| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Y Lai, C D Dibal, G A Armitage, I R Winship, K G Tod. Distinct activation profiles in microglia of different ages: a systematic study in isolated embryonic to aged microglial cultures. Neuroscience. vol 254. 2015-02-23. PMID:24042036. |
upon activation by atp, neo microglia were the most reactive, upregulating nitric oxide, tumor necrosis factor-α, and brain-derived neurotrophic factor release as well as glu uptake. |
2015-02-23 |
2023-08-12 |
rat |
| Xijiang Liu, Huilian Bu, Cheng Liu, Feng Gao, Hui Yang, Xuebi Tian, Aijun Xu, Zhijun Chen, Fei Cao, Yuke Tia. Inhibition of glial activation in rostral ventromedial medulla attenuates mechanical allodynia in a rat model of cancer-induced bone pain. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 32. issue 2. 2014-09-11. PMID:22528236. |
cibp rats showed significant activation of microglia and astrocytes, and also up-regulation of phosphorylated p38 mitogen-activated protein kinase (p38 mapk) and pro-inflammatory mediators released by glial cells (il-1β, il-6, tnf-α and brain-derived neurotrophic factor) in the rvm. |
2014-09-11 |
2023-08-12 |
rat |
| Bernd C Kieseie. Defining a role for laquinimod in multiple sclerosis. Therapeutic advances in neurological disorders. vol 7. issue 4. 2014-07-08. PMID:25002907. |
these include effects on the innate immune system that promote the differentiation of anti-inflammatory/regulatory t cells, the activation of microglia cells, an increase in the expression of brain-derived neurotrophic factor, as well as the prevention of inflammation-induced excitotoxicity. |
2014-07-08 |
2023-08-13 |
Not clear |
| F B Del Guerra, J L I Fonseca, V M Figueiredo, E B Ziff, E Castelon Konkiewit. Human immunodeficiency virus-associated depression: contributions of immuno-inflammatory, monoaminergic, neurodegenerative, and neurotrophic pathways. Journal of neurovirology. vol 19. issue 4. 2014-03-20. PMID:23868513. |
these include inducing chronic elevation of cytokines through activation of microglia and astrocytes; decreasing monoaminergic function; inducing neurotoxicity, especially in dopaminergic neurons; and reducing brain-derived neurotrophic factor. |
2014-03-20 |
2023-08-12 |
human |
| Christopher N Parkhurst, Guang Yang, Ipe Ninan, Jeffrey N Savas, John R Yates, Juan J Lafaille, Barbara L Hempstead, Dan R Littman, Wen-Biao Ga. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. vol 155. issue 7. 2014-02-26. PMID:24360280. |
microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. |
2014-02-26 |
2023-08-12 |
mouse |
| Nadka I Boyadjieva, Dipak K Sarka. Cyclic adenosine monophosphate and brain-derived neurotrophic factor decreased oxidative stress and apoptosis in developing hypothalamic neuronal cells: role of microglia. Alcoholism, clinical and experimental research. vol 37. issue 8. 2014-01-21. PMID:23550806. |
cyclic adenosine monophosphate and brain-derived neurotrophic factor decreased oxidative stress and apoptosis in developing hypothalamic neuronal cells: role of microglia. |
2014-01-21 |
2023-08-12 |
Not clear |
| Sarah Taves, Temugin Berta, Gang Chen, Ru-Rong J. Microglia and spinal cord synaptic plasticity in persistent pain. Neural plasticity. vol 2013. 2013-12-30. PMID:24024042. |
increasing evidence also suggests an important role of spinal cord microglia in the genesis of persistent pain, by releasing the proinflammatory cytokines tumor necrosis factor-alpha (tnfα), interleukine-1beta (il-1β), and brain derived neurotrophic factor (bdnf). |
2013-12-30 |
2023-08-12 |
Not clear |
| Jan H Vranke. Elucidation of pathophysiology and treatment of neuropathic pain. Central nervous system agents in medicinal chemistry. vol 12. issue 4. 2013-06-06. PMID:23033930. |
stimulation of the n-methyl-d-aspartate receptor, activation of microglia, oligodendrocytes, and astrocytes, increased production of nerve growth factor and brain-derived neurotrophic factor together with loss of spinal inhibitory control are responsible for central neuron hyperexcitability and maintenance of neuropathic pain. |
2013-06-06 |
2023-08-12 |
Not clear |
| Caridad Galindo-Romero, F Javier Valiente-Soriano, M Jiménez-López, Diego García-Ayuso, Maria P Villegas-Pérez, Manuel Vidal-Sanz, Marta Agudo-Barrius. Effect of brain-derived neurotrophic factor on mouse axotomized retinal ganglion cells and phagocytic microglia. Investigative ophthalmology & visual science. vol 54. issue 2. 2013-04-02. PMID:23307961. |
effect of brain-derived neurotrophic factor on mouse axotomized retinal ganglion cells and phagocytic microglia. |
2013-04-02 |
2023-08-12 |
mouse |
| Tuan Trang, Simon Beggs, Michael W Salte. Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain. Neuron glia biology. vol 7. issue 1. 2013-01-14. PMID:22613083. |
brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain. |
2013-01-14 |
2023-08-12 |
Not clear |
| Anton B Tonche. Brain ischemia, neurogenesis, and neurotrophic receptor expression in primates. Archives italiennes de biologie. vol 149. issue 2. 2012-06-21. PMID:21701994. |
we found that proliferating postischemic microglia in adult monkey ca1 sector express the neurotrophin receptor trka, while activated astrocytes were labeled for nerve growth factor (ngf), ligand for trka, and the tyrosine kinase trkb, a receptor for brain derived neurotrophic factor (bdnf). |
2012-06-21 |
2023-08-12 |
monkey |
| Yoshinori Hayashi, Kodai Kawaji, Li Sun, Xinwen Zhang, Kiyoshi Koyano, Takeshi Yokoyama, Shinichi Kohsaka, Kazuhide Inoue, Hiroshi Nakanish. Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 48. 2012-02-09. PMID:22131399. |
furthermore, the intrathecal administration of charybdotoxin, a k(ca) channel blocker, significantly inhibited the nerve injury-induced tactile allodynia, the expression of p2x(4) receptors, and the synthesis of brain-derived neurotrophic factor in spinal microglia. |
2012-02-09 |
2023-08-12 |
Not clear |
| Yeong-Ray Wen, Ping-Heng Tan, Jen-Kun Cheng, Yen-Chin Liu, Ru-Rong J. Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 110. issue 8. 2011-12-07. PMID:21783017. |
activation of p38 in spinal microglia results in increased synthesis and release of the neurotrophin brain-derived neurotrophic factor and the proinflammatory cytokines interleukin-1β, interleukin-6, and tumor necrosis factor-α. |
2011-12-07 |
2023-08-12 |
Not clear |
| Hiroyuki Ichikawa, Tadasu Sato, Mitsuhiro Kano, Toshihiko Suzuki, Saburo Matsuo, Hiroyasu Kanetaka, Yoshinaka Shimiz. Masseteric nerve injury increases expression of brain-derived neurotrophic factor in microglia within the rat mesencephalic trigeminal tract nucleus. Cellular and molecular neurobiology. vol 31. issue 4. 2011-08-16. PMID:21225335. |
masseteric nerve injury increases expression of brain-derived neurotrophic factor in microglia within the rat mesencephalic trigeminal tract nucleus. |
2011-08-16 |
2023-08-12 |
rat |
| Hiroyuki Ichikawa, Tadasu Sato, Mitsuhiro Kano, Toshihiko Suzuki, Saburo Matsuo, Hiroyasu Kanetaka, Yoshinaka Shimiz. Masseteric nerve injury increases expression of brain-derived neurotrophic factor in microglia within the rat mesencephalic trigeminal tract nucleus. Cellular and molecular neurobiology. vol 31. issue 4. 2011-08-16. PMID:21225335. |
these findings indicate that the nerve injury increases expression of brain-derived neurotrophic factor in microglia within the mesencephalic trigeminal tract nucleus. |
2011-08-16 |
2023-08-12 |
rat |
| Li-Jun Zhou, Tao Yang, Xiao Wei, Yong Liu, Wen-Jun Xin, Yuan Chen, Rui-Ping Pang, Ying Zang, Yong-Yong Li, Xian-Guo Li. Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat. Brain, behavior, and immunity. vol 25. issue 2. 2011-05-04. PMID:20933591. |
brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat. |
2011-05-04 |
2023-08-12 |
rat |
| Simon Beggs, Michael W Salte. Microglia-neuronal signalling in neuropathic pain hypersensitivity 2.0. Current opinion in neurobiology. vol 20. issue 4. 2011-01-06. PMID:20817512. |
the core signalling pathway is through p2x4 purinergic receptors on the microglia which, via the release of brain-derived neurotrophic factor, cause disinhibition of nociceptive dorsal horn neurons by raising intracellular chloride levels. |
2011-01-06 |
2023-08-12 |
Not clear |
| Gabriel C Tender, Yuan-Yuan Li, Jian-Guo Cu. Brain-derived neurotrophic factor redistribution in the dorsal root ganglia correlates with neuropathic pain inhibition after resiniferatoxin treatment. The spine journal : official journal of the North American Spine Society. vol 10. issue 8. 2010-11-02. PMID:20452292. |
brain-derived neurotrophic factor is produced in the central nervous system microglia in response to noxious stimuli and appear to potentiate central sensitization. |
2010-11-02 |
2023-08-12 |
rat |
| James E Biggs, Van B Lu, Martin J Stebbing, Sridhar Balasubramanyan, Peter A Smit. Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization? Molecular pain. vol 6. 2010-09-23. PMID:20653959. |
although a variety of neuropeptides, cytokines, chemokines and neurotransmitters have been implicated at various points in this process, it is possible that much of the information transfer between activated microglia and neurons, at least in this context, may be explicable in terms of the actions of brain derived neurotrophic factor (bdnf). |
2010-09-23 |
2023-08-12 |
Not clear |
| Yoshito Mizoguchi, Akira Monji, Takahiro Kato, Yoshihiro Seki, Leo Gotoh, Hideki Horikawa, Satoshi O Suzuki, Toru Iwaki, Miyuki Yonaha, Sadayuki Hashioka, Shigenobu Kanb. Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia. Journal of immunology (Baltimore, Md. : 1950). vol 183. issue 12. 2010-02-12. PMID:19923466. |
brain-derived neurotrophic factor induces sustained elevation of intracellular ca2+ in rodent microglia. |
2010-02-12 |
2023-08-12 |
Not clear |