| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takashi Komori, Kazuya Okamura, Minobu Ikehara, Kazuhiko Yamamuro, Nozomi Endo, Kazuki Okumura, Takahira Yamauchi, Daisuke Ikawa, Noriko Ouji-Sageshima, Michihiro Toritsuka, Ryohei Takada, Yoshinori Kayashima, Rio Ishida, Yuki Mori, Kohei Kamikawa, Yuki Noriyama, Yuki Nishi, Toshihiro Ito, Yasuhiko Saito, Mayumi Nishi, Toshifumi Kishimoto, Kenji F Tanaka, Noboru Hiroi, Manabu Makinoda. Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. Molecular psychiatry. 2024-01-19. PMID:38243072. |
brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. |
2024-01-19 |
2024-01-22 |
mouse |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
then, we systematically discuss the possible mechanisms of how microglia regulate adult hippocampal neurogenesis in depression according to recent studies, which involve toll-like receptors, microglial polarization, fractalkine-c-x3-c motif chemokine receptor 1, hypothalamic-pituitary-adrenal axis, cytokines, brain-derived neurotrophic factor, and the microbiota-gut-brain axis, etc. |
2023-10-26 |
2023-11-08 |
Not clear |
| Manabu Makinodan, Takashi Komori, Kazuya Okamura, Minobu Ikehara, Kazuhiko Yamamuro, Nozomi Endo, Kazuki Okumura, Takahira Yamauchi, Daisuke Ikawa, Noriko Ouji-Sageshima, Michihiro Toritsuka, Ryohei Takada, Yoshinori Kayashima, Rio Ishida, Yuki Mori, Kohei Kamikawa, Yuki Noriyama, Yuki Nishi, T Ito, Yasuhiko Saito, Mayumi Nishi, Toshifumi Kishimoto, Kenji Tanaka, Noboru Hiro. Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. Research square. 2023-07-18. PMID:37461488. |
brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. |
2023-07-18 |
2023-08-14 |
mouse |
| Xiaoyu Dong, Dongxue Zha. Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies. CNS neuroscience & therapeutics. 2023-05-15. PMID:37183361. |
the mechanisms are achieved by enhancing monoamine oxidase a (moa) activity, inhibiting microglia activation and inflammatory factor release, anti-oxidative stress, promoting hippocampal nerve regeneration, increasing brain-derived neurotrophic factor secretion, regulating gut microbiome, and activating protein kinase b/collapsin response mediator protein 2 (akt/crmp2) signaling pathway. |
2023-05-15 |
2023-08-14 |
human |
| Peter A Smit. The Known Biology of Neuropathic Pain and Its Relevance to Pain Management. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 2023-02-17. PMID:36799022. |
these promote the release of tertiary mediators such as brain-derived neurotrophic factor and interleukin-1β from microglia and astrocytes. |
2023-02-17 |
2023-08-14 |
Not clear |
| Yawen Zhang, Rui Ma, Qian Deng, Wencheng Wang, Chi Cao, Chunyang Yu, Shulin Li, Lei Shi, Jianying Tia. S-adenosylmethionine Improves Cognitive Impairment in D-galactose-Induced Brain Aging by Inhibiting Oxidative Stress and Neuroinflammation. Journal of chemical neuroanatomy. 2023-01-12. PMID:36632907. |
sam reduced neuronal cell loss, increased brain-derived neurotrophic factor level in the hippocampus, inhibited amyloid-β level and microglia activation, as well as pro-inflammatory factors levels in the hippocampus and serum. |
2023-01-12 |
2023-08-14 |
rat |
| Wei Sun, Min Wen, Min Liu, Qingpeng Wang, Quiqin Liu, Lanjie Li, Hans-Christian Siebert, Gabriele Loers, Ruiyan Zhang, Ning Zhan. Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model. Frontiers in aging neuroscience. vol 14. 2022-12-19. PMID:36533180. |
the results showed that bhb treatment improved behavioral performance, prevented myelin loss, decreased the activation of astrocyte as well as microglia, and up-regulated the neurotrophin brain-derived neurotrophic factor in both the corpus callosum and hippocampus. |
2022-12-19 |
2023-08-14 |
mouse |
| Muhammad S Aldhshan, Gursagar Jhanji, Tooru M Mizun. Glucose and fructose directly stimulate brain-derived neurotrophic factor gene expression in microglia. Neuroreport. vol 33. issue 13. 2022-09-01. PMID:36049163. |
glucose and fructose directly stimulate brain-derived neurotrophic factor gene expression in microglia. |
2022-09-01 |
2023-08-14 |
Not clear |
| Kata Tóth, Tamás Oroszi, Eddy A van der Zee, Csaba Nyakas, Regien G Schoemake. Sex dimorphism in isoproterenol-induced cardiac damage associated neuroinflammation and behavior in old rats. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936761. |
baseline hippocampal microglia activity was lower in females, while iso induced neuroinflammation in both sexes, hippocampal brain-derived neurotrophic factor expression appeared lower in females, without effects of iso. |
2022-08-08 |
2023-08-14 |
rat |
| Nikita Patil Samant, Girdhari Lal Gupt. Gossypetin- based therapeutics for cognitive dysfunction in chronic unpredictable stress- exposed mice. Metabolic brain disease. 2022-04-04. PMID:35377087. |
this pathway indicates that, chronic stress primarily promotes the release of excessive cortisol from the adrenal gland, which tends to activate microglia and further increases kynurenine and its downstream pathway, resulting in excessive quinolinic acid (qa), which further impairs brain derived neurotrophic factor (bdnf) levels and leads to neurodegeneration. |
2022-04-04 |
2023-08-13 |
mouse |
| Wei Quan, Maiquan Li, Ye Jiao, Maomao Zeng, Zhiyong He, Qingwu Shen, Jie Che. Effect of Dietary Exposure to Acrylamide on Diabetes-Associated Cognitive Dysfunction from the Perspectives of Oxidative Damage, Neuroinflammation, and Metabolic Disorders. Journal of agricultural and food chemistry. 2022-04-02. PMID:35364817. |
after the activation of astrocytes and microglia, related cytokines, including interleukin-1β, interleukin-6, tumor necrosis factor-α, and lipopolysaccharide, were released, amyloid β-protein was accumulated, brain-derived neurotrophic factor was decreased, and the expression of caspase-3 and caspase-9 was increased, which aggravated neuroinflammation. |
2022-04-02 |
2023-08-13 |
rat |
| Natalie Prowse, Shawn Hayle. Microglia and BDNF at the crossroads of stressor related disorders: Towards a unique trophic phenotype. Neuroscience and biobehavioral reviews. vol 131. 2021-12-03. PMID:34537262. |
recent studies do suggest that microglia can modulate neuronal plasticity, possibly through brain derived neurotrophic factor (bdnf). |
2021-12-03 |
2023-08-13 |
Not clear |
| Lina Guo, Yang Zhang, Qing Lv, Zongwang Zhan. Nicotine induces P2X4 receptor, interleukin-1 beta, and brain-derived neurotrophic factor expression in BV2 microglia cells. Neuroreport. vol 31. issue 18. 2021-11-15. PMID:33165201. |
nicotine induces p2x4 receptor, interleukin-1 beta, and brain-derived neurotrophic factor expression in bv2 microglia cells. |
2021-11-15 |
2023-08-13 |
Not clear |
| Jun-Jie Ma, Tie-Ming Ma, Lie Wang, Zhe H. [Effect of moxibustion on the expression of microglia and brain-derived neurotrophic factor protein in the spinal cord of rats with myofascial pain syndrome]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 9. 2021-09-27. PMID:34558243. |
[effect of moxibustion on the expression of microglia and brain-derived neurotrophic factor protein in the spinal cord of rats with myofascial pain syndrome]. |
2021-09-27 |
2023-08-13 |
rat |
| Yaling Hu, Weihao Mai, Lunhao Chen, Kelei Cao, Bin Zhang, Zhenjie Zhang, Yijun Liu, Huifang Lou, Shumin Duan, Zhihua Ga. mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP. Glia. vol 68. issue 5. 2021-06-10. PMID:31793691. |
further, inhibition of mtor or glycolysis decreased production of lps-induced proinflammatory cytokines and atp-induced tumor necrosis factor-α (tnf-α) and brain derived neurotrophic factor (bdnf) in microglia. |
2021-06-10 |
2023-08-13 |
Not clear |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
by considering those relationships and microglia related nootrophic factors, such as the brain derived neurotrophic factor (bdnf) in cns, we attempted to assess the relationship between microglia dependent bdnf and its precursor with pain behavior through spinal cell apoptosis as well as the effect of noopept on this relationship. |
2021-05-27 |
2023-08-13 |
Not clear |
| Yasuhisa Ano, Rena Ohya, Yuta Takaichi, Terukatsu Washinuma, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayam. β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline. Journal of Alzheimer's disease : JAD. vol 73. issue 4. 2021-05-06. PMID:31929163. |
intake of β-lactolin and whey digestion rich in β-lactolin reduced the levels of inflammatory cytokines, suppressed the infiltration of activated microglia, decreased the levels of amyloid-β, ameliorated impaired long-term object memory, and attenuated decreased synaptophysin, dopamine, brain-derived neurotrophic factor, and insulin-like growth factor 1 levels in the cortex in 5×fad transgenic mice. |
2021-05-06 |
2023-08-13 |
mouse |
| Dipro Bose, Punnag Saha, Ayan Mondal, Brian Fanelli, Ratanesh K Seth, Patricia Janulewicz, Kimberly Sullivan, Stephen Lasley, Ronnie Horner, Rita R Colwell, Ashok K Shetty, Nancy Klimas, Saurabh Chatterje. Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model. Nutrients. vol 12. issue 9. 2021-03-26. PMID:32927823. |
microbial dysbiosis was also associated with frontal cortex levels of increased il6 and il1β, activated microglia, decreased levels of brain derived neurotrophic factor (bdnf), and higher accumulation of phosphorylated tau, an indicator of neuroinflammation-led increased risk of cognitive deficiencies. |
2021-03-26 |
2023-08-13 |
mouse |
| YunLei Wang, YuGe Zhang, WenZhu Wang, Xu Liu, YaFei Chi, JianFeng Lei, BaoGui Zhang, Tong Zhan. Effects of circadian rhythm disorder on the hippocampus of SHR and WKY rats. Neurobiology of learning and memory. vol 168. 2021-01-13. PMID:31857218. |
crd and hypertension decreased fractional anisotropy values, the number of neurons and astrocytes in the hippocampus, and the expression of brain-derived neurotrophic factor and synapsin 1; it also enhanced the degeneration of neurons and microglia and reduced blood flow in the hippocampus, and increased nuclear factor κb, caspase, neuron-specific enolase, and interleukin-6 levels. |
2021-01-13 |
2023-08-13 |
rat |
| Seemaab Ali, Anthony G Mansour, Wei Huang, Nicholas J Queen, Xiaokui Mo, Jacqueline M Anderson, Quais N Hassan, Ripal S Patel, Ryan K Wilkins, Michael A Caligiuri, Lei Ca. CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice. Aging. vol 12. issue 3. 2021-01-13. PMID:32007953. |
chronic plx treatment depleted 75% of microglia from the hypothalamus and reduced markers of inflammation without affecting brain-derived neurotrophic factor levels induced by ee. |
2021-01-13 |
2023-08-13 |
mouse |