Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Maria J Ramirez, Mitchell K P Lai, Rosa M Tordera, Paul T Franci. Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status. Drugs. vol 74. issue 7. 2015-05-25. PMID:24802806. |
based on preclinical studies, certain serotonin (5-ht) receptor ligands have been suggested to have the ability to modify or improve memory/cognition, specifically 5-ht receptors acting at 5-ht1a, 5-ht4 and 5-ht6 receptors. |
2015-05-25 |
2023-08-13 |
Not clear |
Agnieszka Zagórska, Maciej Pawłowski, Agata Siwek, Grzegorz Kazek, Anna Partyka, Dagmara Wróbel, Magdalena Jastrzębska-Więsek, Anna Wesołowsk. Synthesis and pharmacological evaluation of novel tricyclic[2,1-f]theophylline derivatives. Archiv der Pharmazie. vol 346. issue 11. 2015-04-06. PMID:24123186. |
their binding profile toward monoaminergic receptors (α1, 5-ht(1a), 5-ht(2a), 5-ht6, 5-ht7, d2, d3) was determined as well. |
2015-04-06 |
2023-08-12 |
Not clear |
Bellinda Benhamú, Mar Martín-Fontecha, Henar Vázquez-Villa, Leonardo Pardo, María L López-Rodrígue. Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. Journal of medicinal chemistry. vol 57. issue 17. 2014-12-03. PMID:24850589. |
serotonin 5-ht6 receptor antagonists for the treatment of cognitive deficiency in alzheimer's disease. |
2014-12-03 |
2023-08-13 |
Not clear |
Bellinda Benhamú, Mar Martín-Fontecha, Henar Vázquez-Villa, Leonardo Pardo, María L López-Rodrígue. Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. Journal of medicinal chemistry. vol 57. issue 17. 2014-12-03. PMID:24850589. |
in the search for novel therapeutic strategies, serotonin 5-ht6 receptor (5-ht6r) has been proposed as a promising drug target for cognition enhancement in ad. |
2014-12-03 |
2023-08-13 |
Not clear |
Greg Hostetler, Derek Dunn, Beth Ann McKenna, Karla Kopec, Sankar Chatterje. Lactam and oxazolidinone derived potent 5-hydroxytryptamine 6 receptor antagonists. Bioorganic & medicinal chemistry letters. vol 24. issue 9. 2014-12-01. PMID:24704027. |
lactam and oxazolidinone derived potent 5-hydroxytryptamine 6 (5-ht6) receptor antagonists have been disclosed. |
2014-12-01 |
2023-08-13 |
rat |
Hyun Jung Kim, Seungwoo Kang, Hyun Ju Kim, Sun-Hye Choi, Seungkeun Shin, Hyung Ha Lee, Hyewhon Rhim, Kyung Ho Shi. Effect of acute and chronic electroconvulsive shock on 5-hydroxytrypamine 6 receptor immunoreactivity in rat hippocampus. Experimental neurobiology. vol 23. issue 3. 2014-09-26. PMID:25258570. |
one potential mechanism underlying both the antidepressant and amnesia effect of ecs may involve the regulation of serotonin (5-hydroxytryptamine) 6 (5-ht6) receptor, but less is known about the effects of acute ecs on the changes in 5-ht6 receptor expression in the hippocampus. |
2014-09-26 |
2023-08-13 |
rat |
Agnieszka Nikiforu. The procognitive effects of 5-HT6 receptor ligands in animal models of schizophrenia. Reviews in the neurosciences. vol 25. issue 3. 2014-09-25. PMID:24501158. |
a large body of evidence suggests that the serotonin 6 (5-ht6) receptors may be potential targets for cognitive improvement. |
2014-09-25 |
2023-08-12 |
Not clear |
Anne Quiedeville, Michel Boulouard, Virginie Da Silva Costa-Aze, François Dauphin, Valentine Bouet, Thomas Frere. 5-HT6 receptor antagonists as treatment for age-related cognitive decline. Reviews in the neurosciences. vol 25. issue 3. 2014-09-25. PMID:24622786. |
the 5-ht6 receptor (5-ht6r) is one of the most recently discovered serotonin receptors and has received much attention after observations showing its procognition properties. |
2014-09-25 |
2023-08-12 |
Not clear |
Alfredo Menese. Memory formation and memory alterations: 5-HT6 and 5-HT7 receptors, novel alternative. Reviews in the neurosciences. vol 25. issue 3. 2014-09-25. PMID:24698823. |
agonists and antagonists of the 5-hydroxytryptamine (serotonin) receptor6 (5-ht6) or receptor7 (5-ht7) might improve memory and/or reverse amnesia, although the mechanisms involved are poorly understood. |
2014-09-25 |
2023-08-13 |
Not clear |
Yan A Ivanenkov, Alexander G Majouga, Mark S Veselov, Nina V Chufarova, Sergey S Baranovsky, Gleb I Filko. Computational approaches to the design of novel 5-HT6 R ligands. Reviews in the neurosciences. vol 25. issue 3. 2014-09-25. PMID:24867282. |
5-hydroxytryptamine (5-ht, serotonin) subtype 6 receptor (5-ht6 receptor, 5-ht6 r) belongs to a 5-ht subclass of a relatively wide g protein-coupled receptor (gpcr) family. |
2014-09-25 |
2023-08-13 |
Not clear |
Niels Krogsgaard-Larsen, Anders A Jensen, Tenna J Schrøder, Claus T Christoffersen, Jan Kehle. Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands. Journal of medicinal chemistry. vol 57. issue 13. 2014-09-05. PMID:24878269. |
by introducing distal substituents on a tetracyclic scaffold resembling the ergoline structure, two series of analogues were achieved exhibiting subnanomolar receptor binding affinities for the dopamine d2 and serotonin 5-ht6 receptor subtype, respectively. |
2014-09-05 |
2023-08-13 |
Not clear |
b' Akos Tarcsay, G\\xc3\\xa1bor Paragi, M\\xc3\\xa1rton Vass, Bal\\xc3\\xa1zs J\\xc3\\xb3j\\xc3\\xa1rt, Ferenc Bog\\xc3\\xa1r, Gy\\xc3\\xb6rgy M Keser\\xc5\\xb. The impact of molecular dynamics sampling on the performance of virtual screening against GPCRs. Journal of chemical information and modeling. vol 53. issue 11. 2014-07-08. PMID:24116387.' |
explicit-solvated molecular dynamics simulations (md) were carried out in lipid bilayers to generate an ensemble of protein conformations for the x-ray structures and homology models of both aminergic and peptidergic gpcrs including the chemokine cxcr4, dopamine d3, histamine h4, and serotonin 5ht6 holo receptor complexes. |
2014-07-08 |
2023-08-12 |
Not clear |
Neslihan Akkişi Kumsar, Atila Ero. Olanzapine abuse. Substance abuse. vol 34. issue 1. 2014-05-26. PMID:23327507. |
olanzapine is a thienobenzodiazepine that blocks especially the serontonin (5-hydroxytryptamine [5-ht]) 5-ht2a and the dopamine d2 receptors as well as muscarinic (m1), histamine (h1), 5-ht2c, 5-ht3 to 5-ht6, adrenergic (α(l)), and d4 receptors. |
2014-05-26 |
2023-08-12 |
Not clear |
Saki Shimizu, Yuto Mizuguchi, Ayaka Tatara, Tomoya Kizu, Saki Andatsu, Akira Sobue, Mai Fujiwara, Tomoki Morimoto, Yukihiro Ohn. 5-HT1A agonist alleviates serotonergic potentiation of extrapyramidal disorders via postsynaptic mechanisms. Progress in neuro-psychopharmacology & biological psychiatry. vol 46. 2014-04-22. PMID:23838274. |
we previously demonstrated that 5-ht stimulants, including selective serotonin reuptake inhibitors (ssris), potentiated antipsychotic-induced extrapyramidal symptoms (eps) by stimulating 5-ht2a/2c, 5-ht3 and 5-ht6 receptors. |
2014-04-22 |
2023-08-12 |
mouse |
Alfredo Menese. 5-HT systems: emergent targets for memory formation and memory alterations. Reviews in the neurosciences. vol 24. issue 6. 2014-04-22. PMID:24259245. |
at least agonists and antagonists for 5-ht1a/1b, 5-ht2a/2b/2c, 5-ht3, 5-ht4, 5-ht6, and 5-ht7 receptors as well as serotonin uptake inhibitors seem to have a promnesic and/or antiamnesic effect in different conditions and 5-ht markers seem to be associated to neural changes. |
2014-04-22 |
2023-08-12 |
human |
Donatella Marazziti, Stefano Baroni, Franco Borsini, Michela Picchetti, Elena Vatteroni, Valentina Falaschi, Mario Catena-Dell'Oss. Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology. Current medicinal chemistry. vol 20. issue 3. 2014-01-17. PMID:23157629. |
serotonin receptors of type 6 (5-ht6): from neuroscience to clinical pharmacology. |
2014-01-17 |
2023-08-12 |
Not clear |
Donatella Marazziti, Stefano Baroni, Franco Borsini, Michela Picchetti, Elena Vatteroni, Valentina Falaschi, Mario Catena-Dell'Oss. Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology. Current medicinal chemistry. vol 20. issue 3. 2014-01-17. PMID:23157629. |
the serotonin (5-ht) receptors of type 6 (5-ht6) are quite different from all other 5-ht receptors, as they include a short third cytoplasmatic loop and a long c-terminal tail, and one intron located in the middle of the third cytoplasmatic loop. |
2014-01-17 |
2023-08-12 |
Not clear |
Cecilia Mattsson, Peder Svensson, Henning Boettcher, Clas Sonesso. Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists. European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23542166. |
to further investigate the structure-activity relationship (sar) of the 5-hydroxytryptamine type 6 (5-ht6) receptor agonist 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1h-indole (emd386088, 6), a series of 2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1h-indoles were synthesized, and in vitro affinity to, and functional activity at 5-ht6 receptors was tested. |
2013-11-27 |
2023-08-12 |
Not clear |
Agnieszka Nikiforuk, Katarzyna Fijał, Agnieszka Potasiewicz, Piotr Popik, Tomasz Ko. The 5-hydroxytryptamine (serotonin) receptor 6 agonist EMD 386088 ameliorates ketamine-induced deficits in attentional set shifting and novel object recognition, but not in the prepulse inhibition in rats. Journal of psychopharmacology (Oxford, England). vol 27. issue 5. 2013-11-26. PMID:23479455. |
preclinical data suggest that the 5-hydroxytryptamine (serotonin) 6 (5-ht6) receptor may be a potential target for the development of new therapies for treating cognitive dysfunctions in schizophrenia and other central nervous system disorders. |
2013-11-26 |
2023-08-12 |
rat |
Jaime M Monti, Héctor Jantos, Lee E Schechte. The effects of systemic and local microinjection into the central nervous system of the selective serotonin 5-HT6 receptor agonist WAY-208466 on sleep and wakefulness in the rat. Behavioural brain research. vol 249. 2013-10-21. PMID:23624323. |
the effects of systemic and local microinjection into the central nervous system of the selective serotonin 5-ht6 receptor agonist way-208466 on sleep and wakefulness in the rat. |
2013-10-21 |
2023-08-12 |
rat |