| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alfred J Robison, Vincent Vialou, Michelle Mazei-Robison, Jian Feng, Saïd Kourrich, Miles Collins, Sunmee Wee, George Koob, Gustavo Turecki, Rachael Neve, Mark Thomas, Eric J Nestle. Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 10. 2013-04-26. PMID:23467346. |
importantly, we demonstrate for the first time induction of Δfosb and camkii in the nac of human cocaine addicts, suggesting possible targets for future therapeutic intervention. |
2013-04-26 |
2023-08-12 |
human |
| Zhuo Liu, Xiao-Dong Liu, Jian-Jun Zhang, Long-Chuan Y. Increases in αCaMKII phosphorylated on Thr286 in the nucleus accumbens shell but not the core during priming-induced reinstatement of morphine-seeking in rats. Neuroscience letters. vol 526. issue 1. 2012-12-10. PMID:22884929. |
in this study, we detected the changes of camkii protein levels in the nucleus accumbens (nac), a key nucleus involved in drug-reward, during the reinstatement of morphine-seeking behavior with animal model of morphine self-administration in rats. |
2012-12-10 |
2023-08-12 |
rat |
| Zhuo Liu, Xiao-Dong Liu, Jian-Jun Zhang, Long-Chuan Y. Increases in αCaMKII phosphorylated on Thr286 in the nucleus accumbens shell but not the core during priming-induced reinstatement of morphine-seeking in rats. Neuroscience letters. vol 526. issue 1. 2012-12-10. PMID:22884929. |
moreover, considering that the nac is also involved in the natural reward-related learning and memory, we detected the changes of camkii protein levels in the nac during the reinstatement of natural reward-seeking with animal model of saccharin self-administration as a control. |
2012-12-10 |
2023-08-12 |
rat |
| Zhuo Liu, Jian-Jun Zhang, Xiao-Dong Liu, Long-Chuan Y. Inhibition of CaMKII activity in the nucleus accumbens shell blocks the reinstatement of morphine-seeking behavior in rats. Neuroscience letters. vol 518. issue 2. 2012-10-04. PMID:22579819. |
here, we explored the roles of camkii in the nucleus accumbens (nac) shell in the extinction and reinstatement of morphine-seeking behavior. |
2012-10-04 |
2023-08-12 |
rat |
| Saïd Kourrich, Jason R Klug, Mark Mayford, Mark J Thoma. AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 19. 2012-07-06. PMID:22573680. |
while behavior in rodent addiction models is linked with camkii activity in the nucleus accumbens (nac) shell, the key cellular adaptations that forge this link are unclear. |
2012-07-06 |
2023-08-12 |
mouse |
| Saïd Kourrich, Jason R Klug, Mark Mayford, Mark J Thoma. AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 19. 2012-07-06. PMID:22573680. |
this study identifies camkii regulation of ia in nac shell neurons as a novel cellular contributor to the sensitization of cocaine reward. |
2012-07-06 |
2023-08-12 |
mouse |
| K J Jackson, C L Walters, M I Dama. Beta 2 subunit-containing nicotinic receptors mediate acute nicotine-induced activation of calcium/calmodulin-dependent protein kinase II-dependent pathways in vivo. The Journal of pharmacology and experimental therapeutics. vol 330. issue 2. 2009-08-19. PMID:19435931. |
moreover, we show that when animals are pretreated with the camkii inhibitors 4-[(2s)-2-[(5-isoquinolinylsulfonyl) methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl isoquinolinesulfonic acid ester (kn-62) and n-[2-[[[3-(4-chlorophenyl)-2 propenyl]methylamino]methyl]phenyl]-n-(2-hydroxyethyl)-4-methoxybenzenesulphonamide (kn-93), nicotine-induced increase in the kinase activity and pcreb was attenuated in the vta and nac, whereas pretreatment with (2-[n-(4-methoxybenzenesulfonyl)]amino-n-(4-chlorocinnamyl)-n-methylbenzylamine, phosphate) (kn-92), the inactive analog, did not alter the nicotine-induced increase in pcreb. |
2009-08-19 |
2023-08-12 |
mouse |
| K J Jackson, C L Walters, M I Dama. Beta 2 subunit-containing nicotinic receptors mediate acute nicotine-induced activation of calcium/calmodulin-dependent protein kinase II-dependent pathways in vivo. The Journal of pharmacology and experimental therapeutics. vol 330. issue 2. 2009-08-19. PMID:19435931. |
we first show that administration of nicotine increases camkii activity in the ventral tegmental area (vta), nucleus accumbens (nac), and amygdala. |
2009-08-19 |
2023-08-12 |
mouse |
| K J Jackson, C L Walters, M I Dama. Beta 2 subunit-containing nicotinic receptors mediate acute nicotine-induced activation of calcium/calmodulin-dependent protein kinase II-dependent pathways in vivo. The Journal of pharmacology and experimental therapeutics. vol 330. issue 2. 2009-08-19. PMID:19435931. |
taken together, these data suggest that the nicotine-induced increase in camkii activity may correlate with the nicotine-induced increase in psynapsin i and pcreb in the vta and nac via beta2 subunit-containing nachrs. |
2009-08-19 |
2023-08-12 |
mouse |
| Yan Pan, Ermanda Siregar, Kenneth D Car. Striatal cell signaling in chronically food-restricted rats under basal conditions and in response to brief handling. Neuroscience letters. vol 393. issue 2-3. 2006-03-14. PMID:16239070. |
given the established involvement of mitogen-activated protein kinase (mapk) and camkii in synaptic plasticity, learning and memory, the increase in basal phospho-mek and hyperresponsiveness of camkii in nac may represent adaptive cellular responses to persistent negative energy balance that facilitate associative learning in connection with food-seeking. |
2006-03-14 |
2023-08-12 |
human |
| Yan Pan, Ermanda Siregar, Kenneth D Car. Striatal cell signaling in chronically food-restricted rats under basal conditions and in response to brief handling. Neuroscience letters. vol 393. issue 2-3. 2006-03-14. PMID:16239070. |
specifically, d-1 dopamine (da) receptor agonist challenge produced stronger activation of extracellular signal-regulated kinase (erk), calcium-calmodulin-dependent kinase ii (camkii), and the nuclear transcription factor camp response element binding protein (creb) in nucleus accumbens (nac) of food-restricted (fr) relative to ad libitum fed (al) rats. |
2006-03-14 |
2023-08-12 |
human |