All Relations between camkii and nac

Publication Sentence Publish Date Extraction Date Species
Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior. 2023-03-04. PMID:36870422. the present study demonstrated for the first time that acute as well as subchronic (4 days) administration of the experimental ghs-r1a antagonist jmv2959 in usual intraperitoneal doses including 3 mg/kg, had no influence on memory functions tested in the morris water maze in rats as well as no significant effects on the molecular markers linked with memory processing in selected brain areas in rats, specifically on the β-actin, c-fos, two forms of the calcium/calmodulin-dependent protein kinase ii (camkii, p-camkii) and the camp-response element binding protein (creb, p-creb), within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum, and hippocampus (hipp). 2023-03-04 2023-08-14 rat
Inês M Amaral, Laura Scheffauer, Angelika B Langeder, Alex Hofer, Rana El Rawa. Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens. Biomedicines. vol 9. issue 12. 2021-12-24. PMID:34944702. in order to investigate the role of nac camkii in the expression of reward-related learning of drug versus non-drug stimuli, we inhibited camkii through an infusion of kn-93, a camkii inhibitor, directly into the nac shell or core, before the cpp test in a concurrent paradigm in which social interaction was made available in the compartment alternative to the one associated with cocaine during conditioning. 2021-12-24 2023-08-13 rat
Inês M Amaral, Laura Scheffauer, Angelika B Langeder, Alex Hofer, Rana El Rawa. Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens. Biomedicines. vol 9. issue 12. 2021-12-24. PMID:34944702. however, little is known about the contribution of camkii signaling in the nucleus accumbens (nac) in natural rewards such as social interaction. 2021-12-24 2023-08-13 rat
Inês M Amaral, Laura Scheffauer, Angelika B Langeder, Alex Hofer, Rana El Rawa. Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens. Biomedicines. vol 9. issue 12. 2021-12-24. PMID:34944702. altogether, these results suggest that social interaction reward engages camkii in the nac. 2021-12-24 2023-08-13 rat
Haniyeh Soltani, Mitra-Sadat Sadat-Shirazi, Bahareh Pakpour, Ghorbangol Ashabi, Mohammad-Reza Zarrindas. Toxic effect of calcium/calmodulin kinase II on anxiety behavior, neuronal firing and plasticity in the male offspring of morphine-abstinent rats. Behavioural brain research. vol 395. 2021-10-13. PMID:32841609. the expression level of the c-fos was not significantly altered by the inhibition of camkii in the amygdala, but the c-fos level was reduced in the nac. 2021-10-13 2023-08-13 rat
Haniyeh Soltani, Mitra-Sadat Sadat-Shirazi, Bahareh Pakpour, Ghorbangol Ashabi, Mohammad-Reza Zarrindas. Toxic effect of calcium/calmodulin kinase II on anxiety behavior, neuronal firing and plasticity in the male offspring of morphine-abstinent rats. Behavioural brain research. vol 395. 2021-10-13. PMID:32841609. according to the critical role of calcium/calmodulin protein kinaseii (camkii) in these processes, the present study examined the effect of camkii inhibitor (kn93) on neuronal activity and level of c-fos in the amygdala and nucleus accumbens (nac) in the offspring of morphine-exposed parents. 2021-10-13 2023-08-13 rat
Yu-Gang Lu, Long Wang, Jiang-Long Chen, Jiao Zhu, Xiao-Yan Meng, Zhen-Dong You, Wei-Feng Y. Projections from lateral habenular to tail of ventral tegmental area contribute to inhibitory effect of stress on morphine-induced conditioned place preference. Brain research. vol 1717. 2020-09-24. PMID:30914248. meanwhile, we detected the expression of darpp-32 phosphorylation (p-darpp-32) in the nucleus accumbens (nac), and camkii in lhb. 2020-09-24 2023-08-13 rat
Kia J Jackson, Pretal P Muldoon, Carrie Walters, Mohamad Imad Dama. Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice. Behavioural pharmacology. vol 27. issue 1. 2016-09-19. PMID:26292186. further, we assessed camkii activity in the ventral tegmental area (vta), nucleus accumbens (nac), prefrontal cortex, and hippocampus after nicotine cpp and found significant increases in camkii activity in the mouse vta and nac that were blocked by camkii antagonists. 2016-09-19 2023-08-13 mouse
Kia J Jackson, Pretal P Muldoon, Carrie Walters, Mohamad Imad Dama. Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice. Behavioural pharmacology. vol 27. issue 1. 2016-09-19. PMID:26292186. the findings from this study show that camkii mediates nicotine reward and suggest that increases in camkii activity in the vta and nac are relevant to nicotine reward behaviors. 2016-09-19 2023-08-13 mouse
Yan Li, Ruiming Zhu, Wenjing Wang, Dengqi Fu, Jing Hou, Sen Ji, Bo Chen, Zhengtao Hu, Xue Shao, Xuri Yu, Qian Zhao, Baolai Zhang, Changman Du, Qian Bu, Chunyan Hu, Yun Tang, Lei Zhong, Shengyong Yang, Yinglan Zhao, Xiaobo Ce. Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 37. 2016-01-04. PMID:26377474. additionally, the suppression of prmt1 in nac with lentiviral-short hairpin pmrt1 decreases levels of camkii and cdk5 in the cocaine-treated group, demonstrating that prmt1 affects the ability of cocaine to induce camkii and cdk5 in nac. 2016-01-04 2023-08-13 mouse
Yan Li, Ruiming Zhu, Wenjing Wang, Dengqi Fu, Jing Hou, Sen Ji, Bo Chen, Zhengtao Hu, Xue Shao, Xuri Yu, Qian Zhao, Baolai Zhang, Changman Du, Qian Bu, Chunyan Hu, Yun Tang, Lei Zhong, Shengyong Yang, Yinglan Zhao, Xiaobo Ce. Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 37. 2016-01-04. PMID:26377474. we also found that h4r3me2a is upregulated in nac after repeated cocaine administration, and that h4r3me2a upregulation in turn controls the expression of cdk5 and camkii. 2016-01-04 2023-08-13 mouse
Ji Seon Son, Young Chan Jeong, Young Bae Kwo. Regulatory effect of bee venom on methamphetamine-induced cellular activities in prefrontal cortex and nucleus accumbens in mice. Biological & pharmaceutical bulletin. vol 38. issue 1. 2015-12-15. PMID:25744457. these findings suggest that bv acupuncture may exert a suppressive effect on meth-induced addiction via regulation of signaling cascades of Δfosb, erk, and camkii in pfc and nac. 2015-12-15 2023-08-13 mouse
Hui Bian, Long-Chuan Y. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy. Neuroscience letters. vol 599. 2015-10-16. PMID:26022629. intra-nucleus accumbens (nac) injection of 3 μg, 6 μg and 12 μg of myristoylated autocamtide-2-inhibitory peptide (aip), the camkii inhibitor, dose-dependently increased the hwl to noxious thermal and mechanical stimulation in rats with mononeuropathy. 2015-10-16 2023-08-13 rat
Hui Bian, Long-Chuan Y. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy. Neuroscience letters. vol 599. 2015-10-16. PMID:26022629. taken together, the results showed that intra-nac injection of aip induced significant antinociceptive effects in rats with mononeuropathy, indicating that camkii may play an important role in the transmission and/or modulation of nociceptive information in the nac in rats with mononeuropathy. 2015-10-16 2023-08-13 rat
Hui Bian, Long-Chuan Y. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy. Neuroscience letters. vol 583. 2015-06-05. PMID:25218714. the results demonstrated that intra-nac injection of kn93 induced significant antinociceptive effects in rats with mononeuropathy, indicating camkii may play important roles in transmission of nociceptive information in the nac of mononeuropathic rats. 2015-06-05 2023-08-13 rat
Yan-Li Liu, Ben Liu, Yang-Yang Qu, Hui-Juan Chai, Rui Li, Ling Zhan. [Oxidative stress and calcium/calmodulin-dependent protein kinase II contribute to the development of sustained β adrenergic receptor-stimulated cardiac hypertrophy in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 1. 2015-05-16. PMID:23426507. in this study, we observe how n-acetylcysteine (nac) affects the oxidative stress and calcium/calmodulin-dependent protein kinase ii (camkii) expression in heart of isoproterenol (iso)-stimulated rats, and investigate whether oxidative stress and camkii contribute to the development of sustained βar-stimulated cardiac hypertrophy. 2015-05-16 2023-08-12 rat
A J Robison, Vincent Vialou, Hao-Sheng Sun, Benoit Labonte, Sam A Golden, Caroline Dias, Gustavo Turecki, Carol Tamminga, Scott Russo, Michelle Mazei-Robison, Eric J Nestle. Fluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ΔFosB binding and antidepressant effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24240473. recent work in addiction models demonstrates that the transcription factor Δfosb and protein kinase calmodulin-dependent protein kinase ii (camkii) are co-regulated in nucleus accumbens (nac), a brain reward region implicated in both addiction and depression models including social defeat. 2014-12-01 2023-08-12 mouse
Xiaojie Liu, Yong Liu, Peng Zhong, Brianna Wilkinson, Jinshun Qi, Christopher M Olsen, K Ulrich Bayer, Qing-song Li. CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 4. 2014-10-10. PMID:24154664. we examined whether blocking camkii activity in the vta affected cocaine conditioned place preference (cpp) and cocaine-evoked synaptic plasticity in its target brain region, the nac. 2014-10-10 2023-08-12 Not clear
Xiaojie Liu, Yong Liu, Peng Zhong, Brianna Wilkinson, Jinshun Qi, Christopher M Olsen, K Ulrich Bayer, Qing-song Li. CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 4. 2014-10-10. PMID:24154664. these results suggest that camkii activity in the vta governs cocaine-evoked synaptic plasticity in the nac during the time window of cocaine conditioning. 2014-10-10 2023-08-12 Not clear
Alfred J Robison, Vincent Vialou, Michelle Mazei-Robison, Jian Feng, Saïd Kourrich, Miles Collins, Sunmee Wee, George Koob, Gustavo Turecki, Rachael Neve, Mark Thomas, Eric J Nestle. Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 10. 2013-04-26. PMID:23467346. furthermore, induction of dendritic spines on nac msns and increased behavioral responsiveness to cocaine after nac overexpression of Δfosb are both camkii dependent. 2013-04-26 2023-08-12 human