| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. |
5-ht release on single spines induced structural and functional long-term potentiation (ltp), requiring both 5-ht2a and 5-ht7 receptor signals, in a glutamatergic activity-independent manner. |
2024-02-16 |
2024-02-19 |
mouse |
| Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. |
notably, ltp-inducing 5-ht stimuli increased the long-term survival of newly formed spines ( ≥ 6 h) via 5-ht7 gα |
2024-02-16 |
2024-02-19 |
mouse |
| Xiaoyang Ma, Jeong-Woo Shin, Jae-Hyun Cho, Seung-Won Han, Dong-Hyun Ki. IL-6 expression-suppressing Lactobacillus reuteri strains alleviate gut microbiota-induced anxiety and depression in mice. Letters in applied microbiology. 2023-12-21. PMID:38126116. |
when l1 (weakest in vitro), l3, and l6 were orally administered in mice with pcm-induced depression, l6 most potently suppressed depression-like behaviors and hippocampal tnf-α and il-6 expression and increased hippocampal serotonin, bdnf, 5ht7, gabaarα1, and gababr1b expression, followed by l3 and l1. |
2023-12-21 |
2023-12-23 |
mouse |
| Apeksha Parajulee, Kuglae Ki. Structural studies of serotonin receptor family. BMB reports. 2023-10-11. PMID:37817438. |
the functions of serotonin are mediated by a family of 5-ht receptors including 12 gpcrs belonging to six major families: 5-ht1, 5-ht2, 5-ht4, 5-ht5, 5-ht6 and 5-ht7. |
2023-10-11 |
2023-10-15 |
Not clear |
| Usama Osman, Abishek Latha Kumar, Aishwarya Sadagopan, Anas Mahmoud, Maha Begg, Mawada Tarhuni, Monique N Fotso, Natalie A Gonzalez, Raghavendra R Sanivarap. The Effects of Serotonin Receptor Type 7 Modulation on Bowel Sensitivity and Smooth Muscle Tone in Patients With Irritable Bowel Syndrome. Cureus. vol 15. issue 7. 2023-08-28. PMID:37637561. |
though current research on this topic is in its infancy, some researchers have proven, through experimental studies, that 5-hydroxytryptamine (serotonin) receptor type 7 (5-ht7) affects both visceral sensitivity and smooth muscle tone in the bowel. therefore, this review will be discussing the future possibility of alleviating abdominal pain in patients with ibs and related disorders by modulating the 5-ht7 receptor. |
2023-08-28 |
2023-09-07 |
Not clear |
| Antonio Inserra, Alexandre Piot, Danilo De Gregorio, Gabriella Gobb. Lysergic Acid Diethylamide (LSD) for the Treatment of Anxiety Disorders: Preclinical and Clinical Evidence. CNS drugs. 2023-08-21. PMID:37603260. |
the effect of lsd on anxiety may be mediated by serotonin receptors (5-ht1a/1b, 5-ht2a/2c, and 5-ht7) and/or transporter in brain networks and circuits (default mode network, cortico-striato-thalamo-cortical circuit, and prefrontal cortex-amygdala circuit), involved in the modulation of anxiety. |
2023-08-21 |
2023-09-07 |
human |
| Nuh Mehmet Bozkurt, Gokhan Una. Vortioxetine Improved Negative and Cognitive Symptoms of Schizophrenia in Subchronic MK-801 Induced Schizophrenia Model in Rats. Behavioural brain research. 2023-03-01. PMID:36858318. |
vortioxetine is a new multimodal antidepressant with 5-ht1a agonism, 5-ht1b partial agonism, 5-ht3, 5-ht7, and 5-ht1d antagonism, and serotonin reuptake inhibition. |
2023-03-01 |
2023-08-14 |
rat |
| Kouji Fukuyama, Eishi Motomura, Motohiro Okad. Therapeutic Potential and Limitation of Serotonin Type 7 Receptor Modulation. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768393. |
although a number of mood-stabilising atypical antipsychotics and antidepressants modulate serotonin type 7 receptor (5-ht7), the detailed contributions of 5-ht7 function to clinical efficacy and pathophysiology have not been fully understood. |
2023-02-11 |
2023-08-14 |
Not clear |
| Kouji Fukuyama, Eishi Motomura, Motohiro Okad. Therapeutic Potential and Limitation of Serotonin Type 7 Receptor Modulation. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768393. |
the mood-stabilising antipsychotic agent, lurasidone, and the serotonin partial agonist reuptake inhibitor, vortioxetine, exhibit higher binding affinity to 5-ht7 than other conventional antipsychotics and antidepressants. |
2023-02-11 |
2023-08-14 |
Not clear |
| Swetha B M Gowda, Ayesha Banu, Safa Salim, Kadir A Peker, Farhan Mohamma. Serotonin distinctly controls behavioral states in restrained and freely moving iScience. vol 26. issue 1. 2023-01-19. PMID:36654863. |
we used optogenetics and intersectional genetic approaches to show that, while broader serotonin activation promotes immobility, serotonergic cells in the ventral nerve cord (vnc) regulate immobility states majorly via 5-ht7 receptors. |
2023-01-19 |
2023-08-14 |
Not clear |
| M K Connelly, L L Hernande. Elevated serotonin alters whole-blood expression of serotonin receptor and metabolism genes in the lactating dairy cow. JDS communications. vol 2. issue 5. 2022-11-07. PMID:36338386. |
forty-eight hours from termination of first infusion, the mrna of monoamine oxidase-a, serotonin reuptake transporter, and serotonin receptor 7 were increased in blood relative to the control. |
2022-11-07 |
2023-08-14 |
cattle |
| Venhar Cınar, Zuhal Hamurcu, Ahsen Guler, Nursultan Nurdinov, Bulent Ozpola. Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through FOXM1. Breast cancer (Tokyo, Japan). 2022-08-25. PMID:36006564. |
serotonin 5-ht7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through foxm1. |
2022-08-25 |
2023-08-14 |
Not clear |
| Miaozhen Li, Lei Zhang, Yuchen Wu, Yixun Li, Xin Chen, Jing Chen, Qiuhui Wang, Chenghong Liao, Qian Ha. Deletion of the Serotonin Receptor 7 Gene Changed the Development and Behavior of the Mosquito, Insects. vol 13. issue 8. 2022-07-27. PMID:35893026. |
deletion of the serotonin receptor 7 gene changed the development and behavior of the mosquito, serotonin (5-ht) plays a vital role in many physiological processes in insects, regulating physiological activities such as growth and movement through multiple 5-ht receptors (5-htrs), which were potential targets for some new insecticides. |
2022-07-27 |
2023-08-14 |
Not clear |
| Bilal Sahin, Ercan Ozdemir, Erkan Gumus, Mustafa Ergul, Ahmet Sevki Taskira. The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats. Neurological research. 2022-04-11. PMID:35404776. |
recently, studies have demonstrated that serotonin type 7 receptors (5-ht7) have conflincting effects on neuronal excitability in different brain regions. |
2022-04-11 |
2023-08-13 |
rat |
| Lila Wollman, Andrew Hill, Brady Hasse, Christina Young, Giovanni Hernandez-De La Pena, Richard B Levine, Ralph F Fregos. Influence of developmental nicotine exposure on serotonergic control of breathing-related motor output. Developmental neurobiology. 2022-01-11. PMID:35016263. |
we applied 5ht alone, or together with antagonists of 5ht1a, 5ht2a or 5ht7 receptor subtypes. |
2022-01-11 |
2023-08-13 |
rat |
| Romina Gonzalez-Pons, Kiera McRae, Janice M Thompson, Stephanie W Watt. 5-HT7 Receptor Restrains 5-HT-induced 5-HT2A Mediated Contraction in the Isolated Abdominal Vena Cava. Journal of cardiovascular pharmacology. vol 78. issue 2. 2021-10-29. PMID:34029269. |
5-ht7 receptor antagonism by sb266970 and dr 4458 increased maximum contraction to 5-ht in the isolated vein by over 50% versus control. |
2021-10-29 |
2023-08-13 |
rat |
| Daniela Adamo, Elena Calabria, Noemi Coppola, Giuseppe Pecoraro, Michele Davide Mignogn. Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update. Therapeutic advances in psychopharmacology. vol 11. 2021-09-10. PMID:34497709. |
recent evidence suggests that the top-down inhibitory control of pain involves the engagement and enhancement of descending endogenous opioidergic, cannabinoid and serotonergic systems, with the effect of serotonin being particularly related to the receptor subtypes that are preferentially activated; indeed serotonin induces analgesia via activation of 5-ht7 receptors and hyperalgesia via activation of 5-ht3 receptors. |
2021-09-10 |
2023-08-13 |
Not clear |
| Daniela Adamo, Elena Calabria, Noemi Coppola, Giuseppe Pecoraro, Michele Davide Mignogn. Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update. Therapeutic advances in psychopharmacology. vol 11. 2021-09-10. PMID:34497709. |
this drug inhibits the serotonin transporter with a high affinity, antagonises the 5-ht3, 5-ht1d and 5ht7 serotonin receptors, and activates the 5-ht1a and 5-ht1b receptors. |
2021-09-10 |
2023-08-13 |
Not clear |
| Motohiro Okada, Ryusuke Matsumoto, Yoshimasa Yamamoto, Kouji Fukuyam. Effects of Subchronic Administrations of Vortioxetine, Lurasidone, and Escitalopram on Thalamocortical Glutamatergic Transmission Associated with Serotonin 5-HT7 Receptor. International journal of molecular sciences. vol 22. issue 3. 2021-09-07. PMID:33572981. |
effects of subchronic administrations of vortioxetine, lurasidone, and escitalopram on thalamocortical glutamatergic transmission associated with serotonin 5-ht7 receptor. |
2021-09-07 |
2023-08-13 |
Not clear |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
serotonin 5-ht7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of fragile x syndrome. |
2021-08-18 |
2023-08-13 |
mouse |