| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khawla Q Nuseir, Karem H Alzoubi, Ahmed Alhusban, Areej Bawaane, Mohammed Al-Azzani, Omar F Khabou. Sucrose and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: Role of BDNF and β-endorphin. Physiology & behavior. vol 179. 2018-05-01. PMID:28663110. |
the hippocampus was dissected; levels of brain derived neurotrophic factor (bdnf) and endorphins were assessed using elisa. |
2018-05-01 |
2023-08-13 |
rat |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
behavioral (ambulatory and rearing activity and immobility time), neurochemical [serotonin (5-ht), dopamine (da), norepinephrine (ne) and brain derived neurotrophic factor (bdnf) level], biochemical (mda formation, il-6, tnf-α and antioxidants) changes in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2018-05-01 |
2023-08-13 |
mouse |
| Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Effect of oleuropein on cognitive deficits and changes in hippocampal brain-derived neurotrophic factor and cytokine expression in a rat model of post-traumatic stress disorder. Journal of natural medicines. vol 72. issue 1. 2018-04-24. PMID:28884427. |
effect of oleuropein on cognitive deficits and changes in hippocampal brain-derived neurotrophic factor and cytokine expression in a rat model of post-traumatic stress disorder. |
2018-04-24 |
2023-08-13 |
rat |
| Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Effect of oleuropein on cognitive deficits and changes in hippocampal brain-derived neurotrophic factor and cytokine expression in a rat model of post-traumatic stress disorder. Journal of natural medicines. vol 72. issue 1. 2018-04-24. PMID:28884427. |
additionally, as assessed by immunohistochemistry and reverse transcription-polymerase chain reaction analysis, the administration of ole significantly alleviated memory-associated decreases in the levels of brain-derived neurotrophic factor and camp response element-binding protein and mrna in the hippocampus. |
2018-04-24 |
2023-08-13 |
rat |
| Hiroshi Yamaguchi, Yuta Hara, Yukio Ago, Erika Takano, Shigeru Hasebe, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takum. Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice. Behavioural brain research. vol 333. 2018-04-20. PMID:28655565. |
enriched housing was found to increase hippocampal brain-derived neurotrophic factor mrna levels in both control and vpa-exposed mice. |
2018-04-20 |
2023-08-13 |
mouse |
| Xinran Li, Cen Guo, Yanan Li, Lina Li, Yuxin Wang, Yiming Zhang, Yue Li, Yu Chen, Wenhan Liu, Li Ga. Ketamine administered pregnant rats impair learning and memory in offspring via the CREB pathway. Oncotarget. vol 8. issue 20. 2018-04-16. PMID:28430606. |
simultaneously, the contents of ca2+/calmodulin-dependent protein kinase ii (camkii), p-camkii, camkiv, p-camkiv, extracellular regulated protein kinases (erk), p-erk, protein kinase a (pka), p-pka, camp-response element binding protein (creb), p-creb, and brain derived neurotrophic factor (bdnf) were detected in the hippocampus. |
2018-04-16 |
2023-08-13 |
rat |
| Soledad Récamier-Carballo, Erika Estrada-Camarena, Carolina López-Rubalcav. Maternal separation induces long-term effects on monoamines and brain-derived neurotrophic factor levels on the frontal cortex, amygdala, and hippocampus: differential effects after a stress challenge. Behavioural pharmacology. vol 28. issue 7. 2018-04-16. PMID:28704274. |
maternal separation induces long-term effects on monoamines and brain-derived neurotrophic factor levels on the frontal cortex, amygdala, and hippocampus: differential effects after a stress challenge. |
2018-04-16 |
2023-08-13 |
mouse |
| Min Cao, Tinglin Pu, Linmei Wang, Charles Marshall, Hongliang He, Gang Hu, Ming Xia. Early enriched physical environment reverses impairments of the hippocampus, but not medial prefrontal cortex, of socially-isolated mice. Brain, behavior, and immunity. vol 64. 2018-04-02. PMID:28412142. |
moreover, increased nuclear factor-kappab and interleukin-1β levels, and downregulation of brain-derived neurotrophic factor signaling pathway were normalized in the hippocampus rather than mpfc of these animals. |
2018-04-02 |
2023-08-13 |
mouse |
| Wen-Chung Liu, Chih-Wei Wu, You-Lin Tain, Mu-Hui Fu, Chun-Ying Hung, I-Chun Chen, Lee-Wei Chen, Kay L H W. Oral pioglitazone ameliorates fructose-induced peripheral insulin resistance and hippocampal gliosis but not restores inhibited hippocampal adult neurogenesis. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29054390. |
the suppressed brain-derived neurotrophic factor, camkiiα, and postsynaptic density protein 95 in the hippocampus were effectively reversed by pio. |
2018-03-26 |
2023-08-13 |
rat |
| Zhe Li, Fang Liu, Hong Ma, Paul F White, Roya Yumul, Yanhua Jiang, Na Wang, Xuezhao Ca. Age exacerbates surgery-induced cognitive impairment and neuroinflammation in Sprague-Dawley rats: the role of IL-4. Brain research. vol 1665. 2018-03-22. PMID:28414034. |
brain derived neurotrophic factor (bdnf), synaptophysin, ionized calcium-binding adapter molecule 1 (iba-1), microglial m2 phenotype marker arg1, and cd200 were also examined in the hippocampus. |
2018-03-22 |
2023-08-13 |
rat |
| Weidong Huang, Facai Meng, Jie Cao, Xiaobin Liu, Jie Zhang, Min L. Neuroprotective Role of Exogenous Brain-Derived Neurotrophic Factor in Hypoxia-Hypoglycemia-Induced Hippocampal Neuron Injury via Regulating Trkb/MiR134 Signaling. Journal of molecular neuroscience : MN. vol 62. issue 1. 2018-03-06. PMID:28343294. |
neuroprotective role of exogenous brain-derived neurotrophic factor in hypoxia-hypoglycemia-induced hippocampal neuron injury via regulating trkb/mir134 signaling. |
2018-03-06 |
2023-08-13 |
Not clear |
| Reef Einoch, Orly Weinreb, Nina Mandiuk, Moussa B H Youdim, Warren Bilker, Henry Silve. The involvement of BDNF-CREB signaling pathways in the pharmacological mechanism of combined SSRI- antipsychotic treatment in schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 27. issue 5. 2018-03-06. PMID:28410959. |
this study examined the role of brain derived neurotrophic factor (bdnf)-camp response element binding (creb) protein signaling pathways, including protein kinase b (akt), glycogen synthase kinase (gsk)-3β and related molecules in the molecular response to haloperidol, fluvoxamine, combined haloperidol+fluvoxamine and clozapine treatments in rat frontal cortex, hippocampus and primary cortical neuronal cultures. |
2018-03-06 |
2023-08-13 |
rat |
| Hiroki Tateiwa, Takashi Kawano, Atsushi Nishigaki, Daiki Yamanaka, Bun Aoyama, Marie Shigematsu-Locatelli, Satoru Eguchi, Fabricio M Locatelli, Masataka Yokoyam. The role of hippocampal brain-derived neurotrophic factor in age-related differences in neuropathic pain behavior in rats. Life sciences. vol 197. 2018-03-01. PMID:29409869. |
the role of hippocampal brain-derived neurotrophic factor in age-related differences in neuropathic pain behavior in rats. |
2018-03-01 |
2023-08-13 |
rat |
| Beita Zhao, Bo Ren, Rui Guo, Wentong Zhang, Shaobo Ma, Yuchen Yao, Tian Yuan, Zhigang Liu, Xuebo Li. Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 109. issue Pt 1. 2018-02-26. PMID:28974442. |
lyc ameliorated histopathological damage and restored brain derived neurotrophic factor (bdnf) levels in the hippocampus of mice. |
2018-02-26 |
2023-08-13 |
mouse |
| Min Jia, Wen-Xue Liu, Jiao-Jiao Yang, Ning Xu, Ze-Min Xie, Ling-Sha Ju, Mu-Huo Ji, Anatoly E Martynyuk, Jian-Jun Yan. Role of histone acetylation in long-term neurobehavioral effects of neonatal Exposure to sevoflurane in rats. Neurobiology of disease. vol 91. 2018-02-20. PMID:27001149. |
the sevoflurane-exposed rats had lower hippocampal density of dendritic spines, reduced levels of the brain-derived neurotrophic factor, c-fos protein, microtubule-associated protein 2, synapsin1, postsynaptic density protein 95, pcreb/creb, creb binding protein, and acetylated histones h3 and h4, and increased levels of histone deacetylases 3 and 8. |
2018-02-20 |
2023-08-13 |
human |
| Marion T Turnbull, Elizabeth J Coulso. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27767994. |
our results reveal that the loss of bfcns in pre-symptomatic pr5 (p301l) tau transgenic mice results in a decrease in hippocampal brain-derived neurotrophic factor levels and reduced trkb receptor activation. |
2018-02-20 |
2023-08-13 |
mouse |
| Fei Liu, You-Ping Liu, Gang Lei, Peng Liu, Zheng Chu, Cheng-Ge Gao, Yong-Hui Dan. Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route. Oncotarget. vol 8. issue 6. 2018-02-20. PMID:28052034. |
several depression-like behaviors were observed in social isolation mice, including decreased relative sucrose preference, longer immobility time in forced swimming test, lower plasma corticosterone and decreased brain-derived neurotrophic factor in hippocampus. |
2018-02-20 |
2023-08-13 |
mouse |
| Yura Choi, Ha Jin Jeong, Quan Feng Liu, Seung Tack Oh, Byung-Soo Koo, Yeni Kim, In-Won Chung, Yong Sik Kim, Songhee Jeo. Clozapine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 54. issue 1. 2018-02-09. PMID:26742522. |
clozapine upregulated trk, brain-derived neurotrophic factor, cyclin-dependent kinase-5, and p35 in the cortex and hippocampus of ad mice and activated amp-activated protein kinase (ampk). |
2018-02-09 |
2023-08-13 |
mouse |
| Muhammad Zahid Khan, Xuxu Zhuang, Ling H. GPR40 receptor activation leads to CREB phosphorylation and improves cognitive performance in an Alzheimer's disease mouse model. Neurobiology of learning and memory. vol 131. 2018-02-09. PMID:26976092. |
furthermore, we have observed that activation of gpr40 receptor provoked the phosphorylation of the camp response element binding protein (creb) and significant increase in neurotropic factors including brain derived neurotrophic factor (bdnf), nerve growth factor (ngf), neurotrophin-3 (nt-3), neurotrohin-4 (nt-4) in mouse hippocampal neurons and contribute to neurogenesis. |
2018-02-09 |
2023-08-13 |
mouse |
| S Caughey, A P Harris, J R Seckl, M C Holmes, J L W Ya. Forebrain-Specific Transgene Rescue of 11β-HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain-Derived Neurotrophic Factor mRNA Levels in Aged 11β-HSD1 Deficient Mice. Journal of neuroendocrinology. vol 29. issue 1. 2018-02-08. PMID:27859809. |
forebrain-specific transgene rescue of 11β-hsd1 associates with impaired spatial memory and reduced hippocampal brain-derived neurotrophic factor mrna levels in aged 11β-hsd1 deficient mice. |
2018-02-08 |
2023-08-13 |
mouse |