| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia T Brouard, Judith V Schweimer, Rachel Houlton, Katherine E Burnham, Philip Quérée, Trevor Shar. Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25837696. |
administration of the selective 5-ht6 receptor agonist, way-181187, and antagonist, sb-399885, on the firing of 5-ht neurons in the drn in vivo. |
2016-04-19 |
2023-08-13 |
rat |
| Julia T Brouard, Judith V Schweimer, Rachel Houlton, Katherine E Burnham, Philip Quérée, Trevor Shar. Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25837696. |
in summary, the current data show the modulation of 5-ht neuronal firing by the 5-ht6 ligands way-181187 and sb-399885 and are consistent with the presence of 5-ht6 receptor-mediated positive feedback control of 5-ht neurons. |
2016-04-19 |
2023-08-13 |
rat |
| Daniela Galimberti, Elio Scarpin. Idalopirdine as a treatment for Alzheimer's disease. Expert opinion on investigational drugs. vol 24. issue 7. 2016-03-31. PMID:26022777. |
idalopirdine is an antagonist of the serotonin 6 (5-ht6) receptor, which is expressed in areas of the cns involved with memory. |
2016-03-31 |
2023-08-13 |
Not clear |
| Nozomi Asaoka, Kazuki Nagayasu, Naoya Nishitani, Mayumi Yamashiro, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT₆ receptors in the dorsal raphe nucleus. Neuropharmacology. vol 95. 2016-03-24. PMID:25863120. |
here, we report that olanzapine enhances the ssri-induced increase in extracellular serotonin (5-ht) levels and antidepressant-like effects by inhibiting gabaergic neurons through 5-ht6 receptor antagonism in the dorsal raphe nucleus (drn). |
2016-03-24 |
2023-08-13 |
mouse |
| Nozomi Asaoka, Kazuki Nagayasu, Naoya Nishitani, Mayumi Yamashiro, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT₆ receptors in the dorsal raphe nucleus. Neuropharmacology. vol 95. 2016-03-24. PMID:25863120. |
among many serotonergic agents, the 5-ht6 receptor antagonist sb399885 (1-100 μm) mimicked the effects of olanzapine by enhancing the ssri-induced increase in extracellular 5-ht levels, which was not further augmented by bicuculline or olanzapine. |
2016-03-24 |
2023-08-13 |
mouse |
| Urszula Stępińska, Takashi Kuwana, Bożenna Olszańsk. Serotonin receptors are selectively expressed in the avian germ cells and early embryos. Zygote (Cambridge, England). vol 23. issue 3. 2016-03-15. PMID:24521994. |
we show the presence/absence of nine serotonin transcripts known in birds for receptors 5-ht1a, 5-ht1f, 5-ht2b, 5-ht2c, 5-ht3, 5-ht4, 5-ht5a, 5-ht6 and 5-ht7a in avian germ cells and early embryos. |
2016-03-15 |
2023-08-12 |
Not clear |
| D Eskenazi, M Brodsky, J F Neumaie. Deconstructing 5-HT6 receptor effects on striatal circuit function. Neuroscience. vol 299. 2016-02-29. PMID:25934037. |
whereas d1 and d2 receptors and several neuropeptides, including dynorphin and enkephalin, are differentially expressed in these neurons, 5-hydroxytryptamine 6 receptors (5-ht6) are expressed in both pathways. |
2016-02-29 |
2023-08-13 |
rat |
| D Eskenazi, M Brodsky, J F Neumaie. Deconstructing 5-HT6 receptor effects on striatal circuit function. Neuroscience. vol 299. 2016-02-29. PMID:25934037. |
together these findings further the notion that 5-ht6 signaling causes balanced activation of opposing msn pathways by serotonin in sub-regions of the dorsal striatum allowing for more reflective modalities of behavior. |
2016-02-29 |
2023-08-13 |
rat |
| Grażyna Chłoń-Rzepa, Agnieszka Zagórska, Adam Bucki, Marcin Kołaczkowski, Maciej Pawłowski, Grzegorz Satała, Andrzej J Bojarski, Anna Partyka, Anna Wesołowska, Elżbieta Pękala, Karolina Słoczyńsk. New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773907. |
to obtain potential antidepressants and/or antipsychotics, a series of new long-chain arylpiperazine derivatives of 8-alkoxy-purine-2,6-dione (10-24) and dihydro[1,3]oxazolo[2,3-f]purinedione (30-34) were synthesized and their serotonin (5-ht1a , 5-ht2a , 5-ht6 , 5-ht7 ) and dopamine (d2 ) receptor affinities were determined. |
2016-01-21 |
2023-08-13 |
mouse |
| Ichiro Kusumi, Shuken Boku, Yoshito Takahash. Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis. Psychiatry and clinical neurosciences. vol 69. issue 5. 2016-01-18. PMID:25296946. |
a variety of serotonin (5-ht) receptors, such as 5-ht2a / 2c , 5-ht1a , 5-ht6 and 5-ht7 receptors, may contribute to the mechanisms of action of 'atypicality'. |
2016-01-18 |
2023-08-13 |
Not clear |
| Marcin Kołaczkowski, Monika Marcinkowska, Adam Bucki, Joanna Śniecikowska, Maciej Pawłowski, Grzegorz Kazek, Agata Siwek, Magdalena Jastrzębska-Więsek, Anna Partyka, Anna Wasik, Anna Wesołowska, Paweł Mierzejewski, Przemyslaw Bienkowsk. Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia. European journal of medicinal chemistry. vol 92. 2015-12-01. PMID:25557493. |
we describe a novel class of designed multiple ligands (dmls) combining serotonin 5-ht6 receptor (5-ht6r) antagonism with dopamine d2 receptor (d2r) partial agonism. |
2015-12-01 |
2023-08-13 |
rat |
| Rudolph M Navar. 5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy. Biochimica et biophysica acta. vol 1848. issue 10 Pt B. 2015-11-24. PMID:25838122. |
olanzapine, a fda approved antipsychotic that blocks multiple neurotransmitters: dopamine at d1, d2, d3, d4 brain receptors, serotonin at 5-ht2a, 5-ht2c, 5-ht3, 5-ht6 receptors, catecholamines at alpha1 adrenergic receptors, acetylcholine at muscarinic receptors, and histamine at h1 receptors, has emerged in recent trials as an effective preventative agent for chemotherapy-induced emesis and nausea, as well as a very effective agent for the treatment of breakthrough emesis and nausea. |
2015-11-24 |
2023-08-13 |
Not clear |
| Katarzyna Panczyk, Sylwia Golda, Anna Waszkielewicz, Dorota Zelaszczyk, Agnieszka Gunia-Krzyzak, Henryk Maron. Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands. Current pharmaceutical design. vol 21. issue 13. 2015-11-23. PMID:25412650. |
according to the available data, neuropathic pain mechanisms involve 5-ht1a/1b/1d, 5-ht2a/2b/2c, 5-ht3, 5-ht4, 5-ht6, 5-ht7 receptors and 5-htt serotonin transporter. |
2015-11-23 |
2023-08-13 |
Not clear |
| Guillaume Becker, Julie Colomb, Véronique Sgambato-Faure, Léon Tremblay, Thierry Billard, Luc Zimme. Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging. European journal of nuclear medicine and molecular imaging. vol 42. issue 3. 2015-10-28. PMID:25331460. |
preclinical evaluation of [18f]2fnq1p as the first fluorinated serotonin 5-ht6 radioligand for pet imaging. |
2015-10-28 |
2023-08-13 |
Not clear |
| Guillaume Becker, Julie Colomb, Véronique Sgambato-Faure, Léon Tremblay, Thierry Billard, Luc Zimme. Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging. European journal of nuclear medicine and molecular imaging. vol 42. issue 3. 2015-10-28. PMID:25331460. |
brain serotonin 6 receptor (5-ht6) is one of the most recently identified serotonin receptors. |
2015-10-28 |
2023-08-13 |
Not clear |
| Anna Partyka, Grażyna Chłoń-Rzepa, Anna Wasik, Magdalena Jastrzębska-Więsek, Adam Bucki, Marcin Kołaczkowski, Grzegorz Satała, Andrzej J Bojarski, Anna Wesołowsk. Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25435254. |
continuing our earlier study in a group of purine-2,6-dione derivatives of long chain arylpiperazines (lcaps), a series of 8-unsubstituted 7-phenylpiperazin-4-yl-alkyl (4-14) and 7-tetrahydroisoquinolinyl-alkyl (15-17) analogues were synthesized and their serotonin 5-ht1a, 5-ht2a, 5-ht6, 5-ht7 and dopamine d2 receptor affinities were determined. |
2015-10-22 |
2023-08-13 |
mouse |
| Takayuki Nakagawa, Kazuki Nagayasu, Shuji Kanek. [Utility of organotypic raphe slice cultures to investigate the effects of psychotropic drugs on the function of serotoninergic neurons]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 35. issue 2. 2015-08-21. PMID:26027065. |
here, we show the following results in the raphe slice cultures: 1) acute and sustained treatments with 3,4-methylenedioxymethamphetamine induce the 5-ht efflux via serotonin transporter and ampa receptor-mediated exocytotic 5-ht release, respectively; 2) sustained treatment with antidepressants enhances the exocytotic 5-ht release, which is dependent on ampa receptor stimulation, but not on desensitization of 5-ht(1a/1b) autoreceptors; 3) the augmentation therapy of an atypical antipsychotic, olanzapine, with antidepressants is caused by the decrease in the raphe inhibitory gabaergic tone through 5-ht6 receptor antagonism. |
2015-08-21 |
2023-08-13 |
rat |
| Alfredo Menese. Serotonin, neural markers, and memory. Frontiers in pharmacology. vol 6. 2015-08-10. PMID:26257650. |
5-ht1a, 5-ht4, 5-ht5, 5-ht6, and 5-ht7 receptors as well as sert (serotonin transporter) seem to be useful neural markers and/or therapeutic targets. |
2015-08-10 |
2023-08-13 |
Not clear |
| Yunpeng Du, Megan Cramer, Chieh Allen Lee, Jie Tang, Arivalagan Muthusamy, David A Antonetti, Hui Jin, Krzysztof Palczewski, Timothy S Ker. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25667222. |
this response was reduced or ablated by pharmacologic inhibition of the α1-ar (a gq-coupled receptor) or gs-coupled serotonin (5-ht2, 5-ht4, 5-ht6, and 5-ht7) receptors or by activation of the gi-coupled α2-ar. |
2015-07-30 |
2023-08-13 |
mouse |
| Susanna Tse, Louis Leung, Sangeeta Raje, Mark Seymour, Yoko Shishikura, R Scott Obac. Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals. vol 42. issue 12. 2015-07-01. PMID:25217486. |
cerlapirdine (sam-531, pf-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-ht6) receptor. |
2015-07-01 |
2023-08-13 |
human |