| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior vol issue 2023 36870422 |
the present study demonstrated for the first time that acute as well as subchronic (4\xe2\x80\xafdays) administration of the experimental ghs-r1a antagonist jmv2959 in usual intraperitoneal doses including 3\xe2\x80\xafmg/kg, had no influence on memory functions tested in the morris water maze in rats as well as no significant effects on the molecular markers linked with memory processing in selected brain areas in rats, specifically on the \xce\xb2-actin, c-fos, two forms of the calcium/calmodulin-dependent protein kinase ii (camkii, p-camkii) and the camp-response element binding protein (creb, p-creb), within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum, and hippocampus (hipp). |
2023-03-04 |
2023-03-06 |
rat |
| In\\xc3\\xaas M Amaral, Laura Scheffauer, Angelika B Langeder, Alex Hofer, Rana El Rawa. Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens. Biomedicines vol 9 issue 12 2021 34944702 |
however, little is known about the contribution of camkii signaling in the nucleus accumbens (nac) in natural rewards such as social interaction. |
2021-12-24 |
2023-01-26 |
rat |
| In\\xc3\\xaas M Amaral, Laura Scheffauer, Angelika B Langeder, Alex Hofer, Rana El Rawa. Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens. Biomedicines vol 9 issue 12 2021 34944702 |
in order to investigate the role of nac camkii in the expression of reward-related learning of drug versus non-drug stimuli, we inhibited camkii through an infusion of kn-93, a camkii inhibitor, directly into the nac shell or core, before the cpp test in a concurrent paradigm in which social interaction was made available in the compartment alternative to the one associated with cocaine during conditioning. |
2021-12-24 |
2023-01-26 |
rat |
| In\\xc3\\xaas M Amaral, Laura Scheffauer, Angelika B Langeder, Alex Hofer, Rana El Rawa. Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens. Biomedicines vol 9 issue 12 2021 34944702 |
whereas vehicle infusions led to equal preference to both stimuli, inhibition of camkii by a kn-93 infusion before the cpp test in the shell but not the core of the nac shifted the rats' preference toward the cocaine-associated compartment. |
2021-12-24 |
2023-01-26 |
rat |
| In\\xc3\\xaas M Amaral, Laura Scheffauer, Angelika B Langeder, Alex Hofer, Rana El Rawa. Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens. Biomedicines vol 9 issue 12 2021 34944702 |
altogether, these results suggest that social interaction reward engages camkii in the nac. |
2021-12-24 |
2023-01-26 |
rat |
| Haniyeh Soltani, Mitra-Sadat Sadat-Shirazi, Bahareh Pakpour, Ghorbangol Ashabi, Mohammad-Reza Zarrindas. Toxic effect of calcium/calmodulin kinase II on anxiety behavior, neuronal firing and plasticity in the male offspring of morphine-abstinent rats. Behavioural brain research vol 395 issue 2021 32841609 |
according to the critical role of calcium/calmodulin protein kinaseii (camkii) in these processes, the present study examined the effect of camkii inhibitor (kn93) on neuronal activity and level of c-fos in the amygdala and nucleus accumbens (nac) in the offspring of morphine-exposed parents. |
2021-10-13 |
2023-01-26 |
rat |
| Haniyeh Soltani, Mitra-Sadat Sadat-Shirazi, Bahareh Pakpour, Ghorbangol Ashabi, Mohammad-Reza Zarrindas. Toxic effect of calcium/calmodulin kinase II on anxiety behavior, neuronal firing and plasticity in the male offspring of morphine-abstinent rats. Behavioural brain research vol 395 issue 2021 32841609 |
the expression level of the c-fos was not significantly altered by the inhibition of camkii in the amygdala, but the c-fos level was reduced in the nac. |
2021-10-13 |
2023-01-26 |
rat |
| Haniyeh Soltani, Mitra-Sadat Sadat-Shirazi, Bahareh Pakpour, Ghorbangol Ashabi, Mohammad-Reza Zarrindas. Toxic effect of calcium/calmodulin kinase II on anxiety behavior, neuronal firing and plasticity in the male offspring of morphine-abstinent rats. Behavioural brain research vol 395 issue 2021 32841609 |
results showed that camkii had a role in anxiety-like behavior in the offspring of morphine-exposed parents, and changes in neuronal firing rate and c-fos level in the nac might be involved in this process. |
2021-10-13 |
2023-01-26 |
rat |
| Mengnan Li, Xiaomin Zhang, Chongyang Li, Yanan Liu, Shuang Yang, Shilian X. Galanin Receptor 2 Is Involved in Galanin-Induced Analgesic Effect by Activating PKC and CaMKII in the Nucleus Accumbens of Inflammatory Pain Rats. Frontiers in neuroscience vol 14 issue 2021 33551722 |
furthermore, the camkii inhibitor kn93 and pkc inhibitor go6983 attenuated m1145-induced increases in hwl and hwt in nac of rats with inflammatory pain. |
2021-02-10 |
2023-01-26 |
rat |
| Mengnan Li, Xiaomin Zhang, Chongyang Li, Yanan Liu, Shuang Yang, Shilian X. Galanin Receptor 2 Is Involved in Galanin-Induced Analgesic Effect by Activating PKC and CaMKII in the Nucleus Accumbens of Inflammatory Pain Rats. Frontiers in neuroscience vol 14 issue 2021 33551722 |
these results prove that galr2 is involved in the galanin-induced analgesic effect by activating camkii and pkc in nac of inflammatory pain rats, implying that galr2 agonists probably are potent therapeutic options for inflammatory pain. |
2021-02-10 |
2023-01-26 |
rat |
| Yu-Gang Lu, Long Wang, Jiang-Long Chen, Jiao Zhu, Xiao-Yan Meng, Zhen-Dong You, Wei-Feng Y. Projections from lateral habenular to tail of ventral tegmental area contribute to inhibitory effect of stress on morphine-induced conditioned place preference. Brain research vol 1717 issue 2020 30914248 |
meanwhile, we detected the expression of darpp-32 phosphorylation (p-darpp-32) in the nucleus accumbens (nac), and camkii in lhb. |
2020-09-24 |
2023-01-26 |
rat |
| Kia J Jackson, Pretal P Muldoon, Carrie Walters, Mohamad Imad Dama. Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice. Behavioural pharmacology vol 27 issue 1 2016 26292186 |
further, we assessed camkii activity in the ventral tegmental area (vta), nucleus accumbens (nac), prefrontal cortex, and hippocampus after nicotine cpp and found significant increases in camkii activity in the mouse vta and nac that were blocked by camkii antagonists. |
2016-09-19 |
2023-01-25 |
mouse |
| Kia J Jackson, Pretal P Muldoon, Carrie Walters, Mohamad Imad Dama. Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice. Behavioural pharmacology vol 27 issue 1 2016 26292186 |
the findings from this study show that camkii mediates nicotine reward and suggest that increases in camkii activity in the vta and nac are relevant to nicotine reward behaviors. |
2016-09-19 |
2023-01-25 |
mouse |
| Yan Li, Ruiming Zhu, Wenjing Wang, Dengqi Fu, Jing Hou, Sen Ji, Bo Chen, Zhengtao Hu, Xue Shao, Xuri Yu, Qian Zhao, Baolai Zhang, Changman Du, Qian Bu, Chunyan Hu, Yun Tang, Lei Zhong, Shengyong Yang, Yinglan Zhao, Xiaobo Ce. Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 35 issue 37 2016 26377474 |
we also found that h4r3me2a is upregulated in nac after repeated cocaine administration, and that h4r3me2a upregulation in turn controls the expression of cdk5 and camkii. |
2016-01-04 |
2023-01-25 |
mouse |
| Yan Li, Ruiming Zhu, Wenjing Wang, Dengqi Fu, Jing Hou, Sen Ji, Bo Chen, Zhengtao Hu, Xue Shao, Xuri Yu, Qian Zhao, Baolai Zhang, Changman Du, Qian Bu, Chunyan Hu, Yun Tang, Lei Zhong, Shengyong Yang, Yinglan Zhao, Xiaobo Ce. Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 35 issue 37 2016 26377474 |
additionally, the suppression of prmt1 in nac with lentiviral-short hairpin pmrt1 decreases levels of camkii and cdk5 in the cocaine-treated group, demonstrating that prmt1 affects the ability of cocaine to induce camkii and cdk5 in nac. |
2016-01-04 |
2023-01-25 |
mouse |
| Ji Seon Son, Young Chan Jeong, Young Bae Kwo. Regulatory effect of bee venom on methamphetamine-induced cellular activities in prefrontal cortex and nucleus accumbens in mice. Biological & pharmaceutical bulletin vol 38 issue 1 2015 25744457 |
these findings suggest that bv acupuncture may exert a suppressive effect on meth-induced addiction via regulation of signaling cascades of \xce\x94fosb, erk, and camkii in pfc and nac. |
2015-12-15 |
2023-01-25 |
mouse |
| Hui Bian, Long-Chuan Y. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy. Neuroscience letters vol 599 issue 2015 26022629 |
intra-nucleus accumbens (nac) injection of 3 \xce\xbcg, 6 \xce\xbcg and 12 \xce\xbcg of myristoylated autocamtide-2-inhibitory peptide (aip), the camkii inhibitor, dose-dependently increased the hwl to noxious thermal and mechanical stimulation in rats with mononeuropathy. |
2015-10-16 |
2023-01-25 |
rat |
| Hui Bian, Long-Chuan Y. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy. Neuroscience letters vol 599 issue 2015 26022629 |
taken together, the results showed that intra-nac injection of aip induced significant antinociceptive effects in rats with mononeuropathy, indicating that camkii may play an important role in the transmission and/or modulation of nociceptive information in the nac in rats with mononeuropathy. |
2015-10-16 |
2023-01-25 |
rat |
| Hui Bian, Long-Chuan Y. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy. Neuroscience letters vol 583 issue 2015 25218714 |
the results demonstrated that intra-nac injection of kn93 induced significant antinociceptive effects in rats with mononeuropathy, indicating camkii may play important roles in transmission of nociceptive information in the nac of mononeuropathic rats. |
2015-06-05 |
2023-01-25 |
rat |
| Yan-Li Liu, Ben Liu, Yang-Yang Qu, Hui-Juan Chai, Rui Li, Ling Zhan. [Oxidative stress and calcium/calmodulin-dependent protein kinase II contribute to the development of sustained \\xce\\xb2 adrenergic receptor-stimulated cardiac hypertrophy in rats]. Sheng li xue bao : [Acta physiologica Sinica] vol 65 issue 1 2015 23426507 |
in this study, we observe how n-acetylcysteine (nac) affects the oxidative stress and calcium/calmodulin-dependent protein kinase ii (camkii) expression in heart of isoproterenol (iso)-stimulated rats, and investigate whether oxidative stress and camkii contribute to the development of sustained \xce\xb2ar-stimulated cardiac hypertrophy. |
2015-05-16 |
2023-01-25 |
rat |