All Relations between brain derived neurotrophic factor and spinal cord posterior horn

Reference Sentence Publish Date Extraction Date Species
Jagjit Singh, Surabhi Thapliyal, Ashish Kumar, Pranoy Paul, Nitesh Kumar, Manisha Bisht, Manisha Naithani, Shalinee Rao, Shailendra S Hand. Dimethyl Fumarate Ameliorates Paclitaxel-Induced Neuropathic Pain in Rats. Cureus vol 14 issue 9 2022 36225395 the levels of p38 mitogen-activated protein kinase (mapk) and brain-derived neurotrophic factor (bdnf) were quantified in the dorsal horn of the spinal cord. 2022-10-13 2022-10-25 Not clear
Dian-Ping Yang, Ying Zhang, Pei-Min Lin, An-Qiong Mao, Qing Li. [Analgesic effect and mechanism of electroacupuncture on SNI rats based on microglia-BDNF-neuron signal]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion vol 42 issue 9 2022 36075600 to observe the effect of electroacupuncture (ea) at "huantiao" (gb 30) and "weizhong" (bl 40) on the activation of glial cells, the expression of brain-derived neurotrophic factor (bdnf), excitability and the number of dendritic spines of neurons in the spinal dorsal horn in rats with spared nerve injury (sni) of sciatic nerve, and to explore the analgesic mechanism of ea on sni. 2022-09-08 2022-09-14 Not clear
Thu\\xe1\\xbb\\xb3 Linh Ph\\xe1\\xba\\xa1m, Chan Noh, Chiranjivi Neupane, Ramesh Sharma, Hyun Jin Shin, Ki Duk Park, C Justin Lee, Hyun-Woo Kim, So Yeong Lee, Jin Bong Par. MAO-B inhibitor, KDS2010, alleviates spinal nerve ligation-induced neuropathic pain in rats through competitively blocking the BDNF/TrkB/NR2B signaling. The journal of pain vol issue 2022 35940543 moreover, we discovered that although treatment with kds increased brain-derived neurotrophic factor (bdnf) levels, kds inhibited tropomyosin receptor kinase b (trkb) receptor activation, suppressing increased p-nr2b-induced hyperexcitability in spinal dorsal horn sensory neurons after nerve injury. 2022-08-08 2022-08-15 Not clear
Daniel J Farkas, Laila N Heydari, Jeffery D Foss, Sara Jane Ward, Scott M Rawl. Neurotrophic and Adrenergic Mechanisms Contribute to the Anti-Allodynic Efficacy of the Kratom Alkaloid Mitragynine Against Chemotherapy-Induced Peripheral Neuropathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 36 Suppl 1 issue 2022 35555259 mechanistically, brain-derived neurotrophic factor (bdnf) plays a critical role in cipn pathophysiology, as its expression contributes to dorsal horn hyperexcitability. 2022-05-13 2022-06-13 Not clear
Jamie K Moy, Arkady Khoutorsky, Marina N Asiedu, Gregory Dussor, Theodore J Pric. eIF4E Phosphorylation Influences Frontiers in cellular neuroscience vol 12 issue 2020 29467623 brain-derived neurotrophic factor (bdnf) signaling from nociceptors in the drg to spinal dorsal horn neurons is an important mediator of hyperalgesic priming. 2020-09-30 2022-01-13 Not clear
Jamie K Moy, Jasper L Kuhn, Thomas A Szabo-Pardi, Grishma Pradhan, Theodore J Pric. eIF4E phosphorylation regulates ongoing pain, independently of inflammation, and hyperalgesic priming in the mouse CFA model. Neurobiology of pain (Cambridge, Mass.) vol 4 issue 2020 30211343 this signaling pathway controls changes in excitability that drive acute pain sensitization as well as the translation of mrnas, such as brain-derived neurotrophic factor (bdnf), that enhance plasticity between dorsal root ganglion (drg) nociceptors and second order neurons in the spinal dorsal horn. 2020-09-30 2022-01-13 Not clear
Xiao Wei, Yuqi Sun, Fei Lu. Impaired Spinal Glucocorticoid Receptor Signaling Contributes to the Attenuating Effect of Depression on Mechanical Allodynia and Thermal Hyperalgesia in Rats with Neuropathic Pain. Frontiers in cellular neuroscience vol 11 issue 2020 28579944 of gr agonist dexamethasone (dex; 4 \xce\xbcg/rat/day for 1 week) eliminated the attenuating effect of depression on nociceptive hypersensitivity in ob-snl rats and aggravated neuropathic pain in nob-snl rats, which was associated with the up-regulation of brain-derived neurotrophic factor (bdnf), trkb and nr2b expression in the spinal dorsal horn. 2020-09-29 2022-01-13 Not clear
Jamie K Moy, Thomas Szabo-Pardi, Dipti V Tillu, Salim Megat, Grishma Pradhan, Moeno Kume, Marina N Asiedu, Michael D Burton, Gregory Dussor, Theodore J Pric. Temporal and sex differences in the role of BDNF/TrkB signaling in hyperalgesic priming in mice and rats. Neurobiology of pain (Cambridge, Mass.) vol 5 issue 2020 31194015 brain-derived neurotrophic factor (bdnf) signaling through its cognate receptor, trkb, is a well-known promoter of synaptic plasticity at nociceptive synapses in the dorsal horn of the spinal cord. 2020-09-29 2022-01-13 Not clear
Jiang Wu, Mark Hocevar, Bihua Bie, Joseph F Foss, Mohamed Nagui. Cannabinoid Type 2 Receptor System Modulates Paclitaxel-Induced Microglial Dysregulation and Central Sensitization in Rats. The journal of pain vol 20 issue 5 2020 30414958 we tested the hypothesis that activation of cb2 receptor by mda7 modulates microglial dysregulation, suppresses the overexpression of brain-derived neurotrophic factor (bdnf) in microglia in the dorsal horn, and attenuates the central sensitization and pain behavior induced by paclitaxel. 2020-08-19 2022-01-13 Not clear
Mette Richner, Lone T Pallesen, Maj Ulrichsen, Ebbe T Poulsen, Thomas H Holm, Hande Login, Annie Castonguay, Louis-Etienne Lorenzo, N\\xc3\\xa1dia P Gon\\xc3\\xa7alves, Olav M Andersen, Karin Lykke-Hartmann, Jan J Enghild, Lars C B R\\xc3\\xb8nn, Ibrahim J Malik, Yves De Koninck, Ole J Bjerrum, Christian B V\\xc3\\xa6gter, Anders Nykj\\xc3\\xa6. Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain. Science advances vol 5 issue 6 2020 31223654 a central mechanism is the reduced expression of the potassium chloride cotransporter 2 (kcc2) in dorsal horn neurons induced by brain-derived neurotrophic factor (bdnf), causing neuronal disinhibition within spinal nociceptive pathways. 2020-04-29 2022-01-13 Not clear
Zong-Sheng Wu, Sheng-Hua Wu, Su-Shin Lee, Cen-Hung Lin, Chih-Hau Chang, Jing-Jou Lo, Chee-Yin Chai, Ching-Shuang Wu, Shu-Hung Huan. Dose-Dependent Effect of Hyperbaric Oxygen Treatment on Burn-Induced Neuropathic Pain in Rats. International journal of molecular sciences vol 20 issue 8 2019 31010055 we evaluated the mechanical paw-withdrawal threshold (mwt) and expression of melatonin receptor 1 (mt1), melatonin receptor 2 (mt2), \xce\xbc (mor) and \xce\xba (kor) opioid receptor, brain-derived neurotrophic factor (bdnf), substance p, and calcitonin gene-related peptide (cgrp) in cuneate nucleus, dorsal horn, and hind paw skin by immunohistochemical, immunofluorescence assays and real-time quantitative polymerase chain reaction (rt-pcr). 2019-08-12 2022-01-13 Not clear
Chun-Lin Mai, Xiao Wei, Wen-Shan Gui, Ya-Nan Xu, Jun Zhang, Zhen-Jia Lin, Zhi Tan, Ying-Tong Meng, Yong-Yong Li, Li-Jun Zhou, Xian-Guo Li. Differential regulation of GSK-3\\xce\\xb2 in spinal dorsal horn and in hippocampus mediated by interleukin-1beta contributes to pain hypersensitivity and memory deficits following peripheral nerve injury. Molecular pain vol 15 issue 2019 30632435 mechanistically, both \xce\xb2-catenin and brain-derived neurotrophic factor (bdnf) were upregulated in spinal dorsal horn but downregulated in hippocampus following sni. 2019-05-17 2022-01-13 Not clear
Yuta Matsumura, Tomohiro Yamashita, Atsushi Sasaki, Eriko Nakata, Keita Kohno, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Toshiyasu Imai, Yasushi Kuraishi, Makoto Tsuda, Kazuhide Inou. A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain. Scientific reports vol 6 issue 2018 27576299 this model also showed k(+)/cl(-) cotransporter 2 (kcc2) downregulation, which is implicated in dorsal horn neuron hyperexcitability; this downregulation was restored by intrathecal treatment with np-1815-px or by interfering with brain-derived neurotrophic factor (bdnf) signaling, a p2x4r-activated microglial factor implicated in kcc2 downregulation. 2018-05-22 2022-01-12 Not clear
Yong Liu, Li-Jun Zhou, Jun Wang, Dai Li, Wen-Jie Ren, Jiyun Peng, Xiao Wei, Ting Xu, Wen-Jun Xin, Rui-Ping Pang, Yong-Yong Li, Zhi-Hai Qin, Madhuvika Murugan, Mark P Mattson, Long-Jun Wu, Xian-Guo Li. TNF-\\xce\\xb1 Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 37 issue 4 2017 28123022 mechanistically, tumor necrosis factor-alpha (tnf-\xce\xb1) is upregulated in bilateral hippocampus and in ipsilateral spinal dorsal horn, whereas brain-derived neurotrophic factor (bdnf) is decreased in the hippocampus but increased in the ipsilateral spinal dorsal horn after sni. 2017-08-01 2022-01-13 Not clear
Josiane C S Mapplebeck, Simon Beggs, Michael W Salte. Sex differences in pain: a tale of two immune cells. Pain vol 157 Suppl 1 issue 2016 26785152 activation of p2x4 receptors results in release of brain-derived neurotrophic factor, which acts on neurons to produce disinhibition of dorsal horn neurons which transmit nociceptive information to the brain. 2016-10-17 2022-01-12 Not clear
Bin Wu, Chun Xu, Huan-Huan Huan. [Expression profiles of brain-derived neurotrophic factor in the spinal dorsal horn of young rats with visceral hypersensitivity]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics vol 18 issue 3 2016 26975829 [expression profiles of brain-derived neurotrophic factor in the spinal dorsal horn of young rats with visceral hypersensitivity]. 2016-07-21 2022-01-12 Not clear
Bin Wu, Chun Xu, Huan-Huan Huan. [Expression profiles of brain-derived neurotrophic factor in the spinal dorsal horn of young rats with visceral hypersensitivity]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics vol 18 issue 3 2016 26975829 to explore the relationship between the expression of brain-derived neurotrophic factor (bdnf) in the spinal dorsal horn and the increase in visceral hypersensitivity in young rats by establishing a young rat model of visceral hypersensitivity by neonatal maternal separation (nms). 2016-07-21 2022-01-12 Not clear
Nemat Khan, Richard Gordon, Trent M Woodruff, Maree T Smit. Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signaling in the dorsal horn of the spinal cord. Pharmacology research & perspectives vol 3 issue 3 2015 26171221 fully developed mechanical allodynia in the bilateral hindpaws of vehicle-treated rr-eae mice was accompanied by marked cd3(+) t-cell infiltration, microglia activation, and increased brain-derived neurotrophic factor (bdnf)-tyrosine kinase b (trkb) signaling in the dorsal horn of the lumbar spinal cord. 2015-07-14 2022-01-12 Not clear
Xiao-Hong Jin, Li-Na Wang, Jian-Ling Zuo, Jian-Ping Yang, Si-Lan Li. P2X4 receptor in the dorsal horn partially contributes to brain-derived neurotrophic factor oversecretion and toll-like receptor-4 receptor activation associated with bone cancer pain. Journal of neuroscience research vol 92 issue 12 2015 24984884 p2x4 receptor in the dorsal horn partially contributes to brain-derived neurotrophic factor oversecretion and toll-like receptor-4 receptor activation associated with bone cancer pain. 2015-06-19 2022-01-12 Not clear
Xiao-Hong Jin, Li-Na Wang, Jian-Ling Zuo, Jian-Ping Yang, Si-Lan Li. P2X4 receptor in the dorsal horn partially contributes to brain-derived neurotrophic factor oversecretion and toll-like receptor-4 receptor activation associated with bone cancer pain. Journal of neuroscience research vol 92 issue 12 2015 24984884 with the present rat model of cibp, we demonstrate a critical role of the microglial p2x4r in the enhanced nociceptive transmission, which is associated with tlr4 activation and secretion of brain-derived neurotrophic factor (bdnf) and tnf\xce\xb1 in the dorsal horn. 2015-06-19 2022-01-12 Not clear
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