| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosalinda Mejía-Rodríguez, Daniel Romero-Trejo, Rosa O González, José Segovi. Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways. Biochemistry and biophysics reports. vol 33. 2023-01-30. PMID:36714540. |
we found that the combined treatments with azd5363+azd8542+curcumin and azd8542+curcumin+resveratrol inhibit the pi3k/akt and shh survival pathways by decreasing the activity of akt, the reduction of the expression of smo, pp70s6k, ps6k, gli1, p21 and p27, and the activation of caspase-3 as a marker of apoptosis. |
2023-01-30 |
2023-08-14 |
human |
| Alok Ranjan, Sanjay K Srivastav. Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1. Oncotarget. vol 8. issue 20. 2018-03-13. PMID:28380428. |
inhibiting akt with ly294002 and sirna, or inhibiting gli1 using gant61, cyclopamine, sirna and crispr/cas9 resulted in enhanced cell growth suppressive effects of penfluridol. |
2018-03-13 |
2023-08-13 |
Not clear |
| Alok Ranjan, Sanjay K Srivastav. Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1. Oncotarget. vol 8. issue 20. 2018-03-13. PMID:28380428. |
penfluridol treatment suppressed the phosphorylation of akt at ser473 and reduced the expression of gli1, oct4, nanog and sox2 in several glioblastoma cell lines in a concentration-dependent manner. |
2018-03-13 |
2023-08-13 |
Not clear |
| Monica Benvenuto, Laura Masuelli, Enrico De Smaele, Massimo Fantini, Rosanna Mattera, Danilo Cucchi, Elena Bonanno, Enrica Di Stefano, Giovanni Vanni Frajese, Augusto Orlandi, Isabella Screpanti, Alberto Gulino, Andrea Modesti, Roberto Be. In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. Oncotarget. vol 7. issue 8. 2017-01-06. PMID:26843616. |
gdc-0449 and gant-61 exhibited the following effects: a) inhibited breast cancer cell survival; b) induced apoptosis; c) inhibited hh pathway activity by decreasing the mrna expression levels of gli1 and ptch and inhibiting the nuclear translocation of gli1; d) increased/decreased egfr and erbb2 protein expression, reduced p21-ras and erk1/erk2 mapk activities and inhibited akt activation; and e) decreased the nuclear translocation of nf-κb. |
2017-01-06 |
2023-08-13 |
mouse |
| Jiancheng Zhou, Guodong Zhu, Jun Huang, Lei Li, Yuefeng Du, Yang Gao, Dapeng Wu, Xinyang Wang, Jer-Tsong Hsieh, Dalin He, Kaijie W. Non-canonical GLI1/2 activation by PI3K/AKT signaling in renal cell carcinoma: A novel potential therapeutic target. Cancer letters. vol 370. issue 2. 2016-05-03. PMID:26577809. |
up-regulation of gli1 and gli2 promoted rcc proliferation and clonogenic ability, whereas, a combination of glis inhibitor gant61 and akt inhibitor perifosine synergistically suppressed rcc growth and induced apoptosis in vitro and in vivo. |
2016-05-03 |
2023-08-13 |
human |