladimir Perovic, Jelena Milicevic, Sanja Glisi. In Silico Screening of Natural Compounds for Candidates 5HT6 Receptor Antagonists against Alzheimer's Disease. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35565976. |
one of the targets that attract the most attention for the potential therapy of ad is the serotonin 5ht6 receptor, which is the receptor situated exclusively in cns on glutamatergic and gabaergic neurons. |
2022-05-14 |
2023-08-13 |
Not clear |
| Keita Koizumi, Hideo Nakajim. Serotonin induces the migration of PC12 cells via the serotonin receptor 6/cAMP/ERK pathway. Biomedical reports. vol 2. issue 1. 2021-10-21. PMID:24649064. |
additionally, 5-ht receptor antagonists suggest that 5-ht-induced migration was mediated by serotonin receptor 6 (5-ht |
2021-10-21 |
2023-08-12 |
Not clear |
| Xiaojiao Li, Lei Gao, Jingrui Liu, Hong Zhang, Hong Chen, Lizi Yang, Min Wu, Cuiyun Li, Xiaoxue Zhu, Yanhua Ding, Li Su. Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, HEC30654, in Healthy Chinese Subjects. Frontiers in pharmacology. vol 12. 2021-09-08. PMID:34489712. |
safety, tolerability and pharmacokinetics of the serotonin 5-ht6 receptor antagonist, hec30654, in healthy chinese subjects. |
2021-09-08 |
2023-08-13 |
human |
| Brandon L Oliver, Alma E Pahua, Kristianna Hitchcock, Dionisio A Amode. Serotonin 6 receptor modulation reduces locomotor activity in C57BL/6J mice. Brain research. vol 1757. 2021-07-23. PMID:33548271. |
the serotonin 6 receptor (5-ht6) is a more recently identified therapeutic target for several neuropsychiatric disorders. |
2021-07-23 |
2023-08-13 |
mouse |
| Qinying Wang, Xiaoxu Dong, Tingting Hu, Chao Qu, Jing Lu, Yue Zhou, Jinsong Li, Gang Pe. Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors. Stem cell reports. vol 16. issue 1. 2021-06-07. PMID:33357407. |
serotonin receptor 6 (5-ht |
2021-06-07 |
2023-08-13 |
human |
| Pierre Courault, Stéphane Emery, Sandrine Bouvard, François Liger, Fabien Chauveau, David Meyronet, Anthony Fourier, Thierry Billard, Luc Zimmer, Sophie Lancelo. Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer's Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P. Journal of Alzheimer's disease : JAD. vol 75. issue 4. 2021-05-13. PMID:32417774. |
the 5-ht6 receptor is one of the most recently identified serotonin receptors in the central nervous system. |
2021-05-13 |
2023-08-13 |
Not clear |
| Anna Gorlova, Gabriela Ortega, Jonas Waider, Natalia Bazhenova, Ekaterina Veniaminova, Andrey Proshin, Allan V Kalueff, Daniel C Anthony, Klaus-Peter Lesch, Tatyana Strekalov. Stress-induced aggression in heterozygous TPH2 mutant mice is associated with alterations in serotonin turnover and expression of 5-HT6 and AMPA subunit 2A receptors. Journal of affective disorders. vol 272. 2021-02-15. PMID:32553388. |
stress-induced aggression in heterozygous tph2 mutant mice is associated with alterations in serotonin turnover and expression of 5-ht6 and ampa subunit 2a receptors. |
2021-02-15 |
2023-08-13 |
mouse |
| Julie Le Mestre, Céline Duparc, Yves Reznik, Fidéline Bonnet-Serrano, Philippe Touraine, Olivier Chabre, Jacques Young, Mari Suzuki, Mathilde Sibony, Françoise Gobet, Constantine A Stratakis, Gérald Raverot, Jérôme Bertherat, Hervé Lefebvre, Estelle Louise. Illicit Upregulation of Serotonin Signaling Pathway in Adrenals of Patients With High Plasma or Intra-Adrenal ACTH Levels. The Journal of clinical endocrinology and metabolism. vol 104. issue 11. 2020-06-01. PMID:31074783. |
in primary pigmented nodular adrenocortical disease cells, activation of the camp/protein kinase a (pka) pathway by prkar1a mutations triggers upregulation of the 5-ht synthesizing enzyme tryptophan hydroxylase (tph) and the 5-ht4, 5-ht6, and 5-ht7 receptors. |
2020-06-01 |
2023-08-13 |
human |
| Cagda Celik Sari, Ozgur Gunduz, Ahmet Ulugo. Spinal Serotonin and 5HT6 Receptor Levels During Development of Neuropathy and Influence of Blockade of these Receptors on Thermal Hyperalgesia in Diabetic Mice. Drug research. vol 69. issue 8. 2019-12-31. PMID:30609433. |
spinal serotonin and 5ht6 receptor levels during development of neuropathy and influence of blockade of these receptors on thermal hyperalgesia in diabetic mice. |
2019-12-31 |
2023-08-13 |
mouse |
| Ramakrishna Nirogi, Renny Abraham, Vijay Benade, Rajesh B Medapati, Pradeep Jayarajan, Gopinadh Bhyrapuneni, NageswaraRao Muddana, Venkat R Mekala, Ramkumar Subramanian, Anil Shinde, Ramasastry Kambhampati, Venkat Jast. SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization. Behavioural pharmacology. vol 30. issue 1. 2019-08-06. PMID:29847336. |
serotonin 6 (5-ht6) receptor has long been pursued as a potential target for the symptomatic treatment of alzheimer's disease. |
2019-08-06 |
2023-08-13 |
Not clear |
| Rajiv Radhakrishnan, Nabeel Nabulsi, Edward Gaiser, Jean-Dominique Gallezot, Shannan Henry, Beata Planeta, Shu-Fei Lin, Jim Ropchan, Wendol Williams, Evan Morris, Deepak Cyril D'Souza, Yiyun Huang, Richard E Carson, David Matuske. Age-Related Change in 5-HT Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 59. issue 9. 2019-07-09. PMID:29626125. |
age-related change in 5-ht serotonin receptor 6 (5-hydroxytrypamine-6, or 5-ht |
2019-07-09 |
2023-08-13 |
Not clear |
| Kyeong Seop Kim, Mi Ae Kim, Young Chang Soh. Molecular characterization, expression analysis, and functional properties of multiple 5-hydroxytryptamine receptors in Pacific abalone (Haliotis discus hannai). General and comparative endocrinology. vol 276. 2019-05-17. PMID:30849410. |
a phylogenetic analysis indicated that the molluskan 5-ht receptors are largely classified into four major clades: 5-ht1/5/7, 5-ht2, 5-ht4, and 5-ht6. |
2019-05-17 |
2023-08-13 |
Not clear |
| Changyun Liu, Yuxing Wen, Huapin Huang, Wanhui Lin, Mingzhu Huang, Rong Lin, Ying M. Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment. Journal of molecular neuroscience : MN. vol 67. issue 3. 2019-04-15. PMID:30694481. |
also, serotonin 5-hydroxytryptamine 6 (5-ht6) receptor plays an important role in cognition. |
2019-04-15 |
2023-08-13 |
mouse |