| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas Chaaya, Angela Jacques, Arnauld Belmer, Kate Beecher, Syed A Ali, Fatemeh Chehrehasa, Andrew R Battle, Luke R Johnson, Selena E Bartlet. Contextual Fear Conditioning Alter Microglia Number and Morphology in the Rat Dorsal Hippocampus. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31139053. |
the current study was designed to evaluate how two different contextual fear memories alter amygdala and hippocampus microglia, brain derived neurotrophic factor (bdnf), and phosphorylated cyclic-amp response element binding (pcreb). |
2020-10-01 |
2023-08-13 |
rat |
| Qian Zhang, Li-Xin Zhang, Jing An, Liang Yan, Cui-Cui Liu, Jing-Jing Zhao, Hao Yan. Neural regeneration research. vol 13. issue 12. 2020-09-29. PMID:30323153. |
overall, these data suggest that huangqin flavonoid extraction can promote recovery of spinal cord injury by inducing brain-derived neurotrophic factor and neurofilament protein expression, reducing microglia activation and regulating reactive astrocytes. |
2020-09-29 |
2023-08-13 |
rat |
| Rita Machaalani, Melisande Thawley, Jessica Huang, Hui Che. Effects of prenatal cigarette smoke exposure on BDNF, PACAP, microglia and gliosis expression in the young male mouse brainstem. Neurotoxicology. vol 74. 2020-05-12. PMID:31121239. |
using a mouse model of pre- into post- natal cigarette smoke exposure (se), we aimed to determine the effects on brain derived neurotrophic factor (bdnf) and its receptor trkb, neuropeptide pituitary adenylate cyclase activating polypeptide (pacap) and its receptor pac1, and astrocyte (gfap) and microglia (iba-1) immunohistochemical expression, in seven nuclei of the medulla and the facial (fac) nucleus of the pons. |
2020-05-12 |
2023-08-13 |
mouse |
| Xiaobo Zhu, Jiankun Liu, Shanying Huang, Weiwei Zhu, Yibiao Wang, Ou Chen, Jiang Xu. Neuroprotective effects of isoliquiritigenin against cognitive impairment via suppression of synaptic dysfunction, neuronal injury, and neuroinflammation in rats with kainic acid-induced seizures. International immunopharmacology. vol 72. 2020-01-07. PMID:31030091. |
rats with ka-induced seizures showed longer average escape latency and decreases in the number of platform crossings and average time spent in the target quadrant in the morris water maze; isl pretreatment reversed this decline in cognitive impairment and increased the protein levels of synaptophysin, postsynaptic density-95 and brain-derived neurotrophic factor while reducing the number of fluoro jade b-positive cells, microglia, and astrocytes; cleaved-caspase-3 and -9 protein levels; and tumor necrosis factor-α, interleukin (il)-1β, and il-18 production. |
2020-01-07 |
2023-08-13 |
rat |
| Qixian Zhang, Xue Zhong, Jie Zhang, Hao Zhu, Shang Cai, Junjun Zhang, Yi Cao, Ye Tia. Integration of Neurons Derived from Transplanted BDNF-Overexpressing Neural Stem Cells into Circuit of the Irradiated Hippocampus. Radiation research. vol 192. issue 3. 2019-12-06. PMID:31295088. |
brain-derived neurotrophic factor overexpressing neural stem cells s promoted the expression of brain-derived neurotrophic factor and nerve growth factor and reduced the number of activated microglia caused by radiation. |
2019-12-06 |
2023-08-13 |
rat |
| Eiji Masaki, Kentaro Mizuta, Norimasa Ohtani, Kanta Kid. Early Postoperative Nociceptive Threshold and Production of Brain-Derived Neurotrophic Factor Induced by Plantar Incision Are Not Influenced with Minocycline in a Rat: Role of Spinal Microglia. Neuro-Signals. vol 24. issue 1. 2019-11-20. PMID:26939116. |
early postoperative nociceptive threshold and production of brain-derived neurotrophic factor induced by plantar incision are not influenced with minocycline in a rat: role of spinal microglia. |
2019-11-20 |
2023-08-13 |
rat |
| Xiaoxia Yang, Honglei Ren, Kristofer Wood, Minshu Li, Shenfeng Qiu, Fu-Dong Shi, Cungen Ma, Qiang Li. Depletion of microglia augments the dopaminergic neurotoxicity of MPTP. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 6. 2019-01-15. PMID:29401614. |
in addition, the depletion of microglia did not affect the production of brain-derived neurotrophic factor, but it dramatically augmented the production of inflammatory mediators by astrocytes after mptp treatment. |
2019-01-15 |
2023-08-13 |
mouse |
| Prasant Kumar Jena, Lili Sheng, Jacopo Di Lucente, Lee-Way Jin, Izumi Maezawa, Yu-Jui Yvonne Wa. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 5. 2018-12-31. PMID:29401580. |
the results showed that long-term wd intake reduced hippocampal synaptic plasticity and the level of brain-derived neurotrophic factor mrna in the brain and isolated microglia. |
2018-12-31 |
2023-08-13 |
mouse |
| Min Su, Ye Ran, Zizi He, Mingjie Zhang, Guanqun Hu, Wenjing Tang, Dengfa Zhao, Shengyuan Y. Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation in experimental migraine. Molecular pain. vol 14. 2018-10-22. PMID:29310498. |
higher levels of microglia activation and brain-derived neurotrophic factor release were observed following the administration of the inflammatory soup but were alleviated by tak-242. |
2018-10-22 |
2023-08-13 |
rat |
| Patricia B de la Tremblaye, Simon M Benoit, Sarah Schock, Hélène Plamondo. CRHR1 exacerbates the glial inflammatory response and alters BDNF/TrkB/pCREB signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28647536. |
thirty days post ischemia, brain derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) receptor expression, hippocampal neuronal death and inflammation were determined by analyzing immunoreactivity (ir) of neuron-specific nuclear protein (neun), microglia (iba1, ionized calcium binding adaptor molecule 1), astrocytes (gfap, glial fibrillary acidic protein) and tnfα (tumor necrosis factor alpha) a pro-inflammatory cytokine. |
2018-06-12 |
2023-08-13 |
rat |
| Jianping Wang, Xiaojie Fu, Di Zhang, Lie Yu, Zhengfang Lu, Yufeng Gao, Xianliang Liu, Jiang Man, Sijia Li, Nan Li, Menghan Wang, Xi Liu, Xuemei Chen, Weidong Zang, Qingwu Yang, Jian Wan. Effects of crenolanib, a nonselective inhibitor of PDGFR, in a mouse model of transient middle cerebral artery occlusion. Neuroscience. vol 364. 2018-06-08. PMID:28943249. |
downregulation of the pdgfr signaling pathway on days 7-9 with crenolanib significantly increased apoptosis of the neuroblasts that had migrated to the peri-infarct region, increased the number of activated microglia, and decreased the expression of brain-derived neurotrophic factor, neurotrophin-3, and interleukin-10. |
2018-06-08 |
2023-08-13 |
mouse |
| Lindsay Joy Spielman, Deanna Lynn Gibson, Andis Klegeri. Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors. European journal of cell biology. vol 96. issue 3. 2018-03-02. PMID:28336086. |
moreover, we reveal that incretins upregulate bv-2 microglia expression of brain derived neurotrophic factor (bdnf), glial cell-line derived neurotrophic factor (gdnf) and nerve growth factor (ngf) in a phosphoinositide 3-kinase (pi3k)- and pka-dependent manner. |
2018-03-02 |
2023-08-13 |
human |
| Y-H Shih, S-F Tsai, S-H Huang, Y-T Chiang, M W Hughes, S-Y Wu, C-W Lee, T-T Yang, Y-M Ku. Hypertension impairs hippocampus-related adult neurogenesis, CA1 neuron dendritic arborization and long-term memory. Neuroscience. vol 322. 2016-12-13. PMID:26921651. |
furthermore, 2k1c decreased the levels of hippocampal brain-derived neurotrophic factor, while blood vessel density and activation status of astrocytes and microglia were not affected. |
2016-12-13 |
2023-08-13 |
mouse |
| Jieru Zhou, Wei Cai, Min Jin, Jingwei Xu, Yanan Wang, Yichuan Xiao, Li Hao, Bei Wang, Yanyun Zhang, Jie Han, Rui Huan. 18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination. Scientific reports. vol 5. 2016-09-12. PMID:26329786. |
the induced remyelination can be mediated by the overcome of inflammation-induced blockade of brain-derived neurotrophic factor expression in microglia, as well as enhancing oligodendrocyte precursor cell proliferation. |
2016-09-12 |
2023-08-13 |
mouse |
| LiMei Qin, Ron Bouchard, Subbiah Pugazhenth. Regulation of cyclic AMP response element-binding protein during neuroglial interactions. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26677139. |
conditioned medium from the abeta (aβ)-activated microglia decreased creb phosphorylation and brain-derived neurotrophic factor promoter activity (47%), whereas the same medium induced (p < 0.01) the promoter of cxcl10, a chemokine, in npc-derived neuron-rich cultures. |
2016-08-22 |
2023-08-13 |
human |
| LiMei Qin, Ron Bouchard, Subbiah Pugazhenth. Regulation of cyclic AMP response element-binding protein during neuroglial interactions. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26677139. |
the expression of creb targets, including brain-derived neurotrophic factor, synapsin-1, and birc3 decreased by 50-65% (p < 0.01) in neurons isolated by laser capture microdissection in close proximity of microglia in neuroglial mixed cultures. |
2016-08-22 |
2023-08-13 |
human |
| Kyoung Joo Cho, Juhyun Song, Yumi Oh, Jong Eun Le. MicroRNA-Let-7a regulates the function of microglia in inflammation. Molecular and cellular neurosciences. vol 68. 2016-07-11. PMID:26221772. |
in response to inflammation, mir-let-7a participates in the reduction of nitrite production and the expression of inducible nitric oxide synthase (inos), interleukin (il)-6 and is involved in increased expression of brain derived neurotrophic factor (bdnf), interleukin (il)-10, and il-4 in microglia. |
2016-07-11 |
2023-08-13 |
Not clear |
| A Barragan, J M Weidner, Z Jin, E R Korpi, B Birni. GABAergic signalling in the immune system. Acta physiologica (Oxford, England). vol 213. issue 4. 2015-12-02. PMID:25677654. |
activation of microglia appears to regulate the function of gabaergic neurotransmission in neighbouring neurones through changes induced by secretion of brain-derived neurotrophic factor. |
2015-12-02 |
2023-08-13 |
Not clear |
| Juhyun Song, So Yeong Cheon, Wonsug Jung, Won Taek Lee, Jong Eun Le. Resveratrol induces the expression of interleukin-10 and brain-derived neurotrophic factor in BV2 microglia under hypoxia. International journal of molecular sciences. vol 15. issue 9. 2015-05-14. PMID:25184950. |
resveratrol induces the expression of interleukin-10 and brain-derived neurotrophic factor in bv2 microglia under hypoxia. |
2015-05-14 |
2023-08-13 |
Not clear |
| Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Bogusława Budziszewska, Marta Kubera, Władysław Lasoń, Katarzyna Popiołek-Barczyk, Joanna Mika, Krzysztof Wędzony, Agnieszka Basta-Kai. Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells. Frontiers in cellular neuroscience. vol 9. 2015-03-27. PMID:25814933. |
in addition, we characterized the morphological and biochemical parameters of potentially harmful (no, inos, il-1β, il-18, il-6, tnf-α, ccl2, cxcl12, ccr2, cxcr4) and beneficial (insulin-like growth factor-1 (igf-1), brain derived neurotrophic factor (bdnf)) phenotypes in cultures of microglia obtained from the cortices of 1-2 days old control and prenatally stressed pups. |
2015-03-27 |
2023-08-13 |
rat |